健康成人膀胱储尿功能的大脑静息态功能网络连接研究
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摘要
目的:研究采用静息态功能磁共振(rs-fMRI)成像技术分析健康成人膀胱储尿功能的大脑功能网络连接。方法:2014年10月~2016年10月筛选健康受试者44例,其中男19例,女25例,年龄22~50岁,均为右利手。分别在膀胱空虚状态和膀胱充盈状态进行2次rs-fMRI扫描。扫描后通过rs-fMRI分析软件Matlab、SPM8、DPABI等进行处理分析。选取左侧前额叶(X=-39,Y=45,Z=-12);右侧前额叶(X=3,Y=49,Z=40);左侧前扣带回(X=-7,Y=-30,Z=-6);右侧前扣带回(X=9,Y=42,Z=-6);左侧颞叶(X=-33,Y=-51,Z=6);左侧颞上回(X=-57,Y=-18,Z=9)6个种子点,进行全脑功能连接。结果:6个种子的全脑功能连接区域:左侧前额叶,激活区域为双侧岛叶,右侧额下回;抑制区域为左侧海马旁回,左侧枕叶,左侧前额叶。右侧前额叶,抑制区域为左侧岛叶。左侧颞叶,抑制区域为右侧眶额叶。左侧颞上回,激活区域为左侧前额叶,右侧距状回;抑制区域为右侧小脑。左侧颞叶,激活区域为海马旁回;抑制区域为右侧额下回,右侧旁中央小叶。左侧颞上回,激活区域为左侧前额叶,左侧额中回,左侧中央颞叶;抑制区域为右侧岛叶,左侧小脑,左侧颞上回。结论:通过功能连接(functional connectivity,FC)分析发现大脑控尿区域不是某一区域单独完成的,而是广泛的、存在着功能相关性的多个区域共同协调完成的。
Objective:To observe brain functional network during naturally occurring urinary bladder storage in healthy subjects by examining brain areas that control strong bladder sensation by resting-state functional magnetic resonance imaging(rs-fMRI).Method:From October 2014 to October 2016,44 healthy subjects including19 men and 25 women whose age was 22-50 years old were screened in the study.All subjects were right-handed.All subjects were scanned twice under the following two conditions:empty bladder and full bladder.Brain imaging softwares(Matlab,SPM8,DPABI)were adopted to analyze the difference in brain-blood perfusion between the two conditions.Six seed points were selected to perform a whole brain function connection:the left prefrontal cortex(X=-39,Y=45,Z=-12);the right prefrontal cortex(X=3,Y=49,Z=40);the left anterior cingulate gyrus(X=-7,Y=-30,Z=-6);the right anterior cingulate(X=9,Y=42,Z=-6);the left temporal lobe(X=-33,Y=-51,Z=6);left superior temporal gyrus(X=-57,Y=-18,Z=9).Result:The brain functional connectivity area of these six seed points:the left prefrontal lobe whose activation areas are bilateral insular lobes and right lateral frontal gyrus and the suppressive areas are the left parahippocampal gyrus,left occipital lobe and left prefrontal lobe;the right prefrontal lobe whose suppressive area is the left insular lobe;the left temporal lobe whose suppressive area is the right orbital frontal lobe;the left superior temporal gyrus whose activation areas are the left prefrontal lobe and the right lateral gyrus and the suppressive area is the right cerebellum;the left temporal lobe whose activation area is the parahippocampal gyrus and the suppressive areas are the right lateral frontal gyrus and the right paracentral lobule;the left superior temporal gyrus whose activation areas are the left frontal lobe,the left middle frontal gyrus and the left central temporal lobe,and the suppressive areas are the right insula,the left cerebellum and the left superior temporal gyrus.Conclusion:The functional connectivity analysis found that the brain area of urinary control is not in a region alone,but a wide range of areas.These multiple regional correlations jointly completed the function.
Objective:To observe brain functional network during naturally occurring urinary bladder storage in healthy subjects by examining brain areas that control strong bladder sensation by resting-state functional magnetic resonance imaging(rs-fMRI).Method:From October 2014 to October 2016,44 healthy subjects including19 men and 25 women whose age was 22-50 years old were screened in the study.All subjects were right-handed.All subjects were scanned twice under the following two conditions:empty bladder and full bladder.Brain imaging softwares(Matlab,SPM8,DPABI)were adopted to analyze the difference in brain-blood perfusion between the two conditions.Six seed points were selected to perform a whole brain function connection:the left prefrontal cortex(X=-39,Y=45,Z=-12);the right prefrontal cortex(X=3,Y=49,Z=40);the left anterior cingulate gyrus(X=-7,Y=-30,Z=-6);the right anterior cingulate(X=9,Y=42,Z=-6);the left temporal lobe(X=-33,Y=-51,Z=6);left superior temporal gyrus(X=-57,Y=-18,Z=9).Result:The brain functional connectivity area of these six seed points:the left prefrontal lobe whose activation areas are bilateral insular lobes and right lateral frontal gyrus and the suppressive areas are the left parahippocampal gyrus,left occipital lobe and left prefrontal lobe;the right prefrontal lobe whose suppressive area is the left insular lobe;the left temporal lobe whose suppressive area is the right orbital frontal lobe;the left superior temporal gyrus whose activation areas are the left prefrontal lobe and the right lateral gyrus and the suppressive area is the right cerebellum;the left temporal lobe whose activation area is the parahippocampal gyrus and the suppressive areas are the right lateral frontal gyrus and the right paracentral lobule;the left superior temporal gyrus whose activation areas are the left frontal lobe,the left middle frontal gyrus and the left central temporal lobe,and the suppressive areas are the right insula,the left cerebellum and the left superior temporal gyrus.Conclusion:The functional connectivity analysis found that the brain area of urinary control is not in a region alone,but a wide range of areas.These multiple regional correlations jointly completed the function.
引文
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2高轶,赵玲娜,廖利民.大脑控制膀胱储尿功能的静息态功能核磁成像研究[J].中华泌尿外科杂志,2017,11(38):810-814.
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4梁夏,王金辉,贺永.人脑连接组研究:脑结构网络和脑功能网络[J].科学通报,2010,55(16):1565-1583.
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9 Griffiths D,Derbyshire S,Stenger A,et al.Brain control of normal and overactive bladder[J].J Urol,2005,174:1862-1867.
10 Kuhtz-Buschbeck J P,van der Horst C,Pott C,et al.Cortical representation of the urge to void:A functional magnetic resonance imaging study[J].J Urol,2005,174(4Pt 1):1477-1481.
11 Griffiths D,Tadic S D,Schaefer W,et al.Cerebral control of the bladder in normal and urge incontinent women[J].Neuroimage,2007,37(1):1-7.
12 Sugaya K,Nishijima S,Miyazato M,et al.Central nervous control of micturition and urine storage[J].JSmooth Muscle Res,2005,41(3):117-132.
13 Blok B F,Groen J,Bosch J L,et al.Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators[J].BJU Int,2006,98(6):1238-1243.
14 Margulies D S,Kelly A M,Uddin L Q,et al.Mapping the functional connectivity of anterior cingulate cortex[J].Neuroimage,2007,37(2):579-588.
15 Amodio D M,Frith C D.Meeting of minds:the medial frontal cortex and social cognition[J].Nat Rev Neurosci,2006,7(4):268-277.
16 Burruss J W,Hurley R A,Taber K H,et al.Functional neuroanatomy of the frontal lobe circuits[J].Radiology,2000,214(1):227-230.
17 Andrew J,Nathan P W.Lesions of the anterior frontal lobes and disturbances of micturition and defaecation[J].Brain,1964,87:233-262.
2高轶,赵玲娜,廖利民.大脑控制膀胱储尿功能的静息态功能核磁成像研究[J].中华泌尿外科杂志,2017,11(38):810-814.
3 Friston K J.Functional and effective connectivity:a review[J].Brain Connect,2011,1(1):13-36.
4梁夏,王金辉,贺永.人脑连接组研究:脑结构网络和脑功能网络[J].科学通报,2010,55(16):1565-1583.
5 Blok B F,Willemsen A T,Holstege G.A PET study on brain control of micturition in humans[J].Brain,1997,120(Pt 1):111-121.
6 Nour S,Svarer C,Kristensen J K,et al.Cerebral activation during micturition in normal men[J].Brain,2000,123(Pt 4):781-789.
7 Athwal B S,Berkley K J,Hussain I,et al.Brain responses to changes in bladder volume and urge to void in healthy men[J].Brain,2001,124(Pt 2):369-377.
8 Matsuura S,Kakizaki H,Mitsui T,et al.Human brain region response to distention or cold stimulation of the bladder:apositron emission tomography study[J].JUrol 2002,168(5):2035-2039.
9 Griffiths D,Derbyshire S,Stenger A,et al.Brain control of normal and overactive bladder[J].J Urol,2005,174:1862-1867.
10 Kuhtz-Buschbeck J P,van der Horst C,Pott C,et al.Cortical representation of the urge to void:A functional magnetic resonance imaging study[J].J Urol,2005,174(4Pt 1):1477-1481.
11 Griffiths D,Tadic S D,Schaefer W,et al.Cerebral control of the bladder in normal and urge incontinent women[J].Neuroimage,2007,37(1):1-7.
12 Sugaya K,Nishijima S,Miyazato M,et al.Central nervous control of micturition and urine storage[J].JSmooth Muscle Res,2005,41(3):117-132.
13 Blok B F,Groen J,Bosch J L,et al.Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators[J].BJU Int,2006,98(6):1238-1243.
14 Margulies D S,Kelly A M,Uddin L Q,et al.Mapping the functional connectivity of anterior cingulate cortex[J].Neuroimage,2007,37(2):579-588.
15 Amodio D M,Frith C D.Meeting of minds:the medial frontal cortex and social cognition[J].Nat Rev Neurosci,2006,7(4):268-277.
16 Burruss J W,Hurley R A,Taber K H,et al.Functional neuroanatomy of the frontal lobe circuits[J].Radiology,2000,214(1):227-230.
17 Andrew J,Nathan P W.Lesions of the anterior frontal lobes and disturbances of micturition and defaecation[J].Brain,1964,87:233-262.