尿微量清蛋白在乙型肝炎病毒相关性肾炎早期诊断中的应用价值
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摘要
目的探讨尿微量清蛋白(U-mAlb)在乙型肝炎病毒相关性肾炎(HBV-GN)早期诊断中的应用价值。方法选取2016年3月～2018年2月肇庆市第二人民医院病理确诊为HBV-GN的51例患者为观察A组,HBV感染无肾损害患者45例为观察B组,同时选取HBV标志物阴性健康体检者50例为对照组,分别检测三组的U-mAlb、血肌酐(SCr)、血尿素氮(BUN)、β2-微球蛋白(β2-MG)水平,并进行统计学比较。结果观察A组的U-mAlb、β2-MG、SCr、BUN水平及U-mAlb阳性率明显高于观察B组、对照组,差异有统计学意义(P<0.05)。观察A组的UmAlb阳性率明显高于同组内β2-MG、SCr、BUN,差异有统计学意义(P<0.05)。结论 U-mAlb可用作HBV-GN早期诊断的一种有效无创指标,在临床诊断中有较大的应用价值。
Objective To discuss the application value of urinary microalbumin(U-mAlb) in early diagnosis of hepatitis B virus associated glomerulonephritis(HBV-GN). Methods From March 2016 to February 2018, 51 patients with HBV-GN diagnosed by pathology in the Second People′s Hospital of Zhaoqing City were selected as the observation group A. Forty-five patients with HBV infection without kidney damage were the observation group B, and 50 healthy people with negative HBV markers were selected as the control group. The levels of U-mAlb, serum creatinine(SCr),blood urea nitrogen(BUN), and β2-microglobulin(β2-MG) were detected in the three groups, and compared statistically. Results The levels of U-mAlb, β2-MG, SCr, BUN and the positive rate of U-mAlb in the observation group A were significantly higher than those in the observation group B and control group, and the differences were statistical significant(P<0.05). The positive rate of U-mAlb in the observation group A was significantly higher than of β2-MG, SCr,BUN in the same group(P<0.05). Conclusion U-mAlb can be used as an effective non-invasive marker for early diagnosis of HBV-GN, and has a great application value in clinical diagnosis.
Objective To discuss the application value of urinary microalbumin(U-mAlb) in early diagnosis of hepatitis B virus associated glomerulonephritis(HBV-GN). Methods From March 2016 to February 2018, 51 patients with HBV-GN diagnosed by pathology in the Second People′s Hospital of Zhaoqing City were selected as the observation group A. Forty-five patients with HBV infection without kidney damage were the observation group B, and 50 healthy people with negative HBV markers were selected as the control group. The levels of U-mAlb, serum creatinine(SCr),blood urea nitrogen(BUN), and β2-microglobulin(β2-MG) were detected in the three groups, and compared statistically. Results The levels of U-mAlb, β2-MG, SCr, BUN and the positive rate of U-mAlb in the observation group A were significantly higher than those in the observation group B and control group, and the differences were statistical significant(P<0.05). The positive rate of U-mAlb in the observation group A was significantly higher than of β2-MG, SCr,BUN in the same group(P<0.05). Conclusion U-mAlb can be used as an effective non-invasive marker for early diagnosis of HBV-GN, and has a great application value in clinical diagnosis.
引文
[1]张国山,王芳,安爽,等.乙型肝炎病毒相关性肾炎的研究进展[J].中国老年学杂志,2015,35(2):1130-1132.
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[7]王力芬,叶智明,徐丽霞,等.尿HBVDNA在乙型肝炎病毒相关性肾炎诊断中的价值[J].南方医科大学学报,2014,34(11):1705-1706.
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[11]亣海萍,吕卫华,武琳,等.糖化血红蛋白、同型半胱氨酸及尿微量白蛋白与2型糖尿病合并肾脏微血管病变的关系研究[J].中国实验诊断学,2016,26(18):69-71.
[12]张成诗,吴兵,魏光明.血清CysC、Hcy和U-mAlb联合检测在早期糖尿病肾病诊断中的临床应用研究[J].中国实验诊断学,2014,5(18):733-735.
[13]盛云建,邓存良,宁新文.乙肝病毒感染者早期肾损伤的监测及其影响因素[J].中国煤炭工业医学杂志,2005,8(2):126-127.
[14]Pistrosch F,Herbrig K,Kindel B,et al.Rosiglitazone improves glomerular hyperfiltration,renal endothelial dysfunction,and microalbuminuria of incipient diabetic nephropathy in patients[J].Diabetes,2013,54(7):2206.
[15]孟秀娟,王付得,吴凤荣,等.β2-微球蛋白检测在慢性乙肝早期肾功能损害中的价值[J].河北医药,2002,24(6):461-462.
[16]黄俊,王永红,马华兰.血清胱抑素C、β2-微球蛋白、尿微量白蛋白联合检测在糖尿病肾病早期诊断中的临床价值[J].中国卫生检验杂志,2017,27(1):54-56.
[2]易富,李娅,蔡敏琪,等.HBV感染者肾损害的统计分析[J].西南国防医药,2013,23(12):1343-1344.
[3]王轩,周益,袁伟杰,等.经HBX转染后的肾小管上皮细胞对T细胞激活,分化的影响[J].中华肾脏杂志,2013,29(7):503-508.
[4]邱志洁,蓝健姿,严晓华,等.76例乙肝相关性肾炎的临床资料分析[J].福建中医学院学报,2008,18(3):11-13.
[5]潘宗海.中医药治疗乙肝相关性肾炎的研究进展[A]//中华中医药学会第二十六次肾病分会学术交流会议论文集[C].2013:548-549.
[6]魏日胞,李平,吴杰,等.205例乙型肝炎病毒相关肾炎的临床及病理研究[J].中华实验和临床病毒学杂志,2010,24(6):464-467.
[7]王力芬,叶智明,徐丽霞,等.尿HBVDNA在乙型肝炎病毒相关性肾炎诊断中的价值[J].南方医科大学学报,2014,34(11):1705-1706.
[8]Ayodele OE,Salako BL,Kadiri S,et al.Hepatitisbvirus infection:implicationsin chronic kidney disease, dialysis and transplantation[J].Afr J Med Med Sci,2006,35(2):11l-119.
[9]中华内科杂志编委会.乙型肝炎病毒相关性肾炎座谈会纪要[J].中华内科杂志,1990,29(9):519-521.
[10]甘晓辉,张林,朱静.乙肝相关性肾炎的临床特征[J].四川医学,2013,34(4):489-491.
[11]亣海萍,吕卫华,武琳,等.糖化血红蛋白、同型半胱氨酸及尿微量白蛋白与2型糖尿病合并肾脏微血管病变的关系研究[J].中国实验诊断学,2016,26(18):69-71.
[12]张成诗,吴兵,魏光明.血清CysC、Hcy和U-mAlb联合检测在早期糖尿病肾病诊断中的临床应用研究[J].中国实验诊断学,2014,5(18):733-735.
[13]盛云建,邓存良,宁新文.乙肝病毒感染者早期肾损伤的监测及其影响因素[J].中国煤炭工业医学杂志,2005,8(2):126-127.
[14]Pistrosch F,Herbrig K,Kindel B,et al.Rosiglitazone improves glomerular hyperfiltration,renal endothelial dysfunction,and microalbuminuria of incipient diabetic nephropathy in patients[J].Diabetes,2013,54(7):2206.
[15]孟秀娟,王付得,吴凤荣,等.β2-微球蛋白检测在慢性乙肝早期肾功能损害中的价值[J].河北医药,2002,24(6):461-462.
[16]黄俊,王永红,马华兰.血清胱抑素C、β2-微球蛋白、尿微量白蛋白联合检测在糖尿病肾病早期诊断中的临床价值[J].中国卫生检验杂志,2017,27(1):54-56.