肝型Wilson病患儿智力结构及心理行为特点分析
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摘要
目的研究肝型Wilson病儿童智力结构及心理行为学的特点。方法选取安徽省中医院脑病中心2013年1月至2016年12月收治的40例肝型Wilson病患儿作为观察组,并选取同期40例健康儿童作为对照组。采用中国修订的韦氏儿童智力测验量表(C-WISC)和Achenbach儿童行为量表分别对两组儿童进行测验,比较两组儿童的智力结构及心理行为的差异。结果观察组患儿与对照组儿童智力结构比较差异无统计学意义(P>0.05);观察组患儿在多动、强迫性、交往不良、违纪、攻击性、社交退缩评分均高于对照组,差异有统计学意义(P<0.05)。结论肝型Wilson病患儿智力总体水平与正常儿童无差异性;而其心理行为存在多方面的异常,主要表现为多动、强迫性、交往不良、违纪、攻击性、社交退缩。
Objective To explore the characteristics of intelligence structure and psychological behavior in those children with hepatic type Wilson's disease (WD).Methods 40 patients with hepatic type WD,ever treated in our hospital from Jan 2013 to Dec 2016,were enrolled as the study group,and other 40 healthy children were enrolled simultaneously as the control group.Both groups were tested by Chinese-revised Wechsler intelligence scale for children (C-WISC) and Achenbach child behavior checklist (CBCL),and the differences of intelligence structure and psychological behavior between the two groups were compared.Results There was no significant difference in the intelligence structure between the children of two groups (P > 0.05).The scores of hyperactivity,obsessive-compulsive behavior,poor communication,rule-breaking behavior,aggressive behavior and social withdrawal in the patients of study group were significantly higher than those in the children of control group,with statistically significant differences (all P < 0.05).Conclusion The difference of general intelligence between hepatic type WD patients and healthy children isn't significant,but the children with hepatic type WD have such disorders of psychological behaviors as hyperactivity,obsessive-compulsive behavior,poor communication,rule-breaking behavior,aggressive behavior and social withdrawal.So,correctly identifying these symptoms of psychological behaviors in the hepatic type WD patients would be helpful to intervene early,and alleviate suffering of the patients and their families.
Objective To explore the characteristics of intelligence structure and psychological behavior in those children with hepatic type Wilson's disease (WD).Methods 40 patients with hepatic type WD,ever treated in our hospital from Jan 2013 to Dec 2016,were enrolled as the study group,and other 40 healthy children were enrolled simultaneously as the control group.Both groups were tested by Chinese-revised Wechsler intelligence scale for children (C-WISC) and Achenbach child behavior checklist (CBCL),and the differences of intelligence structure and psychological behavior between the two groups were compared.Results There was no significant difference in the intelligence structure between the children of two groups (P > 0.05).The scores of hyperactivity,obsessive-compulsive behavior,poor communication,rule-breaking behavior,aggressive behavior and social withdrawal in the patients of study group were significantly higher than those in the children of control group,with statistically significant differences (all P < 0.05).Conclusion The difference of general intelligence between hepatic type WD patients and healthy children isn't significant,but the children with hepatic type WD have such disorders of psychological behaviors as hyperactivity,obsessive-compulsive behavior,poor communication,rule-breaking behavior,aggressive behavior and social withdrawal.So,correctly identifying these symptoms of psychological behaviors in the hepatic type WD patients would be helpful to intervene early,and alleviate suffering of the patients and their families.
引文
[1]葛许华,王苗,邵丽.58例肝豆状核变性所致神经精神障碍的临床特点与误诊分析[J].中风与神经疾病杂志,2013,30(5):412-415.
[2]张影,孙万里.2012欧洲肝脏研究会肝豆状核变性(Wilson病)的诊治指南[J].中华临床医师杂志(电子版),2012,6(19):6011-6012.
[3]徐静,陈图农,丁小玲,等.Achenbach儿童行为量表的初步应用分析[J].中国妇幼健康研究,2015,26(2):194-196.
[4]GNTHER P,HERMANN W.Mild cognitive impairment and depressive symptoms in patients with Wilson’s disease under long-term therapy[J].Fortschr Neurol Psychiatr,2012,80(3):149-153.
[5]胡文彬,吴舒梅,杨金鹏,等.非脑型肝豆状核变性成人患者智商测定结果分析[J].安徽医学,2009,30(2):97-100.
[6]王共强,韩咏竹,杨任民,等.肝豆状核变性患者流体智力的神经心理学研究[J].中国临床神经科学杂志,2009,17(5):490-493.
[7]王共强,胡文彬,胡纪源.Wilson病的神经心理功能障碍[J].医学研究杂志,2011,40(1):147-150.
[8]PRASHANTH L K,SINHA S,TALY A B,et al.Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders?An analysis of 100 cases[J].Movment Disorders,2010,25(1):672-678.
[9]周香雪,黄海威,李洵桦.等.肝豆状核变性精神症状特点、影响因素及排铜治疗的临床研究[J].精神医学杂志,2013,26(6):421-425.
[10]STRACCIARI A,GUARINO M,PAZZAGLIA P,et al.Acquired hepatocerebral degeneration:full recovery after liver transplantation[J].J Neurol Neurosurg Psychiatry,2001,70(1):136-137.
[11]张明兴,洪铭范,苏全喜,等.影响肝豆状核变性患者心理状况相关因素分析[J].牡丹江医学院学报,2014,35(3):19-22.
[12]倪玲,戚荣丰,张龙江,等.轻微型肝性脑病患者脑的3T1H-MRS研究[J].医学影像学杂志,2012,22(3):330-335.
[2]张影,孙万里.2012欧洲肝脏研究会肝豆状核变性(Wilson病)的诊治指南[J].中华临床医师杂志(电子版),2012,6(19):6011-6012.
[3]徐静,陈图农,丁小玲,等.Achenbach儿童行为量表的初步应用分析[J].中国妇幼健康研究,2015,26(2):194-196.
[4]GNTHER P,HERMANN W.Mild cognitive impairment and depressive symptoms in patients with Wilson’s disease under long-term therapy[J].Fortschr Neurol Psychiatr,2012,80(3):149-153.
[5]胡文彬,吴舒梅,杨金鹏,等.非脑型肝豆状核变性成人患者智商测定结果分析[J].安徽医学,2009,30(2):97-100.
[6]王共强,韩咏竹,杨任民,等.肝豆状核变性患者流体智力的神经心理学研究[J].中国临床神经科学杂志,2009,17(5):490-493.
[7]王共强,胡文彬,胡纪源.Wilson病的神经心理功能障碍[J].医学研究杂志,2011,40(1):147-150.
[8]PRASHANTH L K,SINHA S,TALY A B,et al.Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders?An analysis of 100 cases[J].Movment Disorders,2010,25(1):672-678.
[9]周香雪,黄海威,李洵桦.等.肝豆状核变性精神症状特点、影响因素及排铜治疗的临床研究[J].精神医学杂志,2013,26(6):421-425.
[10]STRACCIARI A,GUARINO M,PAZZAGLIA P,et al.Acquired hepatocerebral degeneration:full recovery after liver transplantation[J].J Neurol Neurosurg Psychiatry,2001,70(1):136-137.
[11]张明兴,洪铭范,苏全喜,等.影响肝豆状核变性患者心理状况相关因素分析[J].牡丹江医学院学报,2014,35(3):19-22.
[12]倪玲,戚荣丰,张龙江,等.轻微型肝性脑病患者脑的3T1H-MRS研究[J].医学影像学杂志,2012,22(3):330-335.