基于细胞自噬的中医药抗肿瘤作用研究进展
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摘要
自噬是细胞在能量缺乏等代谢压力下,通过包裹细胞内的蛋白、细胞器和胞质,实现细胞成分的循环利用,从而维持细胞的正常代谢和生存。近期的研究表明,自噬在肿瘤的发生、发展和治疗中具有重要意义,既可以诱发肿瘤细胞死亡又可以介导死亡逃避。中医药既可以调控肿瘤细胞的自噬性死亡,又可以影响其保护性自噬,为中医药抗肿瘤研究提供了新的思路。
Autophagy is a cellular physiological pathway in which damaged or superfluous proteins and organelles are cleared. Autophagy can also maintain homeostasis and viability of cells under metabolic stress by the recycling of these intracellular constituents. Recent studies have shown that autophagy plays an important role in the pathogenesis, development and treatment of tumor, such as induces apoptosis of tumor cells or promotes the escape from cell death. Traditional Chinese medicine(TCM) regulates autophagic cell death(ACD), on the other hand, TCM can impact on the protective autophagy of tumor cells. All of these provide new ideas for research of anti-tumor mechanism.
Autophagy is a cellular physiological pathway in which damaged or superfluous proteins and organelles are cleared. Autophagy can also maintain homeostasis and viability of cells under metabolic stress by the recycling of these intracellular constituents. Recent studies have shown that autophagy plays an important role in the pathogenesis, development and treatment of tumor, such as induces apoptosis of tumor cells or promotes the escape from cell death. Traditional Chinese medicine(TCM) regulates autophagic cell death(ACD), on the other hand, TCM can impact on the protective autophagy of tumor cells. All of these provide new ideas for research of anti-tumor mechanism.
引文
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[33]张瑞娟,许建华,孙珏,等.肠胃清方对人结肠癌HCT116/L-OHP裸鼠皮下移植瘤mi R-30a/Beclin1通路的影响.世界华人消化杂志,2017,25(12):1061-1070
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[2]Song J,Qu Z,Guo X,et al.Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells.Autophagy,2009,5(8):1131-1144
[3]Liu X W,Su Y,Zhu H,et al.HIF-1alpha-dependent autophagy protects HeLa cells from fenretinide(4-HPR)-induced apoptosis in hypoxia.Pharmacol Res,2010,62(5):416-425
[4]Kuma A,Hatano M,Matsui M,et al.The role of autophagy during the early neonatal starvation period.Nature,2004,432:1032-1036
[5]Yamamoto H,Fujioka Y,Suzuki S W,et al.The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes.Dev Cell,2016,38(1):86-99
[6]Lozy F,Karantza V.Autophagy and cancer cell metabolism.Seminars in Cell&Developmental Biology,2012,23(4):395-401
[7]Yang Z J,Chee C E,Huang S,et al.The role of autophagy in cancer:therapeutic implications.Molecular Cancer Therapeutics,2011,10(9):1533-1541
[8]Xing J,Wang H,Xu S,et al.Sensitization of suberoylanilide hydroxamic acid(SAHA)on chemoradiation for human cervical cancer cells and its mechanism.Eur J Gynaecol Oncol,2015,36(2):117-122
[9]罗自娟,曹晨,孙娟娟,等.多西紫杉醇与紫杉醇联合顺铂同步放化疗治疗晚期宫颈癌的疗效比较.现代生物医学进展,2016,16(10):1934-1936
[10]Yoshihiro I,Satoshi W,Ayako S,et al.Persistent activation of Nrf2through p62 in hepatocellular carcinoma cells.Journal of Cell Biology,2011,193(2):275-284
[11]Gibson S B.A matter of balance between life and death:targeting reactive oxygen species(ROS)-induced autophagy for cancer therapy.Autophagy,2010,6:835-837
[12]Chen S,Rehman S K,Zhang W,et al.Autophagy is a therapeutic target in anticancer drug resistance.Biochimicaet Biophysica Acta(BBA)-Reviews on Cancer,2010,1806(2):220-229
[13]Schonewolf C A,Mehta M,Schiff D,et al.Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation.World J Gastrointest Oncol,2014,6(3):74-82
[14]Dragowska W H,Weppler S A,Wang J C,et al.Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer.PLoS One,2013,8(10):e76503
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[20]Xiao K,Jiang J,Guan C,et al.Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells.J Pharmacol Sci,2013,123(2):102-109
[21]何聪,陈清勇,王剑,等.姜黄素下调m TOR诱导人肺癌A549细胞自噬的研究.肿瘤学杂志,2014,20(5):363-368
[22]Klionsky D J,Abdalla F C,Abeliovich H,et al.Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy,2012,8(4):445-544
[23]陈明,王举涛,吴珍妮,等.半枝莲总黄酮通过PI3K/AKT/m TOR通路诱导肿瘤细胞自噬的体内实验研究.中国中药杂志,2017,42(7):1358-1364
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[25]朱飞叶,谢冠群,徐珊.乐胃饮对胃癌前病变大鼠模型自噬基因Beclin1的影响.中华中医药杂志,2017,32(1):282-284
[26]Yang Q,Wu J,Luo Y,et al.(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.Oncotarget,2016,7(38):62585-62597
[27]Tseng C Y,Lin C H,Wu L Y,et al.Potential combinational anticancer therapy in non-small cell Lung cancer with traditional Chinese medicine Sun-Bai-Pi extract and cisplatin.Plos One,2016,11(5):e0155469
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[35]Alayev A,Berger S M,Holz M K.Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation.Annals of the New York Academy of Sciences,2015,1348(1):116-123