杞菊地黄汤加减辅助治疗妊娠期高血压疗效观察
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摘要
目的:观察杞菊地黄汤加减与西药结合治疗妊娠期高血压的临床疗效。方法:选取妊娠期高血压的患者82例,并将其随机分为观察组与对照组,对照组41例,单纯采用硝苯地平缓释片治疗;观察组41例,在对照组的基础上给予杞菊地黄汤加减联合治疗。观察两组治疗效果。结果:观察组临床治疗总有效率明显较对照组高(P<0.05),治疗前两组血压及凝血酶指标均无显著差异(P>0.05),治疗后两组血压、血肌酐(Cr)、血尿素氮(BUN)、尿微量清蛋白(MA)、尿β2-微球蛋白(β2-MG)及凝血酶相关指标均较治疗前显著改善(P<0.05),且治疗后观察组血压、PT、APTT、Fib、Cr、BUN、MA、β2-MG均明显较同时期的对照组优,两组数据差异具有统计学意义(P<0.05);治疗后两组心电图、血常规、尿常规及肝肾功能均无明显异常,观察组不良反应发生率显著低于对照组,两组数据存在统计学差异(P<0.05)。结论:运用杞菊地黄汤加减结合西药治疗妊娠期高血压临床疗效显著,可有效降低患者高血压,促进凝血酶及肾功能的改善,缓解患者的临床症状,且患者引起不良反应较少,值得临床运用推广。
Objective:To observe the clinical efficacy of Qiju Dihuang Decoction combined with western medicine in the treatment of gestational hypertension. Methods:Totally 82 cases of pregnancy-induced hypertension were selected and randomly divided into observation group and control group. In the control group, 41 cases were treated with nifedipine sustained-release tablets alone. The observation group's 41 cases, on the basis of the control group were given Qiju Dihuang Decoction. We observed two groups' treatment effect. Results:The total effective rate of the observation group was significantly higher than that in the control group(P<0.05). There was no significant difference in blood pressure or thrombin before treatment between two groups(P>0.05). BUN, MA, β2-MG and thrombin were all significantly improved(P<0.05). After treatment, the blood pressure, PT, APTT, Fib, Cr, BUN, MA and β2-MG were significantly better than those of the control group at the same period and the difference between the two groups was statistically significant(P<0.05). ECG, blood, urine Routine and liver and kidney function had no significant abnormalities. The adverse reactions in the observation group were significantly less than that of the control group and there was a statistically significant difference between the two groups(P<0.05). Conclusion:The treatment of pregnancy-induced hypertension with Qiju Dihuang Decoction combined with western medicine has significant clinical curative effect, which can effectively reduce the patients' hypertension, promote the improvement of thrombin and renal function, relieve the clinical symptoms of patients and cause fewer adverse reactions, worthy of clinical application promotion.
Objective:To observe the clinical efficacy of Qiju Dihuang Decoction combined with western medicine in the treatment of gestational hypertension. Methods:Totally 82 cases of pregnancy-induced hypertension were selected and randomly divided into observation group and control group. In the control group, 41 cases were treated with nifedipine sustained-release tablets alone. The observation group's 41 cases, on the basis of the control group were given Qiju Dihuang Decoction. We observed two groups' treatment effect. Results:The total effective rate of the observation group was significantly higher than that in the control group(P<0.05). There was no significant difference in blood pressure or thrombin before treatment between two groups(P>0.05). BUN, MA, β2-MG and thrombin were all significantly improved(P<0.05). After treatment, the blood pressure, PT, APTT, Fib, Cr, BUN, MA and β2-MG were significantly better than those of the control group at the same period and the difference between the two groups was statistically significant(P<0.05). ECG, blood, urine Routine and liver and kidney function had no significant abnormalities. The adverse reactions in the observation group were significantly less than that of the control group and there was a statistically significant difference between the two groups(P<0.05). Conclusion:The treatment of pregnancy-induced hypertension with Qiju Dihuang Decoction combined with western medicine has significant clinical curative effect, which can effectively reduce the patients' hypertension, promote the improvement of thrombin and renal function, relieve the clinical symptoms of patients and cause fewer adverse reactions, worthy of clinical application promotion.
引文
[1] 杨东艳,田颖.杞菊地黄汤治疗妊娠高血压综合征的临床疗效[J].陕西中医,2016,37(4):387-389.
[2] 文睿婷,黄琳,于芝颖,等.甲基多巴和拉贝洛尔治疗妊娠期高血压疾病的系统评价[J].中国临床药理学杂志,2017,33(17):1710-1712.
[3] 李彩霞,金红梅.盐酸乌拉地尔注射液联合甲钴胺治疗妊娠期高血压疾病的效果[J].中国妇幼保健,2017,32(20):4937-4939.
[4] 吴奇兵.苯磺酸左旋氨氯地平片与苯磺酸氨氯地平片治疗妊娠期高血压疾病的疗效对比分析[J].中国妇幼保健,2017,32(13):2884-2886.
[5] 王晓君,张守焰,徐志平.小剂量普罗帕酮联合磷酸肌酸钠治疗妊娠期高血压合并阵发性室上性心动过速100例分析[J].广西医学,2017,39(3):406-407.
[6] 许娜.中西医结合治疗妊娠期高血压临床疗效及对凝血酶的影响[J].中华中医药学刊,2017,35(3):761-763.
[7] 王玉双,文亚南,司亚茹.复方丹参注射液治疗重度妊娠期高血压疾病的临床研究[J].中国中西医结合杂志,2017,37(11):1400-1402.
[8] 宋苹.硝苯地平控释片联合硫酸镁对妊娠期高血压的治疗价值分析[J].重庆医学,2017,46(A01):363-364.
[9] 王帆.抗氧化药物对妊娠期高血压疾病预测阳性孕妇的治疗效果及对血流动力学的影响[J].中国计划生育学杂志,2017,25(1):47-50.
[10] 陈寒,蒋红清.硫酸镁联合硝苯地平治疗妊娠期高血压疾病患者的疗效及对血流动力学、尿蛋白表达水平的影响[J].中国妇幼保健,2017,32(14):3170-3172.
[11] 黄运福,石玲婷,廖红苑,等.川芎嗪注射液联合拉贝洛尔治疗妊娠期高血压的临床研究[J].现代药物与临床,2017,32(11):2173-2176.
[12] 杨悦旻,徐先明.妊娠期高血压的降压治疗[J].世界临床药物,2017,38(12):805-809.
[13] 郑军,王晓鹏.妊娠期高血压对胎儿及新生儿的影响[J].中国儿童保健杂志,2017,25(11):1086-1089.
[14] 黄广翅,刘彬,张桂芳,等.尼莫地平联合硫酸镁治疗妊娠期高血压综合征的临床疗效[J].实用心脑肺血管病杂志,2017,25(6):140-142.
[15] 刘枚芳,练鹏颖,李佩珊,等.杞菊地黄丸联合西药治疗干眼症疗效与安全性Meta分析[J].辽宁中医药大学学报,2017,19(2):108-111.
[16] 李昭萍.杞菊地黄汤加二仙汤加减对口腔扁平苔藓患者炎症因子及HSP27表达水平的影响[J].四川中医,2017,35(9):145-148.
[17] 刘洋,王立静,李力,等.杞菊地黄丸治疗早期年龄相关性白内障临床观察[J].中药药理与临床,2017,33(3):193-195.
[18] 陶娜,李亚兰,项奕.杞菊地黄丸对白内障术后干眼症患者疗效,BUT,SIT及FL的影响[J].中国实验方剂学杂志,2017,23(23):166-170.
[19] 王晓燕,霍甜甜,李振国.一测多评法同时测定杞菊地黄口服液中4种有效成分的含量[J].药物分析杂志,2017,37(2):290-296.
[20] 陶娜,项奕,张勇.杞菊地黄汤治疗肝肾阴虚型干眼症患者疗效及对泪液分泌的影响[J].中国实验方剂学杂志,2018,24(2):175-179.
[21] 葛丹,姜红.杞菊地黄丸联合天麻钩藤饮加减治疗原发性高血压的临床疗效观察[J].中医药信息,2018,35(1):117-119.
[22] 高芳,孙素芬,李志红,等.药物三联法治疗妊娠期高血压对患者白血病抑制因子表达及围产儿结局的影响分析[J].河北医药,2018,40(3):337-341.
[2] 文睿婷,黄琳,于芝颖,等.甲基多巴和拉贝洛尔治疗妊娠期高血压疾病的系统评价[J].中国临床药理学杂志,2017,33(17):1710-1712.
[3] 李彩霞,金红梅.盐酸乌拉地尔注射液联合甲钴胺治疗妊娠期高血压疾病的效果[J].中国妇幼保健,2017,32(20):4937-4939.
[4] 吴奇兵.苯磺酸左旋氨氯地平片与苯磺酸氨氯地平片治疗妊娠期高血压疾病的疗效对比分析[J].中国妇幼保健,2017,32(13):2884-2886.
[5] 王晓君,张守焰,徐志平.小剂量普罗帕酮联合磷酸肌酸钠治疗妊娠期高血压合并阵发性室上性心动过速100例分析[J].广西医学,2017,39(3):406-407.
[6] 许娜.中西医结合治疗妊娠期高血压临床疗效及对凝血酶的影响[J].中华中医药学刊,2017,35(3):761-763.
[7] 王玉双,文亚南,司亚茹.复方丹参注射液治疗重度妊娠期高血压疾病的临床研究[J].中国中西医结合杂志,2017,37(11):1400-1402.
[8] 宋苹.硝苯地平控释片联合硫酸镁对妊娠期高血压的治疗价值分析[J].重庆医学,2017,46(A01):363-364.
[9] 王帆.抗氧化药物对妊娠期高血压疾病预测阳性孕妇的治疗效果及对血流动力学的影响[J].中国计划生育学杂志,2017,25(1):47-50.
[10] 陈寒,蒋红清.硫酸镁联合硝苯地平治疗妊娠期高血压疾病患者的疗效及对血流动力学、尿蛋白表达水平的影响[J].中国妇幼保健,2017,32(14):3170-3172.
[11] 黄运福,石玲婷,廖红苑,等.川芎嗪注射液联合拉贝洛尔治疗妊娠期高血压的临床研究[J].现代药物与临床,2017,32(11):2173-2176.
[12] 杨悦旻,徐先明.妊娠期高血压的降压治疗[J].世界临床药物,2017,38(12):805-809.
[13] 郑军,王晓鹏.妊娠期高血压对胎儿及新生儿的影响[J].中国儿童保健杂志,2017,25(11):1086-1089.
[14] 黄广翅,刘彬,张桂芳,等.尼莫地平联合硫酸镁治疗妊娠期高血压综合征的临床疗效[J].实用心脑肺血管病杂志,2017,25(6):140-142.
[15] 刘枚芳,练鹏颖,李佩珊,等.杞菊地黄丸联合西药治疗干眼症疗效与安全性Meta分析[J].辽宁中医药大学学报,2017,19(2):108-111.
[16] 李昭萍.杞菊地黄汤加二仙汤加减对口腔扁平苔藓患者炎症因子及HSP27表达水平的影响[J].四川中医,2017,35(9):145-148.
[17] 刘洋,王立静,李力,等.杞菊地黄丸治疗早期年龄相关性白内障临床观察[J].中药药理与临床,2017,33(3):193-195.
[18] 陶娜,李亚兰,项奕.杞菊地黄丸对白内障术后干眼症患者疗效,BUT,SIT及FL的影响[J].中国实验方剂学杂志,2017,23(23):166-170.
[19] 王晓燕,霍甜甜,李振国.一测多评法同时测定杞菊地黄口服液中4种有效成分的含量[J].药物分析杂志,2017,37(2):290-296.
[20] 陶娜,项奕,张勇.杞菊地黄汤治疗肝肾阴虚型干眼症患者疗效及对泪液分泌的影响[J].中国实验方剂学杂志,2018,24(2):175-179.
[21] 葛丹,姜红.杞菊地黄丸联合天麻钩藤饮加减治疗原发性高血压的临床疗效观察[J].中医药信息,2018,35(1):117-119.
[22] 高芳,孙素芬,李志红,等.药物三联法治疗妊娠期高血压对患者白血病抑制因子表达及围产儿结局的影响分析[J].河北医药,2018,40(3):337-341.