植物多酚提取物对致龋菌作用的研究进展
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摘要
植物多酚是指广泛存在于植物的果实、皮、根和叶中的多羟基酚类化合物的总称,又称单宁或鞣质。植物多酚作用广泛,具有较高的抗氧化和抗菌活性,可以有效的抑制致龋菌的毒性作用。植物多酚具有优秀的抗龋作用,值得更加深入的研究。
Plant polyphenol,phenolic compounds which widely exist in plants and fruit,bark,roots and leaves,also known as tannins.Plant polyphenols have a wide range of effects,it has high antioxidant and antimicrobial activity.It can effectively inhibit the toxicity of cariogenic bacteria.Plant polyphenols have excellent anti-caries effect and deserve further study.
Plant polyphenol,phenolic compounds which widely exist in plants and fruit,bark,roots and leaves,also known as tannins.Plant polyphenols have a wide range of effects,it has high antioxidant and antimicrobial activity.It can effectively inhibit the toxicity of cariogenic bacteria.Plant polyphenols have excellent anti-caries effect and deserve further study.
引文
[1] 庞道睿,刘凡,廖森泰,等.植物源多酚类化合物活性研究进展及其应用[J].广东农业科学,2013,40(04):91-94.
[2] 姚瑞祺.植物多酚的分类及生物活性的研究进展[J].农产品加工(学刊),2011,04:99-100.
[3] Aas JA,Griffen AL,Dardis SR,et al.Bacteria of dental caries in primary and permanent teeth in children and young adults.J Clin Microbiol,2008,46(4):1407-1417.
[4] Wu-Yuan CD,Chen C Y,Wu RT.Gallot annins inhabit growth,water-insoluble glucan synthesis,and aggregation of mutans streptococci[J].J Den t Res,1988,67:51-55.
[5] 肖悦,刘天佳,黄正蔚,等.茶多酚对口腔细菌致龋力影响实验研究[J].广东牙病防治,2002,10(01):4-6.
[6] 杨健康,董文刚,方舟,等.龋病相关微生物的致龋性研究概况[J].医学综述,2011,17(08):1134-1137.
[7] 金妮莉.变形链球菌葡糖基转移酶基因研究概况[J].国外医学·口腔医学分册,1998,025(005):268-271.
[8] Ooshima T,et al.Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats[J].Caries Res,1998,32:75.
[9] 肖悦,刘天佳,詹玲,等.茶多酚影响致龋菌在唾液获得性膜粘附的研究[J].华西口腔医学杂志,2000,18(5):336-339.
[10] 林静.没食子酸鞣质对变形链球菌致龋机制作用的研究[D].乌鲁木齐:新疆医科大学,2011.
[11] Lu Y,Ben nick A.Interaction of tannin with hum an salivaryproline-rich proteins[J].Arch Oral Biol,1998,43:717-728.
[12] 刘正,李鸣宇,张国弛.茶浸液对人唾液淀粉酶活性影响的探讨[J].中华口腔医学杂志,1995,30(2):89-91.
[13] Ooshima T,Minami T,Matsumoto M,et al.Comparison of the Cariostatic Effects between Regimens to Administer Oolong Tea Polyphenols in SPF Rats[J].Caries Research,1997,32(J):75-80.
[14] 宛晓春,李大祥,夏涛.茶色素及其药理学功能[J].天然产物研究与开发,2001,13(4):65-70.
[15] 陈冉冉.茶色素抑制变形链球菌和龋病的实验研究[D].杭州:浙江大学,2006.
[16] Tanaka N,Okamura H et al.On the factors affectingvariationof α-amylase activity in saliva of normal subjects:Ⅱ effects of tannin(polyphenol)in a black tea solution on α-amylase activity in saliva[J].Nippon Kasei Gakkaishi,1989,40(7):587-592
[17] Masao H,Tomoc K I,Tsuneo N.Dental caries prevention by traditional medicines x Ⅲ effect of tea polyphenols on gluean synthesis by glucosyltransfase for streptococcas mutans[J].Chem.Pharm.Bull.,1990,38(3):717-720.
[18] 石碧,杜晓.植物原花色素研究利用进展与发展趋势[J].四川大学学报(工程科学版),2006,38(5):16-24.
[19] FengGP,Klein MI,Gregoire S,etal.Specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms[J].NIH Public Access,2013,29(6):629-640.
[20] Halpin RM,Brady DB,Riordan ED,et al.The effect of untreated and enzyme-treated commercial dairy powders on the growth and adhesion of Streptococcus mutans[J].LWT-Food Science and Technology,2011,44:1525-1532.
[21] 毕玲.葡萄籽原花青素提取物预防龋病的实验研究[D].杭州:浙江大学,2008.
[22] 张玲玲.葡萄籽原花青素对黏性放线菌影响的实验研究[D].郑州:郑州大学,2010.
[23] 黄力子,唐林,徐如生,等.龋病发病机理的生物电化学理论(电化学人工龋模型的实验研究)[J].中华口腔医学杂志,1997,32(1):35-37.
[24] 唐林,黄力子,江友福,等.电化学人工龋模型的形成方法[J].现代口腔医学杂志,1998,12(4):254-256+326.
[25] 马中春.葡萄籽原花青素的安全性毒理学评价及抗突变作用研究[D].长春:吉林大学,2005.
[26] Hu C,He J,Eckert R,et al.Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria[J].Int J Oral Sci,2011,3:13-20.
[27] Peters MC,Tallman JA,Braun TM,et al.Clinical reduction of S.mutans in pre-school children using a novel liquorice root extract lollipop:a pilot study[J].Eur Arch Paediatr Dent,2010,11(6):274-278.
[28] Mentes JC,Kang S,Spackman S,et al.Can a licorice lollipop decrease cariogenic bacteria in nursing home residents[J].Res Gerontol Nurs,2012,5(4):233-237.
[29] Almaz ME,Sonmez Is,okte Z,et al.Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcu smutans levels:a randomized controlled trial[J].Clin Oral Investig,2017,21(3):839-845.
[30] 张甜甜,张媛媛,陈红鸽,等.基于微量量热法的金银花抗菌活性部位初筛[J].解放军药学学报,2011,27(3):205-211.
[31] 徐越成.金银花种绿原酸的提取分离及其抑菌作用的研究[D].重庆:重庆大学,2008.
[32] 黄喜茹,刘伟娜,曹冬.金银花的化学成分药理作用研究评析[J].中医药学刊,2005,23(3):418-419.
[33] 冯瑾,李继遥,周学东.厚朴活性成分对致龋菌生长和产酸影响的研究[C]//2007年第七次全国牙体牙髓病学学术会议论文集,上海,2007.
[34] 许颖,李婷,潘亮亮,等.厚朴酚对变形链球菌生物膜致龋毒力因子作用的研究[J].中国微生态学杂志,2013,25(03):299-302.
[35] 齐芳芳,王山,郭洁,等.茶多酚、厚朴酚抑制早期人工根面龋作用的实验研究[J].现代口腔医学杂志,2011,25(5):359-362.
[36] 王德堂,何红,卢志刚.厚朴提取物厚朴酚与氟化物联合防龋的效果研究[J].荆楚理工学院学报,2014,29(4):67-71.
[37] 熊炎斌,李德玲,刘持平,等.几种植物药对变形链球菌生长、产酸、粘附影响的体外实验[J].中华口腔医学杂志,1997,32(5):6.
[38] 王兴.第四次全国口腔健康流行病学调查报告[M].北京:人民卫生出版社,2018.
[39] 周学东.我国龋病学的研究进展[C]//全国第八次牙体牙髓病学学术会议论文汇编,北京,2011.
[2] 姚瑞祺.植物多酚的分类及生物活性的研究进展[J].农产品加工(学刊),2011,04:99-100.
[3] Aas JA,Griffen AL,Dardis SR,et al.Bacteria of dental caries in primary and permanent teeth in children and young adults.J Clin Microbiol,2008,46(4):1407-1417.
[4] Wu-Yuan CD,Chen C Y,Wu RT.Gallot annins inhabit growth,water-insoluble glucan synthesis,and aggregation of mutans streptococci[J].J Den t Res,1988,67:51-55.
[5] 肖悦,刘天佳,黄正蔚,等.茶多酚对口腔细菌致龋力影响实验研究[J].广东牙病防治,2002,10(01):4-6.
[6] 杨健康,董文刚,方舟,等.龋病相关微生物的致龋性研究概况[J].医学综述,2011,17(08):1134-1137.
[7] 金妮莉.变形链球菌葡糖基转移酶基因研究概况[J].国外医学·口腔医学分册,1998,025(005):268-271.
[8] Ooshima T,et al.Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats[J].Caries Res,1998,32:75.
[9] 肖悦,刘天佳,詹玲,等.茶多酚影响致龋菌在唾液获得性膜粘附的研究[J].华西口腔医学杂志,2000,18(5):336-339.
[10] 林静.没食子酸鞣质对变形链球菌致龋机制作用的研究[D].乌鲁木齐:新疆医科大学,2011.
[11] Lu Y,Ben nick A.Interaction of tannin with hum an salivaryproline-rich proteins[J].Arch Oral Biol,1998,43:717-728.
[12] 刘正,李鸣宇,张国弛.茶浸液对人唾液淀粉酶活性影响的探讨[J].中华口腔医学杂志,1995,30(2):89-91.
[13] Ooshima T,Minami T,Matsumoto M,et al.Comparison of the Cariostatic Effects between Regimens to Administer Oolong Tea Polyphenols in SPF Rats[J].Caries Research,1997,32(J):75-80.
[14] 宛晓春,李大祥,夏涛.茶色素及其药理学功能[J].天然产物研究与开发,2001,13(4):65-70.
[15] 陈冉冉.茶色素抑制变形链球菌和龋病的实验研究[D].杭州:浙江大学,2006.
[16] Tanaka N,Okamura H et al.On the factors affectingvariationof α-amylase activity in saliva of normal subjects:Ⅱ effects of tannin(polyphenol)in a black tea solution on α-amylase activity in saliva[J].Nippon Kasei Gakkaishi,1989,40(7):587-592
[17] Masao H,Tomoc K I,Tsuneo N.Dental caries prevention by traditional medicines x Ⅲ effect of tea polyphenols on gluean synthesis by glucosyltransfase for streptococcas mutans[J].Chem.Pharm.Bull.,1990,38(3):717-720.
[18] 石碧,杜晓.植物原花色素研究利用进展与发展趋势[J].四川大学学报(工程科学版),2006,38(5):16-24.
[19] FengGP,Klein MI,Gregoire S,etal.Specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms[J].NIH Public Access,2013,29(6):629-640.
[20] Halpin RM,Brady DB,Riordan ED,et al.The effect of untreated and enzyme-treated commercial dairy powders on the growth and adhesion of Streptococcus mutans[J].LWT-Food Science and Technology,2011,44:1525-1532.
[21] 毕玲.葡萄籽原花青素提取物预防龋病的实验研究[D].杭州:浙江大学,2008.
[22] 张玲玲.葡萄籽原花青素对黏性放线菌影响的实验研究[D].郑州:郑州大学,2010.
[23] 黄力子,唐林,徐如生,等.龋病发病机理的生物电化学理论(电化学人工龋模型的实验研究)[J].中华口腔医学杂志,1997,32(1):35-37.
[24] 唐林,黄力子,江友福,等.电化学人工龋模型的形成方法[J].现代口腔医学杂志,1998,12(4):254-256+326.
[25] 马中春.葡萄籽原花青素的安全性毒理学评价及抗突变作用研究[D].长春:吉林大学,2005.
[26] Hu C,He J,Eckert R,et al.Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria[J].Int J Oral Sci,2011,3:13-20.
[27] Peters MC,Tallman JA,Braun TM,et al.Clinical reduction of S.mutans in pre-school children using a novel liquorice root extract lollipop:a pilot study[J].Eur Arch Paediatr Dent,2010,11(6):274-278.
[28] Mentes JC,Kang S,Spackman S,et al.Can a licorice lollipop decrease cariogenic bacteria in nursing home residents[J].Res Gerontol Nurs,2012,5(4):233-237.
[29] Almaz ME,Sonmez Is,okte Z,et al.Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcu smutans levels:a randomized controlled trial[J].Clin Oral Investig,2017,21(3):839-845.
[30] 张甜甜,张媛媛,陈红鸽,等.基于微量量热法的金银花抗菌活性部位初筛[J].解放军药学学报,2011,27(3):205-211.
[31] 徐越成.金银花种绿原酸的提取分离及其抑菌作用的研究[D].重庆:重庆大学,2008.
[32] 黄喜茹,刘伟娜,曹冬.金银花的化学成分药理作用研究评析[J].中医药学刊,2005,23(3):418-419.
[33] 冯瑾,李继遥,周学东.厚朴活性成分对致龋菌生长和产酸影响的研究[C]//2007年第七次全国牙体牙髓病学学术会议论文集,上海,2007.
[34] 许颖,李婷,潘亮亮,等.厚朴酚对变形链球菌生物膜致龋毒力因子作用的研究[J].中国微生态学杂志,2013,25(03):299-302.
[35] 齐芳芳,王山,郭洁,等.茶多酚、厚朴酚抑制早期人工根面龋作用的实验研究[J].现代口腔医学杂志,2011,25(5):359-362.
[36] 王德堂,何红,卢志刚.厚朴提取物厚朴酚与氟化物联合防龋的效果研究[J].荆楚理工学院学报,2014,29(4):67-71.
[37] 熊炎斌,李德玲,刘持平,等.几种植物药对变形链球菌生长、产酸、粘附影响的体外实验[J].中华口腔医学杂志,1997,32(5):6.
[38] 王兴.第四次全国口腔健康流行病学调查报告[M].北京:人民卫生出版社,2018.
[39] 周学东.我国龋病学的研究进展[C]//全国第八次牙体牙髓病学学术会议论文汇编,北京,2011.