电针预处理改善心肌缺血再灌注损伤机制的研究进展
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摘要
近年来,心血管疾病的发病率逐年增加,而缺血性心脏病是心血管疾病的常见类型,心血管手术中无论是用溶栓、介入、还是外科搭桥手术等治疗方法,冠状动脉再通后都会造成心肌缺血再灌注损伤,严重危害着人们的生命健康。因此,减轻心肌缺血再灌注损伤已在临床上受到越来越多的关注。文章对电针预处理改善心肌缺血再灌注损伤的作用机制进行归纳总结,主要包括减少氧自由基和炎性损伤、保护线粒体、减轻钙超载、抑制细胞凋亡等,以便于为临床防治工作提供理论指导。
引文
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[2]Brown DA,Hale SL,Baines CP,et al.Reduction of early reperfusion injury with the mitochondria-targeting peptide Bendavia[J].J Cardiovasc Pharmacol Ther,2014,19(1):121-132.
[3]Kalogeris T,Bao Y,Korthuis RJ.Mitochondrial reactive oxygen species:A double edged sword in ischemia/reperfusion vs preconditioning[J].Redox Biol,2014(2):702-714.
[4]Chen X.Cardiovascular protection by ginsenosides and their nitric oxide releasing action[J].Clin Exp Pharmacol Physiol,1996,23(8):728-732.
[5]钱钢,翟昌林,胡惠林,等.电针预处理对心肌缺血再灌注损伤保护作用及机制研究[J].心电与循环,2017,36(3):164-169.
[6]张江玲,陈杰,王祥瑞,等.电针“内关”穴预处理对缺血再灌注大鼠心肌的保护作用[J].针刺研究,2010,35(3):182-187.
[7]陈松,韩永丽,吴松,等.针刺“内关”预处理对大鼠缺血再灌注心肌的保护作用及机制研究[J].华中科技大学学报(医学版),2017,46(5):526-530.
[8]Gao J,Fu W,Jin Z,et al.Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of theβ1-adrenoceptor signaling pathway[J].Life Sci,2007,80(16):1484-1489.
[9]黄日龙,韩数,秦黎虹,等.电针预处理对再次心肌缺血模型家兔心肌酶的影响[J].针刺研究,2012,37(3):224-228.
[10]Sanada S,Komuro I,Kitakaze M.Pathophysiology of myocardial reperfusion injury:preconditioning,postconditioning,and translational aspects of protective measures[J].Am J Physiol Heart Circ Physiol,2011,301(5):H1723-H1741.
[11]Ferrari R,Ceconi C,Curello S,et al.Oxygen free radicals and myocardial damage:protective role of thiol-containing agents[J].Am JMed,1991,91(3C):95S-105S.
[12]Zhang H,Liu L,Huang G,et al.Protective effect of electroacupuncture at the Neiguan point in a rabbit model of myocardial ischemiareperfusion injury[J].Can J Cardiol,2009,25(6):359-363.
[13]邵明璐,李洋,崔华峰,等.针刺预处理对大鼠心肌缺血再灌注氧化应激损伤的保护作用[J].中国针灸,2017,37(3):285-290.
[14]黄玉芳.病理学[M].北京:中国中医药出版社,2012:22-24
[15]Pavione MA,Carmona F,Castro MD,et al.Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass:Arandomized controlled trial[J].J Thorac Cardiovasc Surg,2012,144(1):178-183.
[16]张小蕾,薛艺璇,林依梦,等.电针预处理对心肌缺血再灌注损伤大鼠Caspase-9、Caspase-3及CK的影响[J].湖北中医杂志,2018,40(11):3-7.
[17]Zhou HP,Wang MS,Shi F,et al.Effects of acupuncture pre-conditioning on apoptosis in hippocampal neurons following ischemiareperfusion injury in aged rats[J].Zhonghua Yi Xue Za Zhi,2011,91(17):1203-1206.
[18]Wang Y,Yuan Y,Wang X,et al.Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis[J].Med Sci Monit,2017(23):4490-4499.
[19]Li X,Liu J,Lin L,et al.Traditional chinese medicine shuang shen ning xin attenuates myocardial ischemia/reperfusion injury by preserving of mitochondrial function[J].Evid Based Complement Alternat Med,2014(2014):180965.
[20]宋瑾,王超,阳仁达,等.电针内关穴预处理对心肌缺血再灌注损伤大鼠NO、NOS及线粒体膜电位的影响[J].上海针灸杂志,2017,36(10):1247-1252.
[21]陈松,韩永丽,吴松,等.电针内关穴预处理对大鼠心肌缺血再灌注后线粒体功能及超微结构的保护作用[J].中华中医药杂志,2017,32(10):4651-4654.
[22]田岳凤,吴富东,乔海法,等.针刺手厥阴心包经穴对心肌缺血再灌注损伤心肌细胞钙超载的影响[J].针刺研究,2005(3):161-163.
[23]韩永丽,严江天,吴松,等.电针内关预处理对心肌缺血再灌注大鼠模型血管内皮因子及线粒体功能影响[J].中华中医药学刊,2018,36(10):2389-2393.
[24]Yang Z,Klionsky DJ.Eaten alive:a history of macroautophagy[J].Nat Cell Biol,2010,12(9):814-822.
[25]Meng-Qiu Dang,Xiang-Jun Zeng,Bu-Xing Chen,et al.Soluble receptor for advance glycation end-products inhibits ischemia/reperfusion-induced myocardial autophagy via the STAT3 pathway[J].Free Radic Biol Med,2018,1852(2):271-276.
[26]Ma S,Wang Y,Chen Y,et al.The role of the autophagy in myocardial ischemia/reperfusion injury[J].Biochim Biophys Acta,2015,1852(2):271-276.
[27]田国卫,夏豪.自噬在心肌缺血再灌注损伤中的研究进展[J].疑难病杂志,2018,17(10):1179-1184.
[28]Yang Z,Klionsky DJ.Eaten alive:a history of macroautophagy[J].Nat Cell Biol,2010,12(9):814-822
[29]陈婉莹,仲泽昊,白桦,等.不同时间电针预处理抗MIRI的效应差异及其与自噬的相关性[J].中国针灸,2018,38(10):1087-1092.
[30]许荣,王宁,王晓明.自噬在心肌缺血再灌注损伤中的研究进展[J].中华老年心脑血管病杂志,2015,17(12):1327-1328.
[31]谭成富,王超,杜琳,等.电针、艾灸预处理对心肌缺血再灌注损伤大鼠心肌自噬相关蛋白LC 3、Beclin 1表达的影响[J].针刺研究,2018,43(1):1-7.
[32]杜琳.电针、艾灸预处理对心肌缺血/再灌注损伤大鼠心肌细胞自噬和凋亡的影响[D].长沙:湖南中医药大学,2018.
[33]Cheng-Fu T,Chao W,Lin DU,et al.Effect of Electroacupuncture and Moxibustion Pretreatment on Expression of Autophagy Related Proteins LC 3 and Beclin 1 in Rats with Myocardial Ischemiareperfusion Injury[J].Zhen Ci Yan Jiu,2018,43(1):1-7.
[34]贺晓楠.腺苷对缺血再灌注心肌的保护作用[D].长春:吉林大学,2007.
[35]刘兴.芍药苷通过A1腺苷受体对脓毒症小鼠心功能保护作用的研究[D].广州:暨南大学,2015.
[36]孙强,韩翠红,孙学军.缺血预适应和后适应的触发因子研究进展[J].海军医学杂志,2008(2):171-173.
[37]吕磊,江时森.再灌注损伤挽救激酶信号通路在心肌再灌注损伤保护中的研究进展[J].医学研究生学报,2010,23(12):1309-1313.
[38]张佳丽.电针预处理对兔心肌缺血再灌注损伤腺苷A1受体、PKC的影响[D].长沙:湖南中医药大学,2014.
[39]宋瑾,王超,阳仁达,等.电针内关穴预处理对心肌缺血再灌注损伤大鼠NO、NOS及腺苷A1受体的影响[J].中国中医急症,2017,26(4):565-567,587.
[40]Dan H,Jie W,Rui Z,et al.Hydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling[J].Sci Rep.2016 Oct 12;6:35319.
[41]朱怡,李毅,张楠,等.电针预处理对心肌缺血再灌注损伤大鼠“内关”穴区Toll样受体4、髓样分化因子88及核转录因子-κB基因表达的影响[J].针刺研究,2018,43(5):302-306,329.
[42]邵忠华,冯斌.针刺内关穴对大鼠心肌缺血再灌注损伤后HMGB1表达的影响[J].中国中医药科技,2014,21(3):243-245.
[43]苏晓灵,周白丽,王嵘.心肌缺血再灌注损伤后家兔血浆ET、CGRP含量变化的研究[J].青海医药杂志,2006(3):12-13.
[44]林亚平,王晓顺,易受乡,等.不同频率电针“内关”预处理对心肌缺血再灌注损伤大鼠血液内IMA及CGRP含量的影响[J].中华中医药杂志,2012,27(8):2152-2154.
[45]冯果,王超,阳仁达,等.内关电针预处理对心肌缺血再灌注损伤模型大鼠的影响[J].山东中医杂志,2018,37(3):237-240.
[46]蔡荣林,胡玲,申国明,等.电针预处理对急性心肌缺血再灌注损伤大鼠心肌组织水通道蛋白1表达及蛋白激酶C活性的影响[J].中国针灸,2017,37(2):157-161.
[47]Wang C,Xie WJ,Liu M,et al.Effect of electroacupuncture and moxibustion preconditioning on blood endothelin and creatine kinase contents and myocardial HSP 70 expression in rabbits with myocardial ischemia-reperfusion injury[J].Acupuncture Research,2014,39(5):372-376.
[48]Liu PY,Tian Y,Xu SY.Mediated protective effect of electroacupuncture pretreatment by miR-214 on myocardial ischemia/reperfusion injury[J].J Geriatr Cardiol,2014,11(4):303-310.
[2]Brown DA,Hale SL,Baines CP,et al.Reduction of early reperfusion injury with the mitochondria-targeting peptide Bendavia[J].J Cardiovasc Pharmacol Ther,2014,19(1):121-132.
[3]Kalogeris T,Bao Y,Korthuis RJ.Mitochondrial reactive oxygen species:A double edged sword in ischemia/reperfusion vs preconditioning[J].Redox Biol,2014(2):702-714.
[4]Chen X.Cardiovascular protection by ginsenosides and their nitric oxide releasing action[J].Clin Exp Pharmacol Physiol,1996,23(8):728-732.
[5]钱钢,翟昌林,胡惠林,等.电针预处理对心肌缺血再灌注损伤保护作用及机制研究[J].心电与循环,2017,36(3):164-169.
[6]张江玲,陈杰,王祥瑞,等.电针“内关”穴预处理对缺血再灌注大鼠心肌的保护作用[J].针刺研究,2010,35(3):182-187.
[7]陈松,韩永丽,吴松,等.针刺“内关”预处理对大鼠缺血再灌注心肌的保护作用及机制研究[J].华中科技大学学报(医学版),2017,46(5):526-530.
[8]Gao J,Fu W,Jin Z,et al.Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of theβ1-adrenoceptor signaling pathway[J].Life Sci,2007,80(16):1484-1489.
[9]黄日龙,韩数,秦黎虹,等.电针预处理对再次心肌缺血模型家兔心肌酶的影响[J].针刺研究,2012,37(3):224-228.
[10]Sanada S,Komuro I,Kitakaze M.Pathophysiology of myocardial reperfusion injury:preconditioning,postconditioning,and translational aspects of protective measures[J].Am J Physiol Heart Circ Physiol,2011,301(5):H1723-H1741.
[11]Ferrari R,Ceconi C,Curello S,et al.Oxygen free radicals and myocardial damage:protective role of thiol-containing agents[J].Am JMed,1991,91(3C):95S-105S.
[12]Zhang H,Liu L,Huang G,et al.Protective effect of electroacupuncture at the Neiguan point in a rabbit model of myocardial ischemiareperfusion injury[J].Can J Cardiol,2009,25(6):359-363.
[13]邵明璐,李洋,崔华峰,等.针刺预处理对大鼠心肌缺血再灌注氧化应激损伤的保护作用[J].中国针灸,2017,37(3):285-290.
[14]黄玉芳.病理学[M].北京:中国中医药出版社,2012:22-24
[15]Pavione MA,Carmona F,Castro MD,et al.Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass:Arandomized controlled trial[J].J Thorac Cardiovasc Surg,2012,144(1):178-183.
[16]张小蕾,薛艺璇,林依梦,等.电针预处理对心肌缺血再灌注损伤大鼠Caspase-9、Caspase-3及CK的影响[J].湖北中医杂志,2018,40(11):3-7.
[17]Zhou HP,Wang MS,Shi F,et al.Effects of acupuncture pre-conditioning on apoptosis in hippocampal neurons following ischemiareperfusion injury in aged rats[J].Zhonghua Yi Xue Za Zhi,2011,91(17):1203-1206.
[18]Wang Y,Yuan Y,Wang X,et al.Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis[J].Med Sci Monit,2017(23):4490-4499.
[19]Li X,Liu J,Lin L,et al.Traditional chinese medicine shuang shen ning xin attenuates myocardial ischemia/reperfusion injury by preserving of mitochondrial function[J].Evid Based Complement Alternat Med,2014(2014):180965.
[20]宋瑾,王超,阳仁达,等.电针内关穴预处理对心肌缺血再灌注损伤大鼠NO、NOS及线粒体膜电位的影响[J].上海针灸杂志,2017,36(10):1247-1252.
[21]陈松,韩永丽,吴松,等.电针内关穴预处理对大鼠心肌缺血再灌注后线粒体功能及超微结构的保护作用[J].中华中医药杂志,2017,32(10):4651-4654.
[22]田岳凤,吴富东,乔海法,等.针刺手厥阴心包经穴对心肌缺血再灌注损伤心肌细胞钙超载的影响[J].针刺研究,2005(3):161-163.
[23]韩永丽,严江天,吴松,等.电针内关预处理对心肌缺血再灌注大鼠模型血管内皮因子及线粒体功能影响[J].中华中医药学刊,2018,36(10):2389-2393.
[24]Yang Z,Klionsky DJ.Eaten alive:a history of macroautophagy[J].Nat Cell Biol,2010,12(9):814-822.
[25]Meng-Qiu Dang,Xiang-Jun Zeng,Bu-Xing Chen,et al.Soluble receptor for advance glycation end-products inhibits ischemia/reperfusion-induced myocardial autophagy via the STAT3 pathway[J].Free Radic Biol Med,2018,1852(2):271-276.
[26]Ma S,Wang Y,Chen Y,et al.The role of the autophagy in myocardial ischemia/reperfusion injury[J].Biochim Biophys Acta,2015,1852(2):271-276.
[27]田国卫,夏豪.自噬在心肌缺血再灌注损伤中的研究进展[J].疑难病杂志,2018,17(10):1179-1184.
[28]Yang Z,Klionsky DJ.Eaten alive:a history of macroautophagy[J].Nat Cell Biol,2010,12(9):814-822
[29]陈婉莹,仲泽昊,白桦,等.不同时间电针预处理抗MIRI的效应差异及其与自噬的相关性[J].中国针灸,2018,38(10):1087-1092.
[30]许荣,王宁,王晓明.自噬在心肌缺血再灌注损伤中的研究进展[J].中华老年心脑血管病杂志,2015,17(12):1327-1328.
[31]谭成富,王超,杜琳,等.电针、艾灸预处理对心肌缺血再灌注损伤大鼠心肌自噬相关蛋白LC 3、Beclin 1表达的影响[J].针刺研究,2018,43(1):1-7.
[32]杜琳.电针、艾灸预处理对心肌缺血/再灌注损伤大鼠心肌细胞自噬和凋亡的影响[D].长沙:湖南中医药大学,2018.
[33]Cheng-Fu T,Chao W,Lin DU,et al.Effect of Electroacupuncture and Moxibustion Pretreatment on Expression of Autophagy Related Proteins LC 3 and Beclin 1 in Rats with Myocardial Ischemiareperfusion Injury[J].Zhen Ci Yan Jiu,2018,43(1):1-7.
[34]贺晓楠.腺苷对缺血再灌注心肌的保护作用[D].长春:吉林大学,2007.
[35]刘兴.芍药苷通过A1腺苷受体对脓毒症小鼠心功能保护作用的研究[D].广州:暨南大学,2015.
[36]孙强,韩翠红,孙学军.缺血预适应和后适应的触发因子研究进展[J].海军医学杂志,2008(2):171-173.
[37]吕磊,江时森.再灌注损伤挽救激酶信号通路在心肌再灌注损伤保护中的研究进展[J].医学研究生学报,2010,23(12):1309-1313.
[38]张佳丽.电针预处理对兔心肌缺血再灌注损伤腺苷A1受体、PKC的影响[D].长沙:湖南中医药大学,2014.
[39]宋瑾,王超,阳仁达,等.电针内关穴预处理对心肌缺血再灌注损伤大鼠NO、NOS及腺苷A1受体的影响[J].中国中医急症,2017,26(4):565-567,587.
[40]Dan H,Jie W,Rui Z,et al.Hydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling[J].Sci Rep.2016 Oct 12;6:35319.
[41]朱怡,李毅,张楠,等.电针预处理对心肌缺血再灌注损伤大鼠“内关”穴区Toll样受体4、髓样分化因子88及核转录因子-κB基因表达的影响[J].针刺研究,2018,43(5):302-306,329.
[42]邵忠华,冯斌.针刺内关穴对大鼠心肌缺血再灌注损伤后HMGB1表达的影响[J].中国中医药科技,2014,21(3):243-245.
[43]苏晓灵,周白丽,王嵘.心肌缺血再灌注损伤后家兔血浆ET、CGRP含量变化的研究[J].青海医药杂志,2006(3):12-13.
[44]林亚平,王晓顺,易受乡,等.不同频率电针“内关”预处理对心肌缺血再灌注损伤大鼠血液内IMA及CGRP含量的影响[J].中华中医药杂志,2012,27(8):2152-2154.
[45]冯果,王超,阳仁达,等.内关电针预处理对心肌缺血再灌注损伤模型大鼠的影响[J].山东中医杂志,2018,37(3):237-240.
[46]蔡荣林,胡玲,申国明,等.电针预处理对急性心肌缺血再灌注损伤大鼠心肌组织水通道蛋白1表达及蛋白激酶C活性的影响[J].中国针灸,2017,37(2):157-161.
[47]Wang C,Xie WJ,Liu M,et al.Effect of electroacupuncture and moxibustion preconditioning on blood endothelin and creatine kinase contents and myocardial HSP 70 expression in rabbits with myocardial ischemia-reperfusion injury[J].Acupuncture Research,2014,39(5):372-376.
[48]Liu PY,Tian Y,Xu SY.Mediated protective effect of electroacupuncture pretreatment by miR-214 on myocardial ischemia/reperfusion injury[J].J Geriatr Cardiol,2014,11(4):303-310.