靶向烟碱型乙酰胆碱受体的芋螺毒素研究进展
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摘要
芋螺毒素是由海洋肉食性芋螺所分泌的用于捕杀猎物的高活性生物多肽类毒素,据估计,全世界范围内约含100万种不同的芋螺毒素,按照保守的信号区可分为A、B2、C、D、O、M、T等27个超家族。不同家族的芋螺毒素能够特异性的靶向各种离子通道和受体,因而成为了具有潜在药用价值的先导化合物和研究神经药理学的分子探针。当前报道的靶向烟碱型乙酰胆碱受体的芋螺毒素来自10个超家族,分别为A、B3、C、D、J、L、S、O1、M和T。本文对这10个超家族中靶向烟碱型乙酰胆碱受体的芋螺毒素的序列、结构及功能进行综述。
Conotoxins were highly bioactive peptides utilized by marine predatory cone snails(Conus species)to subdue their preys.It was estimated that there were more than 1 000 000 different conotoxins around the world.According to the highly conserved signal region,conotoxins could be classified into 27 superfamilies:A,B2,C,D,O,M and T-superfamily,etc.Each superfamily of the conotoxins selectively targeted a specific subtype of ion channels or receptors.Due to their highly pharmacological potency and target selectivity,Conus peptides had been developed as lead compounds for drugs or as new research tools in neuroscience field.Currently,conotoxins from ten superfamilies(A,B3,C,D,J,L,S,O1,M and T)had been reported to specifically target nicotinic acetylcholine receptors(nAChRs).This review aimed to give a brief summary of the studies on sequence characters,structures and functions of the conotoxins that specifically targeted nAChRs.
Conotoxins were highly bioactive peptides utilized by marine predatory cone snails(Conus species)to subdue their preys.It was estimated that there were more than 1 000 000 different conotoxins around the world.According to the highly conserved signal region,conotoxins could be classified into 27 superfamilies:A,B2,C,D,O,M and T-superfamily,etc.Each superfamily of the conotoxins selectively targeted a specific subtype of ion channels or receptors.Due to their highly pharmacological potency and target selectivity,Conus peptides had been developed as lead compounds for drugs or as new research tools in neuroscience field.Currently,conotoxins from ten superfamilies(A,B3,C,D,J,L,S,O1,M and T)had been reported to specifically target nicotinic acetylcholine receptors(nAChRs).This review aimed to give a brief summary of the studies on sequence characters,structures and functions of the conotoxins that specifically targeted nAChRs.
引文
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