摘要
目的:探讨甲胎蛋白(AFP)、高尔基体糖蛋白73(GP73)、超氧化物歧化酶(SOD)联合检测对原发性肝癌的诊断价值。方法:选取收治的原发性肝癌和肝硬化患者各100例(分别为肝癌组和肝硬化组),抽取患者静脉血,采用电化学发光法检测AFP、酶联免疫吸附法检测GP73、黄嘌呤氧化酶法检测SOD,并与100例同期健康体检者(对照组)进行对照,绘制受试者工作特征曲线(ROC),观察AFP、GP73及SOD联合检测对原发性肝癌的诊断价值。结果:肝癌组血清AFP、GP73显著高于肝硬化组和对照组(P<0.05),SOD水平明显低于肝硬化组和对照组(P<0.05)。AFP、GP73及SOD单纯检测在原发性肝癌患者诊断中最佳节点分别为150.29μg/L、214.78μg/L和55.61 IU/m L,联合检测AUC高达0.902,明显高于单纯检测AFP、GP73及SOD的0.726、0.813及0.791。结论:AFP、GP73及SOD联合检测用于原发性肝癌的诊断,可显著提高检出率。
引文
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