肥大细胞糜酶的研究现状
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摘要
<正>糜酶是肥大细胞分泌的主要中性蛋白酶之一,是近年来关注度较高的一种糜蛋白样的丝氨酸蛋白酶。其与心血管、肝肾、代谢疾病等都有密切的关系,是血管紧张素Ⅱ(Ang-Ⅱ)生成途径中特别是局部组织生成途径中的重要酶类。本文就国内外肥大细胞糜酶
引文
[1]赵晓燕,苏金林,张兴凯.糜酶与心血管疾病间关系的研究进展[J].宁夏医学杂志,2010,32(1):91-92.
[2] AHMAD S,WEI CC,TALLAJ J,et al.Chymase mediates angiotensin-(1-12)metabolism in normal human hearts[J].J Am Soc Hypertens,2013,7(2):128-136.
[3] FERRARIO CM,MULLICK AE.Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease[J].Pharmacol Res,2017,125(Pt A):57-71.
[4] REYES S,VARAGIC J,AHMAD S,et al.Novel cardiac intracrine mechanisms based on Ang-(1-12)/Chymase axis require a revision of therapeutic approaches in human heart disease[J].Curr Hypertens Rep,2017,19(2):16.
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[6] NAGATA S,VARAGIC J,KON ND,et al.Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue[J].Ther Adv Cardiovasc Dis,2015,9(4):168-180.
[7] OLA MS,ALHOMIDA AS,FERRARIO CM,et al.Role of tissue renin-angiotensin system and the Chymase/angiotensin-(1-12)Axis in the pathogenesis of diabetic retinopathy[J].Curr Med Chem,2017,24(28):3104-3114.
[8] FERRARIO CM,AHMAD S,VARAGIC J,et al.Intracrine angiotensin II functions originate from noncanonical pathways in the human heart[J].Am J Physiol Heart Circ Physiol,2016,311(2):H404-414.
[9] DUSING R.Mega clinical trials which have shaped the RAS intervention clinical practice[J].Ther Adv Cardiovasc Dis,2016,10(3):133-150.
[10]HOOSHDARAN B,KOLPAKOV MA,GUO X,et al.Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury[J].Basic Res Cardiol,2017,112(6):62.
[11]KAREINEN I,BAUMANN M,NGUYEN SD,et al.Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192)and compromises its cardioprotective activity[J].J Lipid Res,2018,59(6):945-957.
[12]FROOGH G,PINTO JT,LE Y,et al.Chymase-dependent production of angiotensin II:an old enzyme in old hearts[J].Am J Physiol Heart Circ Physiol,2017,312(2):H223-231.
[13]ZHANG H,WANG J,WANG L,et al.Induction of mast cell accumulation by chymase via an enzymatic activity-and intercellular adhesion molecule-1-dependent mechanism[J].Br J Pharmacol,2018,175(4):678-692.
[14]CHEN H,XU Y,YANG G,et al.Mast cell chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating TGF-beta1/Smads signaling pathway[J].Exp Ther Med,2017,14(5):4438-4442.
[15]JIMI S,MATSUMURA H.Effect of chymase activity on skin thickness in the Clawn miniature pig hypertrophic scarring model[J].J Plast Surg Hand Surg,2017,51(6):446-452.
[16]WANG R,CHEN J,ZHANG Z,et al.Role of chymase in the local renin-angiotensin system in keloids:inhibition of chymase may be an effective therapeutic approach to treat keloids[J].Drug Des Devel Ther,2015,9:4979-4988.
[17]SAARINEN J,KALKKINEN N,WELGUS HG,et al.Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84bond by mast cell chymase[J].J Biol Chem,1994,269(27):18134-18140.
[18]MATSUMOTO M,KUNIMITSU S,WADA K,et al.Mast cell distribution,activation,and phenotype in xanthoma[J].J Am Acad Dermatol,2007,56(6):1006-1012.
[19]WANG Z,SHEN XH,FENG WM,et al.Mast cell specific immunological biomarkers and metabolic syndrome among middle-aged and older Chinese adults[J].Endocr J,2017,64(3):245-253.
[20]RUBINO SM,NAE AM,JOHN V,et al.Chymase/Angiotensin I axis:apathway for Angiotensin II generation in diabetic human vitreous[J].Invest Ophthalmol Vis Sci,2016,57:5431.
[21]NABE T,KIJITANI Y,KITAGAWA Y,et al.Involvement of chymase in allergic conjunctivitis of guinea pigs[J].Exp Eye Res,2013,113:74-79.
[22]HARRISON-BERNARD LM,DE GARAVILLA L,BIVONA BJ.Enhanced vascular chymase-dependent conversion of endothelin in the diabetic kidney[J].Ochsner J,2013,13(1):49-55.
[23]ZHANG M,HUANG W,BAI J,et al.Chymase inhibition protects diabetic rats from renal lesions[J].Mol Med Rep,2016,14(1):121-128.
[24]PONS M,ALI L,BEGHDADI W,et al.Mast cells and MCPT4chymase promote renal impairment after partialu ureteral obstruction[J].Front Immunol,2017,8:450.
[25]李海滨,尹明实.糜酶对肝星状细胞转化生长因子β1/Smad3信号通路的影响[J].中国病毒病杂志,2016,6(5):332-335.
[26]王洋,尹明实.糜酶对肝星状细胞增殖及转分化的影响[J].免疫学杂志,2016,32(1):29-33.
[27]MIYAOKA Y,JIN D,TASHIRO K,et al.Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet[J].J Pharmacol Sci,2017,134(3):139-146.
[28]SVERRILD A,BERGQVIST A,BAINES KJ,et al.Airway responsiveness to mannitol in asthma is associated with chymasepositive mast cells and eosinophilic airway inflammation[J].Clin Exp Allergy,2016,46(2):288-297.
[29]KOSANOVIC D,LUITEL H,DAHAL BK,et al.Chymase:a multifunctional player in pulmonary hypertension associated with lung fibrosis[J].Eur Respir J,2015,46(4):1084-1094.
[30]KOMEDA K,TAKAI S,JIN D,et al.Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters[J].Hepatol Res,2010,40(8):832-840.
[31]MCMURRAY JJ,KRUM H,ABRAHAM WT,et al.Aliskiren,enalapril,or aliskiren and enalapril in heart failure[J].N Engl J Med,2016,374(16):1521-1532.
[32]PARVING HH,BRENNER BM,MCMURRAY JJ,et al.Cardiorenal end points in a trial of aliskiren for type 2diabetes[J].N Engl J Med,2012,367(23):2204-2213.
[2] AHMAD S,WEI CC,TALLAJ J,et al.Chymase mediates angiotensin-(1-12)metabolism in normal human hearts[J].J Am Soc Hypertens,2013,7(2):128-136.
[3] FERRARIO CM,MULLICK AE.Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease[J].Pharmacol Res,2017,125(Pt A):57-71.
[4] REYES S,VARAGIC J,AHMAD S,et al.Novel cardiac intracrine mechanisms based on Ang-(1-12)/Chymase axis require a revision of therapeutic approaches in human heart disease[J].Curr Hypertens Rep,2017,19(2):16.
[5] FERRARIO CM,VONCANNON J,JIAO Y,et al.Cardiac angiotensin-(1-12)expression and systemic hypertension in rats expressing the human angiotensinogen gene[J].Am J Physiol Heart Circ Physiol,2016,310(8):H995-1002.
[6] NAGATA S,VARAGIC J,KON ND,et al.Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue[J].Ther Adv Cardiovasc Dis,2015,9(4):168-180.
[7] OLA MS,ALHOMIDA AS,FERRARIO CM,et al.Role of tissue renin-angiotensin system and the Chymase/angiotensin-(1-12)Axis in the pathogenesis of diabetic retinopathy[J].Curr Med Chem,2017,24(28):3104-3114.
[8] FERRARIO CM,AHMAD S,VARAGIC J,et al.Intracrine angiotensin II functions originate from noncanonical pathways in the human heart[J].Am J Physiol Heart Circ Physiol,2016,311(2):H404-414.
[9] DUSING R.Mega clinical trials which have shaped the RAS intervention clinical practice[J].Ther Adv Cardiovasc Dis,2016,10(3):133-150.
[10]HOOSHDARAN B,KOLPAKOV MA,GUO X,et al.Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury[J].Basic Res Cardiol,2017,112(6):62.
[11]KAREINEN I,BAUMANN M,NGUYEN SD,et al.Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192)and compromises its cardioprotective activity[J].J Lipid Res,2018,59(6):945-957.
[12]FROOGH G,PINTO JT,LE Y,et al.Chymase-dependent production of angiotensin II:an old enzyme in old hearts[J].Am J Physiol Heart Circ Physiol,2017,312(2):H223-231.
[13]ZHANG H,WANG J,WANG L,et al.Induction of mast cell accumulation by chymase via an enzymatic activity-and intercellular adhesion molecule-1-dependent mechanism[J].Br J Pharmacol,2018,175(4):678-692.
[14]CHEN H,XU Y,YANG G,et al.Mast cell chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating TGF-beta1/Smads signaling pathway[J].Exp Ther Med,2017,14(5):4438-4442.
[15]JIMI S,MATSUMURA H.Effect of chymase activity on skin thickness in the Clawn miniature pig hypertrophic scarring model[J].J Plast Surg Hand Surg,2017,51(6):446-452.
[16]WANG R,CHEN J,ZHANG Z,et al.Role of chymase in the local renin-angiotensin system in keloids:inhibition of chymase may be an effective therapeutic approach to treat keloids[J].Drug Des Devel Ther,2015,9:4979-4988.
[17]SAARINEN J,KALKKINEN N,WELGUS HG,et al.Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84bond by mast cell chymase[J].J Biol Chem,1994,269(27):18134-18140.
[18]MATSUMOTO M,KUNIMITSU S,WADA K,et al.Mast cell distribution,activation,and phenotype in xanthoma[J].J Am Acad Dermatol,2007,56(6):1006-1012.
[19]WANG Z,SHEN XH,FENG WM,et al.Mast cell specific immunological biomarkers and metabolic syndrome among middle-aged and older Chinese adults[J].Endocr J,2017,64(3):245-253.
[20]RUBINO SM,NAE AM,JOHN V,et al.Chymase/Angiotensin I axis:apathway for Angiotensin II generation in diabetic human vitreous[J].Invest Ophthalmol Vis Sci,2016,57:5431.
[21]NABE T,KIJITANI Y,KITAGAWA Y,et al.Involvement of chymase in allergic conjunctivitis of guinea pigs[J].Exp Eye Res,2013,113:74-79.
[22]HARRISON-BERNARD LM,DE GARAVILLA L,BIVONA BJ.Enhanced vascular chymase-dependent conversion of endothelin in the diabetic kidney[J].Ochsner J,2013,13(1):49-55.
[23]ZHANG M,HUANG W,BAI J,et al.Chymase inhibition protects diabetic rats from renal lesions[J].Mol Med Rep,2016,14(1):121-128.
[24]PONS M,ALI L,BEGHDADI W,et al.Mast cells and MCPT4chymase promote renal impairment after partialu ureteral obstruction[J].Front Immunol,2017,8:450.
[25]李海滨,尹明实.糜酶对肝星状细胞转化生长因子β1/Smad3信号通路的影响[J].中国病毒病杂志,2016,6(5):332-335.
[26]王洋,尹明实.糜酶对肝星状细胞增殖及转分化的影响[J].免疫学杂志,2016,32(1):29-33.
[27]MIYAOKA Y,JIN D,TASHIRO K,et al.Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet[J].J Pharmacol Sci,2017,134(3):139-146.
[28]SVERRILD A,BERGQVIST A,BAINES KJ,et al.Airway responsiveness to mannitol in asthma is associated with chymasepositive mast cells and eosinophilic airway inflammation[J].Clin Exp Allergy,2016,46(2):288-297.
[29]KOSANOVIC D,LUITEL H,DAHAL BK,et al.Chymase:a multifunctional player in pulmonary hypertension associated with lung fibrosis[J].Eur Respir J,2015,46(4):1084-1094.
[30]KOMEDA K,TAKAI S,JIN D,et al.Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters[J].Hepatol Res,2010,40(8):832-840.
[31]MCMURRAY JJ,KRUM H,ABRAHAM WT,et al.Aliskiren,enalapril,or aliskiren and enalapril in heart failure[J].N Engl J Med,2016,374(16):1521-1532.
[32]PARVING HH,BRENNER BM,MCMURRAY JJ,et al.Cardiorenal end points in a trial of aliskiren for type 2diabetes[J].N Engl J Med,2012,367(23):2204-2213.