鱼类C-型凝集素结构特征及其免疫功能
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摘要
<正>凝集素是一类不具有酶催化活性的蛋白或糖蛋白,能特异性地识别并结合微生物表面的糖蛋白或糖基复合物而启动先天免疫反应[1-3]。根据糖的结合特性和钙离子依赖性,鱼类凝集素可分为C-型凝集素、F-型凝集素、半乳糖凝集素和鼠李糖结合凝集素等[4]。其中C-型凝集素在鱼体感染致病微生物的过程中发挥重要的免疫功能[2,5]。各种类型的C-型凝集素在诸多鱼类中已被发现[6-25],如斑马
引文
[1] Dam T K, Brewer C F. Lectins as pattern recognition molecules: the effects of epitope density in innate immunity [J]. Glycobiology,2010,20(3):270-279.
[2] 黄智慧, 马爱军, 雷霁霖. 鱼类体表粘液凝集素研究进展[J]. 动物学研究,2013,34(6):674-679.
[3] 关鑫, 梁一. 凝集素及其应用的研究进展[J]. 检验医学与临床,2016,13(9):1268-1270.
[4] Ng T B, Fai Cheung R C, Wing Ng C C, et al. A review of fish lectins [J]. Current Protein & Peptide Science,2015,16(4):337-351.
[5] 刘博宇, 李盼, 杨桂连. C-型凝集素受体在寄生虫感染免疫调节中的作用[J]. 中国寄生虫学与寄生虫病杂志,2015,33(3):228-232.
[6] Nikolakopoulou K, Zarkadis I K. Molecular cloning and characterization of two homologues of mannose-binding lectin in rainbow trout [J]. Fish & Shellfish Immunology,2006,21(3):305-314.
[7] Lin A F, Xiang L X, Wang Q L, et al. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity [J]. Journal of Immunology,2009,183(11):7398-7410.
[8] 郑菲菲. 斑马鱼甘露糖受体的分子克隆和功能研究[D]. 武汉:华中农业大学,2016.
[9] Zhang M, Hu Y H, Sun L. Identification and molecular analysis of a novel C-type lectin from Scophthalmus maximus [J]. Fish & Shellfish Immunology,2010,29(1):82-88.
[10] 夏丹丹. 大菱鲆C-型和Lily型凝集素基因的克隆、表达及功能研究[D]. 上海:上海海洋大学,2016.
[11] Wei J G, Xu D, Zhou J G, et al. Molecular cloning, characterization and expression analysis of a C-type lectin (Ec-CTL) in orange-spotted grouper, Epinephelus coioides[J]. Fish & Shellfish Immunology,2010,28(1):178-186.
[12] 吉华松. 斜带石斑鱼类C-型凝集素CTLP和硫氧还蛋白相关蛋白Txndcl2的克隆和分子特征分析[D]. 海口:海南大学,2013.
[13] Lopesferreira M, Magalhāes G S, Fernandez J H, et al. Structural and biological characterization of nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri[J]. Biochimie,2011,93(6):971-980.
[14] Liu F, Li J, Fu J, et al. Two novel homologs of simple C-type lectin in grass carp (Ctenopharyngodon idellus): potential role in immune response to bacteria[J]. Fish & Shellfish Immunology,2011,31(6):765-773.
[15] Zhang H,Peatman E, Liu H, et al. Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus)[J]. Research in Veterinary Science,2012,92(3):408-413.
[16] Yu S, Yang H, Chai Y, et al. Molecular cloning and characterization of a C-type lectin in roughskin sculpin (Trachidermus fasciatus)[J]. Fish & Shellfish Immunology,2013,34(2):582-592.
[17] Zhou Z J, Sun L. CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif[J]. Developmental & Comparative Immunology,2015,50(2):69-77.
[18] Yang G J, Lu X J, Chen Q, et al. Molecular characterization and functional analysis of a novel C-type lectin receptor-like gene from a teleost fish, Plecoglossus altivelis[J]. Fish & Shellfish Immunology,2015,44(2):603-610.
[19] Ma H L, Shi Y H, Zhang X H, et al. A transmembrane C-type lectin receptor mediates LECT2 effects on head kidney-derived monocytes/macrophages in a teleost,Plecoglossus altivelis [J]. Fish & Shellfish Immunology,2016(51):70-76.
[20] 蔡佳, 张雪利, 吴灶和,等. 红笛鲷(Lutjanus sanguineus)C-型凝集素基因的克隆与组织表达分析[J]. 生物技术通报,2015,31(5):179-185.
[21] 赵晓恒. 团头鲂甘露糖受体CTLD4-8结构域抗体制备及功能分析[D]. 武汉:华中农业大学,2015.
[22] 刘小玲, 王虹, 樊启学,等. 黄颡鱼甘露糖受体基因的克隆和功能分析[J]. 水产学报,2017,41(7):1036-1043.
[23] 吕常欢. 大黄鱼凝集素galectin-9和nattectin-like的功能研究[D]. 厦门:集美大学,2016.
[24] Liu Y, Li N Q, Zhao X P, et al.A C-type lectin that inhibits bacterial infection and facilitates viral invasion in black rockfish, Sebastes schlegelii[J]. Fish & Shellfish Immunology,2016(57):309-317.
[25] Mu L L, Yin X X, Liu J, et al. Identification and characterization of a mannose-binding lectin from Nile tilapia (Oreochromis niloticus)[J]. Fish & Shellfish Immunology,2017(67):244-253.
[26] Kilpatrick D C. Mannan-binding lectin and its role in innate immunity [J]. Transfusion Medicine,2002,12(6):335-352.
[27] Zelensky A N, Gready J E. Comparative analysis of structural properties of the C-type-lectin-like domain (CTLD)[J]. Proteins—Structure Function & Bioinformatics,2003,52(3):466-477.
[28] Akira S,Uematsu S, Takeuchi O. Pathogen recognition and innate immunity[J]. Cell,2006,124(4):783-801.
[29] Zelensky A N, Gready J E. The C-type lectin-like domain superfamily[J]. FEBS Journal,2005,272(24):6179-6217.
[30] Drickamer K. Evolution of Ca2+-dependent animal lectins[J]. Progress in Nucleic Acid Research & Molecular Biology,1993(45):207-232.
[31] Drickamer K, Fadden A J. Genomic analysis of C-type lectins[J]. Biochemical Society Symposium,2002(69):59-72.
[32] Zelensky A N, Gready J E. C-type lectin-like domains in Fugu rubripes[J]. BMC Genomics,2004,5(1):51-72.
[33] Wang L, Jie Z, Kong X, et al. A C-type lectin, nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria[J]. Fish & Shellfish Immunology,2017(67):382-392.
[34] Brissett N C, Perkins S J. The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily[J]. Febs Letters,1996,388(2/3):211-216.
[35] Hamburger Z A, Brown M S,Isberg R R, et al. Crystal structure of invasin: a bacterial integrin-binding protein[J]. Science,1999,286(5438):291-295.
[36] Drickamer K. C-type lectin-like domains[J]. Current Opinion in Structural Biology,1999,9(5):585-590.
[37] Geijtenbeek T B, van Vliet S J, Engering A, et al. Self- and nonself-recognition by C-type lectins on dendritic cells[J]. Annual Review of Immunology,2004(22):33-54.
[38] Weis W I,Drickamer K, Hendrickson W A. Structure of a C-type mannose-binding protein complexed with an oligosaccharide[J]. Nature,1992,360(6400):127-134.
[39] Feinberg H, Mitchell D A,Drickamer K, et al. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR[J]. Science,2001,294(5549):2163-2166.
[40] Iobst S T, Drickamer K. Binding of sugar ligands to Ca2+-dependent animal lectins. Ⅱ. Generation of high-affinity galactose binding by site-directed mutagenesis[J]. Journal of Biological Chemistry,1994,269(22):15512-15519.
[41] Drickamer K. Engineering galactose-binding activity into a C-type mannose-binding protein [J]. Nature,1992,360(6400):183-186.
[42] Osorio F, Sousa C R. Myeloid C-type lectin receptors in pathogen recognition and host defense [J]. Immunity,2011,34(5):651-664.
[43] Vasta G R, Ahmed H, Odom E W. Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates[J]. Current Opinion in Structural Biology,2004,14(5):617-630.
[44] van Vliet S J,Garcíavallejo J J, Van K Y. Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses[J]. Immunology & Cell Biology,2008,86(7):580-587.
[45] Yang L, Bu L, Sun W, et al. Functional characterization of mannose-binding lectin in zebrafish:implication for a lectin-dependent complement system in early embryos[J]. Developmental & Comparative Immunology,2014,46(2):314-322.
[46] 顾圆圆, 夏正坤. 甘露糖结合凝集素的研究进展[J]. 医学研究生学报,2008,21(5):537-541.
[47] 刘梅,赵忠利,仲跻峰,等. 甘露糖结合凝集素基因的研究进展[J]. 中国畜牧兽医,2009,36(6):45-49.
[48] Straight A F, Cheung A,Limouze J, et al. Dissecting temporal and spatial control of cytokinesis with a myosin Ⅱ inhibitor[J]. Science,2003,299(5613):1743-1747.
[49] Obungu V H, Burns A L, Agarwal S K, et al. Menin, a tumor suppressor, associates with nonmuscle myosin Ⅱ-A heavy chain[J]. Oncogene,2003,22(41):6347-6358.
[50] Tsutsumi A, Takahashi R, Sumida T. Mannose binding lectin: genetics and autoimmune disease[J]. Autoimmunity Reviews,2005,4(6):364-372.
[51] Turner M W. The role of mannose-binding lectin in health and disease [J]. Molecular Immunology,2003,40(7):423-429.
[52] Boshra H, Li J, Sunyer J O. Recent advances on the complement system of teleost fish[J]. Fish & Shellfish Immunology,2006,20(2):239-262.
[53] 刘俊丽, 曹诚, 马清钧. MBL调控MASP激活补体系统[J]. 生物技术通讯,2006,17(4):624-625.
[54] Wang Z, Han Y. Response of gene expression to LPS challenge manifests the ontogeny and maturation of the complement system in zebrafish larvae[J]. Journal of the Marine Biological Association of the UK,2013,93(7):1965-1971.
[55] K?bis J M, Rebl A, Kühn C, et al. Comprehensive and comparative transcription analyses of the complement pathway in rainbow trout[J]. Fish & Shellfish Immunology,2015,42(1):98-107.
[56] Nakao M,Kajiya T, Sato Y, et al. Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)[J]. Journal of Immunology,2006,177(8):5471-5479.
[57] Kania P W, Sorensen R R, Koch C, et al. Evolutionary conservation of mannan-binding lectin (MBL) in bony fish: identification, characterization and expression analysis of three bona fide collectin homologues of MBL in the rainbow trout (Oncorhynchus mykiss)[J]. Fish & Shellfish Immunology,2010,29(6):910-920.
[58] 杨丽丽. 斑马鱼甘露糖结合凝集素基因的表达和免疫功能的研究[D]. 青岛:中国海洋大学,2014.
[59] Goel C, Barat A,Pande V, et al. Molecular cloning and characterization of mannose binding lectin homologue from snow trout (Schizothorax richardsonii)[J]. Protein Journal,2015,34(1):1-8.
[60] 党云飞. 草鱼抗菌免疫基因筛选及补体凝集素途径基因功能研究[D]. 上海:上海海洋大学,2017.
[2] 黄智慧, 马爱军, 雷霁霖. 鱼类体表粘液凝集素研究进展[J]. 动物学研究,2013,34(6):674-679.
[3] 关鑫, 梁一. 凝集素及其应用的研究进展[J]. 检验医学与临床,2016,13(9):1268-1270.
[4] Ng T B, Fai Cheung R C, Wing Ng C C, et al. A review of fish lectins [J]. Current Protein & Peptide Science,2015,16(4):337-351.
[5] 刘博宇, 李盼, 杨桂连. C-型凝集素受体在寄生虫感染免疫调节中的作用[J]. 中国寄生虫学与寄生虫病杂志,2015,33(3):228-232.
[6] Nikolakopoulou K, Zarkadis I K. Molecular cloning and characterization of two homologues of mannose-binding lectin in rainbow trout [J]. Fish & Shellfish Immunology,2006,21(3):305-314.
[7] Lin A F, Xiang L X, Wang Q L, et al. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity [J]. Journal of Immunology,2009,183(11):7398-7410.
[8] 郑菲菲. 斑马鱼甘露糖受体的分子克隆和功能研究[D]. 武汉:华中农业大学,2016.
[9] Zhang M, Hu Y H, Sun L. Identification and molecular analysis of a novel C-type lectin from Scophthalmus maximus [J]. Fish & Shellfish Immunology,2010,29(1):82-88.
[10] 夏丹丹. 大菱鲆C-型和Lily型凝集素基因的克隆、表达及功能研究[D]. 上海:上海海洋大学,2016.
[11] Wei J G, Xu D, Zhou J G, et al. Molecular cloning, characterization and expression analysis of a C-type lectin (Ec-CTL) in orange-spotted grouper, Epinephelus coioides[J]. Fish & Shellfish Immunology,2010,28(1):178-186.
[12] 吉华松. 斜带石斑鱼类C-型凝集素CTLP和硫氧还蛋白相关蛋白Txndcl2的克隆和分子特征分析[D]. 海口:海南大学,2013.
[13] Lopesferreira M, Magalhāes G S, Fernandez J H, et al. Structural and biological characterization of nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri[J]. Biochimie,2011,93(6):971-980.
[14] Liu F, Li J, Fu J, et al. Two novel homologs of simple C-type lectin in grass carp (Ctenopharyngodon idellus): potential role in immune response to bacteria[J]. Fish & Shellfish Immunology,2011,31(6):765-773.
[15] Zhang H,Peatman E, Liu H, et al. Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus)[J]. Research in Veterinary Science,2012,92(3):408-413.
[16] Yu S, Yang H, Chai Y, et al. Molecular cloning and characterization of a C-type lectin in roughskin sculpin (Trachidermus fasciatus)[J]. Fish & Shellfish Immunology,2013,34(2):582-592.
[17] Zhou Z J, Sun L. CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif[J]. Developmental & Comparative Immunology,2015,50(2):69-77.
[18] Yang G J, Lu X J, Chen Q, et al. Molecular characterization and functional analysis of a novel C-type lectin receptor-like gene from a teleost fish, Plecoglossus altivelis[J]. Fish & Shellfish Immunology,2015,44(2):603-610.
[19] Ma H L, Shi Y H, Zhang X H, et al. A transmembrane C-type lectin receptor mediates LECT2 effects on head kidney-derived monocytes/macrophages in a teleost,Plecoglossus altivelis [J]. Fish & Shellfish Immunology,2016(51):70-76.
[20] 蔡佳, 张雪利, 吴灶和,等. 红笛鲷(Lutjanus sanguineus)C-型凝集素基因的克隆与组织表达分析[J]. 生物技术通报,2015,31(5):179-185.
[21] 赵晓恒. 团头鲂甘露糖受体CTLD4-8结构域抗体制备及功能分析[D]. 武汉:华中农业大学,2015.
[22] 刘小玲, 王虹, 樊启学,等. 黄颡鱼甘露糖受体基因的克隆和功能分析[J]. 水产学报,2017,41(7):1036-1043.
[23] 吕常欢. 大黄鱼凝集素galectin-9和nattectin-like的功能研究[D]. 厦门:集美大学,2016.
[24] Liu Y, Li N Q, Zhao X P, et al.A C-type lectin that inhibits bacterial infection and facilitates viral invasion in black rockfish, Sebastes schlegelii[J]. Fish & Shellfish Immunology,2016(57):309-317.
[25] Mu L L, Yin X X, Liu J, et al. Identification and characterization of a mannose-binding lectin from Nile tilapia (Oreochromis niloticus)[J]. Fish & Shellfish Immunology,2017(67):244-253.
[26] Kilpatrick D C. Mannan-binding lectin and its role in innate immunity [J]. Transfusion Medicine,2002,12(6):335-352.
[27] Zelensky A N, Gready J E. Comparative analysis of structural properties of the C-type-lectin-like domain (CTLD)[J]. Proteins—Structure Function & Bioinformatics,2003,52(3):466-477.
[28] Akira S,Uematsu S, Takeuchi O. Pathogen recognition and innate immunity[J]. Cell,2006,124(4):783-801.
[29] Zelensky A N, Gready J E. The C-type lectin-like domain superfamily[J]. FEBS Journal,2005,272(24):6179-6217.
[30] Drickamer K. Evolution of Ca2+-dependent animal lectins[J]. Progress in Nucleic Acid Research & Molecular Biology,1993(45):207-232.
[31] Drickamer K, Fadden A J. Genomic analysis of C-type lectins[J]. Biochemical Society Symposium,2002(69):59-72.
[32] Zelensky A N, Gready J E. C-type lectin-like domains in Fugu rubripes[J]. BMC Genomics,2004,5(1):51-72.
[33] Wang L, Jie Z, Kong X, et al. A C-type lectin, nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria[J]. Fish & Shellfish Immunology,2017(67):382-392.
[34] Brissett N C, Perkins S J. The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily[J]. Febs Letters,1996,388(2/3):211-216.
[35] Hamburger Z A, Brown M S,Isberg R R, et al. Crystal structure of invasin: a bacterial integrin-binding protein[J]. Science,1999,286(5438):291-295.
[36] Drickamer K. C-type lectin-like domains[J]. Current Opinion in Structural Biology,1999,9(5):585-590.
[37] Geijtenbeek T B, van Vliet S J, Engering A, et al. Self- and nonself-recognition by C-type lectins on dendritic cells[J]. Annual Review of Immunology,2004(22):33-54.
[38] Weis W I,Drickamer K, Hendrickson W A. Structure of a C-type mannose-binding protein complexed with an oligosaccharide[J]. Nature,1992,360(6400):127-134.
[39] Feinberg H, Mitchell D A,Drickamer K, et al. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR[J]. Science,2001,294(5549):2163-2166.
[40] Iobst S T, Drickamer K. Binding of sugar ligands to Ca2+-dependent animal lectins. Ⅱ. Generation of high-affinity galactose binding by site-directed mutagenesis[J]. Journal of Biological Chemistry,1994,269(22):15512-15519.
[41] Drickamer K. Engineering galactose-binding activity into a C-type mannose-binding protein [J]. Nature,1992,360(6400):183-186.
[42] Osorio F, Sousa C R. Myeloid C-type lectin receptors in pathogen recognition and host defense [J]. Immunity,2011,34(5):651-664.
[43] Vasta G R, Ahmed H, Odom E W. Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates[J]. Current Opinion in Structural Biology,2004,14(5):617-630.
[44] van Vliet S J,Garcíavallejo J J, Van K Y. Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses[J]. Immunology & Cell Biology,2008,86(7):580-587.
[45] Yang L, Bu L, Sun W, et al. Functional characterization of mannose-binding lectin in zebrafish:implication for a lectin-dependent complement system in early embryos[J]. Developmental & Comparative Immunology,2014,46(2):314-322.
[46] 顾圆圆, 夏正坤. 甘露糖结合凝集素的研究进展[J]. 医学研究生学报,2008,21(5):537-541.
[47] 刘梅,赵忠利,仲跻峰,等. 甘露糖结合凝集素基因的研究进展[J]. 中国畜牧兽医,2009,36(6):45-49.
[48] Straight A F, Cheung A,Limouze J, et al. Dissecting temporal and spatial control of cytokinesis with a myosin Ⅱ inhibitor[J]. Science,2003,299(5613):1743-1747.
[49] Obungu V H, Burns A L, Agarwal S K, et al. Menin, a tumor suppressor, associates with nonmuscle myosin Ⅱ-A heavy chain[J]. Oncogene,2003,22(41):6347-6358.
[50] Tsutsumi A, Takahashi R, Sumida T. Mannose binding lectin: genetics and autoimmune disease[J]. Autoimmunity Reviews,2005,4(6):364-372.
[51] Turner M W. The role of mannose-binding lectin in health and disease [J]. Molecular Immunology,2003,40(7):423-429.
[52] Boshra H, Li J, Sunyer J O. Recent advances on the complement system of teleost fish[J]. Fish & Shellfish Immunology,2006,20(2):239-262.
[53] 刘俊丽, 曹诚, 马清钧. MBL调控MASP激活补体系统[J]. 生物技术通讯,2006,17(4):624-625.
[54] Wang Z, Han Y. Response of gene expression to LPS challenge manifests the ontogeny and maturation of the complement system in zebrafish larvae[J]. Journal of the Marine Biological Association of the UK,2013,93(7):1965-1971.
[55] K?bis J M, Rebl A, Kühn C, et al. Comprehensive and comparative transcription analyses of the complement pathway in rainbow trout[J]. Fish & Shellfish Immunology,2015,42(1):98-107.
[56] Nakao M,Kajiya T, Sato Y, et al. Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)[J]. Journal of Immunology,2006,177(8):5471-5479.
[57] Kania P W, Sorensen R R, Koch C, et al. Evolutionary conservation of mannan-binding lectin (MBL) in bony fish: identification, characterization and expression analysis of three bona fide collectin homologues of MBL in the rainbow trout (Oncorhynchus mykiss)[J]. Fish & Shellfish Immunology,2010,29(6):910-920.
[58] 杨丽丽. 斑马鱼甘露糖结合凝集素基因的表达和免疫功能的研究[D]. 青岛:中国海洋大学,2014.
[59] Goel C, Barat A,Pande V, et al. Molecular cloning and characterization of mannose binding lectin homologue from snow trout (Schizothorax richardsonii)[J]. Protein Journal,2015,34(1):1-8.
[60] 党云飞. 草鱼抗菌免疫基因筛选及补体凝集素途径基因功能研究[D]. 上海:上海海洋大学,2017.