不同镀层钕铁硼磁体抗胆汁腐蚀的体外研究
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摘要
目的:利用体外浸泡法评价镍镀层、氮化钛镀层和镍-氮化钛复合镀层后的钕铁硼磁体抗胆汁腐蚀的效果,为临床磁压榨技术在胆道重建中的应用提供表面改性方案。方法:收集临床患者胆汁,采用体外恒温38℃浸泡磁体,定期称量磁体质量并更换浸泡液,检测浸泡液铁离子浓度。浸泡30天后计算各组磁体质量丢失率,扫描电镜观察磁体表面结构。结果:胆汁浸泡30天后,裸磁体、镍镀层、氮化钛镀层、镍-氮化钛复合镀层组磁体质量丢失率分别为0.57%、0.35%、0.34%、0.19%,不同时间点浸泡液铁离子浓度不同。电镜观察结果显示各组浸泡后磁体表面均出现不同程度的腐蚀斑,镀层出现脱落。结论:镍-氮化钛复合镀层表面改性处理后的钕铁硼磁体抗腐蚀能力明显优于单纯镍镀层和氮化钛镀层的磁体。
Objective: To evaluate the effect of Nd-Fe-B magnets coated with Ni, Ti N and Ni-Ti N composite coatings on the bile corrosion through the in vitro immersion method, and provide a surface modification scheme for the clinical application of magnetic compression technique in biliary reconstruction. Methods: The bile of clinical patients was collected, and the magnets were immersed at38 ℃ in vitro. The weight of magnets was periodically weighed and the soaking solution was replaced to measure the iron ion concentration of the soaking solution. After 30 days of immersion, the weight loss rate of each group of magnets were calculated, and the surface structure of magnets were observed by scanning electron microscopy. Results: After 30 days of bile soaking, the weight loss rates of magnets of bare magnet, nickel plating, titanium nitride coating and nickel-titanium nitride composite coating were 0.57%, 0.35%,0.34%, and 0.19%, respectively. The concentration of iron in the soaking solution is different in each time points. Electron microscopy showed that the surface of each group of magnets showed different degrees of corrosion spots after immersion, and the coating appeared to fall off. Conclusions: The corrosion resistance of NdFeB magnets after surface modification of nickel-titanium nitride composite coating was significantly better than that of pure nickel coating and titanium nitride coating.
Objective: To evaluate the effect of Nd-Fe-B magnets coated with Ni, Ti N and Ni-Ti N composite coatings on the bile corrosion through the in vitro immersion method, and provide a surface modification scheme for the clinical application of magnetic compression technique in biliary reconstruction. Methods: The bile of clinical patients was collected, and the magnets were immersed at38 ℃ in vitro. The weight of magnets was periodically weighed and the soaking solution was replaced to measure the iron ion concentration of the soaking solution. After 30 days of immersion, the weight loss rate of each group of magnets were calculated, and the surface structure of magnets were observed by scanning electron microscopy. Results: After 30 days of bile soaking, the weight loss rates of magnets of bare magnet, nickel plating, titanium nitride coating and nickel-titanium nitride composite coating were 0.57%, 0.35%,0.34%, and 0.19%, respectively. The concentration of iron in the soaking solution is different in each time points. Electron microscopy showed that the surface of each group of magnets showed different degrees of corrosion spots after immersion, and the coating appeared to fall off. Conclusions: The corrosion resistance of NdFeB magnets after surface modification of nickel-titanium nitride composite coating was significantly better than that of pure nickel coating and titanium nitride coating.
引文
[1]田波彦,马佳,刘豪,等.磁控腹腔镜手术内置抓钳离合系统的设计[J].中国医疗设备, 2018, 33(08):70-73
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[15]严小鹏,高燕凤,邹余粮,等.基于磁压榨技术的直肠阴道瘘一期修补装置[J].生物医学工程学杂志, 2015, 32(5):1096-1099
[16] Yan XP, Zou YL, She ZF, et al. Magnet compression tech nique:a novel method for rectovaginal fistula repair[J]. Int J Colorectal Dis,2016, 31:937-938
[17] She ZF, Yan XP, Ma F, et al. Treatment of rectovaginal fistula by magnetic compression[J]. Int Urogynecol J, 2017, 28:241-247
[18]付珊,马佳,赵广宾,等.磁压榨直肠阴道瘘闭合修补装置的改良设计[J].中国医疗设备, 2018, 33(04):46-49
[19] Yan X, Fan C, Ma J, et al. Portacaval Shunt Established in Six Dogs Using Magnetic Compression Technique[J]. PLoS One, 2013, 8(9):e76873
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[22]严小鹏,吕毅,马佳,等.基于磁压榨技术的介入下肝外门腔分流器械的研制[J].中国医疗器械杂志, 2013, 37(6):421-422+436
[23] Klima U, Mac Vaugh H, Bagaev E, et al. Magnetic Vascular Port in minimally invasive direct coronary artery bypass grafting[J].Circulation, 2004, 110(11):Ⅱ55-60
[24] Wang SP, Yan XP, Xue F, et al. Fast magnetic reconstruction of the portal vein with allogeneic blood vessels in canines[J]. Hepatobiliary Pancreat Dis Int, 2015, 14(3):293-299
[25]严小鹏,任冯刚,刘雯雁,等.磁压榨技术联合内镜实施犬胃造瘘术[J].中华胃肠外科杂志, 2015, 18(8):832-834
[26]严小鹏,任冯刚,刘雯雁,等.磁锚定技术联合磁压榨技术实现超微创胃造瘘[J].中华实验外科杂志, 2016, 33(2):291-294
[27] Uygun I, Okur MH, Arayici Y, et al. Magnetic compression ostomy for simple tube colostomy in rats-magnacolostomy[J]. Adv Clin Exp Med, 2012, 21(3):301-305
[28] Uygun I, Okur MH, Cimen H, et al. Magnetic compression gastrostomy in the rat[J]. Pediatr Surg Int, 2012, 28(5):529-532
[29]唐镇,吴建勇,陈溪.不同镀膜钕铁硼磁体抗腐蚀性的体外实验研究[J].实用口腔医学杂志, 2013, 29(2):195-197
[30]曹晓明,侯志明,楚明.镀氮化钛膜钕铁硼磁体细胞毒性的实验研究[J].上海口腔医学, 2008, 17(2):191-195
[31] Liu XM, Yan XP, Zhang HK, et al. Magnetic anastomosis for biliojejunostomy:first prospective clinical trial[J]. World J Surg,2018. doi:10.1007/s00268-018-4710-y.[Epub ahead of print]
[32]严小鹏,刘雯雁,李涤尘,等.消化外科手术的内镜化途径:磁吻合联合内镜[J].世界华人消化杂志, 2014, 22(19):2716-2721
[2] An Y, Zhang Y, Liu H, et al. Gastrojejunal anastomosis in rats using the magnetic compression technique[J]. Sci Rep, 2018, 8:11620
[3] Ma F, Ma J, Ma S, et al. A novel magnetic compression technique for small intestinal end-to-side anastomosis in rats[J]. J Pediatr Surg,2018. doi:10.1016/j.jpedsurg.2018.07.011.[Epub ahead of print]
[4] Leroy J, Perretta S, Diana M, et al. An original endoluminal magnetic anastomotic device allowing pure NOTES transgastric and transrectal sigmoidectomy in a porcine model:proof of concept[J]. Surg Innov,2012, 19(2):109-116
[5] Gonzales KD, Douglas G, Pichakron KO, et al. Magnamosis III:delivery of a magnetic compression anastomosis device using minimally invasive endoscopic techniques[J]. J Pediatr Surg, 2012, 47(6):1291-1295
[6] Ryou M, Cantillon-Murphy P, Azagury D, et al. Smart SelfAssembling MagnetS for ENdoscopy(SAMSEN)for transoral endoscopic creation of immediate gastrojejunostomy(with video)[J].Gastrointest Endosc, 2011, 73(2):353-359
[7] Jianhui Li, Yi Lv, Bo Qu, et al. Applicationof a new type of sutureless magnetic biliary-enteric anatomosis stent for one-stage reconstruction of the biliary-enteric continuity after acute bile ductinjury:an experimental study[J]. J Surg Res, 2008, 148:136-142
[8] Fan Chao, Yan Xiao-peng, Liu Shi-qi, et al. Roux-en-Y choledochojejunostomy using novel magnetic compressive anastomats in canine model of obstructive jaundice[J]. Hepatobiliary Panccreat Dis Int, 2012, 11(1):81-88
[9] Fan C, Zhang H, Yan X, et al. Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models[J]. Surg Endosc, 2018, 32(2):779-789
[10] Avaliani M, Chigogidze N, Nechipai A, et al. Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice:initial clinical results[J]. J Vasc Interv Radiol, 2009, 20(5):614-623
[11] Ellebaek MBB, Qvist N, Rasmussen L. Magnetic compression anastomosis in long-gap esophageal atresia gross type A:a case report[J]. European J Pediatr Surg Rep, 2018, 6(1):e37-e39
[12] Woo R, Wong CM, Trimble Z, et al. Magnetic compression stricturoplasty for treatment of refractory esophageal strictures in children:technique and lessons learned[J]. Surg Innov, 2017, 24(5):432-439
[13] Bouchard S, Huberty V, Blero D, et al. Magnetic compression for treatment of large oesophageal diverticula:a new endoscopic approach for a risky surgical disease?[J]. Gut, 2015, 64(11):1678-1679
[14] Zaritzky M, Ben R, Zylberg, GI, et al. Magnetic compression anastomosis as a nonsurgical treatment for esophageal atresia[J].Pediatr Radiol, 2009, 39(9):945-949
[15]严小鹏,高燕凤,邹余粮,等.基于磁压榨技术的直肠阴道瘘一期修补装置[J].生物医学工程学杂志, 2015, 32(5):1096-1099
[16] Yan XP, Zou YL, She ZF, et al. Magnet compression tech nique:a novel method for rectovaginal fistula repair[J]. Int J Colorectal Dis,2016, 31:937-938
[17] She ZF, Yan XP, Ma F, et al. Treatment of rectovaginal fistula by magnetic compression[J]. Int Urogynecol J, 2017, 28:241-247
[18]付珊,马佳,赵广宾,等.磁压榨直肠阴道瘘闭合修补装置的改良设计[J].中国医疗设备, 2018, 33(04):46-49
[19] Yan X, Fan C, Ma J, et al. Portacaval Shunt Established in Six Dogs Using Magnetic Compression Technique[J]. PLoS One, 2013, 8(9):e76873
[20] Yan XP, Liu WY, Ma J, et al. Extrahepatic portacaval shunt via magnetic compression technique:a cadaveric feasibility study[J].World J Gastroenterol, 2015, 21(26):8073-8080
[21] Wang HH, Ma J, wang SP, et al. Magnetic anastomosis rings to create portacaval shunt in a canine model of portal hypertension[J]. J Gastrointest Surg, 2018.doi:10.1007/s11605-018-3888-5[Epub ahead of print]
[22]严小鹏,吕毅,马佳,等.基于磁压榨技术的介入下肝外门腔分流器械的研制[J].中国医疗器械杂志, 2013, 37(6):421-422+436
[23] Klima U, Mac Vaugh H, Bagaev E, et al. Magnetic Vascular Port in minimally invasive direct coronary artery bypass grafting[J].Circulation, 2004, 110(11):Ⅱ55-60
[24] Wang SP, Yan XP, Xue F, et al. Fast magnetic reconstruction of the portal vein with allogeneic blood vessels in canines[J]. Hepatobiliary Pancreat Dis Int, 2015, 14(3):293-299
[25]严小鹏,任冯刚,刘雯雁,等.磁压榨技术联合内镜实施犬胃造瘘术[J].中华胃肠外科杂志, 2015, 18(8):832-834
[26]严小鹏,任冯刚,刘雯雁,等.磁锚定技术联合磁压榨技术实现超微创胃造瘘[J].中华实验外科杂志, 2016, 33(2):291-294
[27] Uygun I, Okur MH, Arayici Y, et al. Magnetic compression ostomy for simple tube colostomy in rats-magnacolostomy[J]. Adv Clin Exp Med, 2012, 21(3):301-305
[28] Uygun I, Okur MH, Cimen H, et al. Magnetic compression gastrostomy in the rat[J]. Pediatr Surg Int, 2012, 28(5):529-532
[29]唐镇,吴建勇,陈溪.不同镀膜钕铁硼磁体抗腐蚀性的体外实验研究[J].实用口腔医学杂志, 2013, 29(2):195-197
[30]曹晓明,侯志明,楚明.镀氮化钛膜钕铁硼磁体细胞毒性的实验研究[J].上海口腔医学, 2008, 17(2):191-195
[31] Liu XM, Yan XP, Zhang HK, et al. Magnetic anastomosis for biliojejunostomy:first prospective clinical trial[J]. World J Surg,2018. doi:10.1007/s00268-018-4710-y.[Epub ahead of print]
[32]严小鹏,刘雯雁,李涤尘,等.消化外科手术的内镜化途径:磁吻合联合内镜[J].世界华人消化杂志, 2014, 22(19):2716-2721