小儿肺热咳喘口服液联合阿奇霉素治疗儿童支原体肺炎的疗效观察
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摘要
目的观察小儿肺热咳喘口服液联合阿奇霉素治疗儿童支原体肺炎的疗效。方法选取2016年1月—2018年1月于我院治疗的200例支原体肺炎患儿作为研究对象,按照随机数字表法将患儿分为对照组(100例)与观察组(100例)。对照组采用阿奇霉素序贯治疗,观察组在对照组治疗基础上给予小儿肺热咳喘口服液辅助治疗,比较2组患儿治疗前后的临床疗效。结果治疗3周后,观察组患儿咳嗽、咳痰、喘促、发热等症状消失时间均短于对照组(P均<0.05);CRP、降钙素原及铁蛋白水平下降幅度均大于对照组(P均<0.05)。结论小儿肺热咳喘口服液联合阿奇霉素治疗支原体肺炎,能够快速缓解患儿临床症状和体征,降低炎性因子水平。
Objective To observe the efficacy of infantile feire kechuan oral solution combined with azithromycin in the treatment of children mycoplasma pneumonia. Methods The clinical data of 200 children with mycoplasma pneumonia who were treated from January 2016 to January 2018 in our hospital were collected. The involved children were divided into control group(100 cases) and observation group(100 cases) with random digital method. In the control group, children were treated with azithromycin sequential therapy. In the observation group, children were treated with infantile feire kechuan oral solution as adjuvant treatment on the basis of treatment in the control group. Clinical efficacy of children in 2 groups was compared before and after treatment. Results After 3 weeks of treatment, the disappearance time of symptoms such as cough, sputum, asthma and fever in the observation group was shorter than those in the control group(P <0.05) and the decrease of CRP, procalcitonin and ferritin were more obvious than those in the control group(P <0.05). Conclusions The combined therapy of infantile feire kechuan oral solution and azithromycin for the treatment of mycoplasma pneumonia can rapidly relieve the clinical symptoms and signs of the affected children and reduce the level of inflammatory factors.
Objective To observe the efficacy of infantile feire kechuan oral solution combined with azithromycin in the treatment of children mycoplasma pneumonia. Methods The clinical data of 200 children with mycoplasma pneumonia who were treated from January 2016 to January 2018 in our hospital were collected. The involved children were divided into control group(100 cases) and observation group(100 cases) with random digital method. In the control group, children were treated with azithromycin sequential therapy. In the observation group, children were treated with infantile feire kechuan oral solution as adjuvant treatment on the basis of treatment in the control group. Clinical efficacy of children in 2 groups was compared before and after treatment. Results After 3 weeks of treatment, the disappearance time of symptoms such as cough, sputum, asthma and fever in the observation group was shorter than those in the control group(P <0.05) and the decrease of CRP, procalcitonin and ferritin were more obvious than those in the control group(P <0.05). Conclusions The combined therapy of infantile feire kechuan oral solution and azithromycin for the treatment of mycoplasma pneumonia can rapidly relieve the clinical symptoms and signs of the affected children and reduce the level of inflammatory factors.
引文
[1]刘雪梅,徐飞,谈华,等.进展为难治性支原体肺炎的危险因素分析[J].山东医药,2018,58(28):86-88.
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[10]范家应,马融,杨洋,等.小儿肺热咳喘口服液联合阿奇霉素治疗支原体肺炎的Meta-分析[J].药物评价研究,2018,41(4):527-533.
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[13]罗有同,孔小娣,林泽州,等.小儿肺热咳喘口服液佐治支原体肺炎的疗效及其对患儿血清炎症因子的影响[J].海南医学,2017,28(4):589-591.
[14]邸顺祥.小儿肺热咳喘口服液治疗小儿肺炎的临床效果及短期复发情况分析[J].中国处方药,2018,16(1):113-114.
[15]牟淑娟,孙树雅,沈鸿渺,等.麻杏石甘汤合苏葶定喘丸化裁对痰热闭肺证支原体肺炎小儿症状缓解、血清因子水平的影响[J].环球中医药,2018,11(11):1809-1812.
[16]孙文娟,陈欣,郭建光,等.玉屏风颗粒辅助治疗小儿难治性支原体肺炎的临床观察[J].临床肺科杂志,2017,22(8):1393-1396.
[17]Kumar S,Garg IB,Sethi GR,et al.Detection of immunoglobulin Mand immunoglobulin G antibodies to Mycoplasma pneumoniae in children with community-acquired lower respiratory tract infections[J].Indian J Pathol Microbiol,2018,61(2):214-218.
[18]王伟,王珂,秦殊,等.T细胞亚群及PCT监测在学龄前儿童支原体肺炎诊治中的价值[J].中国现代医学杂志,2017,27(14):83-86.
[19]陈巧琳,申昆玲,谢正德,等.血清铁蛋白水平与儿童社区获得性肺炎病情严重程度的关系[J].中华实用儿科临床杂志,2018,33(10):753-757.
[2]王良玉,辛德莉.肺炎支原体感染实验室诊断的研究进展[J].传染病信息,2017(1):51-55.
[3]肖新广,谷梅兰,张新明,等.儿童支原体肺炎合并细菌感染的CT影像学特点分析[J].中华医院感染学杂志,2017,27(2):429-431.
[4]胡亚美,江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2002.
[5]Rodman JB,Krivec U,Praprotnik M,et al.Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children[J].Eur J Clin Microbiol Infect Dis,2018,37(7):1265-1272.
[6]黄艳华,张永兰.儿童重症肺炎支原体肺炎的相关危险因素分析[J].中国临床医生杂志,2018,46(7):113-115.
[7]廖震,楼凌云.小儿肺咳颗粒辅助治疗儿童支原体肺炎的疗效及其对血清活化蛋白C和白介素1受体1型水平的影响[J].中国妇幼保健,2018,33(2):369-371.
[8]刘春燕,初灵芝.甲强龙冲击疗法治疗小儿难治性支原体肺炎的临床效果[J].系统医学,2017,2(3):70-72,87.
[9]李怡芳.清肺活血止咳汤治疗小儿支原体肺炎的临床研究[J].中国临床医生杂志,2017,45(4):105-107.
[10]范家应,马融,杨洋,等.小儿肺热咳喘口服液联合阿奇霉素治疗支原体肺炎的Meta-分析[J].药物评价研究,2018,41(4):527-533.
[11]姚亮.阿奇霉素联合特步他林雾化吸入治疗小儿支原体肺炎的临床疗效[J].中国保健营养,2017,27(20):132.
[12]余莉,何艳.痰热清、氨溴索联合阿奇霉素治疗小儿支原体肺炎的机制研究[J].海南医学院学报,2017,23(2):178-181.
[13]罗有同,孔小娣,林泽州,等.小儿肺热咳喘口服液佐治支原体肺炎的疗效及其对患儿血清炎症因子的影响[J].海南医学,2017,28(4):589-591.
[14]邸顺祥.小儿肺热咳喘口服液治疗小儿肺炎的临床效果及短期复发情况分析[J].中国处方药,2018,16(1):113-114.
[15]牟淑娟,孙树雅,沈鸿渺,等.麻杏石甘汤合苏葶定喘丸化裁对痰热闭肺证支原体肺炎小儿症状缓解、血清因子水平的影响[J].环球中医药,2018,11(11):1809-1812.
[16]孙文娟,陈欣,郭建光,等.玉屏风颗粒辅助治疗小儿难治性支原体肺炎的临床观察[J].临床肺科杂志,2017,22(8):1393-1396.
[17]Kumar S,Garg IB,Sethi GR,et al.Detection of immunoglobulin Mand immunoglobulin G antibodies to Mycoplasma pneumoniae in children with community-acquired lower respiratory tract infections[J].Indian J Pathol Microbiol,2018,61(2):214-218.
[18]王伟,王珂,秦殊,等.T细胞亚群及PCT监测在学龄前儿童支原体肺炎诊治中的价值[J].中国现代医学杂志,2017,27(14):83-86.
[19]陈巧琳,申昆玲,谢正德,等.血清铁蛋白水平与儿童社区获得性肺炎病情严重程度的关系[J].中华实用儿科临床杂志,2018,33(10):753-757.