四君子汤对胃肠道药理作用的研究进展
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摘要
四君子汤出自宋代《太平惠民和剂局方》,又名白术汤,具有补气、益气健脾之效,是治疗脾胃气虚证的经典方剂,其对气短乏力、食少便溏、面色萎白等导致的不良症状具有很好的治疗效果。在临床上,尤其是胃肠道方面,四君子汤应用广泛且取得了良好的效果。其主要用于治疗脾胃气虚证,具有调节胃肠运动、促进消化吸收、抗黏膜损伤、改善肠道黏膜免疫等多种作用。未来,深入研究四君子汤的药理作用,将为其临床合理应用提供参考依据。
Decoction of Four Mild Drugs,earliest recorded in the Taiping Huimin Heji Ju Fang of the Song Dynasty,also called rhizoma atractylodis macrocephalae decoction,having the effect of supplementing qi and improving qi and spleen,is a classic recipe for the therapy of syndrome of deficiency of spleen qi and stomach qi. The recipe has a good therapeutic effect on shortness of bread,weakness,appetite loss and loose stool,pale complexion and symptoms caused by syndrome of deficiency of spleen qi and stomach qi. In clinical,especially in gastrointestinal tract treatment,Decoction of Four Mild Drugs has been widely used and achieved good results. It is mainly used in the treatment of spleen-stomach qi deficiency syndrome. It has many functions,such as regulating gastrointestinal motility,promoting digestion and absorption,resisting mucosal injury and improving intestinal mucosal immunity. In the future,in-depth study of the pharmacological effects of Decoction of Four Mild Drugs will provide reference for its rational clinical application.
Decoction of Four Mild Drugs,earliest recorded in the Taiping Huimin Heji Ju Fang of the Song Dynasty,also called rhizoma atractylodis macrocephalae decoction,having the effect of supplementing qi and improving qi and spleen,is a classic recipe for the therapy of syndrome of deficiency of spleen qi and stomach qi. The recipe has a good therapeutic effect on shortness of bread,weakness,appetite loss and loose stool,pale complexion and symptoms caused by syndrome of deficiency of spleen qi and stomach qi. In clinical,especially in gastrointestinal tract treatment,Decoction of Four Mild Drugs has been widely used and achieved good results. It is mainly used in the treatment of spleen-stomach qi deficiency syndrome. It has many functions,such as regulating gastrointestinal motility,promoting digestion and absorption,resisting mucosal injury and improving intestinal mucosal immunity. In the future,in-depth study of the pharmacological effects of Decoction of Four Mild Drugs will provide reference for its rational clinical application.
引文
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[28]李茹柳,陶玉珠,曾丹,等.党参、甘草糖提取物对小肠上皮细胞迁移多胺信号通路的影响[J].中国药理学通报,2016,32(2):245-251.
[29]宋盼厚,陈昫,李茹柳.Rho鸟苷三磷酸酶调节细胞迁移中细胞骨架结构的研究进展[J].广州中医药大学学报,2013,30(2):275-280.
[30]涂小华,李茹柳,邓娇,等.四君子汤多糖对IEC-6细胞迁移、钙通道蛋白及膜电位的影响[J].中药材,2016,39(4):856-862.
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[33]黄子慧,任丹丹,曹程鸣,等.加味四君子汤对仔猪血清免疫因子水平及肠黏膜免疫的影响[J].西北农林科技大学学报,2017,45(3):75-81.
[34]张博,窦逾常,王垂杰,等.脾虚老龄大鼠肠黏膜SIgA、CD、CD8水平变化及四君子汤对其的影响[J].中国老年学杂志,2014,34(11):3063-3064.
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[36]刘良,周华,胡英杰,等.四君子汤复方总多糖对小鼠肠道黏膜相关淋巴组织的影响[J].中医中药与免疫,2000,17(4):204-206.
[37]Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[38]Cani PD,Delzenne NM.Gut microflora as a target for energy and metabolic homeostasis[J].Curr Opin Clin Nutr Metab Care,2007,10(6):729-734.
[39]Cerf-Bensussan N,Gaboriau-Routhiau V.The immune system and the gut microbiota:Friends or foes[J].Nat Rev Immunology,2010,10(10):735-744.
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[41]吴秀,周联,罗霞,等.四君子汤多糖对脾虚小鼠肠道菌群及免疫功能的影响[J].中药药理与临床,2014,30(2):12-14.
[42]鞠宝玲,唐小云,海艳洁,等.四君子汤对脱污染小鼠肠道菌群及肠黏膜免疫功能影响的研究[J].中药药理与临床,2008,24(5):1-3.
[43]孟良艳,陈秀琴,郭世宁,等.四君子汤对脾虚大鼠肠道菌群多样性的影响[J].畜牧兽医学报,2013,44(12):2029-2035.
[2]潘大洲.对中医内科疾病脾胃虚证给予四君子汤治疗的效果分析[J/CD].中西医结合心血管病电子杂志,2018,6(2):178.
[3]广州中医学院脾胃研究组药理小组.四君子汤对动物离体小肠运动的影响(一)[J].新中医,1978,10(5):53-55.
[4]吕林,唐旭东,王凤云,等.基于内质网应激角度探讨中医脾虚本质[J].中华中医药学刊,2018,36(4):819-823.
[5]刘佳,郭文峰,任理,等.四君子汤对脾气虚证模型大鼠小肠葡萄糖吸收功能作用的影响[J].中国中西医结合杂志,2013,33(10):1389-1393.
[6]黄丽花,王素军,钟运鸣,等.四君子汤对脾虚大鼠空肠黏膜的修复及对葡萄糖吸收的影响[J].中国实验方剂学杂志,2016,22(3):94-97.
[7]田今华,王晓民,韩济生.c AMP反应序列蛋白及其家族的转录调节[J].生理科学进展,1996,27(3):227-232.
[8]Caruso C,Carniglia L,Durand D,et al.Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-Protein kinase A pathway[J].Mol Cell Endocrinol,2012,348(1):47-54.
[9]何丽娟,贾连群,张立德,等.脾气虚证大鼠c AMP-PKA信号通路基因表达变化及四君子汤干预作用[J].中华中医药杂志,2015,30(11):4124-4027.
[10]成映霞,段永强,梁玉杰,等.四君子汤对脾气虚大鼠小肠黏膜SDH、LDH活性和细胞因子免疫应答平衡的影响[J].中药材,2015,38(9):1929-1932.
[11]刘友章,王昌俊,周俊亮,等.四君子汤修复脾虚大鼠线粒体细胞色素氧化酶的作用及机制[J].中国临床康复,2006,10(35):118-122.
[12]汪章平,郑国荣.中西医结合治疗治疗胃肠动力障碍性疾病的简况[J].实用中医内科杂志,2017,31(5):88-90.
[13]王汝俊,胡英杰,杜群,等.四君子汤对胃肠运动双向调节作用的物质基础研究(Ⅰ)[J].中药药理与临床,2001,17(6):3-4.
[14]巫燕莉,李燕舞.四君子汤单味药对家兔离体小肠运动的影响[J].现代中西医结合杂志,2010,19(5):532-533,536.
[15]Martinsen A,Dessy C,Morel N.Regulation of calcium channels in smooth muscle:New insights into the role of myosin light chain kinase[J].Channels(Austin),2014,8(5):402-413.
[16]钟子勋,张海燕,张望,等.四君子汤对脾虚证胃肠动力障碍大鼠胃平滑肌CaM-MLCK信号通路及机制探究[J].中国实验方剂学杂志,2018,24(5):95-99.
[17]修宗昌,陈群,尚文璠,等.脾虚证小肠运动异常的VIP/NO信号转导机制初探[J].上海中医药杂志,2006,40(2):55-56.
[18]王欢,黄永坤,刘梅.胃肠激素与胃肠道功能及疾病的关系[J].医学综述,2013,19(15):2735-2738.
[19]苏壬春,王俊平.胃泌素与胃癌发病机制的研究进展[J].中国药物与临床,2018,18(1):47-49.
[20]甘静宜,巩忠福,程桂林,等.四君子汤对胃虚大鼠血清消化酶及胃肠激素的影响[J].中国兽医杂志,2011,47(2):43-45.
[21]Carlini VP,Ghersi M,Schi9th HB,et al.Ghrelin and memory:Differential effects on acquisition and retrieval[J].Peptides,2010,31(6):1190-1193.
[22]王璐,王杰,刁一芮,等.四君子汤对脾气虚大鼠5-HIAA、MLT表达影响随机平行对照研究[J].实用中医内科杂志,2017,31(8):37-39.
[23]孙晓芬,程卫东,段永强,等.脾虚大鼠血清及胃组织中胃肠激素SS、GAS和CCK的变化及中药干预研究[J].时珍国医国药,2014,25(3):756-758.
[24]Sato M,Nakahara K,Goto S,et al.Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord[J].Biochem Biophys Res Commun,2006,350(3):598-603.
[25]吕林,黄穗平,唐旭东,等.四君子汤对脾虚证大鼠血清生长激素释放肽及胃窦肥大细胞的影响[J].中华中医药杂志,2015,30(2):390-394.
[26]刘春水,陆雪.胃黏膜的防御因子[J].中国医药指南,2010,8(19):229-230.
[27]Rao JN,Rathor N,Zou T,et al.STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+signaling after wounding[J].Am J Physiol Cell Physiol,2010,299(3):C579-588.
[28]李茹柳,陶玉珠,曾丹,等.党参、甘草糖提取物对小肠上皮细胞迁移多胺信号通路的影响[J].中国药理学通报,2016,32(2):245-251.
[29]宋盼厚,陈昫,李茹柳.Rho鸟苷三磷酸酶调节细胞迁移中细胞骨架结构的研究进展[J].广州中医药大学学报,2013,30(2):275-280.
[30]涂小华,李茹柳,邓娇,等.四君子汤多糖对IEC-6细胞迁移、钙通道蛋白及膜电位的影响[J].中药材,2016,39(4):856-862.
[31]涂小华,李茹柳,邓娇,等.四君子汤多糖对小肠上皮细胞迁移多胺信号通路钙离子调控的影响[J].中华中医药杂志,2016,31(5):1665-1673.
[32]Maroilley T,Berri M,Lemonnier G,et al.Immunome differences between porcine ileal and jejunal Peyer's patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues[J].Sci Rep,2018,8(1):9077.
[33]黄子慧,任丹丹,曹程鸣,等.加味四君子汤对仔猪血清免疫因子水平及肠黏膜免疫的影响[J].西北农林科技大学学报,2017,45(3):75-81.
[34]张博,窦逾常,王垂杰,等.脾虚老龄大鼠肠黏膜SIgA、CD、CD8水平变化及四君子汤对其的影响[J].中国老年学杂志,2014,34(11):3063-3064.
[35]Da Silva C,Wagner C,Bonnardel J,et al.The Peyer's Patch Mononuclear Phagocyte System at Steady State and during Infection[J].Front Immunol,2017,8:1254.
[36]刘良,周华,胡英杰,等.四君子汤复方总多糖对小鼠肠道黏膜相关淋巴组织的影响[J].中医中药与免疫,2000,17(4):204-206.
[37]Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[38]Cani PD,Delzenne NM.Gut microflora as a target for energy and metabolic homeostasis[J].Curr Opin Clin Nutr Metab Care,2007,10(6):729-734.
[39]Cerf-Bensussan N,Gaboriau-Routhiau V.The immune system and the gut microbiota:Friends or foes[J].Nat Rev Immunology,2010,10(10):735-744.
[40]Nicholson JK,Holmes E,Kinross J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.
[41]吴秀,周联,罗霞,等.四君子汤多糖对脾虚小鼠肠道菌群及免疫功能的影响[J].中药药理与临床,2014,30(2):12-14.
[42]鞠宝玲,唐小云,海艳洁,等.四君子汤对脱污染小鼠肠道菌群及肠黏膜免疫功能影响的研究[J].中药药理与临床,2008,24(5):1-3.
[43]孟良艳,陈秀琴,郭世宁,等.四君子汤对脾虚大鼠肠道菌群多样性的影响[J].畜牧兽医学报,2013,44(12):2029-2035.