指长比与男性胃癌的相关性分析
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摘要
研究宁夏汉族男性指长比(2D:4D)与胃癌的关系。采用体质测量法,比较宁夏汉族男性186例(对照组93例,胃癌患者组93例)左右手指长比(2D:3D、2D:4D、2D:5D、3D:4D、3D:5D、4D:5D)均值及其差异性,分析2D:4D与年龄、肿瘤大小、淋巴结转移程度及转移距离间的相关性。宁夏汉族男性胃癌患者组各指长比均值均低于对照组,2D:4D、3D:4D差异有统计学意义;胃癌患者组2D:4D<1的比例显著高于对照组;2D:4D均值与胃癌患者年龄、肿瘤大小、淋巴结转移程度及转移距离无相关性。指长比,尤其是2D:4D与宁夏汉族男性胃癌有关,可能是胃癌早期筛查的间接指标之一。
Objective: To study the relationship between digit ratio and gastric cancer in males of Han nationality from Ningxia. Method: Using anthropometry, the differences of digit ratio(2 D : 3 D, 2 D : 4 D, 2 D : 5 D, 3 D : 4 D, 3 D : 5 D, 4 D:5 D) of 186 male participants(control group: 93; gastric cancer group: 93) were compared,and the relationship between2 D : 4 D and age,tumor size(T),lymph node involvement(N),distant metastases(M)) was analyzed. Results: The mean value of each digit ratio was lower in cancer cases than that in control group. Significant differences of 2 D: 4 D and 3 D: 4 D were found between two groups. Compared with control group, the percentage of 2 D:4 D<1 was significantly higher in cancer cases. No relationships were found between 2 D: 4 D and age, T, N, M. Conclusion: Digit ratio, especially 2 D: 4 D,is correlated to males with gastric cancer of Han nationality from Ningxia, and it may be one of the indirect indices for early screening for this disease.
Objective: To study the relationship between digit ratio and gastric cancer in males of Han nationality from Ningxia. Method: Using anthropometry, the differences of digit ratio(2 D : 3 D, 2 D : 4 D, 2 D : 5 D, 3 D : 4 D, 3 D : 5 D, 4 D:5 D) of 186 male participants(control group: 93; gastric cancer group: 93) were compared,and the relationship between2 D : 4 D and age,tumor size(T),lymph node involvement(N),distant metastases(M)) was analyzed. Results: The mean value of each digit ratio was lower in cancer cases than that in control group. Significant differences of 2 D: 4 D and 3 D: 4 D were found between two groups. Compared with control group, the percentage of 2 D:4 D<1 was significantly higher in cancer cases. No relationships were found between 2 D: 4 D and age, T, N, M. Conclusion: Digit ratio, especially 2 D: 4 D,is correlated to males with gastric cancer of Han nationality from Ningxia, and it may be one of the indirect indices for early screening for this disease.
引文
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[12]Jung H,Kim K H,Yoon S J,et al.Second to fourth digit ratio:a predictor of prostate-specific antigen level and the presence of prostate cancer[J].BJU Int,2011,107(4):591-596.
[13]Lu H,Ma Z B,Shi Z Y,et al.Digit ratio(2D:4D)in Chinese women with breast cancer[J].Am J Hum Biol,2014,26(4):562-564.
[14]Waters M,Rebholz C M,Wood B,et al.Second to fourth digit ratio and prostate cancer severity[J].Prostate Cancer Prostatic Dis,2013,16(1):107-110.
[15]Ladeiras-Lopes R,Pereira A K,Nogueira A,et al.Smoking and gastric cancer:systematic review and meta-analysis of cohort studies[J].Cancer Causes Control,2008,19(7):689-701.
[2]Ronald G,Phillips D I,Godfrey K M,et al.The ratio of second to fourth digit length:a marker of impaired fetal growth[J].Early Hum Dev,2002,68(1):21-26.
[3]Lu H,Ma Z,Zhao J,et al.Second to fourth digit ratio(2D:4D)and coronary heart disease[J].Early Hum Dev,2015,91(7):417-420.
[4]Qian W,Huo Z,Lu H,et al.Digit ratio(2D:4D)in a Chinese population with schizophrenia[J].Early Hum Dev,2016,98:45-48.
[5]于皓臣,盛优静,耿芝,等.男性不育患者指长比与BMI相关性分析[J].中华男科学杂志,2015,21(11):977-981.
[6]Ohtani M,García A,Rogers A B,et al.Protective role of 17beta-estradiol against the development of Helicobacter pyloriinduced gastric cancer in INS-GAS mice[J].Carcinogenesis,2007,28(12):2597-2604.
[7]Li Y L,Liu L,Xiao Y,et al.14-3-3σis an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer[J].Oncol Lett,2015,9(1):290-294.
[8]Zheng Z,Cohn M J.Developmental basis of sexually dimorphic digit ratios[J].Proc Natl Acad Sci U S A,2011,108(39):16289-16294.
[9]Sun M,Uozaki H,Hino R,et al.SOX9 expression and its methylation status in gastric cancer[J].Virchows Arch,2012,460(3):271-279.
[10]Nicolas Hopp R,de Souza Lima N C,Filho J L,et al.Digit ratio(2D:4D)is associated with gastric cancer[J].Early Hum Dev,2013,89(5):327-329.
[11]Muller D C,Baglietto L,Manning J T,et al.Second to fourth digit ratio(2D:4D),breast cancer risk factors,and breast cancer risk:a prospective cohort study[J].Br J Cancer,2012,107(9):1631-1636.
[12]Jung H,Kim K H,Yoon S J,et al.Second to fourth digit ratio:a predictor of prostate-specific antigen level and the presence of prostate cancer[J].BJU Int,2011,107(4):591-596.
[13]Lu H,Ma Z B,Shi Z Y,et al.Digit ratio(2D:4D)in Chinese women with breast cancer[J].Am J Hum Biol,2014,26(4):562-564.
[14]Waters M,Rebholz C M,Wood B,et al.Second to fourth digit ratio and prostate cancer severity[J].Prostate Cancer Prostatic Dis,2013,16(1):107-110.
[15]Ladeiras-Lopes R,Pereira A K,Nogueira A,et al.Smoking and gastric cancer:systematic review and meta-analysis of cohort studies[J].Cancer Causes Control,2008,19(7):689-701.