乙型肝炎病毒感染动物模型研究进展
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摘要
乙型肝炎病毒(HBV)感染引起的肝炎及其并发症是严重的全球性健康问题。但该病毒的狭窄宿主范围和组织嗜性特点限制了它的研究。因此,建立合适的动物模型对HBV致病机制和感染的防治措施研究均有重要意义。本文作者就HBV感染动物模型的研究进展进行简要综述。
Hepatitis B and its complications caused by hepatitis B virus(HBV)infection are serious global health problems. However, the narrow host range and tissue tropism of the virus limit its research. Therefore, the establishment of a suitable animal model is of great significance for the study of the pathogenesis of HBV and the prevention and treatment of infection. The authors briefly review the research progress of animal models of HBV infection.
Hepatitis B and its complications caused by hepatitis B virus(HBV)infection are serious global health problems. However, the narrow host range and tissue tropism of the virus limit its research. Therefore, the establishment of a suitable animal model is of great significance for the study of the pathogenesis of HBV and the prevention and treatment of infection. The authors briefly review the research progress of animal models of HBV infection.
引文
[1] World Health Organization Hepatitis B fact sheet,2018.https://www.who.int/en/news-room/ fact-sheets/detail/hepatitis-b.
[2] LI L,BARRY V,DAFFIS S,et al.Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells[J].J Hepatol,2018,68(5):912-921.
[3] FIORAVANTI J,DI LUCIA P,MAGINI D,et al.Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology[J].J Hepatol,2017,67(3):543-548.
[4] WOODDELL C I,YUEN M F,CHAN L Y,et al.RNAi-based treatment of chronically infected patients and chimpanzees implicates integrated hepatitis B virus DNA as a source of HBsAg[J].Sci Transl Med,2017,9(409):1-14.
[5] YANG C,RUAN P,OU C,et al.Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews(Tupaia belangeri chinensis)[J].Virol J,2015,12(1):26.
[6] KAYESH M E H,EZZIKOURI S,CHI H,et al.Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri[J].Virus Res,2017,237:47-57.
[7] LUO M T,FAN Y,MU D,et al.Molecular cloning and characterization of APOBEC3 family in tree shrew[J].Gene,2018,646:143-152.
[8] XIA Y,SCHLAPSCHY M,MORATH V,et al.PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice[J].Antiviral Res,2019,161:134-143.
[9] KRIEGER J,RIEDL P,STIFTER K,et al.Endogenously expressed antigens bind mammalian RNA via cationic domains that enhance priming of effector CD8+T cells by DNA vaccination[J].Mol Ther,2019,27(3):661-672.
[10] LIN C T,HSIEH Y T,YANG Y J,et al.B-cell lymphoma 6(BCL6)is a host restriction factor that can suppress HBV gene expression and modulate immune responses[J].Front Microbiol,2019,9:3253.
[11] LIU Y,ZHAO M,GONG M,et al.Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus[J].Antiviral Res,2018,152:58-67.
[12] YUAN L,LIU X,ZHANG L,et al.Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection[J].Emerg Microbes Infect,2018,7(1):144.
[13] KLUMPP K,SHIMADA T,ALLWEIDD L,et al.Efficacy of NVR 3-778,alone and in combination with pegylated interferon,vs entecavir in uPA/SCID mice with humanized livers and HBV infection[J].Gastroenterology,2018,154(3):652-662.
[14] YUAN L,JIANG J,LIU X,et al.HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation[J].Gut 2019,doi:10.1136/gutjnl-2018-316091.
[15] MOUZANNAR K,FUSIL F,LACOMBE B,et al.Farnesoid X receptor-α is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo[J].FASEB J,2019,33(2):2472-2483.
[16] LUCIFORA J,SALVETTI A,MARNIQUET X,et al.Detection of the hepatitis B virus(HBV)covalently-closed-circular DNA(cccDNA)in mice transduced with a recombinant AAV-HBV vector[J].Antiviral Res,2017,145:14-19.
[17] WILLIAMS J B,HVPPNER A,MULROONEY-COUSINS P M,et al.Differential Expression of Woodchuck Toll-Like Receptors 1-10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection[J].Front Microbiol,2018,9:3007.
[18] SURESH M,KOROLOWICA K E,BALAREZO M,et al.Antiviral efficacy and host immune response induction during sequential treatment with SB9200 followed by entecavir in woodchucks[J].PLoS ONE,2017,12(1):e0169631.
[19] BALSITIS S,GALI V,MSAON P J,et al.Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection[J].PLoS One,2018,13(2):e0190058.
[20] LI Y,LIU Z,HUI L,et al.Transbody against virus core protein potently inhibits hepadnavirus replication in vivo:evidence from a duck model of hepatitis B virus[J].Br J Pharmacol,2017,174(14):2261-2272.
[21] QUINET J,JANSRD C,BURTIN M,et al.Nucleic acid polymer REP 2139 and nucleos(T)ide analogues act synergistically against chronic hepadnaviral infection in vivo in Pekin ducks[J].Hepatology,2018,67(6):2127-2140.
[22] ZHOU Z Y,BI X X.Evaluation of the inactivation effect of riboflavin photochemical method on duck hepatitis B virus[J].Exp Ther Med,2018,15(1):751-754.
[23] NIE F Y,LIN X D,HAO Z Y,et al.Extensive diversity and evolution of hepadnaviruses in bats in China[J].Virology,2018,514:88-97.
[24] LAUBER C,SEITZ S,MATTEI S,et al.Deciphering the origin and evolution of hepatitis B viruses by means of a family of non-enveloped fish viruses[J].Cell Host Microbe,2017,22(3):387-399.
[25] VIEIRA Y R,SILVA M F,SANTOS D R,et al.Serological and molecular evidence of hepadna virus infection in swine[J].Ann Agric Environ Med,2015,22(1):11-16.
[2] LI L,BARRY V,DAFFIS S,et al.Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells[J].J Hepatol,2018,68(5):912-921.
[3] FIORAVANTI J,DI LUCIA P,MAGINI D,et al.Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology[J].J Hepatol,2017,67(3):543-548.
[4] WOODDELL C I,YUEN M F,CHAN L Y,et al.RNAi-based treatment of chronically infected patients and chimpanzees implicates integrated hepatitis B virus DNA as a source of HBsAg[J].Sci Transl Med,2017,9(409):1-14.
[5] YANG C,RUAN P,OU C,et al.Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews(Tupaia belangeri chinensis)[J].Virol J,2015,12(1):26.
[6] KAYESH M E H,EZZIKOURI S,CHI H,et al.Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri[J].Virus Res,2017,237:47-57.
[7] LUO M T,FAN Y,MU D,et al.Molecular cloning and characterization of APOBEC3 family in tree shrew[J].Gene,2018,646:143-152.
[8] XIA Y,SCHLAPSCHY M,MORATH V,et al.PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice[J].Antiviral Res,2019,161:134-143.
[9] KRIEGER J,RIEDL P,STIFTER K,et al.Endogenously expressed antigens bind mammalian RNA via cationic domains that enhance priming of effector CD8+T cells by DNA vaccination[J].Mol Ther,2019,27(3):661-672.
[10] LIN C T,HSIEH Y T,YANG Y J,et al.B-cell lymphoma 6(BCL6)is a host restriction factor that can suppress HBV gene expression and modulate immune responses[J].Front Microbiol,2019,9:3253.
[11] LIU Y,ZHAO M,GONG M,et al.Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus[J].Antiviral Res,2018,152:58-67.
[12] YUAN L,LIU X,ZHANG L,et al.Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection[J].Emerg Microbes Infect,2018,7(1):144.
[13] KLUMPP K,SHIMADA T,ALLWEIDD L,et al.Efficacy of NVR 3-778,alone and in combination with pegylated interferon,vs entecavir in uPA/SCID mice with humanized livers and HBV infection[J].Gastroenterology,2018,154(3):652-662.
[14] YUAN L,JIANG J,LIU X,et al.HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation[J].Gut 2019,doi:10.1136/gutjnl-2018-316091.
[15] MOUZANNAR K,FUSIL F,LACOMBE B,et al.Farnesoid X receptor-α is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo[J].FASEB J,2019,33(2):2472-2483.
[16] LUCIFORA J,SALVETTI A,MARNIQUET X,et al.Detection of the hepatitis B virus(HBV)covalently-closed-circular DNA(cccDNA)in mice transduced with a recombinant AAV-HBV vector[J].Antiviral Res,2017,145:14-19.
[17] WILLIAMS J B,HVPPNER A,MULROONEY-COUSINS P M,et al.Differential Expression of Woodchuck Toll-Like Receptors 1-10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection[J].Front Microbiol,2018,9:3007.
[18] SURESH M,KOROLOWICA K E,BALAREZO M,et al.Antiviral efficacy and host immune response induction during sequential treatment with SB9200 followed by entecavir in woodchucks[J].PLoS ONE,2017,12(1):e0169631.
[19] BALSITIS S,GALI V,MSAON P J,et al.Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection[J].PLoS One,2018,13(2):e0190058.
[20] LI Y,LIU Z,HUI L,et al.Transbody against virus core protein potently inhibits hepadnavirus replication in vivo:evidence from a duck model of hepatitis B virus[J].Br J Pharmacol,2017,174(14):2261-2272.
[21] QUINET J,JANSRD C,BURTIN M,et al.Nucleic acid polymer REP 2139 and nucleos(T)ide analogues act synergistically against chronic hepadnaviral infection in vivo in Pekin ducks[J].Hepatology,2018,67(6):2127-2140.
[22] ZHOU Z Y,BI X X.Evaluation of the inactivation effect of riboflavin photochemical method on duck hepatitis B virus[J].Exp Ther Med,2018,15(1):751-754.
[23] NIE F Y,LIN X D,HAO Z Y,et al.Extensive diversity and evolution of hepadnaviruses in bats in China[J].Virology,2018,514:88-97.
[24] LAUBER C,SEITZ S,MATTEI S,et al.Deciphering the origin and evolution of hepatitis B viruses by means of a family of non-enveloped fish viruses[J].Cell Host Microbe,2017,22(3):387-399.
[25] VIEIRA Y R,SILVA M F,SANTOS D R,et al.Serological and molecular evidence of hepadna virus infection in swine[J].Ann Agric Environ Med,2015,22(1):11-16.