兰坪乌骨绵羊乌质性状的研究进展
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摘要
兰坪乌骨绵羊是世界上绝无仅有的地方珍稀物种资源,主要分布在云南省兰坪县。乌骨绵羊有褐色或淡黑色的牙龈、淡乌色的眼结膜、乌黑色的肛门,对乌骨绵羊解剖后发现乌骨绵羊有乌色的肌肉、骨骼、内脏和气管。乌骨绵羊的乌骨乌肉特征使其与普通绵羊区分开来。前期的研究表明,乌骨绵羊的乌质性状主要是由于高含量的黑色素沉积所致,黑色素是一种天然色素家族,哺乳动物中存在两类黑色素,一类是真黑色素,另一类是脱黑色素。文章主要从乌骨绵羊乌质性状的特征、黑色素的生物合成、黑色素合成代谢相关的候选基因和转录组测序四个方面概述了乌骨绵羊乌质性状的研究进展。
Lanping black-boned sheepwhich has brown or light black gums,light color eye conjunctiva,jet-blackanus,black muscles,bones,internal organs and trachea,is a rare species resources and mainly distributesin Lanping county of Yunnanprovince. Previous research showed thatthe melanin traits of Lanping black-bonedsheep were mainly due to thehigh levels ofmelanindeposition. Melanin is a natural pigment and there aretwo classes of melanin inmammals,one iseumelanin,another is pheomelanin. The paper mainly described the research progress on melanin traitcharacteristics,melanin biosynthesis,candidate genes related to melanin synthesis metabolism and transcriptome sequencingof Lanping black-boned sheep.
Lanping black-boned sheepwhich has brown or light black gums,light color eye conjunctiva,jet-blackanus,black muscles,bones,internal organs and trachea,is a rare species resources and mainly distributesin Lanping county of Yunnanprovince. Previous research showed thatthe melanin traits of Lanping black-bonedsheep were mainly due to thehigh levels ofmelanindeposition. Melanin is a natural pigment and there aretwo classes of melanin inmammals,one iseumelanin,another is pheomelanin. The paper mainly described the research progress on melanin traitcharacteristics,melanin biosynthesis,candidate genes related to melanin synthesis metabolism and transcriptome sequencingof Lanping black-boned sheep.
引文
[1]毛华明,邓卫东,孙守荣,等.云南乌骨绵羊的发现及其特征性状的研究[J].云南农业大学学报,2005,20(1):89-93.
[2]邓卫东,席冬梅,苟潇,等.乌骨绵羊的发现及其种质特征[J].中国科技成果,2009(22):21.
[3]邓卫东,毛华明,孙守荣,等.乌骨绵羊和非乌骨绵羊血液生理生化指标的比较研究[J].中国畜牧杂志,2006,42(17):13-16.
[4]DENG W D,YANG S L,HUO Y Q,et al.Physiological and genetic characteristics of black-boned sheep(Ovis aries)[J].Anim Genet,2006,37(6):586-588.
[5]王鑫玉.乌骨绵羊乌质性状的生理生化特征[D].昆明:云南农业大学,2008.
[6]何奕多.兰坪乌骨绵羊TYR、TYRP1、TYRP2和SLC7A11基因mRNA表达水平与乌质性状的关联分析[D].昆明:云南农业大学,2010.
[7]杨春玲.乌骨绵羊体内黑色素含量和黑色素细胞分布特征的研究[D].昆明:云南农业大学,2013.
[8]ITO S.The IFPCS presidential lecture:A chemist’s view of melanogenesis[J].Pigment Cell Res,2003,16(3):230-236.
[9]BUSCA R,BALLOTTI R.Cyclic AMP a key messenger in the regulation of skin pigmentation[J].Pigment Cell Res,2000,13(2):60-69.
[10]SULAIMON S S,KITCHELL B E.The biology of melanocytes[J].Vet Dermatol,2003,14(2):57-65.
[11]HOU L,PAVAN W J.Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development:do all roads lead to Mitf[J].Cell Res,2008,18:1163-1176.
[12]VACHTENHEIM J,BOROVANSKY J.Transcription physiology of formation in melanocytes:central role of MITF[J].Exp Dermatol,2010,19(7):617-627.
[13]HALLA M,ORLOW S J.Degradation of tyrosinase induced by phenylthiourea occurs following golgi maturation[J].Pigment Cell Res,2005,18(2):122-129.
[14]ITO S,WAKAMATSU K,OZEKI H.Chemical analysis of melanins and its application to the study of the regulation of melanogenesis[J].Pigment Cell Res,2000,13(Suppl 8):103-109.
[15]ANCANS J,TOBIND J,HOOGDUIJN M J,et al.Melanosomal p H controls rate of melanogenesis,eumelanin/phaeomelanin ratio and melanosome maturayion in melanocytes and melanoma cells[J].Exp Cell Res,2001,268(1):26-35.
[16]DENGW D,XI D M,MAO H M,et al.Pigmentation in blackboned sheep(Ovis aries):association with polymorphism of the Tyrosinase gene[J].Mol Biol Rep,2007,35(3):379-385.
[17]李文.乌骨绵羊酪氨酸酶基因(TYR)的分子特征及其单核苷酸多态性研究[D].昆明:云南农业大学,2007.
[18]刘丽.乌骨绵羊酪氨酸酶基因组(TYR)的克隆及其启动子多态性分析[D].昆明:云南农业大学,2010.
[19]曹绣娟.乌骨绵羊酪氨酸酶相关蛋白1基因(TYRP1)多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2008.
[20]谭玉文.乌骨绵羊酪氨酸酶相关蛋白2基因(TYRP2)多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2008.
[21]闵彦,田野苹.α-黑素细胞刺激素作用的信号转导机制[J].生命的化学,2001,31(5):671-674.
[22]DENGW D,SHU W,YANG S L,et al.Pigmentation in Blackboned sheep(Ovis aries):association with polymorphism of the MC1R gene[J].Mol Biol Rep,2009,36:431-436.
[23]CERESAB P,BAHRS J.Rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome[J].Biol Chem,2006,281(2):1099-1106.
[24]KAWAKAMI A,SAKANE F,IMAI S,et al.Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv[J].J Invest Dermatol,2008,128(1):43-50.
[25]JIMBOW K,PARK J S,KATO F,et al.Assembly,target-signaling and intracellular transport of tyrosinase gene family proteins in the initial stage of melanosome biogenesis[J].Pigment Cell Res,2000,13(4):222-229.
[26]HE Y D,LIU D D,XI D M,et al.Isolation,sequence identification and expression profile of three novel genes Rab2A,Rab3A and Rab7Afrom black-boned sheep(Ovis aries)[J].Mol Biol(Mosk),2010 44(1):20-27.
[27]CHINTALA S,LI W,LAMOREUX M L,et al,SLC7A11 gene controls production of pheomelanin pigment and proliferation of cultured cells[J].PNAS,2005,102(31):10964-10969.
[28]苗鲁旭.乌骨绵羊SLC24A5基因多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2009.
[29]LAMASON R L,MOHIDEEN M A,MEST J R,et al.SLC24A5,a putative cation exchanger,affects pigment ationin zebrafish and humans[J].Science,2005,310(5755):1782-1786.
[30]崔嘉.乌骨绵羊SLC24A5基因多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2009.
[31]DU F,YANG R,MA H L,et al.Expression of transcriptional repressor slug gene in mouse endometrium and its effect during embryo implantation[J].Appl Biochem Biotechnol,2009,157(2):346-355.
[32]XI D,HE Y,SUN Y,et al.Molecular cloning,sequence identification and tissue expression profile of three novel genes Sfxn1,Snai2and cno from black-boned sheep(Ovis aries)[J].Mol Biol Rep,2011,38(3):1883-1887.
[33]MATSUNAGA Y,KODA M,MURAWAKI Y.Expression of matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases(TIMPs)in hepatocellular carcinoma tissue,compared with the surrounding non-tumor tissue[J].Res Commun Mol Pathol Pharmacol,2004(115/116):143-150.
[34]YONGGANG L,SHIZHENG G.A novel sheep gene,MMP7,differentially expressed in muscles from black-boned sheep and local common sheep[J].J Appl Genet,2009,50(3):253–256.
[35]COSTA V,ANGELINI C,FEIS I D,et al.Uncovering the complexity of transcriptomes with RNA-Seq[J].J Biomed Biotechnol,2010,27:1-19.
[36]李强飞.兰坪本地绵羊肝脏转录组组装及其分子特征研究[D].昆明:云南农业大学,2014.
[37]郝甜甜.乌骨绵羊黑色素形成的分子代谢网络及其相关基因解析[D].昆明:云南农业大学,2015.
[38]陈禹翰.转录组测序筛选乌骨绵羊黑色素合成相关基因[D].昆明:云南农业大学,2016.
[2]邓卫东,席冬梅,苟潇,等.乌骨绵羊的发现及其种质特征[J].中国科技成果,2009(22):21.
[3]邓卫东,毛华明,孙守荣,等.乌骨绵羊和非乌骨绵羊血液生理生化指标的比较研究[J].中国畜牧杂志,2006,42(17):13-16.
[4]DENG W D,YANG S L,HUO Y Q,et al.Physiological and genetic characteristics of black-boned sheep(Ovis aries)[J].Anim Genet,2006,37(6):586-588.
[5]王鑫玉.乌骨绵羊乌质性状的生理生化特征[D].昆明:云南农业大学,2008.
[6]何奕多.兰坪乌骨绵羊TYR、TYRP1、TYRP2和SLC7A11基因mRNA表达水平与乌质性状的关联分析[D].昆明:云南农业大学,2010.
[7]杨春玲.乌骨绵羊体内黑色素含量和黑色素细胞分布特征的研究[D].昆明:云南农业大学,2013.
[8]ITO S.The IFPCS presidential lecture:A chemist’s view of melanogenesis[J].Pigment Cell Res,2003,16(3):230-236.
[9]BUSCA R,BALLOTTI R.Cyclic AMP a key messenger in the regulation of skin pigmentation[J].Pigment Cell Res,2000,13(2):60-69.
[10]SULAIMON S S,KITCHELL B E.The biology of melanocytes[J].Vet Dermatol,2003,14(2):57-65.
[11]HOU L,PAVAN W J.Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development:do all roads lead to Mitf[J].Cell Res,2008,18:1163-1176.
[12]VACHTENHEIM J,BOROVANSKY J.Transcription physiology of formation in melanocytes:central role of MITF[J].Exp Dermatol,2010,19(7):617-627.
[13]HALLA M,ORLOW S J.Degradation of tyrosinase induced by phenylthiourea occurs following golgi maturation[J].Pigment Cell Res,2005,18(2):122-129.
[14]ITO S,WAKAMATSU K,OZEKI H.Chemical analysis of melanins and its application to the study of the regulation of melanogenesis[J].Pigment Cell Res,2000,13(Suppl 8):103-109.
[15]ANCANS J,TOBIND J,HOOGDUIJN M J,et al.Melanosomal p H controls rate of melanogenesis,eumelanin/phaeomelanin ratio and melanosome maturayion in melanocytes and melanoma cells[J].Exp Cell Res,2001,268(1):26-35.
[16]DENGW D,XI D M,MAO H M,et al.Pigmentation in blackboned sheep(Ovis aries):association with polymorphism of the Tyrosinase gene[J].Mol Biol Rep,2007,35(3):379-385.
[17]李文.乌骨绵羊酪氨酸酶基因(TYR)的分子特征及其单核苷酸多态性研究[D].昆明:云南农业大学,2007.
[18]刘丽.乌骨绵羊酪氨酸酶基因组(TYR)的克隆及其启动子多态性分析[D].昆明:云南农业大学,2010.
[19]曹绣娟.乌骨绵羊酪氨酸酶相关蛋白1基因(TYRP1)多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2008.
[20]谭玉文.乌骨绵羊酪氨酸酶相关蛋白2基因(TYRP2)多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2008.
[21]闵彦,田野苹.α-黑素细胞刺激素作用的信号转导机制[J].生命的化学,2001,31(5):671-674.
[22]DENGW D,SHU W,YANG S L,et al.Pigmentation in Blackboned sheep(Ovis aries):association with polymorphism of the MC1R gene[J].Mol Biol Rep,2009,36:431-436.
[23]CERESAB P,BAHRS J.Rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome[J].Biol Chem,2006,281(2):1099-1106.
[24]KAWAKAMI A,SAKANE F,IMAI S,et al.Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv[J].J Invest Dermatol,2008,128(1):43-50.
[25]JIMBOW K,PARK J S,KATO F,et al.Assembly,target-signaling and intracellular transport of tyrosinase gene family proteins in the initial stage of melanosome biogenesis[J].Pigment Cell Res,2000,13(4):222-229.
[26]HE Y D,LIU D D,XI D M,et al.Isolation,sequence identification and expression profile of three novel genes Rab2A,Rab3A and Rab7Afrom black-boned sheep(Ovis aries)[J].Mol Biol(Mosk),2010 44(1):20-27.
[27]CHINTALA S,LI W,LAMOREUX M L,et al,SLC7A11 gene controls production of pheomelanin pigment and proliferation of cultured cells[J].PNAS,2005,102(31):10964-10969.
[28]苗鲁旭.乌骨绵羊SLC24A5基因多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2009.
[29]LAMASON R L,MOHIDEEN M A,MEST J R,et al.SLC24A5,a putative cation exchanger,affects pigment ationin zebrafish and humans[J].Science,2005,310(5755):1782-1786.
[30]崔嘉.乌骨绵羊SLC24A5基因多态性与乌骨绵质性状的关联分析[D].昆明:云南农业大学,2009.
[31]DU F,YANG R,MA H L,et al.Expression of transcriptional repressor slug gene in mouse endometrium and its effect during embryo implantation[J].Appl Biochem Biotechnol,2009,157(2):346-355.
[32]XI D,HE Y,SUN Y,et al.Molecular cloning,sequence identification and tissue expression profile of three novel genes Sfxn1,Snai2and cno from black-boned sheep(Ovis aries)[J].Mol Biol Rep,2011,38(3):1883-1887.
[33]MATSUNAGA Y,KODA M,MURAWAKI Y.Expression of matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases(TIMPs)in hepatocellular carcinoma tissue,compared with the surrounding non-tumor tissue[J].Res Commun Mol Pathol Pharmacol,2004(115/116):143-150.
[34]YONGGANG L,SHIZHENG G.A novel sheep gene,MMP7,differentially expressed in muscles from black-boned sheep and local common sheep[J].J Appl Genet,2009,50(3):253–256.
[35]COSTA V,ANGELINI C,FEIS I D,et al.Uncovering the complexity of transcriptomes with RNA-Seq[J].J Biomed Biotechnol,2010,27:1-19.
[36]李强飞.兰坪本地绵羊肝脏转录组组装及其分子特征研究[D].昆明:云南农业大学,2014.
[37]郝甜甜.乌骨绵羊黑色素形成的分子代谢网络及其相关基因解析[D].昆明:云南农业大学,2015.
[38]陈禹翰.转录组测序筛选乌骨绵羊黑色素合成相关基因[D].昆明:云南农业大学,2016.