脑缺血性脑卒中患者血栓弹力图检查结果分析
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摘要
目的探讨脑缺血性脑卒中患者血栓弹力图(TEG)检查价值和结果。方法选取2016年1月～2018年2月我院收治的46例缺血性脑卒中患者设为观察组,46例非缺血性脑卒中患者设为对照组,两组均行TEG检查。对照组不作干预,观察组行阿替普酶静脉溶栓治疗,比较分析两组溶栓前及观察组溶栓前后凝血反应时间(R值),凝血形成时间(K值)、血栓最大弹力度(MA值)、凝固角(Angle角)结果。结果溶栓前,观察组R值和K值低于对照组,MA值、Angle角高于对照组,差异有统计学意义(P<0.05)。溶栓后1 h,观察组R值和K值高于溶栓前,Angle角和MA值低于溶栓前,差异有统计学意义(P<0.05)。溶栓后3h,观察组R值和K值高于溶栓前,差异有统计学意义(P<0.05);Angle角和MA值与溶栓前比较,差异无统计学意义(P>0.05)。溶栓后12 h,观察组R值、K值、Angle角和MA值与溶栓前比较,差异无统计学意义(P>0.05)。结论 TEG检查可有效反映缺血性脑卒中患者的血凝状态,为该病临床诊疗提供参考依据。
Objective To investigate the value and results of thromboelastogram(TEG) examination in patients with cerebral ischemic stroke.Methods 46 patients with ischemic stroke admitted to our hospital from January 2016 to February 2018 were enrolled in the observation group.Forty-six patients with non-ischemic stroke were enrolled in the control group. TEG was performed in both groups. The control group did not intervene. The observation group underwent intravenous thrombolytic therapy with alteplase. The coagulation reaction time(R value), coagulation formation time(K value) and maximum thrombus strength of the two groups before and after thrombolysis were compared.(MA value), solidification angle(Angle) result. Results Before thrombolysis, the R and K values of the observation group were lower than those of the control group, the MA value and Angle were higher than that of the control group, the difference was statistically significant( P<0.05). At 1 h after thrombolysis, the R and K values of the observation group were higher than those before thrombolysis, and the Angle and MA value were lower than those before thrombolysis,the difference was statistically significant(P<0.05). At 3 h after thrombolysis, the R and K values of the observation group were higher than those before thrombolysis,the difference was statistically significant(P <0.05); the Angle and MA value were not significantly different from those before thrombolysis(P>0.05). At 12 h after thrombolysis, the R value, K value, Angle and MA value of the observation group were not significantly different from those before thrombolysis(P>0.05). Conclusion TEG examination can effectively reflect the blood coagulation status of patients with ischemic stroke, and provide a reference for the clinical diagnosis and treatment of this disease.
Objective To investigate the value and results of thromboelastogram(TEG) examination in patients with cerebral ischemic stroke.Methods 46 patients with ischemic stroke admitted to our hospital from January 2016 to February 2018 were enrolled in the observation group.Forty-six patients with non-ischemic stroke were enrolled in the control group. TEG was performed in both groups. The control group did not intervene. The observation group underwent intravenous thrombolytic therapy with alteplase. The coagulation reaction time(R value), coagulation formation time(K value) and maximum thrombus strength of the two groups before and after thrombolysis were compared.(MA value), solidification angle(Angle) result. Results Before thrombolysis, the R and K values of the observation group were lower than those of the control group, the MA value and Angle were higher than that of the control group, the difference was statistically significant( P<0.05). At 1 h after thrombolysis, the R and K values of the observation group were higher than those before thrombolysis, and the Angle and MA value were lower than those before thrombolysis,the difference was statistically significant(P<0.05). At 3 h after thrombolysis, the R and K values of the observation group were higher than those before thrombolysis,the difference was statistically significant(P <0.05); the Angle and MA value were not significantly different from those before thrombolysis(P>0.05). At 12 h after thrombolysis, the R value, K value, Angle and MA value of the observation group were not significantly different from those before thrombolysis(P>0.05). Conclusion TEG examination can effectively reflect the blood coagulation status of patients with ischemic stroke, and provide a reference for the clinical diagnosis and treatment of this disease.
引文
[1]任丽萍.血栓弹力图检测急性脑梗死患者凝血与血小板功能的临床研究[J].山西医药杂志,2018,47(24):3007-3008.
[2]徐孝敬,陈上上,文强国,等.颅脑损伤患者血栓弹力图试验指标变化的分析[J].临床神经外科杂志,2018,15(6):463-466.
[3]洪二春,戴李华,王海嵘,等.凝血功能及血栓弹力图在急性缺血性脑卒中静脉溶栓预后中的预警作用[J].东南国防医药,2018,20(5):485-489.
[4]王自然,崔言森,雷红艳,等.急性缺血性脑卒中患者阿替普酶静脉溶栓前后血凝状态的血栓弹力图观测[J].中国医药导报,2015,12(26):115-118.
[5]刘莹,董艳娟,魏微.血栓弹力图在缺血性脑卒中患者抗血小板药物选择中的应用[J].中国医学装备,2017,14(8):95-98.
[6]刘莹,芮丽,黄勇华.血栓弹力图指导脑卒中二级预防临床研究[J].中华保健医学杂志,2016,18(5):374-377.
[7]张雯君,朱伟民,吴秋义,等.血栓弹力图在脑缺血性脑卒中患者中的应用[J].辽宁医学杂志,2015,29(5):276-277.
[2]徐孝敬,陈上上,文强国,等.颅脑损伤患者血栓弹力图试验指标变化的分析[J].临床神经外科杂志,2018,15(6):463-466.
[3]洪二春,戴李华,王海嵘,等.凝血功能及血栓弹力图在急性缺血性脑卒中静脉溶栓预后中的预警作用[J].东南国防医药,2018,20(5):485-489.
[4]王自然,崔言森,雷红艳,等.急性缺血性脑卒中患者阿替普酶静脉溶栓前后血凝状态的血栓弹力图观测[J].中国医药导报,2015,12(26):115-118.
[5]刘莹,董艳娟,魏微.血栓弹力图在缺血性脑卒中患者抗血小板药物选择中的应用[J].中国医学装备,2017,14(8):95-98.
[6]刘莹,芮丽,黄勇华.血栓弹力图指导脑卒中二级预防临床研究[J].中华保健医学杂志,2016,18(5):374-377.
[7]张雯君,朱伟民,吴秋义,等.血栓弹力图在脑缺血性脑卒中患者中的应用[J].辽宁医学杂志,2015,29(5):276-277.