摘要
目的:分析常染色体19个短串联重复序列(STR)位点在新疆蒙古族群体中的遗传多态性分布,为其法医学应用提供数据支持。创新点:丰富了新疆蒙古族群体的常染色体STR遗传数据。方法:从新疆地区采集1133个无血缘关系的蒙古族健康个体,应用一个包含常染色体19个STR位点的复合扩增体系对这些样本进行基因分型检测。同时,基于15个共有的STR位点,采用多维尺度分析、遗传距离(DA)和遗传分化系数(FST)的方法探讨了新疆蒙古族群体和既往报道的20个群体间的群体遗传关系。结论:研究的19个STR位点在新疆蒙古族群体中表现出高度的多态性,获得的累积非父排除概率和累计个体识别率分别为0.999 999 992 163和0.999 999 999 999 999 999 999 995 67,表明这19个STR位点可很好地应用于新疆蒙古族群体的个体识别和亲缘关系鉴识研究。群体遗传分析的结果显示:相比其他洲际群体,新疆蒙古族群体和维吾尔族、锡伯族以及其他中国群体具有更近的遗传距离。
引文
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