知黄溃疡合剂对口腔溃疡模型大鼠的药效学研究
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摘要
目的探讨知黄溃疡合剂治疗大鼠口腔溃疡的药效学。方法口腔黏膜下注射20%醋酸,建立大鼠口腔溃疡模型,知黄溃疡合剂(4 g原生药/kg,8 g原生药/kg,16 g原生药/kg)灌胃给药,每天2次,连续5 d,观察药物对大鼠口腔溃疡的治疗效果。结果知黄溃疡合剂8 g原生药/kg能显著改善大鼠口腔溃疡组织损伤,与模型对照组比较有显著性差异(P <0.01)。结论知黄溃疡合剂具有治疗口腔溃疡的作用。
Objective To investigate the pharmacodynamics of Zhihuang Ulcer Mixture in the treatment of oral ulcer in rats.Methods Oral ulcer rat models were established by injecting 20% acetic acid into oral mucosa,and then given intragastric administration of Zhihuang Ulcer Mixture [ 4 g(dried medicinal herbs)/kg,8 g(dried medicinal herbs)/kg,16 g(dried medicinal herbs)/kg ],twice a day for 5 consecutive days.The therapeutic effect of Zhihuang Ulcer Mixture on the oral ulcer in rats was observed.Results Zhihuang Ulcer Mixture of 8 g(dried medicinal herbs)/kg can significantly improve the damage of oral ulcer tissue in rats,and there was a significant difference compared with the model control group(P < 0.01).Conclusion Zhihuang Ulcer Mixture has the function of treating oral ulcer.
Objective To investigate the pharmacodynamics of Zhihuang Ulcer Mixture in the treatment of oral ulcer in rats.Methods Oral ulcer rat models were established by injecting 20% acetic acid into oral mucosa,and then given intragastric administration of Zhihuang Ulcer Mixture [ 4 g(dried medicinal herbs)/kg,8 g(dried medicinal herbs)/kg,16 g(dried medicinal herbs)/kg ],twice a day for 5 consecutive days.The therapeutic effect of Zhihuang Ulcer Mixture on the oral ulcer in rats was observed.Results Zhihuang Ulcer Mixture of 8 g(dried medicinal herbs)/kg can significantly improve the damage of oral ulcer tissue in rats,and there was a significant difference compared with the model control group(P < 0.01).Conclusion Zhihuang Ulcer Mixture has the function of treating oral ulcer.
引文
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[12]杨敬宁,袁敏,邹每伶,等.黄柏对大鼠口腔溃疡的作用及其对TNF-α水平的影响[J].中国中医药科技,2013,20(6):614-615.
[2]陈卓,王金磊,庄朋伟,等.清咽滴丸治疗大鼠口腔溃疡的实验研究[J].中草药,2016,47(1):106-109.
[3]廉冰,杨婷,熊昀,等.独一味提取物对大鼠和兔口腔溃疡模型的影响[J].中药药理与临床,2015,31(3):115-117.
[4]赵志宇,郭兰,韩淑英.槲皮素壳聚糖被膜治疗口腔溃疡的实验研究[J].实用口腔医学杂志,2012,28(4):482-485.
[5]刘月娥,买迁,何润凯.甘草外用对口腔溃疡动物模型的作用分析[J].宁夏医学杂志,2015,37(12):1118-1120.
[6]胡建东,孙靖,薛鸾,等.复发性口腔溃疡中医分型与临床因素的相关性研究[J].中华中医药学刊,2012,30(10):2348-2351.
[7]刘洪.复发性口腔溃疡中西医病因研究与治疗进展[J].中医药临床杂志,2011,23(8):748-749.
[8]李亚朋,李军,杨永进.复发性口腔溃疡中医药临床研究进展[J].中国中医药信息杂志,2008,15(5):104-105.
[9]范才斌.复发性口腔溃疡药物治疗的研究进展[J].上海医药,2013,34(10):34-36.
[10]幸梦琳,张永慧,刘海枝.复发性口腔溃疡中医药治疗进展[J].光明中医,2013,28(7):1524-1527.
[11]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2015:305-306.
[12]杨敬宁,袁敏,邹每伶,等.黄柏对大鼠口腔溃疡的作用及其对TNF-α水平的影响[J].中国中医药科技,2013,20(6):614-615.