血管生成相关因子在口腔白斑癌变过程中的表达及意义
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摘要
目的检测血管生成相关因子细胞间黏附分子-1(ICAM-1)和血管细胞间黏附分子-1(VCAM-1)在正常口腔黏膜、口腔白斑伴轻-中度异常增生及口腔白斑癌变组织中的表达情况。探讨ICAM-1和VCAM-1在口腔黏膜白斑癌变过程中的临床意义。方法应用免疫组织化学技术分析临床收集的15例口腔正常黏膜组织、10例口腔白斑伴轻-中度异常增生组织及10例口腔白斑癌变组织中ICAM-1和VCAM-1的表达情况。结果免疫组化结果显示,从正常口腔黏膜→口腔白斑伴轻-中度异常增生→口腔白斑癌变,ICAM-1和VCAM-1表达呈增加趋势,各组之间差异有显著性(P <0.05)。结论 ICAM-1和VCAM-1在口腔白斑癌变过程中发挥重要作用。
Objective To assess the expression and clinical significance of intercellular adhesion molecular-1(ICAM-1)and vascular cell adhesion molecular-1(VCAM-1)in oral leukoplakia canceration. Methods 15 cases of nomal controls,10 cases of oral leukoplakia with mild to moderate epithelial dysplasia,10 cases of oral leukoplakia canceration were enrolled in the study. Immunohistochemical analysis was used to detect the expresssion level of oral leukoplakia canceration. Results The expression level of ICAM-1 and VCAM-1 in oral leukoplakia canceration were higher than those in mild to moderate epithelial dysplasia(P < 0.05),and the expression level in mild to moderate epithelial dysplasia were higher than in nomal controls(P < 0.05). Conclusion High expression was related to oral leukoplakia canceration,which may be involved in the malignant transformation of oral leukoplakia.
Objective To assess the expression and clinical significance of intercellular adhesion molecular-1(ICAM-1)and vascular cell adhesion molecular-1(VCAM-1)in oral leukoplakia canceration. Methods 15 cases of nomal controls,10 cases of oral leukoplakia with mild to moderate epithelial dysplasia,10 cases of oral leukoplakia canceration were enrolled in the study. Immunohistochemical analysis was used to detect the expresssion level of oral leukoplakia canceration. Results The expression level of ICAM-1 and VCAM-1 in oral leukoplakia canceration were higher than those in mild to moderate epithelial dysplasia(P < 0.05),and the expression level in mild to moderate epithelial dysplasia were higher than in nomal controls(P < 0.05). Conclusion High expression was related to oral leukoplakia canceration,which may be involved in the malignant transformation of oral leukoplakia.
引文
[1]孟文霞,周红梅.口腔黏膜白斑组织转化生长因子-β受体Ⅱ及受体Ⅲ的表达[J].广东牙病防治,2013,21(4):173-176.
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[4]CHAWLA H,URS A B,AUGUSTINE J.Association of macrophages with angiogenesis in oral epithelial dysplasia,oral verrucous carcinoma,and oral squamous cell carcinoma:an immunohistochemical study[J].Appl Immunohistochem Mol Morphol,2017,25(3):203-208.
[5]BAR-SHAI A,SHENHAR-TSARFATY S,AHIMOR A,et al.A novel combined score of biomarkers in sputum may be an indicator for lung cancer:A pilot study[J].Clin Chim Acta,2018,487:139-144.
[6]PENG H,LI H,LI M.High glucose induces dysfunction of human umbilical vein endothelial cells by upregulating mi R-137 in gestational diabetes mellitus[J].Microvasc Res,2018,118:90-100.
[7]KUESSEL L,WENZL R,PROESTLING K,et al.Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis[J].Hum Reprod,2017,32(4):770-779.
[8]HABAS K,SHANG L.Alterations in intercellular adhesion molecule 1(ICAM-1)and vascular cell adhesion molecule 1(VCAM-1)in human endothelial cells[J].Tissue Cell,2018,54:139-143.
[9]ZHANG C,ZHANG M,SONG S.Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation[J].Cancer Letters,2018,438:105-115.
[10]OLIVARES-SILVA F,LANDAETA R,ARANGUIZ P,et al.Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression[J].Biochim Biophys Acta Mol Basis Dis,2018,1864(3):831-842.
[11]BHARADWAJ A S,STEMPEL A J,OLIVAS A,et al.Molecular signals involved in human B cell migration into the retina:in vitro investigation of ICAM-1,VCAM-1,and CXCL13[J].Ocul Immunol Inflamm,2017,25(6):811-819.
[12]THIEM D,SCHNEIDER S,VENKATRAMAN N T,et al.Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia[J].J Oral Pathol Med,2017,46(9):710-716.
[2]LIU W,WANG Y F,ZHOU H W,et al.Malignant transformation of oral leukoplakia:a retrospective cohort study of 218 Chinese patients[J].BMC Cancer,2010,10:685.
[3]孟文霞,郭薇,李志强,等.血管生成相关因子在口腔扁平苔藓中的表达[J].口腔疾病防治,2017,25(11):712-717.
[4]CHAWLA H,URS A B,AUGUSTINE J.Association of macrophages with angiogenesis in oral epithelial dysplasia,oral verrucous carcinoma,and oral squamous cell carcinoma:an immunohistochemical study[J].Appl Immunohistochem Mol Morphol,2017,25(3):203-208.
[5]BAR-SHAI A,SHENHAR-TSARFATY S,AHIMOR A,et al.A novel combined score of biomarkers in sputum may be an indicator for lung cancer:A pilot study[J].Clin Chim Acta,2018,487:139-144.
[6]PENG H,LI H,LI M.High glucose induces dysfunction of human umbilical vein endothelial cells by upregulating mi R-137 in gestational diabetes mellitus[J].Microvasc Res,2018,118:90-100.
[7]KUESSEL L,WENZL R,PROESTLING K,et al.Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis[J].Hum Reprod,2017,32(4):770-779.
[8]HABAS K,SHANG L.Alterations in intercellular adhesion molecule 1(ICAM-1)and vascular cell adhesion molecule 1(VCAM-1)in human endothelial cells[J].Tissue Cell,2018,54:139-143.
[9]ZHANG C,ZHANG M,SONG S.Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation[J].Cancer Letters,2018,438:105-115.
[10]OLIVARES-SILVA F,LANDAETA R,ARANGUIZ P,et al.Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression[J].Biochim Biophys Acta Mol Basis Dis,2018,1864(3):831-842.
[11]BHARADWAJ A S,STEMPEL A J,OLIVAS A,et al.Molecular signals involved in human B cell migration into the retina:in vitro investigation of ICAM-1,VCAM-1,and CXCL13[J].Ocul Immunol Inflamm,2017,25(6):811-819.
[12]THIEM D,SCHNEIDER S,VENKATRAMAN N T,et al.Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia[J].J Oral Pathol Med,2017,46(9):710-716.