乙肝病毒X蛋白调控肝癌干细胞维持肝细胞癌生物学行为的研究进展
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摘要
肝细胞癌是我国常见的恶性肿瘤之一,慢性乙型肝炎病毒(HBV)感染已经被认为是肝细胞癌发生的危险因素。乙型肝炎病毒X蛋白(HBx)是一个多功能的调节因子,能够调节相关信号通路以及表观遗传的基因表达,并且能参与细胞增殖、凋亡等途径。HBx能促进肝癌干细胞(LCSCs)自我更新能力、分化、抵抗化疗等生物学行为,进而促使肿瘤转移、浸润和复发。笔者对HBx调控LCSCs维持肝细胞癌的生物学行为进行综述。
Hepatocellular carcinoma(HCC) is one of the common malignant tumors in China. Chronic hepatitis B virus(HBV) infection has been considered as a risk factor for HCC. Hepatitis B virus X protein(HBx) is a multifunctional regulator that regulates signal transduction and epigenetic gene expressions, and also is involved in cell proliferation and apoptotic pathways. HBx can promote the self-renewal ability, differentiation, and resistance to chemotherapy and other biological behaviors of the liver cancer stem cells(LCSCs), and thereby promote tumor metastasis, infiltration and recurrence. The authors address HBx regulating LCSCs to maintain the biological behaviors of HCC.
Hepatocellular carcinoma(HCC) is one of the common malignant tumors in China. Chronic hepatitis B virus(HBV) infection has been considered as a risk factor for HCC. Hepatitis B virus X protein(HBx) is a multifunctional regulator that regulates signal transduction and epigenetic gene expressions, and also is involved in cell proliferation and apoptotic pathways. HBx can promote the self-renewal ability, differentiation, and resistance to chemotherapy and other biological behaviors of the liver cancer stem cells(LCSCs), and thereby promote tumor metastasis, infiltration and recurrence. The authors address HBx regulating LCSCs to maintain the biological behaviors of HCC.
引文
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