长链非编码RNA-重编码调控因子与肿瘤的研究进展
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摘要
长链非编码RNA(LncRNA)是一类长度超过200核苷酸且不编码蛋白质的RNA分子。肿瘤基因组学的快速发展使LncRNA在人类肿瘤研究方面的功能更加显著。基因间LncRNA(LincRNA)-重编码调控因子(ROR)作为一种新型LncRNA,其作用机制在结直肠癌、胰腺癌、乳腺癌的发生发展过程中有报道。我们就LincRNA-ROR在肿瘤中的相关调控机制以及在不同肿瘤中的研究现状做简要综述,以便对其有进一步了解。
Long non-coding RNA(LncRNA) is a class of RNA molecules with a length of over 200 nt and no protein-coding capacity. The rapid development of tumor genomics has made the function of LncRNA more significant in human tumor research. As a new type of LncRNA, large intergenic non-coding RNA(LincRNA)-regulator of reprogramming(ROR) has been reported in the occurrence and development of colorectal cancer, pancreatic cancer and breast cancer. Here, we briefly summarized the related regulation mechanism of LincRNA-ROR on tumors and the research status in different tumors, in order to have further system comprehensive knowledge of LincRNAROR.
Long non-coding RNA(LncRNA) is a class of RNA molecules with a length of over 200 nt and no protein-coding capacity. The rapid development of tumor genomics has made the function of LncRNA more significant in human tumor research. As a new type of LncRNA, large intergenic non-coding RNA(LincRNA)-regulator of reprogramming(ROR) has been reported in the occurrence and development of colorectal cancer, pancreatic cancer and breast cancer. Here, we briefly summarized the related regulation mechanism of LincRNA-ROR on tumors and the research status in different tumors, in order to have further system comprehensive knowledge of LincRNAROR.
引文
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[5] Qu C H,Sun Q Y,Zhang F M,et al. Long non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression[J]. Eur Rev Med Pharmacol Sci, 2017,21(18):4087-4091.
[6] Loewer S,Cabili M N, Guttman M,et al. Large intergenic non-coding RNA-RoR modulates reprogramming of humaninduced pluripotent stem cells[J]. Nat Genet,2010,42(12):1113-1117.
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[8] Rezaei M, Emadi-Baygi M, Hoffmann M J, et al. Altered expression of LINC-ROR in cancer cell lines and tissues[J]. Tumour Biol,2016,37(2):1763-1769.
[9] Takahashi K,Yan I K,Haga H,et al. Modulation of hypoxia signaling pathways by extracellular line-RoR[J]. Cell Sci, 2014,127:1585-1594.
[10] Feng S,Yao J,Chen Y,et al. Expression and functional role of reprogramming-related long noncoding RNA(lincRNA-ROR)in glioma[J]. Mol Neurosci, 2015,56:623-630.
[11] Hansen T B,Jensen T I,Clausen B H, et al. Natural RNA circles function as efficient microRNA sponges[J]. Nature, 2013,495:384-388.
[12] Gao S, Wang P, Hua Y, et al. ROR functions as a ceRNA to regulate Nanog expression by spongingmiR-145 and predicts poor prognosis in pancreatic cancer[J]. Oncotarget, 2016,7(2):1608-1618.
[13] Duru N, Gernapudi R, Lo P K, et al. Characterization of the CD49f+/CD44+/CD24-single-cell derived stem cell population in basal-like DCIS cells[J]. Oncotarget,2016,7(30):47511-47525.
[14] Zhou P,Sun L, Liu D, et al. Long non-coding RNA lincRNA-ROR promotes the progression of colon cancer and holds prognostic value by associating with miR-145[J]. Pathol Oncol Res, 2016,22:733-740.
[15] Zou G, Liu T, GuoL,et al. miR-145 modulates IncRNA-ROR and Sox2 expression to maintain human amniotic epithelial stem cell pluripotency and beta islet-like cell differentiation efficiency[J]. Gene, 2016,591:48-57.
[16] Yin D D, Zhang E B, You L H, et al. Downregulation of IncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic beta cells[J]. Cell Physiol Biochem, 2015,35:1892-1904.
[17] Jiang F,Zhou X, Huang J. Long non-coding RNAROR mediates the reprogramming in cardiac hypertrophy[J]. PLoS One, 2016,11:e0152767.
[18] Hou P, Zhao Y, Li Z, et al. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis[J]. Cell Death Dis, 2014,5:e1287.
[19] Chen Y M, Liu Y, Wei H Y, et al. Linc-ROR induces epithelial-mesenchymal transition and contributes to drug resistance and invasion of breast cancer cells[J]. Tumour Biol, 2016,37:10861-10870.
[20] Zhan H X, Wang Y, Li C, et al. LincRNA-ROR promotes invasion, metastasis and tumor growth in pancre-atic cancer through activating ZEB1 pathway[J]. Cancer Lett, 2016,374:261-271.
[21] Fan J,Xing Y, Wen X, et al. Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis[J]. Genome Biol, 2015,16:139.
[22] Zullig L L, Smith V A,Jackson G L, et al. Colorectal cancer statistics from the veterans affairs central cancer registry[J]. Clin Colorectal Cancer, 2016,15:e199-e204.
[23] Li H, Jiang X, Niu X, et al. Long non-coding RNA reprogramming(ROR)promotes cell proliferation in colorectal cancer via affecting P53[J]. Med Sci Monit,2017,23:919-928.
[24] Peng W,Huang J, Yang L, et al. Linc-RoR promotes MAPK/ERK signalingand confers estrogen-independent growth of breast cancer[J]. Mol Cancer, 2017,16:161.
[25] Eades G, Wolfson B, Zhang Y, et al. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6[J]. Mol Cancer Res,2015,13(2):330-338.
[26] Ma J, Yang Y, Huo D, et al. LincRNA-RoR/miR-145promote invasion and metastasis in triple-negative breast cancer via targeting MUC 1[J]. Biochem Biophys Res Commun, 2018,500(3):614-620.
[27] Jie J, Zhang Y, Zhou H, et al. CpG ODN1826 as a promisingmucinl-maltose-binding protein vaccine adjuvant induced DC maturation and enhanced antitumor immunity[J]. Int J Mol Sci, 2018,19(3):920.
[28] Huang H L, Wu H Y, Chu P C, et al. Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells[J].Oncogenesis, 2017,6(7):e359.
[2] Hanaban D, Weinberg R. Hallmarks of cancer:the next generation[J]. Cell, 2011,144(5):646-674.
[3]张爱兴,王玉明,段勇.长链非编码RNA与之肿瘤之间关系的研究进展[J].实验与检验医学,2015,33(5):600-604.
[4] Tay Y, Rinn J, Pandolfi P P. The multilayered complexity of ceRNA crosstalk and competition[J]. Nature,2014,505(7483):344-352.
[5] Qu C H,Sun Q Y,Zhang F M,et al. Long non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression[J]. Eur Rev Med Pharmacol Sci, 2017,21(18):4087-4091.
[6] Loewer S,Cabili M N, Guttman M,et al. Large intergenic non-coding RNA-RoR modulates reprogramming of humaninduced pluripotent stem cells[J]. Nat Genet,2010,42(12):1113-1117.
[7] Wang Y,Xu Z,Jiang J,et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal[J].Dev Cell, 2013,25:69-80.
[8] Rezaei M, Emadi-Baygi M, Hoffmann M J, et al. Altered expression of LINC-ROR in cancer cell lines and tissues[J]. Tumour Biol,2016,37(2):1763-1769.
[9] Takahashi K,Yan I K,Haga H,et al. Modulation of hypoxia signaling pathways by extracellular line-RoR[J]. Cell Sci, 2014,127:1585-1594.
[10] Feng S,Yao J,Chen Y,et al. Expression and functional role of reprogramming-related long noncoding RNA(lincRNA-ROR)in glioma[J]. Mol Neurosci, 2015,56:623-630.
[11] Hansen T B,Jensen T I,Clausen B H, et al. Natural RNA circles function as efficient microRNA sponges[J]. Nature, 2013,495:384-388.
[12] Gao S, Wang P, Hua Y, et al. ROR functions as a ceRNA to regulate Nanog expression by spongingmiR-145 and predicts poor prognosis in pancreatic cancer[J]. Oncotarget, 2016,7(2):1608-1618.
[13] Duru N, Gernapudi R, Lo P K, et al. Characterization of the CD49f+/CD44+/CD24-single-cell derived stem cell population in basal-like DCIS cells[J]. Oncotarget,2016,7(30):47511-47525.
[14] Zhou P,Sun L, Liu D, et al. Long non-coding RNA lincRNA-ROR promotes the progression of colon cancer and holds prognostic value by associating with miR-145[J]. Pathol Oncol Res, 2016,22:733-740.
[15] Zou G, Liu T, GuoL,et al. miR-145 modulates IncRNA-ROR and Sox2 expression to maintain human amniotic epithelial stem cell pluripotency and beta islet-like cell differentiation efficiency[J]. Gene, 2016,591:48-57.
[16] Yin D D, Zhang E B, You L H, et al. Downregulation of IncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic beta cells[J]. Cell Physiol Biochem, 2015,35:1892-1904.
[17] Jiang F,Zhou X, Huang J. Long non-coding RNAROR mediates the reprogramming in cardiac hypertrophy[J]. PLoS One, 2016,11:e0152767.
[18] Hou P, Zhao Y, Li Z, et al. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis[J]. Cell Death Dis, 2014,5:e1287.
[19] Chen Y M, Liu Y, Wei H Y, et al. Linc-ROR induces epithelial-mesenchymal transition and contributes to drug resistance and invasion of breast cancer cells[J]. Tumour Biol, 2016,37:10861-10870.
[20] Zhan H X, Wang Y, Li C, et al. LincRNA-ROR promotes invasion, metastasis and tumor growth in pancre-atic cancer through activating ZEB1 pathway[J]. Cancer Lett, 2016,374:261-271.
[21] Fan J,Xing Y, Wen X, et al. Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis[J]. Genome Biol, 2015,16:139.
[22] Zullig L L, Smith V A,Jackson G L, et al. Colorectal cancer statistics from the veterans affairs central cancer registry[J]. Clin Colorectal Cancer, 2016,15:e199-e204.
[23] Li H, Jiang X, Niu X, et al. Long non-coding RNA reprogramming(ROR)promotes cell proliferation in colorectal cancer via affecting P53[J]. Med Sci Monit,2017,23:919-928.
[24] Peng W,Huang J, Yang L, et al. Linc-RoR promotes MAPK/ERK signalingand confers estrogen-independent growth of breast cancer[J]. Mol Cancer, 2017,16:161.
[25] Eades G, Wolfson B, Zhang Y, et al. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6[J]. Mol Cancer Res,2015,13(2):330-338.
[26] Ma J, Yang Y, Huo D, et al. LincRNA-RoR/miR-145promote invasion and metastasis in triple-negative breast cancer via targeting MUC 1[J]. Biochem Biophys Res Commun, 2018,500(3):614-620.
[27] Jie J, Zhang Y, Zhou H, et al. CpG ODN1826 as a promisingmucinl-maltose-binding protein vaccine adjuvant induced DC maturation and enhanced antitumor immunity[J]. Int J Mol Sci, 2018,19(3):920.
[28] Huang H L, Wu H Y, Chu P C, et al. Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells[J].Oncogenesis, 2017,6(7):e359.