微量元素碘、硒、铜、锌与甲状腺乳头状癌的相关性研究
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摘要
目的探讨微量元素碘、硒、铜、硒与甲状腺乳头状癌相关性。方法收集新疆医科大学第一附属医院2017年12月-2018年10月在甲状腺外科经病理诊断为甲状腺乳头状癌和结节性甲状腺肿的患者各200例,同期收取健康人群200例。检测3组术前甲状腺功能、甲状腺自身抗体、尿碘、血硒、血铜和血锌水平并进行统计学分析。结果三组患者的尿碘、血硒、血铜、血锌经检验,均有统计学差异(P<0.05)。分别将三组的四项做两两比较,结甲组与甲癌组患者的尿碘、血硒、血铜、血锌对比经检验,均有统计学意义(P<0.05)。结甲组与健康组患者的尿碘、血硒、血锌对比经检验,均有统计学意义(P<0.05)。甲癌组与健康组的患者尿碘、血硒、血铜、血锌对比经检验,均有统计学意义(P<0.05)。结论性别、尿碘、血硒是甲状腺乳头状癌发病的危险因素。
Objective To investigate the correlation between trace elements iodine, selenium, copper and selenium and thyroid papillary carcinom.Methods To Collected the first affiliated hospital of xinjiang medical university in December 2017 to October 2018 in thyroid surgical pathologic diagnosis of papillary thyroid carcinoma and nodular goiter patients 200 cases respectively, During the same period, 200 healthy people were collected. The preoperative thyroid function, thyroid autoantibodies, urinary iodine, blood selenium,blood copper and blood zinc levels in the three groups were detected and statistically analyzed.Results There were statistically significant differences in urine iodine, blood selenium, blood copper and blood zinc among the three groups(P < 0.05).Four items of the three groups were paged for comparison, the comparison of urine iodine, blood selenium, blood copper blood zinc between the Nodular thyroid group and the PTC group showed statistical significance(P < 0.05).The comparison of urinary iodine, blood selenium and blood zinc between the Nodular thyroid group and healthy group showed statistical significance(P < 0.05).The comparison of urine iodine, blood selenium,blood copper blood zinc between the PTC group and the healthy group showed statistical significance(P < 0.05).Conclusion Gender,urine iodine and blood selenium are risk factors of thyroid papillary carcinoma.
Objective To investigate the correlation between trace elements iodine, selenium, copper and selenium and thyroid papillary carcinom.Methods To Collected the first affiliated hospital of xinjiang medical university in December 2017 to October 2018 in thyroid surgical pathologic diagnosis of papillary thyroid carcinoma and nodular goiter patients 200 cases respectively, During the same period, 200 healthy people were collected. The preoperative thyroid function, thyroid autoantibodies, urinary iodine, blood selenium,blood copper and blood zinc levels in the three groups were detected and statistically analyzed.Results There were statistically significant differences in urine iodine, blood selenium, blood copper and blood zinc among the three groups(P < 0.05).Four items of the three groups were paged for comparison, the comparison of urine iodine, blood selenium, blood copper blood zinc between the Nodular thyroid group and the PTC group showed statistical significance(P < 0.05).The comparison of urinary iodine, blood selenium and blood zinc between the Nodular thyroid group and healthy group showed statistical significance(P < 0.05).The comparison of urine iodine, blood selenium,blood copper blood zinc between the PTC group and the healthy group showed statistical significance(P < 0.05).Conclusion Gender,urine iodine and blood selenium are risk factors of thyroid papillary carcinoma.
引文
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[12] Wu Q, Rayman MP, Lv H, et al. Low population selenium status is associated with increased prevalence of thyroid disease[J]. J Clin Endocrinol Metab, 2015,100(11):4037-4047.
[13] Dragutinovi V V, Tati S B, Nikoli?mandi? S D, et al. Copper as ancillary diagnostic tool in preoperative evaluation of possible papillary thyroid carcinoma in patients with benign thyroid disease.[J].Biological Trace Element Research, 2014, 160(3):311-315.
[14] Kucharzewski M, Braziewicz J, Majewska U, et al. Copper, zinc and selenium in whole blood and thyroid tissue of people with various thyroid diseases[J]. Biol Trace Elem Res, 2003,93(1-3):9-18.
[15] ZANE M,PARELLO C,PENNELLI G,et al.Estrogen and thyroid cancer is a stem affair:A preliminary study[J].Biomed Pharmacother,2016,26(85):399-411.
[16]王溪,王战建。雌激素及抗雌激素药物与甲状腺癌[J]。中华内分泌代谢杂志,2014,30(12):1128-1131.
[17] WUQ,RAYMAN M P,LYU H.Low population selenium status is associated with increased prevalence of thyroid disease[J]. J Clin Endocrinol Metab,2015,100(11):4037-4047.
[18] ZIMMERMANN M B,GALETTI V.Iodine intake as a risk factor for thyroid cancer:a comprehensive review of animal and human studies[J].Thyroid Res,2015,8(1):8.
[2]李才淑,楼蔓藤,李增禧,等.血清微量元素含量与疾病相关性数据[J].广东微量元素科学,2012,19(11):25-56.
[3]刘树利.微量元素测定在肿瘤患者诊断及防治中的意义[J].检验医学与临床,2013,10(6):673-674.
[4] Fuziwara CS, Kimura ET. High iodine blocks a Notch/miR-19 loopactivated by the BRAF(V600E)oncoprotein and restores the respons e to TGFb eta in thyroid follicular c ells[J]. Thyroid, 2014, 24(3):453-462.
[5]姜海霞,李艳波.碘对甲状腺疾病影响及机制的研究进展[J].中华实用诊断与治疗杂志,2016,30(7):639—641.
[6]郭振清,赵腾,孙谟健,等.青岛地区1306例甲状腺癌的临床病理特征分析[J].中国癌症杂志,2016,11(1):53-59.
[7]张颖,李俞莹,姚旋,等.碘与甲状腺疾病[J].生命科学,2012,24(8):901-908.
[8]崔俊生,倪劲松,孔庆杨,等.食盐加碘前后甲状腺恶性肿瘤检出率及组织学类型分析[J].吉林大学学报:医学版,2008,34(6):1075-1078.
[9] Hye JK, Hyeong KP, Dong WB, et al. Iodine intake as a risk factor for BRAF mutations in papillary thyroid cancer patients from an iodinereplete area[J].Eur J Nutr, 2016,24(5),76-83.
[10] RaymanMP. Selenium in cancer prevention:a review of the evidence and mechanism of action[J]. Proc Nutr Soc, 2005,64(4):527-542.
[11] Jonklaas J, Danielsen M, Wang H. A pilot study of serum selenium,vitamin D, and thyrotropin concentrations in patients with thyroid cancer[J]. Thyroid, 2013,23(9):1079-1086.
[12] Wu Q, Rayman MP, Lv H, et al. Low population selenium status is associated with increased prevalence of thyroid disease[J]. J Clin Endocrinol Metab, 2015,100(11):4037-4047.
[13] Dragutinovi V V, Tati S B, Nikoli?mandi? S D, et al. Copper as ancillary diagnostic tool in preoperative evaluation of possible papillary thyroid carcinoma in patients with benign thyroid disease.[J].Biological Trace Element Research, 2014, 160(3):311-315.
[14] Kucharzewski M, Braziewicz J, Majewska U, et al. Copper, zinc and selenium in whole blood and thyroid tissue of people with various thyroid diseases[J]. Biol Trace Elem Res, 2003,93(1-3):9-18.
[15] ZANE M,PARELLO C,PENNELLI G,et al.Estrogen and thyroid cancer is a stem affair:A preliminary study[J].Biomed Pharmacother,2016,26(85):399-411.
[16]王溪,王战建。雌激素及抗雌激素药物与甲状腺癌[J]。中华内分泌代谢杂志,2014,30(12):1128-1131.
[17] WUQ,RAYMAN M P,LYU H.Low population selenium status is associated with increased prevalence of thyroid disease[J]. J Clin Endocrinol Metab,2015,100(11):4037-4047.
[18] ZIMMERMANN M B,GALETTI V.Iodine intake as a risk factor for thyroid cancer:a comprehensive review of animal and human studies[J].Thyroid Res,2015,8(1):8.