扶正祛邪法干预肿瘤微环境作用机制研究进展
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摘要
近年来中医药调节肿瘤微环境的研究已成为中医药治疗恶性肿瘤的热点之一。运用扶正祛邪法对恶性肿瘤微环境的干预发挥了重要的作用。该文综合分析扶正祛邪法对恶性肿瘤微环境中肿瘤相关巨噬细胞和肿瘤相关成纤维细胞作用机制的研究,可为今后中医药干预恶性肿瘤治疗提供新的防治思路。
In recent years,the research of Chinese medicine regulating tumor microenvironment has become one of the hot topics of traditional Chinese medicine in the treatment of malignant tumors. The application of strengthening body resistance to eliminate pathogenic factors has played an important role in the intervention of malignant tumor microenvironment. The mechanism of strengthening body resistance to eliminate pathogenic factors on tumor associated macrophages and tumor-associated fibroblasts in malignant tumor microenvironment is comprehensively analyzed in this paper,it can provide a new way of prevention and treatment for the treatment of malignant tumors in the future.
In recent years,the research of Chinese medicine regulating tumor microenvironment has become one of the hot topics of traditional Chinese medicine in the treatment of malignant tumors. The application of strengthening body resistance to eliminate pathogenic factors has played an important role in the intervention of malignant tumor microenvironment. The mechanism of strengthening body resistance to eliminate pathogenic factors on tumor associated macrophages and tumor-associated fibroblasts in malignant tumor microenvironment is comprehensively analyzed in this paper,it can provide a new way of prevention and treatment for the treatment of malignant tumors in the future.
引文
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[24]Pikarsky E,Porat R M,Stein I,et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer[J]. Nature,2004,431(7007):461-466.
[25]GONG D,SHI W,YI SJ,et al. TGF-βsignaling plays a critical role in promoting alternative macrophage activation[J]. BMC Immunology,2012,13(1):1-10.
[26]Goswami K K,Barik S,Sarkar M,et al. Targeting STAT3phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2macrophages[J]. Molecular Immunology,2014,59(2):119-127.
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[29]Xing F,Saidou J,Watabe K,et al. Cancer associated fibroblasts(CAFS)in tumor microenvironment[J]. Front Biosci,2011,15(1):166-179.
[30]Garin-Chesa P,Old L J,Rettig W J,et al. Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers[J]. Proc Natl Acad Sci USA,1990,87(18):7235-7239.
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[32]Drake L E,Macleod K F. Tumour suppressor gene function in carcinoma-associated fibroblasts:from tumour cells via EMT and back again?[J]. Journal of Pathology,2014,232(3):283-288.
[33]Mishra P J,Mishra P J,Humeniuk R,et al. Carcinomaassociated fibroblast-like differentiation of human mesenchymal stem cells[J]. Cancer Research,2008,68(11):4331-4339.
[34]Potenta S,Zeisberg E,Kalluri R,et al. The role of endothelialto-mesenchymal transition in cancer progression[J]. British Journal of Cancer,2008,99(9):1375-1379.
[35]Crisan M,Yap S,Casteilla L,et al. A perivascular origin for mesenchymal stem cells in multiple human organs[J]. Cell Stem Cell,2008,3(3):301-313.
[36]Mueller M M,Fusenig N E. Friends or foes-bipolar effects of the tumour stroma in cancer[J]. Nature Reviews Cancer,2004,4(11):839-849.
[37]Tlsty T D. Stromal cells can contribute oncogenic signals[J].Seminars in Cancer Biology,2001,11(2):97-104.
[38]Elenbaas B,Weinberg R A. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation[J].Experimental Cell Research,2001,264(1):169.
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[41]Frick V O,Rubie C,Wagner M,et al. Enhanced ENA-78 and IL-8 expression in patients with malignant pancreatic diseases[J]. Pancreatology,2008,8(4-5):488-497.
[42]Bandapalli O R,Ehrmann F,Ehemann V,et al. Downregulation of CXCL1 inhibits tumor growth in colorectal liver metastasis[J]. Cytokine,2012,57(1):46-53.
[43]DONG QM,ZHANG JQ,LI Q,et al. Clinical significance of serum expression of GROβin esophageal squamous cell carcinoma[J].World Journal of Gastroenterology,2011,17(21):2658.
[44]Killian P H,Kronski E,Michalik K M,et al. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and-2[J]. Carcinogenesis,2012,33(12):2507-2519.
[45]Kavandi L,Collier M A,Nguyen H,et al. Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2in ovarian and endometrial cancer cells[J]. Journal of Cellular Biochemistry,2012,113(10):3143-3152.
[46]BergersG,BrekkenR,McmahonG,etal.Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis[J]. Nature Cell Biology,2000,2(10):737.
[47]DeryuginaEI,QuigleyJP.Pleiotropicrolesofmatrix metalloproteinasesintumorangiogenesis:Contrasting,overlapping and compensatory functions[J]. Biochimica Et Biophysica Acta Molecular Cell Research,2010,1803(1):103-120.
[48]Masson V,Lr D L B,Munaut C,et al. Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes[J]. Faseb Journal,2005,19(2):234-236.
[49]杨兰.中医正气学说探析[J].辽宁中医杂志,2004,31(2):113-114.
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