中药治疗肺癌干细胞研究进
|
摘要
近年来随着研究的不断深入,有学者提出肿瘤的发生与肿瘤干细胞密切相关。肿瘤干细胞是一类具有自我更新、无限增殖分化、高致瘤性和耐药性的细胞。基于肿瘤干细胞理论学者认为肺癌干细胞是肺癌起病、耐药、休眠、复发的根源。中医药在治疗肺癌干细胞方面具有副作用低、疗效突出以及靶向治疗的优势已经被认可,目前中医药治疗肺癌干细胞已经成为又一研究热点。本文就中医药对肺癌干细胞的影响展开综述。
In recent years, with the deepening of research, some scholars have suggested that the occurrence of tumors is closely related to cancer stem cells. Cancer stem cells are a type of cells with self-renewal, infinite proliferation, high tumorigenicity, and drug resistance. Based on cancer stem cell theorists, lung cancer stem cells are the root cause of onset, drug resistance, dormancy, and recurrence of lung cancer. Traditional Chinese medicine has the advantages of low side-effects, outstanding curative effect, and targeted treatment in the treatment of lung cancer stem cells. It has been recognized that Chinese medicine treatment of lung cancer stem cells has become another research hot spot. This article reviews the impact of Chinese medicine on lung cancer stem cells.
In recent years, with the deepening of research, some scholars have suggested that the occurrence of tumors is closely related to cancer stem cells. Cancer stem cells are a type of cells with self-renewal, infinite proliferation, high tumorigenicity, and drug resistance. Based on cancer stem cell theorists, lung cancer stem cells are the root cause of onset, drug resistance, dormancy, and recurrence of lung cancer. Traditional Chinese medicine has the advantages of low side-effects, outstanding curative effect, and targeted treatment in the treatment of lung cancer stem cells. It has been recognized that Chinese medicine treatment of lung cancer stem cells has become another research hot spot. This article reviews the impact of Chinese medicine on lung cancer stem cells.
引文
[1]屈若祎,周宝森.2004-2010年中国肺癌死亡分布及趋势分析[J].中国卫生统计2014,31(6):932.
[2]Jemal A,Bray F,Center MM,Ferlay J,Ward E,Forman D.Global cancerstatistics.CA Cancer J Clin.2011,61(2):69.
[3]白春学,内科学[M].第8版,北京:人民卫生出版社,2013,75.
[4]Magee JA,Piskounova E,Morrison SJ.Cancer stem cells:Impact,heteroogeneity,and uncertainty[J].Cancer Cell,2012,21:283.
[5]Zhang JJ,Song JC.Development of cancer stem cell.Intl JBiomed Eng,2006,2(4):246.
[6]Bonnet D,Dick JE.Human acute myeloid leukemia is Organized as a hierarchy that originates from a primitive hematopoietic cell[J].Nat Med.1997,3(7):730.
[7]Weissman IL.Stem cells:units of development,units of regeneration,and units in evolution[J].Cell,2000,100(1):157.
[8]Al-Hajj M,Wicha MS,Benit-Hernandez A,et al.Prospective identification o f tumorigenic breast cancer cells.Proc Natl Acad Sci USA,2003,100(7):3983.
[9]Ramo A.Lotti F,Sette G,et al.Identification and expansion of the tumorigenic lung cancer stem cell population[J].Cell Death Dif-fer,2008,15(3):504.
[10]Singh SK,Hawkins C,Clarke ID,et al.Identification of human brain tumour initiating cells[J].Nature,2004,432(7015):396.
[11]Ci-Vitiani L,Lombardi DG,Pilozzi E,et al.Identification and expansion of human colon-cancer-initiating cells[J].Nature,2007,445(7123):111.
[12]Collins AT,Berry PA,Hyde C,et al.Prospective identification of tumorigenic prostate cancer stem cells[J].Cancer Bes,2005,65(23):109.
[13]Kim CF,Jackson EL,Woolfenden AE,et al.Identification of bronchioalveolar stem cells in normal lung and lung cancer.Cell,2005;121(6):823.
[14]赵黎.肺癌的中医治疗[J].现代中西医结合杂志2007,16(31):4605.
[15]张艺严,高冰.中西医结合治疗肺癌临床思路[J].亚太传统医药,2017,13(1):51.
[16]关天宇,谷言芳.谷铭三教授治疗晚期肺癌用药经验[J].实用中医内科杂志,2011,25(5):17.
[17]谈馨媛,路枝红,吴蕾等,刘伟胜教授辨治肺癌的经验整理[J].时珍国医国药,2013,24(12):3032.
[18]谭芊任,崔峻松,肖政华.名老中医凌湘力运用芪术汤治疗肺癌术后经验撷要[J].亚太传统医药,2017,13(1):98.
[19]杨栋,张培彤,王耀晗,等.川芎嗪对P G干细胞样样细胞VEGF、HIF-α蛋白表达的影响[J]中国肿瘤,2015,24(3):234.
[20]杨栋,张培彤,王耀晗,等.川芎嗪对PGc、ABCG-2蛋白影响的研究[J].杏林中医药,2015,35(8):833.
[21]武有明,张齐,刘永琦,等.当归多糖对肺癌微环境中骨髓间充质干细胞增殖及TAFs相关分子表达的影响[J].中国细胞生物学学报,2015,37(9):1271.
[22]武有明,张齐,刘永琦,等.黄芪多糖对肺癌微环境中BMSCs增殖及TAFs分化的影响[J].中药药理与临床,2015,31(6):76.
[23]赵雅瑞,张立凡,刘特.姜黄素上调caspase-3和p53表达后对人肺癌干细胞增殖与侵袭的影响[J].国临床医学,2013,20(3):259.
[24]曹晓诚,肖立红,肖荞,等.蔓荆子总黄酮抑制NCI-H446细胞系肺癌干细胞自我更新[J].中草药,2014,45(9):1284.
[25]姜贻乾,郭庆敏,莫永祥,等.南方红豆杉水提物逆转非小细胞肺癌干细胞耐药作用的实验[J].肿瘤防治研究,2016,43(11):933.
[26]陈恭让,安东建,曹建国,等.紫花牡荆素抑制小细胞肺癌NCI-H 446细胞系肺癌干细胞样细胞侵袭和转移的研究[J]中南药学,2014,12(10):984.
[27]孙彦珍,李珍,袁征.小檗碱对肺癌干细胞增殖和凋亡的影响及其机制[J].中国组织工程研究,2017,21(9):1313.
[28]王爽,王立芳,徐振晔,等.肺岩宁方对肺癌干细胞Wnt信号通路的影响[J].上海中医药大学学报,2012,26(6):77.
[2]Jemal A,Bray F,Center MM,Ferlay J,Ward E,Forman D.Global cancerstatistics.CA Cancer J Clin.2011,61(2):69.
[3]白春学,内科学[M].第8版,北京:人民卫生出版社,2013,75.
[4]Magee JA,Piskounova E,Morrison SJ.Cancer stem cells:Impact,heteroogeneity,and uncertainty[J].Cancer Cell,2012,21:283.
[5]Zhang JJ,Song JC.Development of cancer stem cell.Intl JBiomed Eng,2006,2(4):246.
[6]Bonnet D,Dick JE.Human acute myeloid leukemia is Organized as a hierarchy that originates from a primitive hematopoietic cell[J].Nat Med.1997,3(7):730.
[7]Weissman IL.Stem cells:units of development,units of regeneration,and units in evolution[J].Cell,2000,100(1):157.
[8]Al-Hajj M,Wicha MS,Benit-Hernandez A,et al.Prospective identification o f tumorigenic breast cancer cells.Proc Natl Acad Sci USA,2003,100(7):3983.
[9]Ramo A.Lotti F,Sette G,et al.Identification and expansion of the tumorigenic lung cancer stem cell population[J].Cell Death Dif-fer,2008,15(3):504.
[10]Singh SK,Hawkins C,Clarke ID,et al.Identification of human brain tumour initiating cells[J].Nature,2004,432(7015):396.
[11]Ci-Vitiani L,Lombardi DG,Pilozzi E,et al.Identification and expansion of human colon-cancer-initiating cells[J].Nature,2007,445(7123):111.
[12]Collins AT,Berry PA,Hyde C,et al.Prospective identification of tumorigenic prostate cancer stem cells[J].Cancer Bes,2005,65(23):109.
[13]Kim CF,Jackson EL,Woolfenden AE,et al.Identification of bronchioalveolar stem cells in normal lung and lung cancer.Cell,2005;121(6):823.
[14]赵黎.肺癌的中医治疗[J].现代中西医结合杂志2007,16(31):4605.
[15]张艺严,高冰.中西医结合治疗肺癌临床思路[J].亚太传统医药,2017,13(1):51.
[16]关天宇,谷言芳.谷铭三教授治疗晚期肺癌用药经验[J].实用中医内科杂志,2011,25(5):17.
[17]谈馨媛,路枝红,吴蕾等,刘伟胜教授辨治肺癌的经验整理[J].时珍国医国药,2013,24(12):3032.
[18]谭芊任,崔峻松,肖政华.名老中医凌湘力运用芪术汤治疗肺癌术后经验撷要[J].亚太传统医药,2017,13(1):98.
[19]杨栋,张培彤,王耀晗,等.川芎嗪对P G干细胞样样细胞VEGF、HIF-α蛋白表达的影响[J]中国肿瘤,2015,24(3):234.
[20]杨栋,张培彤,王耀晗,等.川芎嗪对PGc、ABCG-2蛋白影响的研究[J].杏林中医药,2015,35(8):833.
[21]武有明,张齐,刘永琦,等.当归多糖对肺癌微环境中骨髓间充质干细胞增殖及TAFs相关分子表达的影响[J].中国细胞生物学学报,2015,37(9):1271.
[22]武有明,张齐,刘永琦,等.黄芪多糖对肺癌微环境中BMSCs增殖及TAFs分化的影响[J].中药药理与临床,2015,31(6):76.
[23]赵雅瑞,张立凡,刘特.姜黄素上调caspase-3和p53表达后对人肺癌干细胞增殖与侵袭的影响[J].国临床医学,2013,20(3):259.
[24]曹晓诚,肖立红,肖荞,等.蔓荆子总黄酮抑制NCI-H446细胞系肺癌干细胞自我更新[J].中草药,2014,45(9):1284.
[25]姜贻乾,郭庆敏,莫永祥,等.南方红豆杉水提物逆转非小细胞肺癌干细胞耐药作用的实验[J].肿瘤防治研究,2016,43(11):933.
[26]陈恭让,安东建,曹建国,等.紫花牡荆素抑制小细胞肺癌NCI-H 446细胞系肺癌干细胞样细胞侵袭和转移的研究[J]中南药学,2014,12(10):984.
[27]孙彦珍,李珍,袁征.小檗碱对肺癌干细胞增殖和凋亡的影响及其机制[J].中国组织工程研究,2017,21(9):1313.
[28]王爽,王立芳,徐振晔,等.肺岩宁方对肺癌干细胞Wnt信号通路的影响[J].上海中医药大学学报,2012,26(6):77.