MiRNA调控非小细胞肺癌转移的研究进展
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摘要
微小RNA是内源性的非编码小RNA分子,通过与靶mRNA的结合在转录后水平调控基因的表达,从而参与众多生命活动的调控。NSCLC是严重威胁人类健康的恶性肿瘤,侵袭转移是其主要特征,也是其治疗失败和死亡的主要原因。miRNA可以通过促进上皮-间质转化、金属基质蛋白酶表达,以及血管生成来促进NSCLC转移,而且miRNA在调节肺癌干细胞特性中也发挥着重要作用。转移相关的miRNA已成为肺癌靶向治疗的新靶点。
MicroRNAs(miRNAs) are endogenous non-coding small RNA molecules, which regulates the gene expression at the post-transcriptional level by binding to target mRNAs, thus participating in the regulation of many biological processes. Non-small-cell lung carcinoma(NSCLC) is a malignant tumor seriously threatening human health. Invasion and metastasis are main characteristics and causes of treatment failure and death in NSCLC. MiRNAs can enhance NSCLC metastasis by promoting epithelial-mesenchymal transition,metal matrix protease expression, and angiogenesis, as well as the stemness of lung cancer stem cells. It has been established that metastasis-related miRNAs are new targets for lung cancer therapy.
MicroRNAs(miRNAs) are endogenous non-coding small RNA molecules, which regulates the gene expression at the post-transcriptional level by binding to target mRNAs, thus participating in the regulation of many biological processes. Non-small-cell lung carcinoma(NSCLC) is a malignant tumor seriously threatening human health. Invasion and metastasis are main characteristics and causes of treatment failure and death in NSCLC. MiRNAs can enhance NSCLC metastasis by promoting epithelial-mesenchymal transition,metal matrix protease expression, and angiogenesis, as well as the stemness of lung cancer stem cells. It has been established that metastasis-related miRNAs are new targets for lung cancer therapy.
引文
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[2]K?hler J.Second-line treatment of NSCLC-the PanErbB inhibitor Afatinib in times of shifting paradigms.Front Med,2017,4:9
[3]Winter J,Jung S,Keller S,et al.Many roads to maturity:microRNA biogenesis pathways and their regulation.Nat Cell Biol,2009,11(3):228-234
[4]Shao Y,Liang B,Long F.Diagnostic microRNA biomarker discovery for non-small-cell lung cancer adenocarcinoma by integrative bioinformatics analysis.Biomed Res Int,2017:2563085
[5]Cheng Y,Xiang G,Meng Y.MiRNA-183-5p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting the PDCD4.Reprod Biol,2016,16(3):225-233
[6]Wu SY,Rupaimoole R,Shen F,et al.A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.Nat Commun,2016,7:11169
[7]Rice MA,Ishteiwy RA,Magani F,et al.The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related.Oncogene,2016,35(36):4752-4761
[8]Ji W,Sun B,Su C.Targeting microRNAs in cancer gene therapy.Genes,2017,8(1):21
[9]Cipollini M,Landi S.Bonafide targets of deregulated microRNAs in non-small cell lung cancer as tool to identify novel therapeutic targets:a review.Curr Pharm Design,2017,23(1):55-72
[10]Yang L,Yang J,Li J,et al.MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer.Sci Rep-UK,2015,5:13677
[11]Shi H,Ji Y,Zhang D,et al.MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells.Biochem Bioph Res Commun,2015,465(1):125-130
[12]Li J,Wang Y,Luo J,et al.miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in nonsmall cell lung cancer cells.FEBS Lett,2012,586(20):3761-3765
[13]Ke Y,Zhao W,Xiong J.MiR-149 inhibits non-small-cell lung cancer cells EMT by targeting FOXM1.Biol Res Int,2013:506731
[14]Cao M,Li Y,Lu H,et al.MiR-23a-mediated migration/invasion is rescued by its target,IRS-1,in non-small cell lung cancer cells.J Cancer Res Clin,2014,140(10):1661-1670
[15]Legras A,Pécuchet N,Imbeaud S,et al.Epithelial-tomesenchymal transition and microRNAs in lung cancer.Cancers,2017,9(8):101
[16]Su C,Cheng X,Li Y,et al.MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1.Cancer Med,2018,7(6):2485-2503
[17]Zhou S,Zhang Z,Zheng P,et al.MicroRNA-1285-5p influences the proliferation and metastasis of non-smallcell lung carcinoma cells via downregulating CDH1 and Smad4.Tumour Biol,2017,39(6):1010428317705513
[18]Frixa T,Sacconi A,Cioce M,et al.MicroRNA-128-3pmediated depletion of Drosha promotes lung cancer cell migration.Carcinogenesis,2018,39(2):293-304
[19]Hida Y.Differential expressions of matrix metalloproteinases,a disintegrin and metalloproteinases,and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers.Anticancer Agents Med Chem,2012,12(7):744-752
[20]Winer A,Adams S.Matrix metalloproteinase inhibitors in cancer therapy:turning past failures into future successes.Mol Cancer Ther,2018,17(6):1147-1155
[21]Wang H,Guan X,Tu Y,et al.MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN.J Exp Clin Canc Res,2015,34:59
[22]Tsuru A,Setoguchi T,Matsunoshita Y,et al.Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression.Brit J Cancer,2015,112(7):1232-1240
[23]He W,Zhang H,Wang Y,et al.CTHRC1 induces nonsmall cell lung cancer(NSCLC)invasion through upregulating MMP-7/MMP-9.BMC Cancer,2018,18(1):400
[24]Shi L,Zhang B,Sun X,et al.MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1.Brit J Cancer,2014,111(12):2316-2327
[25]Li D,Wei Y,Wang D,et al.MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-κB/MMP-9/VEGF pathways.Biochem Bioph Res Commun,2016,472(3):465-470
[26]Wei S,Zhang ZY,Fu SL,et al.Hsa-miR-623 suppresses tumor progression in human lung adenocarcinoma.Cell Death Dis,2017,8(5):e2829
[27]Wu A,Li J,Wu K,et al.MiR-373-3p promotes invasion and metastasis of lung adenocarcinoma cells.Zhongguo Fei Ai Za Zhi,2015,18(7):427-435
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[29]Chen QY,Jiao DM,Wu YQ,et al.MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met/PI3k/Akt/mTOR pathway.Oncotarget,2016,7(14):18247-18261
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