江苏省射阳县胃癌危险因素病例对照研究
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摘要
目的探讨江苏省射阳县的胃癌主要危险因素,为预防射阳县人群胃癌的发生提供线索,为制定胃癌的预防控制策略和措施提供基础数据。方法采用以人群为基础的病例对照研究方法,将病例和对照按照年龄和性别进行成组匹配,对189名胃癌患者和189名健康人群进行问卷调查。用单因素、多因素非条件Logistic回归方法进行分析。结果超重(BMI>23. 9)(OR=9. 002)、饮食偏咸(OR=3. 290)、食用腌菜每周(1～3)次(OR=6. 892)、食用腌菜每周超过3次(OR=3. 851)、经历不幸事件(OR=4. 699)、患胃部疾病(OR=3. 973)是胃癌发生的危险因素,高年收入相比年收入低(OR=0. 533)、饮水量大相比每天饮水少(OR=0. 622)是胃癌的保护因素。结论超重、饮食偏咸、食用腌菜、患胃部疾病等因素影响胃癌的发生,应加强体育锻炼、改变不良生活习惯、多饮水和放松心情来预防胃癌的发生。
Objectives To explore the main risk factors of gastric cancer in Sheyang County of Jiangsu Province,and to provide clues for preventing the occurrence of gastric cancer in Sheyang County,and to provide basic data for formulating the prevention and control strategies and measures of gastric cancer. Methods A population-based case-control study was conducted to investigate 189 cases of gastric cancer and 189 healthy controls by matching cases and controls according to age and gender. Univariate and multivariate unconditional Logistic regression method were used to analyze. Results Overweight( BMI > 23. 9)( OR = 9. 002),salty diet( OR = 3. 290),eating pickles( 1 ～ 3) times a week( OR = 6. 892),eating pickles more than three times a week( OR = 3. 851),experiencing unfortunate events( OR = 4. 699),and suffering from gastric diseases( OR = 3. 973) were risk factors of gastric cancer. Higher annual income( OR = 0. 533),increased daily water intake( OR = 0. 622) were protective factors of gastric cancer. Conclusions Overweight,salty diet,eating pickles,suffering from stomach diseases and other factors affect the occurrence of gastric cancer,we should strengthen physical exercise,change bad living habits,drink more water,relax moods to prevent the occurrence of gastric cancer.
Objectives To explore the main risk factors of gastric cancer in Sheyang County of Jiangsu Province,and to provide clues for preventing the occurrence of gastric cancer in Sheyang County,and to provide basic data for formulating the prevention and control strategies and measures of gastric cancer. Methods A population-based case-control study was conducted to investigate 189 cases of gastric cancer and 189 healthy controls by matching cases and controls according to age and gender. Univariate and multivariate unconditional Logistic regression method were used to analyze. Results Overweight( BMI > 23. 9)( OR = 9. 002),salty diet( OR = 3. 290),eating pickles( 1 ～ 3) times a week( OR = 6. 892),eating pickles more than three times a week( OR = 3. 851),experiencing unfortunate events( OR = 4. 699),and suffering from gastric diseases( OR = 3. 973) were risk factors of gastric cancer. Higher annual income( OR = 0. 533),increased daily water intake( OR = 0. 622) were protective factors of gastric cancer. Conclusions Overweight,salty diet,eating pickles,suffering from stomach diseases and other factors affect the occurrence of gastric cancer,we should strengthen physical exercise,change bad living habits,drink more water,relax moods to prevent the occurrence of gastric cancer.
引文
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[18]王冰霜,单晓梅,沈登辉,等.淮河流域水体持久性有毒污染物的研究现状[J].环境卫生学杂志,2014,4(5):499-503.(In English:WANG BS,SHAN XM,SHEN DH,et al.Current Status of Persistent Toxic Substances in Huaihe River Basin[J].Journal of Environmental Hygiene,2014,4(5):499-503.)
[19]朱永义,李静,钟祥银,等.四川省内江市城市饮用水水质和水性疾病调查分析[J].环境卫生学杂志,2012,2(1):9-13.(In English:ZHU YY,LI J,ZHONG XY,et al.Investigation and Analysis on the Quality of Drinking Water and Water-borne Diseases in Neijiang City,Sichuan Province[J].Journal of Environmental Hygiene,2012,2(1):9-13.)
[2]邢艳敏,谢广茹,潘战宇,等.青年胃癌53例临床病理特征与预后分析[J].中国肿瘤临床,2011,38(2):97-99,103.(In English:XING YM,XIE GR,PAN ZY,et al.Clinicopathologic Features and Prognosis of Gastric Cancer in53 Yung Adults[J].Chinese Journal of Clinical Oncology,2011,38(2):97-99,103.)
[3]赫捷,陈万青.2016中国肿瘤登记年报[M].北京:清华大学出版社,2017:72-260.(In English:HE J,CHEN WQ.Annual Report of Cancer Registration in China 2016[J].Tsinghua university press,2017:72-260.)
[4]韩仁强,武鸣,俞浩,等.2010年江苏省肿瘤登记地区恶性肿瘤发病与死亡[J].江苏预防医学,2015,26(1):5-10.(In English:HAN RQ,WU M,YU H,et al.Cancer incidence and mortality in registration areas in Jiangsu Province,2010[J].Jiangsu Journal of Preventive Medicine,2015,26(1):5-10.)
[5]薛清萍,潘雄飞,李思齐,等.四川省胃癌与生活习惯和行为影响因素关系分析[J].现代预防医学,2015,42(7):1257-1260.(In English:XUE QP,PAN XF,LI SQ,et al.Association between lifestyle factors and behaviors and risk of gastric cancer,Sichuan Province[J].Modern Preventive Medicine,2015,42(7):1257-1260.)
[6]Ooi EE,Phoon MC,Ishak B,et al.Seroepidemiology of Human Enterovirus 71,Singapore[J].Emerging Infectious Diseases,2002,8(9):995-997.
[7]赵风源,贺圣文,赵仁宏,等.胃癌危险因素的Meta分析[J].中国卫生统计,2010,27(2):146-148.(In English:ZHAO FY,HE SW,ZHAO RH,et al.Meta-analysis of the risk factors of gastric cancer in China[J].Chinese Journal of Health Statistics,2010,27(2):146-148.).
[8]顾晓平,王银存,智恒奎,等.大丰市食管癌、胃癌发病危险因素及其聚集性病例对照研究[J].中国公共卫生,2016,32(10):1406-1409.(In English:GU XP,WANG YC,ZHI HK,et al.Risk factors of esophageal and stomach cancer and their clustering in Dafeng municipality:a case-control study[J].Chin J Public Health,2016,32(10):1406-1409.)
[9]李玉民,陈立仁,薛群基,等.武威市腌菜中亚硝基化合物的测定及其胃癌高发原因的分析[J].分析测试技术与仪器,2003,9(2):88-90.(In English:LI YM,CHEN LR,XUE QJ,et al.The determination and analysis of N-Nitroso-compounds of Pickles in Wuwei city of Gansu Province[J].Analysis and Testing Technology and Instruments,2003,9(2):88-90.)
[10]Spiegelhalder B,Eisenbrand G,Preussmann R.Influence of dietary nitrate on nitrite content of human saliva:possible relevance to in vivo formation of N-nitroso compounds[J].Food Cosmet Toxicol.1976,14(6):545-548.
[11]韩嘉艺,李晓明,钱乐,等.微量分光光度法测定饮用水中亚硝酸盐氮检测结果的有效性评估[J].环境卫生学杂志,2016,6(5):360-364.(In English:HAN JY,LI XM,QIAN L,et al.Assessment on Validity Nitrite-nitrogen Results in Drinking-water by Micro-spectrophotometry[J].Journal of Environmental Hygiene,2016,6(5):360-364.)
[12]Jayalekshmi P A,Hassani S,Nandakumar A,et al.Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala,India-Karunagappally cohort study[J].World J Gastroenterol.2015,21(44):12676-12685.
[13]陈炜,周朝晖,张拥军,等.福建省2010-2011年肠道病毒71型VP1区基因特征分析[J].中国病毒病杂志,2013,3(1):32-36.(In English:CHEN W,ZHOU CH,ZHANG YJ,et al.Genetic characterization of the VP1 region of enterovirus 71strains isolated during 2010 to 2011 in Fujian,China[J].Chinese Journal of Viral Diseases,2013,3(1):32-36.)
[14]Minami Y,Kawai M,Fujiya T,et al.Family history,body mass index and survival in Japanese patients with stomach cancer:a prospective study[J].International Journal of Cancer,2015,136(2):411-424.
[15]Ellisonloschmann L,Sporle A,Corbin M,et al.Risk of stomach cancer in Aotearoa/New Zealand:A Māori population based case-control study[J].Plos One,2017,12(7):e0181581.
[16]Correa P.Human gastric carcinogenesis:a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention[J].Cancer Research,1992,52(24):6735-6740.
[17]戴涤新,陆建邦,孙喜斌,等.林州居民胃部疾病与胃癌关系的病例对照研究[J].中国肿瘤,1999(6):255-256.(In English:DAI DX,LU JB,SUN XB,et al.A case-control study on the relationship between gastric diseases and gastric cancer in Linzhou residents[J].China Cancer,1999(6):255-256.)
[18]王冰霜,单晓梅,沈登辉,等.淮河流域水体持久性有毒污染物的研究现状[J].环境卫生学杂志,2014,4(5):499-503.(In English:WANG BS,SHAN XM,SHEN DH,et al.Current Status of Persistent Toxic Substances in Huaihe River Basin[J].Journal of Environmental Hygiene,2014,4(5):499-503.)
[19]朱永义,李静,钟祥银,等.四川省内江市城市饮用水水质和水性疾病调查分析[J].环境卫生学杂志,2012,2(1):9-13.(In English:ZHU YY,LI J,ZHONG XY,et al.Investigation and Analysis on the Quality of Drinking Water and Water-borne Diseases in Neijiang City,Sichuan Province[J].Journal of Environmental Hygiene,2012,2(1):9-13.)