血清PCT、CRP与IL-6对乳腺癌手术后切口感染检测的诊断意义
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摘要
目的分析血清降钙素原(PCT)、C-反应蛋白(CRP)与白介素-6(IL-6)对乳腺癌手术后切口感染检测的诊断意义。方法选择2016年6月～2018年4月我院收治的152例乳腺癌患者为研究对象。所有患者均行手术治疗。依据术后是否发生切口感染分成对照组(未感染,n=114)和观察组(切口感染,n=38)。两组患者均于术后第2天测定其血清PCT、CRP、IL-6水平。结果观察组平均手术时间、住院时间长于对照组(P<0.05)。观察组血清PCT、CRP及IL-6均高于对照组(P<0.05)。观察组阳性率高于对照组(P<0.05)。结论血清PCT、CRP、IL-6检测用于乳腺癌手术患者,可为患者术后切口感染的预测提供良好的参照依据。
Objective To analyze the diagnostic value of serum procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6(IL-6) in the detection of incision infection after breast cancer surgery. Methods A total of 152 breast cancer patients admitted to our hospital from June 2016 to April 2018 were enrolled. All patients were given surgery.According to whether the wound infection occurred after operation, the patients were divided into control group(not infected, n=114) and observation group(infected, n=38). The serum levels of PCT, CRP and IL-6 were measured in the two groups on the 2 nd postoperative day. Results The average operation time and hospital stay in the observation group were longer than those in the control group(P<0.05). The serum levels of PCT, CRP and IL-6 in the observation group were higher than those in the control group(P<0.05). The positive rate of the observation group was higher than that of the control group(P<0.05). Conclusion In patients with breast cancer surgery, serum PCT, CRP and IL-6 detection can provide a good reference for the prediction of postoperative incision infection.
Objective To analyze the diagnostic value of serum procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6(IL-6) in the detection of incision infection after breast cancer surgery. Methods A total of 152 breast cancer patients admitted to our hospital from June 2016 to April 2018 were enrolled. All patients were given surgery.According to whether the wound infection occurred after operation, the patients were divided into control group(not infected, n=114) and observation group(infected, n=38). The serum levels of PCT, CRP and IL-6 were measured in the two groups on the 2 nd postoperative day. Results The average operation time and hospital stay in the observation group were longer than those in the control group(P<0.05). The serum levels of PCT, CRP and IL-6 in the observation group were higher than those in the control group(P<0.05). The positive rate of the observation group was higher than that of the control group(P<0.05). Conclusion In patients with breast cancer surgery, serum PCT, CRP and IL-6 detection can provide a good reference for the prediction of postoperative incision infection.
引文
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[15]Gradishar WJ.New approaches to endocrine therapy for breast cancer[J].Natl Compr Canc Netw,2017,15(5S):679-681.
[16]王运福.早期乳腺癌保乳手术临床治疗效果观察[J].中国现代药物应用,2017,11(23):32-33.
[17]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2015版)[J].中国癌症杂志,2015,25(9):692-754.
[18]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2017年版)[J].中国癌症杂志,2017,27(9):695-759.
[2]刘凤娟.宫颈癌术后切口感染危险因素分析及患者血清PCT、CRP和IL-6水平变化[J].中国妇幼保健,2018,33(7):1486-1488.
[3]孙靖婷.血清PCT、CRP在下呼吸道细菌感染诊断中的意义[J].医药论坛杂志,2017,11(9):135-137.
[4]钱霄君,黄黎明,陈巍,等.乳腺癌术后化疗患者感染的高危因素分析及干预措施[J].中华医院感染学杂志,2016,26(11):2553-2555.
[5]Schwartzberg LS.Use of biomarkers and multigene assays in breast cancer[J].Natl Compr Canc Netw,2017,15(5S):676-678.
[6]Renoux B,Raes F,Legigan T,et al.Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers[J].Chem Sci,2017,8(5):3427-3433.
[7]张翔云,郭勇.乳腺癌的中西医结合治疗现状及展望[J].黑龙江中医药,2016,45(2):79-81.
[8]Klevos GA,Collado-Mesa F,Net JM,et al.Utility of sup-plemental screening with breast ultrasound in asymptomatic women with dense breast tissue who are not at high risk for breast cancer[J].Indian Radiol Imaging,2017,27(1):52-58.
[9]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2015版)[J].中国癌症杂志,2015,25(9):692.
[10]魏荣富,金茂勇.参麦注射液联合TP化疗方案对乳腺癌术后患者的疗效观察及生存质量的影响[J].实用癌症杂志,2016,31(7):1088-1090.
[11]Lin W,Huang J,Yuan Z,et al.Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triplenegative breast cancer cells[J].Sci Rep,2017,7(1):2022-2030.
[12]魏晓晨,朱立勤,王春革,等.参麦注射液预防恶性肿瘤化疗所致周围神经毒性效果的系统评价[J].山东医药,2016,56(28):45-47.
[13]Salerno KE.NCCN guidelines update:Evolving radiation therapy recommendations for breast cancer[J].Natl Compr Canc Netw,2017,15(5S):682-684.
[14]潘改燕,张妮.参麦注射液对乳腺癌患者术后化疗导致心肌损害的保护作用[J].现代中西医结合杂志,2016,25(30):3327-3329.
[15]Gradishar WJ.New approaches to endocrine therapy for breast cancer[J].Natl Compr Canc Netw,2017,15(5S):679-681.
[16]王运福.早期乳腺癌保乳手术临床治疗效果观察[J].中国现代药物应用,2017,11(23):32-33.
[17]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2015版)[J].中国癌症杂志,2015,25(9):692-754.
[18]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2017年版)[J].中国癌症杂志,2017,27(9):695-759.