肌苷注射液联合醒脑静治疗DEACMP的临床研究
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摘要
目的探究肌苷注射液联合醒脑静治疗一氧化碳中毒迟发性脑病(DEACMP)的临床效果。方法将85例DEACMP患者以给药方案不同分为联合组45例与参照组40例,联合组给予肌苷注射液联合醒脑静注射液治疗,参照组给予肌苷注射液治疗,比较两组治疗前后脑功能和实验室指标变化及疗效差异。结果治疗后,两组简易智能精神状态量表(MMSE)评分、蒙特利尔量表(Mo CA)评分及改良Barthel指数(MBI)评分皆大幅升高,且联合组升高幅度大于参照组(P <0.05);两组血清超氧化物歧化酶(SOD)活性升高,丙二醛(MDA)、肌钙蛋白(cTnI)水平和磷酸肌酸激酶(CK)活性降低,且联合组改善幅度大于参照组(P <0.05)。联合组治疗总有效率达95.56%,明显高于参照组的80.00%(P <0.05)。结论肌苷注射液联合醒脑静注射液治疗DEACMP,可有效缓解患者脑组织和心肌损伤,提高临床疗效。
Objective To explore the clinical effect of inosine injection combined with Xingnaojing in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP). Methods A total of 85 patients with DEACMP were divided into a combined group(n=45) and a control group(n=40). The combined group was treated with inosine injection combined with Xingnaojing injection, and the control group was treated with inosine injection. The changes of brain function and laboratory indicators before and after the treatment were compared between the two groups. Results After the treatment, the scores of MMSE, MoCA and improved Barthel index(MBI) increased significantly in both groups, and the increase of SOD activity, malondialdehyde(MDA), troponin(cTnI)and creatine phosphate kinase in the combined group was greater than that in the control group(P < 0.05). The activity of serum superoxide dismutase(SOD) increased, and the levels of malondialdehyde(MDA) and troponin(cTnI) as well as the activity of creatine kinase(CK) decreased in both groups; the improvement of the combined group was greater than that of the control group(P < 0.05).The total effective rate of the combined group was 95.56%, which was significantly higher than that of the control group 80.00%(P <0.05). Conclusion inosine Injection combined with Xingnaojing Injection in the treatment of DEACMP can effectively alleviate brain tissue and myocardial injury and improve clinical efficacy.
Objective To explore the clinical effect of inosine injection combined with Xingnaojing in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP). Methods A total of 85 patients with DEACMP were divided into a combined group(n=45) and a control group(n=40). The combined group was treated with inosine injection combined with Xingnaojing injection, and the control group was treated with inosine injection. The changes of brain function and laboratory indicators before and after the treatment were compared between the two groups. Results After the treatment, the scores of MMSE, MoCA and improved Barthel index(MBI) increased significantly in both groups, and the increase of SOD activity, malondialdehyde(MDA), troponin(cTnI)and creatine phosphate kinase in the combined group was greater than that in the control group(P < 0.05). The activity of serum superoxide dismutase(SOD) increased, and the levels of malondialdehyde(MDA) and troponin(cTnI) as well as the activity of creatine kinase(CK) decreased in both groups; the improvement of the combined group was greater than that of the control group(P < 0.05).The total effective rate of the combined group was 95.56%, which was significantly higher than that of the control group 80.00%(P <0.05). Conclusion inosine Injection combined with Xingnaojing Injection in the treatment of DEACMP can effectively alleviate brain tissue and myocardial injury and improve clinical efficacy.
引文
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[11]张姣,马全瑞,丁娟,等.肌苷对CPZ介导的急性脱髓鞘小鼠行为学及皮质髓鞘的影响[J].神经解剖学杂志, 2016, 32(2):201-204.
[12]刘英杰,刘艳红.扶正益心汤治疗病毒性心肌炎疗效及对心功能和免疫功能的影响[J].现代中西医结合杂志, 2017, 26(17):1915-1917.
[13]刘宝梁,韩华柱,齐延伟,等.补阳醒脑方联合还原型谷胱甘肽钠治疗急性一氧化碳中毒后迟发性脑病疗效观察[J].陕西中医,2017, 38(4):417-418.
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[15]李伟,肖青勉,刘倩,等.舒血宁注射液对急性重度一氧化碳中毒患者脑氧利用率和丙二醛以及超氧化物歧化酶的影响和意义[J].临床急诊杂志, 2017, 18(10):732-734.
[16]曹文元,刘庆新.血清c TnI、Lac、CK-MB、LDH、CRP及NSE与一氧化碳中毒迟发性脑病的关系[J].蚌埠医学院学报, 2017, 39(11):1479-1482.
[2]郭薇,牛军.银杏叶提取物注射液对一氧化碳中毒迟发性脑病的疗效分析[J].中国医药导刊, 2017, 19(6):580-581.
[3]郑瑞娟.急性一氧化碳后迟发型脑病危险因素及基因多态性分析[J].中西医结合心脑血管病杂志, 2016, 14(10):1183-1184.
[4]陈灏珠,廖履坦,杨秉辉,等.实用内科学12版[M].北京:人民卫生出版社, 2005:1575.
[5]周小炫,谢敏,陶静,等.简易智能精神状态检查量表的研究和应用[J].中国康复医学杂志, 2016, 31(6):694-696.
[6]张建强,高红安,宋程光,等.酒石酸卡巴拉汀联合盐酸多奈哌齐对阿尔茨海默病病人轻度认知功能障碍的影响[J].中西医结合心脑血管病杂志, 2017, 15(3):368-370.
[7]李瀛,高慧娟,卢战.颅脑损伤患者早期智能康复训练对下肢功能的影响[J].重庆医学, 2018, 24(1):105-106.
[8]李雄.奥拉西坦联合小牛血清去蛋白注射液治疗急性一氧化碳中毒迟发性脑病的疗效观察[J].现代药物与临床, 2017, 32(1):42-45.
[9]陈粤明,李志文,柯道.认知功能训练联合高压氧治疗一氧化碳中毒迟发性脑病的临床观察[J].中华生物医学工程杂志, 2016,20(1):62-66.
[10]唐祯,徐兰,陶晓璇,等.注射用辅酶A、三磷酸腺苷二钠及肌苷注射液配伍稳定性考察[J].中国药师, 2017, 20(1):184-186.
[11]张姣,马全瑞,丁娟,等.肌苷对CPZ介导的急性脱髓鞘小鼠行为学及皮质髓鞘的影响[J].神经解剖学杂志, 2016, 32(2):201-204.
[12]刘英杰,刘艳红.扶正益心汤治疗病毒性心肌炎疗效及对心功能和免疫功能的影响[J].现代中西医结合杂志, 2017, 26(17):1915-1917.
[13]刘宝梁,韩华柱,齐延伟,等.补阳醒脑方联合还原型谷胱甘肽钠治疗急性一氧化碳中毒后迟发性脑病疗效观察[J].陕西中医,2017, 38(4):417-418.
[14]姜保周,艾文婷,刘丹平.醒脑静注射液联用高压氧治疗一氧化碳中毒的临床效果[J].中国医药, 2017, 12(1):59-61.
[15]李伟,肖青勉,刘倩,等.舒血宁注射液对急性重度一氧化碳中毒患者脑氧利用率和丙二醛以及超氧化物歧化酶的影响和意义[J].临床急诊杂志, 2017, 18(10):732-734.
[16]曹文元,刘庆新.血清c TnI、Lac、CK-MB、LDH、CRP及NSE与一氧化碳中毒迟发性脑病的关系[J].蚌埠医学院学报, 2017, 39(11):1479-1482.