花色苷抗阿尔兹海默症的研究进展
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摘要
花色苷作为天然色素最主要的成分,在人类的植物性膳食中广泛存在,具有多种生物活性。它们健康有益的效果已经在许多体内外研究中得到证实。已有证据表明,花色苷可以减缓阿尔兹海默症的进程,从而降低其较高的发生率和病死率。文章试图总结关于花色苷的分子结构以及对阿尔兹海默症的防治作用,并分别从抗氧化、抑制细胞凋亡、抗炎、自噬方面进行探讨,以期为日后的研究提供参考依据。
Anthocyanins are one of the most common families of natural pigments in the plant kingdom. They are widely found in human plant foods and have many biological activities. Many in vitro and in vivo experiments have confirmed their healthy beneficial effects. Recent studies have shown that anthocyanins can inhibit the occurrence and development of Alzheimer's disease, thereby reducing its incidence and mortality. This review attempts to summarize the molecular structure of anthocyanins and the prevention and treatment of Alzheimer's disease, and to explore its mechanism of action from the aspects of anti-oxidation, inhibition of apoptosis, anti-inflammatory and autophagy, aiming to provide a basis for future research.
Anthocyanins are one of the most common families of natural pigments in the plant kingdom. They are widely found in human plant foods and have many biological activities. Many in vitro and in vivo experiments have confirmed their healthy beneficial effects. Recent studies have shown that anthocyanins can inhibit the occurrence and development of Alzheimer's disease, thereby reducing its incidence and mortality. This review attempts to summarize the molecular structure of anthocyanins and the prevention and treatment of Alzheimer's disease, and to explore its mechanism of action from the aspects of anti-oxidation, inhibition of apoptosis, anti-inflammatory and autophagy, aiming to provide a basis for future research.
引文
[1]Goate A,Hardy J.Twenty years of Alzheimer’s disease-causing mutations.Journal of Neurochemistry,2011,120(s1):3-8
[2]Brown M K,Naidoo N.The endoplasmic reticulum stress response in aging and age-related diseases.Frontiers in Physiology,2012,3:263-272
[3]童鑫,张名位,池建伟,等.花色苷的制备及其主要生物活性研究进展.食品科技,2016,41(8):233-238
[4]Kreilaus F,Spiro A S,Hannan A J,et al.Therapeutic effects of Anthocyanins and environmental enrichment in R6/1 Huntington’s disease mice.J Huntingtons Dis,2016,5(3):285-296
[5]Shin W H,Park S J,Kim E J.Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats.Life Sciences,2006,79(2):130-137
[6]Cassidy A,O’ReillyéJ,Kay C,et al.Habitual intake of flavonoid subclasses and incident hypertension in adults.American Journal of Clinical Nutrition,2011,93(2):338-347
[7]Shih P H,Hwang S L,Yeh C T,et al.Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2transduction pathways.J Agric Food Chem,2016,60(11):2924-2933
[8]Subash S,Essa M M,Awlad-Thani K,et al.Memory deficits and learning skills improved in transgenic mouse model of Alzheimer’s disease after date-rich diet supplementation.Ghana Journal of Forestry,2014,28(1):26-30
[9]Barbara S H,Bielinski D F,Lau F C,et al.The beneficial effects of berries on cognition,motor behaviour and neuronal function in ageing.Br J Nutr,2015,114(10):1542-1549
[10]Mcghie T K,Walton M C.The bioavailability and absorption of anthocyanins:Towards a better understanding.Molecular Nutrition&Food Research,2010,51(6):702-713
[11]Li D,Wang P,Luo Y,et al.Health benefits of anthocyanins and molecular mechanisms:Update from recent decade.Crit Rev Food Sci Nutr,2017,57(8):1729-1741
[12]Sun L L,Gao W,Zhang M M,et al.Composition and antioxidant activity of the anthocyanins of the fruit of Berberis heteropoda Schrenk.Molecules,2014,19(11):19078-19096
[13]Cui C,Zhang S,You L,et al.Antioxidant capacity of anthocyanins from Rhodomyrtus tomentosa(Ait.)and identification of the major anthocyanins.Food Chemistry,2013,139(1-4):1-8
[14]Verbeyst L,Crombruggen K V,Van d P I,et al.Anthocyanin degradation kinetics during thermal and high pressure treatments of raspberries.Journal of Food Engineering,2011,105(3):513-521
[15]柴莹莹,何霞,宫颖慧,等.玫瑰花色苷分子稳定性及其生物活性研究进展.中国野生植物资源,2017,36(3):37-41
[16]林欢,李修英,杜健,等.花色苷的研究进展.中国老年学,2014,34(20):5917-5919
[17]El Mohsen M A,Marks J,Kuhnle G,et al.Absorption,tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats.British Journal of Nutrition,2006,95(1):51-58
[18]Subash S,Essa M M,Braidy N,et al.Diet rich in date palm fruits improves memory,learning and reduces beta amyloid in transgenic mouse model of Alzheimer’s disease.Journal of Ayurveda&Integrative Medicine,2015,6(2):111-120
[19]刘伟.花色苷改善阿尔茨海默病认知障碍的自噬与表观遗传调控机制.北京:中国人民解放军军事医学科学院,2016
[20]Shih P H,Chan Y C,Liao J W,et al.Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry(Morus atropurpurea L.)on senescence-accelerated mice and prevention of Alzheimer’s disease.Journal of Nutritional Biochemistry,2010,21(7):598-605
[21]张波.杨梅花色苷对胰岛细胞氧化应激损伤的保护作用及其机制探讨.杭州:浙江大学,2010
[22]Kim S M,Mi J C,Ha T J,et al.Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids.Life Sciences,2012,90(21-22):874-882
[23]宋楠.矢车菊素-3-O-葡萄糖苷对APPSWEPS1△E9转基因阿尔茨海默病模型小鼠神经保护的作用机制及对其肠道菌群的影响.北京:北京协和医学院,2016
[24]M You,Y Cai,Z Fan,et al.Protective effect of Cy-3G on PC12 cells against beta-amyloid-induced apoptosis and the possible mechanism.International Journal of Clinical&Experimental Medicine,2017,10(3):4565-4573
[25]Badshah H,Kim T H,Kim M O.Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro.Neurochemistry International,2015,80:51-59
[26]Song N,Yang H,Pang W,et al.Mulberry extracts alleviate Aβ25-35-induced injury and change the gene expression profile in PC12cells.Evidence-Based Complementary and Alternative Medicine,2014,2014(3):150617-150625
[27]Serra D,Paix?o J,Nunes C,et al.Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells:Comparison with 5-aminosalicylic acid.Plos One,2013,8(9):e73001-e73009
[28]Rehman S U,Shah S A,Ali T,et al.Anthocyanins reversed D-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats.Molecular Neurobiology,2017,54(1):255-271
[29]张国坤.花楸花色苷对衰老的干预作用及机制研究.沈阳:辽宁大学,2017
[30]李建光,阳莹,刘倩芸,等.黑果小檗总花色苷对Aβ25-35诱导的AD小鼠及小胶质细胞神经炎性反应模型的影响.中华中医药杂志,2017,32(2):822-825
[31]闫亚韵.Aβ损伤致PC12细胞AD模型PS1介导的自噬功能研究.长春:吉林大学,2017
[32]Jiang T,Yu J T,Zhu X C,et al.Temsirolimus promotes autophagic clearance of amyloid-βand provides protective effects in cellular and animal models of Alzheimer’s disease.Pharmacological Research,2014,81:54-63
[33]邓皓月.白藜芦醇通过诱导自噬改善Aβ25-35引起的神经细胞损伤的作用及机制研究.重庆:第三军医大学,2016
[34]李肃,孙海明,孙冬琳,等.AMPK-m TOR-ULK1/2信号通路与自噬.国际遗传学杂志,2017,40(1):39-44
[35]张蕾,周杰,骆俊,等.桑葚花色苷诱导人胃癌SGC-7901细胞自噬凋亡的研究.中药材,2016,39(5):1134-1138
[36]金鑫.飞燕草素葡萄糖苷在血管内皮细胞的摄取利用及损伤保护效应研究.重庆:第三军医大学,2013
[37]TarozziA,MerliccoA,MorroniF,etal.Cyanidin3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity.Neuroreport,2008,19(15):1483-1486
[38]Amin F U,Shah S A,Badshah H,et al.Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1-42-induced oxidative stress.Journal of Nanobiotechnology,2017,15(1):12-27
[2]Brown M K,Naidoo N.The endoplasmic reticulum stress response in aging and age-related diseases.Frontiers in Physiology,2012,3:263-272
[3]童鑫,张名位,池建伟,等.花色苷的制备及其主要生物活性研究进展.食品科技,2016,41(8):233-238
[4]Kreilaus F,Spiro A S,Hannan A J,et al.Therapeutic effects of Anthocyanins and environmental enrichment in R6/1 Huntington’s disease mice.J Huntingtons Dis,2016,5(3):285-296
[5]Shin W H,Park S J,Kim E J.Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats.Life Sciences,2006,79(2):130-137
[6]Cassidy A,O’ReillyéJ,Kay C,et al.Habitual intake of flavonoid subclasses and incident hypertension in adults.American Journal of Clinical Nutrition,2011,93(2):338-347
[7]Shih P H,Hwang S L,Yeh C T,et al.Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2transduction pathways.J Agric Food Chem,2016,60(11):2924-2933
[8]Subash S,Essa M M,Awlad-Thani K,et al.Memory deficits and learning skills improved in transgenic mouse model of Alzheimer’s disease after date-rich diet supplementation.Ghana Journal of Forestry,2014,28(1):26-30
[9]Barbara S H,Bielinski D F,Lau F C,et al.The beneficial effects of berries on cognition,motor behaviour and neuronal function in ageing.Br J Nutr,2015,114(10):1542-1549
[10]Mcghie T K,Walton M C.The bioavailability and absorption of anthocyanins:Towards a better understanding.Molecular Nutrition&Food Research,2010,51(6):702-713
[11]Li D,Wang P,Luo Y,et al.Health benefits of anthocyanins and molecular mechanisms:Update from recent decade.Crit Rev Food Sci Nutr,2017,57(8):1729-1741
[12]Sun L L,Gao W,Zhang M M,et al.Composition and antioxidant activity of the anthocyanins of the fruit of Berberis heteropoda Schrenk.Molecules,2014,19(11):19078-19096
[13]Cui C,Zhang S,You L,et al.Antioxidant capacity of anthocyanins from Rhodomyrtus tomentosa(Ait.)and identification of the major anthocyanins.Food Chemistry,2013,139(1-4):1-8
[14]Verbeyst L,Crombruggen K V,Van d P I,et al.Anthocyanin degradation kinetics during thermal and high pressure treatments of raspberries.Journal of Food Engineering,2011,105(3):513-521
[15]柴莹莹,何霞,宫颖慧,等.玫瑰花色苷分子稳定性及其生物活性研究进展.中国野生植物资源,2017,36(3):37-41
[16]林欢,李修英,杜健,等.花色苷的研究进展.中国老年学,2014,34(20):5917-5919
[17]El Mohsen M A,Marks J,Kuhnle G,et al.Absorption,tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats.British Journal of Nutrition,2006,95(1):51-58
[18]Subash S,Essa M M,Braidy N,et al.Diet rich in date palm fruits improves memory,learning and reduces beta amyloid in transgenic mouse model of Alzheimer’s disease.Journal of Ayurveda&Integrative Medicine,2015,6(2):111-120
[19]刘伟.花色苷改善阿尔茨海默病认知障碍的自噬与表观遗传调控机制.北京:中国人民解放军军事医学科学院,2016
[20]Shih P H,Chan Y C,Liao J W,et al.Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry(Morus atropurpurea L.)on senescence-accelerated mice and prevention of Alzheimer’s disease.Journal of Nutritional Biochemistry,2010,21(7):598-605
[21]张波.杨梅花色苷对胰岛细胞氧化应激损伤的保护作用及其机制探讨.杭州:浙江大学,2010
[22]Kim S M,Mi J C,Ha T J,et al.Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids.Life Sciences,2012,90(21-22):874-882
[23]宋楠.矢车菊素-3-O-葡萄糖苷对APPSWEPS1△E9转基因阿尔茨海默病模型小鼠神经保护的作用机制及对其肠道菌群的影响.北京:北京协和医学院,2016
[24]M You,Y Cai,Z Fan,et al.Protective effect of Cy-3G on PC12 cells against beta-amyloid-induced apoptosis and the possible mechanism.International Journal of Clinical&Experimental Medicine,2017,10(3):4565-4573
[25]Badshah H,Kim T H,Kim M O.Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro.Neurochemistry International,2015,80:51-59
[26]Song N,Yang H,Pang W,et al.Mulberry extracts alleviate Aβ25-35-induced injury and change the gene expression profile in PC12cells.Evidence-Based Complementary and Alternative Medicine,2014,2014(3):150617-150625
[27]Serra D,Paix?o J,Nunes C,et al.Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells:Comparison with 5-aminosalicylic acid.Plos One,2013,8(9):e73001-e73009
[28]Rehman S U,Shah S A,Ali T,et al.Anthocyanins reversed D-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats.Molecular Neurobiology,2017,54(1):255-271
[29]张国坤.花楸花色苷对衰老的干预作用及机制研究.沈阳:辽宁大学,2017
[30]李建光,阳莹,刘倩芸,等.黑果小檗总花色苷对Aβ25-35诱导的AD小鼠及小胶质细胞神经炎性反应模型的影响.中华中医药杂志,2017,32(2):822-825
[31]闫亚韵.Aβ损伤致PC12细胞AD模型PS1介导的自噬功能研究.长春:吉林大学,2017
[32]Jiang T,Yu J T,Zhu X C,et al.Temsirolimus promotes autophagic clearance of amyloid-βand provides protective effects in cellular and animal models of Alzheimer’s disease.Pharmacological Research,2014,81:54-63
[33]邓皓月.白藜芦醇通过诱导自噬改善Aβ25-35引起的神经细胞损伤的作用及机制研究.重庆:第三军医大学,2016
[34]李肃,孙海明,孙冬琳,等.AMPK-m TOR-ULK1/2信号通路与自噬.国际遗传学杂志,2017,40(1):39-44
[35]张蕾,周杰,骆俊,等.桑葚花色苷诱导人胃癌SGC-7901细胞自噬凋亡的研究.中药材,2016,39(5):1134-1138
[36]金鑫.飞燕草素葡萄糖苷在血管内皮细胞的摄取利用及损伤保护效应研究.重庆:第三军医大学,2013
[37]TarozziA,MerliccoA,MorroniF,etal.Cyanidin3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity.Neuroreport,2008,19(15):1483-1486
[38]Amin F U,Shah S A,Badshah H,et al.Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1-42-induced oxidative stress.Journal of Nanobiotechnology,2017,15(1):12-27