81例氨磺必利所致不良反应的临床分析
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摘要
目的:了解氨磺必利引起不良反应的规律,为临床合理用药提供参考。方法:检索2010～2017年CNKI、万方数据库、维普数据库中收载的氨磺必利不良反应文献个案报道13例,收集汇总江门市第三人民医院和广州医科大学附属脑科医院2013～2017年上报的氨磺必利不良反应68例,进行归纳统计分析。结果:81例氨磺必利引起的不良反应,男性35例,女性46例,20～39岁年龄段较多(占58.03%),循环系统和神经系统损害为常见,主要表现为QT间期延长、心动徐缓、震颤、流涎,严重不良反应多发生在循环系统和血液系统。结论:近年来,氨磺必利在治疗精神病中广泛应用,临床使用时应对心电图、血常规等指标密切关注,减少药物不良反应。
Objective:To understand and clarify the regularity and characteristics of arrhythmia caused by adverse reactions,and to provide reference for rational use of drugs by clinicians. Methods:A total of 13 cases of aboroxin adverse reactions reported in CNKI,Wanfang database and Weipu database from 2010 to 2017 were retrieved. The third hospital of Jiangmen City and the affiliated brain hospital of Guangzhou Medical University were collected and collected from 2013 to 2017. Reported 67 cases of amisulpride adverse reactions,inductive statistical analysis. Results:81 cases of amisulpride caused adverse reactions,including 35 males,46 females,and more patients in the 20～39 Y age group(accounting for 58.03%). The circulatory system and nervous system damage were common,mainly in the QT interval. Prolonged,bradycardia,tremors,drooling,serious adverse reactions occur in the circulatory system and the blood system. Conclusion:In recent years,amisulpride has been widely used in the treatment of psychosis. In clinical use,it should pay close attention to the indicators such as electrocardiogram and blood routine,and reduce the occurrence of adverse reactions.
Objective:To understand and clarify the regularity and characteristics of arrhythmia caused by adverse reactions,and to provide reference for rational use of drugs by clinicians. Methods:A total of 13 cases of aboroxin adverse reactions reported in CNKI,Wanfang database and Weipu database from 2010 to 2017 were retrieved. The third hospital of Jiangmen City and the affiliated brain hospital of Guangzhou Medical University were collected and collected from 2013 to 2017. Reported 67 cases of amisulpride adverse reactions,inductive statistical analysis. Results:81 cases of amisulpride caused adverse reactions,including 35 males,46 females,and more patients in the 20～39 Y age group(accounting for 58.03%). The circulatory system and nervous system damage were common,mainly in the QT interval. Prolonged,bradycardia,tremors,drooling,serious adverse reactions occur in the circulatory system and the blood system. Conclusion:In recent years,amisulpride has been widely used in the treatment of psychosis. In clinical use,it should pay close attention to the indicators such as electrocardiogram and blood routine,and reduce the occurrence of adverse reactions.
引文
[1]任虹,孙俊伟,赵伟,等.氨磺必利治疗首发精神分裂症有效性及安全性回顾性分析[J].山西医科大学学报,2013,44(10):816-818.
[2]梁英,刘登堂,司天梅,等.氨磺必利治疗精神分裂症临床应用专家意见[J].中国心理卫生杂志,2017,31(6):425-431.
[3]周慧民.氨磺必利临床研究进展[J].医学综述,2017,23(2):323-326.
[4]李淑新.小剂量氨磺必利合并抗抑郁药治疗抑郁症78例的疗效分析[J].贵阳中医学院学报,2013,35(2):158-159.
[5]梁瑞华,陆晓姿,冯玉芳.碳酸锂合并氨磺必利治疗双相障碍I型抑郁发作的对照研究[J].四川精神卫生,2014,27(3):264-266.
[6]郝伟,于欣.精神病学[M].第7版,北京:人民卫生出版社,2013.
[7]刘艳艳,孙凌云.氨磺必利的药理学进展与临床应用评价[J].海峡药学,2016,28(7):187-188.
[8]杨和增,朱华琛,曾慧.氨磺必利对精神分裂症患者心电图的影响[J].精神医学杂志,2013,26(3):196-198.
[9]沈一峰,李华芳,顾牛范.新型抗精神病药氨磺必利[J].中国临床药学杂志,2000,9(2):123-126.
[10]Isbister G K,Murray L,John S. Amisulpride deliberate selfpoisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes[J]. Med J Aust,2006,184(7):364-366.
[11]GK I,CR B. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes.[J]. J Clin Psychopharmacol,2010,30(4):391-395.
[12]李茂生,邬志美.氨磺必利致白细胞和血小板减少[J].药物不良反应杂志,2017,19(2):130-131.
[13]汪莲籽.迟发性运动障碍研究进展[J].临床精神医学杂志,2016,26(3):209-210.
[14]黄素培,张瑞岭,王来海,等.氨磺必利的药理学进展与临床应用评价[J].中国医院用药评价与分析,2011,11(8):679-683.
[15]孙振晓,于相芬.氨磺必利的临床应用及其不良反应[J].精神医学杂志,2014,27(5):392-397.
[16]刘丽辉.不同剂量氨磺必利治疗精神分裂症的疗效比较及安全性分析[J].临床合理用药,2016,9(12C):31-32.
[2]梁英,刘登堂,司天梅,等.氨磺必利治疗精神分裂症临床应用专家意见[J].中国心理卫生杂志,2017,31(6):425-431.
[3]周慧民.氨磺必利临床研究进展[J].医学综述,2017,23(2):323-326.
[4]李淑新.小剂量氨磺必利合并抗抑郁药治疗抑郁症78例的疗效分析[J].贵阳中医学院学报,2013,35(2):158-159.
[5]梁瑞华,陆晓姿,冯玉芳.碳酸锂合并氨磺必利治疗双相障碍I型抑郁发作的对照研究[J].四川精神卫生,2014,27(3):264-266.
[6]郝伟,于欣.精神病学[M].第7版,北京:人民卫生出版社,2013.
[7]刘艳艳,孙凌云.氨磺必利的药理学进展与临床应用评价[J].海峡药学,2016,28(7):187-188.
[8]杨和增,朱华琛,曾慧.氨磺必利对精神分裂症患者心电图的影响[J].精神医学杂志,2013,26(3):196-198.
[9]沈一峰,李华芳,顾牛范.新型抗精神病药氨磺必利[J].中国临床药学杂志,2000,9(2):123-126.
[10]Isbister G K,Murray L,John S. Amisulpride deliberate selfpoisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes[J]. Med J Aust,2006,184(7):364-366.
[11]GK I,CR B. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes.[J]. J Clin Psychopharmacol,2010,30(4):391-395.
[12]李茂生,邬志美.氨磺必利致白细胞和血小板减少[J].药物不良反应杂志,2017,19(2):130-131.
[13]汪莲籽.迟发性运动障碍研究进展[J].临床精神医学杂志,2016,26(3):209-210.
[14]黄素培,张瑞岭,王来海,等.氨磺必利的药理学进展与临床应用评价[J].中国医院用药评价与分析,2011,11(8):679-683.
[15]孙振晓,于相芬.氨磺必利的临床应用及其不良反应[J].精神医学杂志,2014,27(5):392-397.
[16]刘丽辉.不同剂量氨磺必利治疗精神分裂症的疗效比较及安全性分析[J].临床合理用药,2016,9(12C):31-32.