补骨脂饮片的粉末均匀化研究
|
摘要
[目的]补骨脂饮片的粉末均匀化工艺研究。[方法]以补骨脂苷、异补骨脂苷、补骨脂素、异补骨脂素为指标成分,采用不同目数药筛制备不同粒度的补骨脂饮片粉末,对粉末分布及其对指标成分的影响进行研究,并以粉碎时间、粉碎次数、投料量为因素采用正交实验法确定其最佳粉碎工艺。[结果]生补骨脂最佳粉碎工艺条件:投料量体积占粉碎室体积的1/4,单次粉碎30 s,粉碎3次,过50目筛;盐补骨脂最佳粉碎工艺条件:投料量体积占粉碎室体积的1/3,单次粉碎30 s,粉碎2次,过50目筛。[结论]通过试验验证,确定补骨脂饮片最佳粉碎工艺,为制定补骨脂标准饮片均匀化技术规范提供参考依据。
[Objective] The study of powder homogenization for Fructus Psoraleae. [Methods] Psoralenoside,isopsoralenoside,psoralen and isopsoralen as index components,we used various medicinal sieves to prepare Fructus Psoraleae powder with different sizes,and studied the distribution of powder and its influence on the index components. The optimum pulverization process was determined by orthogonal experimental design based on the pulverization time,the number of pulverization times and the inventory of Fructus Psoraleae.[Results] For the raw Fructus Psoraleae,the inventory of Fructus Psoraleae accounted for 1/4 the volume of pulverizer,the single pulverizing time was 30 s,the powder was pulverized 3 times and sieved through 50 meshes. For salt-processed Fructus Psoraleae,the inventory of Fructus Psoraleae accounted for 1/3 the volume of pulverizer,the single pulverizing time was 30 s,the powder was pulverized2 times and sieved through 50 meshes. [Conclusion] Through the test verification,the best grinding technology of Fructus Psoraleae was determined,which provided a reference for the development of technical specifications for the standardization of Fructus Psoraleae.
[Objective] The study of powder homogenization for Fructus Psoraleae. [Methods] Psoralenoside,isopsoralenoside,psoralen and isopsoralen as index components,we used various medicinal sieves to prepare Fructus Psoraleae powder with different sizes,and studied the distribution of powder and its influence on the index components. The optimum pulverization process was determined by orthogonal experimental design based on the pulverization time,the number of pulverization times and the inventory of Fructus Psoraleae.[Results] For the raw Fructus Psoraleae,the inventory of Fructus Psoraleae accounted for 1/4 the volume of pulverizer,the single pulverizing time was 30 s,the powder was pulverized 3 times and sieved through 50 meshes. For salt-processed Fructus Psoraleae,the inventory of Fructus Psoraleae accounted for 1/3 the volume of pulverizer,the single pulverizing time was 30 s,the powder was pulverized2 times and sieved through 50 meshes. [Conclusion] Through the test verification,the best grinding technology of Fructus Psoraleae was determined,which provided a reference for the development of technical specifications for the standardization of Fructus Psoraleae.
引文
[1]国家药典委员会.中华人民共和国药典[S].一部.北京:中国医药科技出版社,2015:187-188.
[2]Wang X,Cheng K,Han Y,et al.Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J].Biol Pharm Bull,2016,39(5):815-822.
[3]Aboul-Enein HY,Kladna A,Kruk I,et al.Effect of psoralens on Fenton-like reaction generating reactive oxygen species[J].Biopolymers,2003,72(1):59-68.
[4]王天晓,尹震花,张伟,等.补骨脂抗氧化、抑制α-葡萄糖苷酶和抗菌活性成分研究[J].中国中药杂志,2013,38(14):2328-2333.
[5]Chen CH,Hwang TL,Chen LC,et al.Isoflavones and antiinflammatory constituents from the fruits of Psoralea corylifolia[J].Phytochemistry,2017,143:186-193.
[6]Liu X,Nam JW,Song YS,et al.Psoralidin,a coumestan analogue,as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia[J].Bioorg Med Chem Lett,2014,24(5):1403-1406.
[7]肖芳,覃艺,范润勇,等.杜仲及盐杜仲饮片的均匀化分析[J].中国实验方剂学杂志,2017,23(4):1-6.
[8]翟文泽,任晶,孟江,等.制何首乌标准饮片的均匀化工艺研究[J].广东药科大学学报,2017,33(2):172-176.
[9]Yang JJ,Yang J,Wang YF,et al.General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae[J].J Food Drug Anal,2018,2(26):807-814.
[10]杨静,江振作,柴欣,等.中药注射液“Q-Markers”的辨析研究-丹红注射液研究实例[J].世界科学技术-中医药现代化,2016,18(12):2056-2061.
[11]江振作,王跃飞.基于“药材基原-物质基础-质量标志物-质控方法”层级递进的中药质量标准模式研究[J].中草药,2016,47(23):4127-4133.
[12]李敏,杨君君,杨静,等.补骨脂果皮和种子中化学成分的分布规律研究[J].天津中医药,2018,35(9):706-709.
[2]Wang X,Cheng K,Han Y,et al.Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J].Biol Pharm Bull,2016,39(5):815-822.
[3]Aboul-Enein HY,Kladna A,Kruk I,et al.Effect of psoralens on Fenton-like reaction generating reactive oxygen species[J].Biopolymers,2003,72(1):59-68.
[4]王天晓,尹震花,张伟,等.补骨脂抗氧化、抑制α-葡萄糖苷酶和抗菌活性成分研究[J].中国中药杂志,2013,38(14):2328-2333.
[5]Chen CH,Hwang TL,Chen LC,et al.Isoflavones and antiinflammatory constituents from the fruits of Psoralea corylifolia[J].Phytochemistry,2017,143:186-193.
[6]Liu X,Nam JW,Song YS,et al.Psoralidin,a coumestan analogue,as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia[J].Bioorg Med Chem Lett,2014,24(5):1403-1406.
[7]肖芳,覃艺,范润勇,等.杜仲及盐杜仲饮片的均匀化分析[J].中国实验方剂学杂志,2017,23(4):1-6.
[8]翟文泽,任晶,孟江,等.制何首乌标准饮片的均匀化工艺研究[J].广东药科大学学报,2017,33(2):172-176.
[9]Yang JJ,Yang J,Wang YF,et al.General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae[J].J Food Drug Anal,2018,2(26):807-814.
[10]杨静,江振作,柴欣,等.中药注射液“Q-Markers”的辨析研究-丹红注射液研究实例[J].世界科学技术-中医药现代化,2016,18(12):2056-2061.
[11]江振作,王跃飞.基于“药材基原-物质基础-质量标志物-质控方法”层级递进的中药质量标准模式研究[J].中草药,2016,47(23):4127-4133.
[12]李敏,杨君君,杨静,等.补骨脂果皮和种子中化学成分的分布规律研究[J].天津中医药,2018,35(9):706-709.