肾炎康复片与雷公藤多苷片联合对系膜增生性肾小球肾炎患者肾功能和血清生化指标的影响
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摘要
目的:探讨肾炎康复片与雷公藤多苷片联合对系膜增生性肾小球肾炎(MsPGN)患者肾功能和血清生化指标的影响。方法:选取2015年1月至2016年12月北京王府中西医结合医院收治的MsPGN患者62例,按照随机数字表法分为对照组和观察组,每组31例。对照组采用常规西药治疗,观察组在对照组的基础上加用肾炎康复片联合雷公藤多苷片治疗,2组均连续治疗1个月。比较2组临床疗效及治疗前后中医证候积分、肾功能指标及生化指标变化。结果:治疗后观察组的总有效率为93. 55%,显著高于对照组的74. 19%(P <0. 05);与治疗前比较,2组疲倦乏力、口干、盗汗、浮肿、蛋白尿及血尿等中医证候积分,血清肌酐(Scr)、血尿素氮(BUN)、肿瘤坏死因子(TNF-α)、总胆固醇(TC)、三酰甘油(TG)和尿蛋白(UAER)均显著下降,差异有统计学意义(P <0. 05),且观察组明显低于对照组,差异有统计学意义(P <0. 05),治疗后2组肾小球滤过率(GFR)和血清白蛋白(ALB)水平较治疗前升高,且观察组改善优于对照组,差异有统计学意义(P <0. 05)。结论:肾炎康复片与雷公藤多苷片联合治疗MsPGN可有效改善患者中医证候及肾功能,改善血清生化指标,疗效明显。
Objective: To explore the effects of Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the renal function and serum biochemical indicators of patients with mesangial proliferative glomerulonephritis. Methods: A total of 62 cases of patients with mesangial proliferative glomerulonephritis (MsPGN) in Beijing Wangfu Integrated Chinese and Western Medicine Hospital from January 2015 to Deceomber 2016 were selected and divided randomly into observation group and control group,with 31 cases in each group. The control group were treated with routine western medicine,and the observation group were treated with Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the basis of the control group,the 2 groups were treated for a month continuously. The clinical efficacy traditional Chinese medicine score (TCM),and renal function indexes and serum biochemical indexes of 2 groups before and after treatment were compared. Results: After treatment,the total effective rates of observation group was 93. 55%,which was obviously higher than that 74. 19% in control group (P < 0. 05); Compared with before treatment,TCM scores of fatigue,dry mouth,night sweats,edema,proteinuria and hematuria,the levels of serum,serum creatinine (Scr),blood urea nitrogen (BUN),tumor necrosis factor-α (TNF-α),total cholesterol (TC),triacylglycerol (TG)and urinary albumin excretion rate (UAER) of 2 groups decreased obviously (P < 0. 05),and the observation group was obviously lower than the control group (P < 0. 05). The glomerular filtration rate (GFR) and serum albumin (ALB) of 2 groups increased obviously after treatment,and observation group was obviously higher than control group (P < 0. 05). Conclusion: Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets in the treatment of MsPGN can improve the TCM scores and renal function,and improve the serum biochemical indicators that the clinical efficacy is outstanding.
Objective: To explore the effects of Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the renal function and serum biochemical indicators of patients with mesangial proliferative glomerulonephritis. Methods: A total of 62 cases of patients with mesangial proliferative glomerulonephritis (MsPGN) in Beijing Wangfu Integrated Chinese and Western Medicine Hospital from January 2015 to Deceomber 2016 were selected and divided randomly into observation group and control group,with 31 cases in each group. The control group were treated with routine western medicine,and the observation group were treated with Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the basis of the control group,the 2 groups were treated for a month continuously. The clinical efficacy traditional Chinese medicine score (TCM),and renal function indexes and serum biochemical indexes of 2 groups before and after treatment were compared. Results: After treatment,the total effective rates of observation group was 93. 55%,which was obviously higher than that 74. 19% in control group (P < 0. 05); Compared with before treatment,TCM scores of fatigue,dry mouth,night sweats,edema,proteinuria and hematuria,the levels of serum,serum creatinine (Scr),blood urea nitrogen (BUN),tumor necrosis factor-α (TNF-α),total cholesterol (TC),triacylglycerol (TG)and urinary albumin excretion rate (UAER) of 2 groups decreased obviously (P < 0. 05),and the observation group was obviously lower than the control group (P < 0. 05). The glomerular filtration rate (GFR) and serum albumin (ALB) of 2 groups increased obviously after treatment,and observation group was obviously higher than control group (P < 0. 05). Conclusion: Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets in the treatment of MsPGN can improve the TCM scores and renal function,and improve the serum biochemical indicators that the clinical efficacy is outstanding.
引文
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[14]喻国安,余效辉,吕莺姿.肾炎康复片联合治疗慢性肾炎患者的疗效及免疫功能改善效果分析[J].当代医学,2017,23(16):48-50.
[15]霍岩,吴敏.雷公藤多苷联合心肝宝治疗早期糖尿病肾病的临床疗效观察[J].中国实用医药,2016,11(21):132-133.
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[17]崔艳和.雷公藤多苷片联合阿魏酸钠治疗慢性肾小球肾炎的疗效观察[J].现代药物与临床,2016,31(1):33-36.
[18]彭心怡,夏智明,梅国斌,等.肾炎康复片联合缬沙坦治疗慢性肾小球肾炎疗效观察[J].海南医学,2015,26(3):412-413.
[19]邓菲,张萍,冯静,等.来氟米特对慢性肾小球肾炎大鼠炎症介质和免疫功能的影响[J].四川大学学报:医学版,2016,47(2):217-221.
[20]操轩.雷公藤多甙片对慢性肾小球肾炎患者的疗效研究[J].河北医药,2014,36(19):2924-2925.
[2]刘玉臻,韩传美,郭兆安.系膜增生性肾炎的中药治疗研究进展[J].中国中西医结合肾病杂志,2013,14(9):842-843.
[3]李英娟,林宏初,刘宇星,等.黄葵胶囊联合缬沙坦治疗非Ig A系膜增生性肾小球肾炎轻中度蛋白尿的临床研究[J].中国中西医结合肾病杂志,2013,14(7):613-614.
[4]南红梅,金惠英,黄昌男,等.益肾化浊通络方治疗慢性肾炎肾衰97例临床观察[J].世界中医药,2013,8(1):42-45.
[5]叶婷婷,沈建明,邓妍妍,等.肾炎康复片对大鼠肾间质纤维化的保护作用[J].郧阳医学院学报,2008,27(5):401-404.
[6]贾秀琴,李映红,杨敏,等.保肾冲剂对系膜增生性肾小球肾炎大鼠肾功能的影响[J].深圳中西医结合杂志,2016,26(22):1-3.
[7]陆再英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008.
[8]国家食品药品管理局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:18-20.
[9]韦绪性.中医内科学[M].北京:军事医学科学出版社,2013:20-30.
[10]廖菲芸.雷公藤多甙片治疗慢性肾小球肾炎疗效观察[J].按摩与康复医学,2015,6(13):55-56.
[11]卫艳玲.益肾饮对雷公藤多甙治疗系膜增殖性肾小球肾炎减毒增效的实验研究[D].南京:山东中医药大学,2007.
[12]刘玉臻.益气养阴为主治疗系膜增生性肾小球肾炎的临床研究[D].南京:山东中医药大学,2014.
[13]王蓓,汤绚丽.肾炎康复片联合缬沙坦治疗80例慢性肾小球肾炎的临床观察[J].中国现代医生,2015,53(6):109-111.
[14]喻国安,余效辉,吕莺姿.肾炎康复片联合治疗慢性肾炎患者的疗效及免疫功能改善效果分析[J].当代医学,2017,23(16):48-50.
[15]霍岩,吴敏.雷公藤多苷联合心肝宝治疗早期糖尿病肾病的临床疗效观察[J].中国实用医药,2016,11(21):132-133.
[16]任桐,杨洪涛.系膜增生性肾炎与特发性膜性肾病的中医证型特点及中医诊治优化方案疗效研究[J].中国医药导报,2016,13(24):160-165.
[17]崔艳和.雷公藤多苷片联合阿魏酸钠治疗慢性肾小球肾炎的疗效观察[J].现代药物与临床,2016,31(1):33-36.
[18]彭心怡,夏智明,梅国斌,等.肾炎康复片联合缬沙坦治疗慢性肾小球肾炎疗效观察[J].海南医学,2015,26(3):412-413.
[19]邓菲,张萍,冯静,等.来氟米特对慢性肾小球肾炎大鼠炎症介质和免疫功能的影响[J].四川大学学报:医学版,2016,47(2):217-221.
[20]操轩.雷公藤多甙片对慢性肾小球肾炎患者的疗效研究[J].河北医药,2014,36(19):2924-2925.