原发性肝细胞癌患者TACE治疗前后血清血管生成素-2水平的变化及其临床意义
摘要
目的:探讨血管生成素-2(Ang-2)基因多态性与经皮肝动脉化疗栓塞(TACE)治疗肝细胞癌(HCC患者预后的关系。方法:收集2016年1月至2017年10月于宝鸡市人民医院行TACE治疗的202例HCC患者的临床资料,另选取100例健康体检者作为对照组,采用酶联免疫吸附试验法(ELISA)检测血清Ang-2水平,比较TACE治疗前、后血清Ang-2水平,探讨血清Ang-2水平与临床特征的关系,绘制受试者工作特征曲线(ROC曲线)以评价TACE治疗前、后Ang-2水平判断TACE疗效的效能。结果:HCC患者术前及术后1 d、1周、1个月血清Ang-2水平中位数依次为1 842. 7及1 901. 8、2 695. 3、1 887. 7 pg·ml-1,均明显高于对照组的1 040. 3 pg·ml-1(均P <0. 01)。术后1周血清Ang-2水平较术前显著升高(P <0. 01)。术前血清Ang-2水平与BCLC分级、肿瘤数目及肿瘤大小相关。TACE术前和术后1周Ang-2评估术后近期疗效的ROC曲线下面积(AUC)分别是0. 902和0. 919。Logistic多因素分析结果显示术后1周血清Ang-2水平是影响TACE术后近期预后的独立危险因素(OR=2. 611,95%CI为1. 258～3. 366,P <0. 001)。结论:血清Ang-2水平与HCC患者TACE术后近期预后密切相关。
引文
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[5]LI C,LI Q,CAI Y,et al. Overexpression of angiopoietin 2 promotes the formation of oral squamous cell carcinoma by increasing epithelial-mesenchymal transition-induced angiogenesis[J]. Cancer Gene Ther,2016,23(9):295-302.
[6]FANG J H,ZHOU H C,ZHANG C,et al. A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an EMT-independent manner[J]. Hepatology,2015,62(2):452-465.
[7]VINCENZI B,MAIO M D,SILLETTA M,et al. Prognostic relevance of objective response according to EASL criteria and mRECIST criteria in hepatocellular carcinoma patients treated with loco-regional therapies:a literature-based meta-analysis[J]. PLo S One,2015,10(7):e0133488.
[8]GUAN Q,GU J,ZHANG H,et al. Correlation between vascular endothelial growth factor levels and prognosis of hepatocellular carcinoma patients receiving radiofrequency ablation[J]. Biotechnol Biotechnol Equip,2015,29(1):119-123.
[9]ZHANG W,KIM R,QUINTINI C,et al. Prognostic role of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma undergoing liver transplantation[J]. Liver Transpl,2015,21(1):101-111.
[10]CHEN J,LAI L,LIU S,et al. Targeting HIF-1αand VEGF by lentivirus-mediated RNA interference reduces liver tumor cells migration and invasion under hypoxic conditions[J]. Neoplasma,2016,63(6):934-940.
[11]HE F F,LI H Q,HUANG Q X,et al. Tumor necrosis factor-alpha and 8-hydroxy-2'-deoxyguanosine are associated with elevated urinary angiopoietin-2 level in type 2 diabetic patients with albuminuria[J]. Kidney Blood Press Res,2015,40(4):355-365.
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[13]WANG F,DONG X,XIU P,et al. T7 peptide inhibits angiogenesis via downregulation of angiopoietin-2 and autophagy[J]. Onco Rep,2015,33(2):675-684.
[14]HSIEH M Y,LIN Z Y,CHUANG W L. Serial serum VEGFA,angiopoietin-2,and endostatin measurements in cirrhotic patients with hepatocellular carcinoma treated by transcatheter arterial chemoembolization[J]. Kaohsiung J Med Sci,2011,27(8):314-322.
[15]RONALD J,NIXON A B,MARIN D,et al. Pilot evaluation of angiogenesis signaling factor response after transcatheter arterial embolization for hepatocellular carcinoma[J]. Radiology,2017,285(1):311-318.