补肾益气活血方药治疗冠心病心绞痛随机对照试验系统评价
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摘要
目的:评价补肾益气活血方药治疗冠心病心绞痛的效果及安全性,以期对临床提供借鉴与指导。方法:计算机检索中文及外文数据库(时间从各库建库到2016年12月)所收录的补肾益气活血方药治疗冠心病心绞痛的随机对照临床试验,筛选出符合标准的试验研究,并对其进行质量评价,并且用Rev Man软件对纳入文献提取的数据进行数据分析。结果:共纳入随机对照试验9个,涉及冠心病心绞痛患者1184例;文献纳入的质量偏低;Meta分析结果显示补肾益气活血方药干预的试验组在总有效率、中医症状、心电图疗效、血脂、血压、心率方面均优于对照组(P<0.05),且不良反应偏低。结论:补肾益气活血方药治疗冠心病心绞痛有良好的疗效和安全性,但由于文献质量偏低,上述其稳定性和可靠性需要更多高质量的随机对照临床研究加以证实。
Objective:To evaluate the efficacy and safety of prescription for tonifying kidney and Qi and activating blood in treating coronary heart disease and in order to provide reference and guidance for clinical.Methods:Randomized controlled clinical trial of prescription for tonifying kidney and replenishing Qi and activating blood in treating coronary heart disease were selected by searching the literature in the Chinese and foreign language database(time from each library to December 2016),and to evaluate its quality,and included in the data extracted from the literature and the data was analyzed by Rev Man software. And its quality were evaluated and analyzing the data by Rev Man. Results:9 trials were included,and there are 1187 patients,but the qualities of those trials were low. The results of Meta-analysis shows that the experimental group was better than the control group in the total effective rate,TCM symptoms,ECG,blood lipids,blood pressure,heart rate(P<0.05),and the adverse reaction is low. Conclusion:The efficacy and safety of prescription for tonifying kidney and replenishing Qi and activating blood in treating coronary heart disease are good. But the qualities of those trials were low,so more high-quality randomized controlled clinical trials shoud be done to confirm the above stability and reliability.
Objective:To evaluate the efficacy and safety of prescription for tonifying kidney and Qi and activating blood in treating coronary heart disease and in order to provide reference and guidance for clinical.Methods:Randomized controlled clinical trial of prescription for tonifying kidney and replenishing Qi and activating blood in treating coronary heart disease were selected by searching the literature in the Chinese and foreign language database(time from each library to December 2016),and to evaluate its quality,and included in the data extracted from the literature and the data was analyzed by Rev Man software. And its quality were evaluated and analyzing the data by Rev Man. Results:9 trials were included,and there are 1187 patients,but the qualities of those trials were low. The results of Meta-analysis shows that the experimental group was better than the control group in the total effective rate,TCM symptoms,ECG,blood lipids,blood pressure,heart rate(P<0.05),and the adverse reaction is low. Conclusion:The efficacy and safety of prescription for tonifying kidney and replenishing Qi and activating blood in treating coronary heart disease are good. But the qualities of those trials were low,so more high-quality randomized controlled clinical trials shoud be done to confirm the above stability and reliability.
引文
[1]唐明,周景想,李洁.冠心病证素研究现状[J].中华中医药学刊,2010,28(2):380-382.
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[4]王彩路,焦富英,孙丽斌,等.补肾通脉汤治疗冠心病疗效观察[J].中华中医药学刊,2007(4):851-852.
[5]牛铁,康启,董静,等.补肾益气活血方联合西药治疗冠心病心绞痛的有效性和安全性评价[J].现代生物医学进展,2013(13):2532-2535.
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[7]季向东,姜俊香,姜延,等.参乌冠心颗粒治疗冠心病心绞痛肾虚血瘀证60例临床观察[J].广州中医药大学学报,2008(5):391-394.
[8]王昃睿,刘中华,袁安冬.益气活血补肾汤治疗冠心病不稳定型心绞痛临床观察[J].湖北中医杂志,2007(8):27-28.
[9]刘中华.益气活血补肾汤治疗冠心病不稳定型心绞痛临床研究[D].武汉:湖北中医学院,2004.
[10]王建华.舒心散加减治疗老年冠心病心绞痛74例临床分析[J].河南诊断与治疗杂志,1998(2):12.
[11]杨培君.温补肾气为主治疗老年男性冠心病心绞痛的临床研究[J].陕西中医学院学报,1998(2):1-4.
[12]陈嘉兴.许心如学术思想和临床经验总结及三参通脉合剂治疗胸痹的临床研究[D].北京:北京中医药大学,2011.
[2]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.冠心病诊断和治疗指南(2007版)[J].中华心血管病杂志,2007,35(3):195-206.
[3]郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:68-73.
[4]王彩路,焦富英,孙丽斌,等.补肾通脉汤治疗冠心病疗效观察[J].中华中医药学刊,2007(4):851-852.
[5]牛铁,康启,董静,等.补肾益气活血方联合西药治疗冠心病心绞痛的有效性和安全性评价[J].现代生物医学进展,2013(13):2532-2535.
[6]覃松柏,刘程,李平,等.补肾益气活血方治疗冠心病心绞痛的临床观察[J].湖北中医杂志,2012(3):5-6.
[7]季向东,姜俊香,姜延,等.参乌冠心颗粒治疗冠心病心绞痛肾虚血瘀证60例临床观察[J].广州中医药大学学报,2008(5):391-394.
[8]王昃睿,刘中华,袁安冬.益气活血补肾汤治疗冠心病不稳定型心绞痛临床观察[J].湖北中医杂志,2007(8):27-28.
[9]刘中华.益气活血补肾汤治疗冠心病不稳定型心绞痛临床研究[D].武汉:湖北中医学院,2004.
[10]王建华.舒心散加减治疗老年冠心病心绞痛74例临床分析[J].河南诊断与治疗杂志,1998(2):12.
[11]杨培君.温补肾气为主治疗老年男性冠心病心绞痛的临床研究[J].陕西中医学院学报,1998(2):1-4.
[12]陈嘉兴.许心如学术思想和临床经验总结及三参通脉合剂治疗胸痹的临床研究[D].北京:北京中医药大学,2011.