野生动物重金属污染研究进展
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摘要
重金属污染问题已成为全球热点,会对野生动物及环境造成严重危害。野生动物体内重金属主要来自食物链的传递,植物从空气和土壤中吸收重金属离子及其化合物,被采食后富集到草食性动物体内,逐级传递,最终会进入野生动物体内,对野生动物健康造成严重危害。体内重金属超标可以导致鸟类产生生殖障碍,降低种群数量,同时也会影响鸟类的行为。体内重金属超标会对哺乳动物骨骼发育、生殖健康等方面产生极大危害,对哺乳动物繁衍生息产生影响。文中主要综述重金属污染对野生鸟类、野生哺乳动物生长发育的影响;重金属在生物链传递过程的富集机制及其对野生鸟类、野生哺乳动物的毒理分子机制,以期对重金属环境污染的预防与治理提供理论基础。
Heavy metal pollution has become a global hotspot, causing serious damage to wildlife and environment. The heavy metals in wild animals are mostly from food chains. The plants absorb heavy metal ions and their compounds from air and soil. When the plants are eaten, heavy metals can be enriched in herbivores. They are passed among wild animals and eventually enter their bodies, thereby causing serious harm to them. Excessive amount of heavy metals stored in the body can cause reproductive disorders in birds, reduce their population size, and also affect their behavior. Excessive heavy metals in the body can also do great harm to mammalian bone development and reproductive health, having an impact on mammalian reproduction. Herein, the effects of heavy metal pollution on the growth and development of wild birds and mammals, the enrichment mechanism of heavy metals in the process of biological chain transfer and their toxicological molecular mechanisms were reviewed, which would provide theoretical basis for prevention and management of heavy metal pollution.
Heavy metal pollution has become a global hotspot, causing serious damage to wildlife and environment. The heavy metals in wild animals are mostly from food chains. The plants absorb heavy metal ions and their compounds from air and soil. When the plants are eaten, heavy metals can be enriched in herbivores. They are passed among wild animals and eventually enter their bodies, thereby causing serious harm to them. Excessive amount of heavy metals stored in the body can cause reproductive disorders in birds, reduce their population size, and also affect their behavior. Excessive heavy metals in the body can also do great harm to mammalian bone development and reproductive health, having an impact on mammalian reproduction. Herein, the effects of heavy metal pollution on the growth and development of wild birds and mammals, the enrichment mechanism of heavy metals in the process of biological chain transfer and their toxicological molecular mechanisms were reviewed, which would provide theoretical basis for prevention and management of heavy metal pollution.
引文
[1]SCHALIE W H,GARDNER H J,BANTLE J A,et al.Animals as sentinels of human health hazards of environmental chemicals[J].Environmental Health Perspectives,1999,107(4):309-315.
[2]BACKER L C,GRINDEM C B,CORBETT W T,et al.Pet dogs as sentinels for environmental contamination[J].Science of the Total Environment,2001,274(1-3):161-169.
[3]REGLERO M M,TAGGART M A,CASTELLANOS P,et al.Reduced sperm quality in relation to oxidative stress in red deer from a lead mining area[J].Environmental Pollution,2009,157(8-9):2209-2215.
[4]BEYER W N,GASTON G,BRAZZLE R,et al.Deer exposed to exceptionally high concentrations of lead near the Continental Mine in Idaho,USA[J].Environmental Toxicology and Chemistry,2007,26(5):1040-1046.
[5]RODRIGUEZ-ESTIVAL J,ALVAREZ-LLORET P,RODRI-GUEZ-NAVARRO A B,et al.Chronic effects of lead(Pb)on bone properties in red deer and wild boar:relationship with vitamins A and D3[J].Environmental Pollution,2013,174:142-149.
[6]RODRIGUEZ-ESTIVAL J,BARASONA J A,MATEO R.Blood Pb and delta-ALAD inhibition in cattle and sheep from a Pbpolluted mining area[J].Environmental Pollution,2012,160(1):118-124.
[7]REGLERO M M,MONSALVE-GONZALEZ L,TAGGART MA,et al.Transfer of metals to plants and red deer in an old lead mining area in Spain[J].Science of the Total Environment,2008,406(1-2):287-297.
[8]STANSLEY W,ROSCOE D E,HAWTHORNE E,et al.Food chain aspects of chlordane poisoning in birds and bats[J].Archives of Environmental Contamination and Toxicology,2001,40(2):285-291.
[9]FACEMIRE C F,GROSS T S,GUILLETTE L J.Reproductive impairment in the Florida panther:nature or nurture?[J].Environmental Health Perspectives,1995,103(suppl.4):79-86.
[10]CLATTERBUCK C A,LEWISON R L,DODDER N G,et al.Seabirds as regional biomonitors of legacy toxicants on an ur banized coastline[J].Science of the Total Environment,2017,619-620:460-469.
[11]ZHANG W W,MA J Z.Waterbirds as bioindicators of wetland heavy metal pollution[J].Procedia Environmental Sciences,2011,10:2769-2774.
[12]ALLEVA E,FRANCIA N,PANDOLFI M,et al.Organochlorine and heavy-metal contaminants in wild mammals and birds of Urbino-Pesaro Province,Italy:an analytic overview for potential bioindicators[J].Archives of Environmental Contamination and Toxicology,2006,51(1):123-134.
[13]KAABI R,ABDERRABBA M,GOMEZ-RUIZ S,et al.Bioinspired materials based on glutathione-functionalized SBA-15for electrochemical Cd(Ⅱ)detection[J].Microporous and Mesoporous Materials,2016,234:336-346.
[14]ABBASI N A,JASPERS V L,CHAUDHRY M J,et al.Influence of taxa,trophic level,and location on bioaccumulation of toxic metals in bird’s feathers:a preliminary biomonitoring study using multiple bird species from Pakistan[J].Chemosphere,2015,120:527-537.
[15]KOIVULA M J,EEVA T.Metal-related oxidative stress in birds[J].Environmental Pollution,2010,158(7):2359-2370.
[16]GARCIA-FERNANDEZ A J,ESPIN S,MARTINEZ-LOPEZE.Feathers as a biomonitoring tool of polyhalogenated compounds:a review[J].Environmental Science Technology,2013,47(7):3028-3043.
[17]SANCHEZ-VIROSTA P,ESPIN S,GARCIA-FERNANDEZ A J,et al.A review on exposure and effects of arsenic in passerine birds[J].Science of the Total Environment,2015,512-513:506-525.
[18]周立志,李进华,尹华宝,等.三种重金属元素在鹭卵中富集特征的初步研究[J].应用生态学报(ZHOU Li-zhi,LI Jin-hua,YIN Hua-bao,et al.Enrichment characteristics of heavy met als in heron eggs[J].Chinese Journal of Applied Ecology),2005,16(10):1932-1937.
[19]阮禄章,张迎梅,赵东芹,等.白鹭作为无锡太湖地区环境污染指示生物的研究[J].应用生态学报(RUAN Lu-zhang,ZHANGYing-mei,ZHAO Dong-qin,et al.Egretta garzetta as a bioindicator of environmental pollution in Tai Lake region[J].Chinese Journal of Applied Ecology),2003,14(2):263-268.
[20]LODENIUS M,SOLONEN T.The use of feathers of birds of prey as indicators of metal pollution[J].Ecotoxicology,2013,22(9):1319-1334.
[21]ESPIN S,MARTINEZ-LOPEZ E,LEON-ORTEGA M,et al.Factors that influence mercury concentrations in nestling eagle owls(Bubo bubo)[J].Science of the Total Environment,2014,470-471:1132-1139.
[22]RAINIO M J,KANERVA M,SALMINEN J P,et al.Oxidative status in nestlings of three small passerine species exposed to metal pollution[J].Science of the Total Environment,2013,454-455:466-473.
[23]宫茜茜,金志民,邹红菲.鸡西地区[树]麻雀组织中铅、镉、铬的残留量[J].东北林业大学学报(GONG Qian-qian,JIN Zhi-min,ZOU Hong-fei.Concentrations of lead,cadmium and chromium in Passer montanus at Jixi Mining Area in Heilongjiang Province[J].Journal of Northeast Forestry University,2012,40(6):95-98.
[24]吕尤,宫茜茜,李自亲.牡丹江市工业区麻雀体内重金属残留分析[J].生态与农村环境学报(L譈-You,GONG Qian-qian,LI Zi-qin.Heavy metal contents in organs of sparrow in Mudanjiang[J].Journal of Ecology and Rural Environment),2008,24(3):94-96.
[25]BURGER J.Temporal trends(1989-2011)in levels of mercury and other heavy metals in feathers of fledgling great egrets nesting in Barnegat Bay,NJ[J].Environmental Research,2013,122:11-17.
[26]KOUDDANE N,MOUHIR L,FEKHAOUI M,et al.Monitoring air pollution at Mohammedia(Morocco):Pb,Cd and Zn in the blood of pigeons(Columba livia)[J].Ecotoxicology,2016,25(4):720-726.
[27]ABDULLAH M,FASOLA M,MUHAMMAD A,et al.Avian feathers as a non-destructive bio-monitoring tool of trace metals signatures:a case study from severely contaminated areas[J].Chemosphere,2015,119:553-561.
[28]CARNEIRO M,COLACO B,BRANDAO R,et al.Assessment of the exposure to heavy metals in griffon vultures(Gyps fulvus)from the Iberian Peninsula[J].Ecotoxicology and Environmental Safety,2015,113:295-301.
[29]FENSTAD A A,BUSTNES J O,BINGHAM C G,et al.DNAdouble-strand breaks in incubating female common eiders(Somateria mollissima):comparison between a low and a high polluted area[J].Environmental Research,2016,151:297-303.
[30]TSIPOURA N,BURGER J,NEWHOUSE M,et al.Lead,mercury,cadmium,chromium,and arsenic levels in eggs,feathers,and tissues of Canada geese of the New Jersey Meadowlands[J].Environmental Research,2011,111(6):775-784.
[31]PLESSL C,JANDRISITS P,KRACHLER R,et al.Heavy metals in the mallard Anas platyrhynchos from eastern Austria[J].Science of the Total Environment,2017,580:670-676.
[32]COOPER Z,BRINGOLF R,COOPER R,et al.Heavy metal bioaccumulation in two passerines with differing migration strategies[J].Science of the Total Environment,2017,592:25-32.
[33]HASHMI M Z,MALIK R N,SHAHBAZ M.Heavy metals in eggshells of cattle egret(Bubulcus ibis)and little egret(Egretta garzetta)from the Punjab Province,Pakistan[J].Ecotoxicology and Environmental Safety,2013,89:158-165.
[34]NACCARI C,CRISTANI M,CIMINO F,et al.Common buzzards(Buteo buteo)bio-indicators of heavy metals pollution in Sicily(Italy)[J].Environment International,2009,35(3):594-598.
[35]FERREIRA D S E,FREIRE A P,SALGUEIRO A R,et al.Quantitative-spatial assessment of soil contamination in S.Francisco de Assis due to mining activity of the Panasqueira mine(Portugal)[J].Environmental Science and Pollution Research,2013,20(11):7534-7549.
[36]SEYFFERTH A L,MCCURDY S,SCHAEFER M V,et al.Arsenic concentrations in paddy soil and rice and health implica tions for major rice-growing regions of Cambodia[J].Environmental Science&Technology,2014,48(9):4699-4706.
[37]LI J,LI C,SUN H J,et al.Arsenic relative bioavailability in contaminated soils:comparison of animal models,dosing schemes,and biological end points[J].Environmental Science&Technology,2016,50(1):453-461.
[38]CHANG C Y,XU X H,LIU C P,et al.Heavy metal accumulation in balsam pear and cowpea related to the geochemical factors of variable-charge soils in the Pearl River Delta,South China[J].Environmental Science and Pollution Research,2014,16(7):1790-1798.
[39]SINGH R D,TIWARI R,KHAN H,et al.Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells[J].Toxicology Letters,2015,237:1-10.
[40]ADEMUYIWA O,AGARWAL R,CHANDRA R,et al.Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues[J].Journal of Trace Elements in Medicine and Biology,2010,24(3):207-211.
[41]JANKOVSKAI,MIHOLOVA D,LANGROVA I,et al.Influence of parasitism on the use of small terrestrial rodents in environmental pollution monitoring[J].Environmental Pollution,2009,157(8-9):2584-2586.
[42]XUE S,SHI L,WU C,et al.Cadmium,lead,and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines[J].Environmental Research,2017,156:23-30.
[43]KWOK C K,YANG S M,MAK N K,et al.Ecotoxicological study on sediments of Mai Po marshes,Hong Kong using organ isms and biomarkers[J].Ecotoxicology and Environmental Safety,2010,73(4):541-549.
[44]CHASAPIS C T,LOUTSIDOU A C,SPILIOPOULOU C A,et al.Zinc and human health:an update[J].Archives of Toxicology,2012,86(4):521-534.
[45]DITTMER K E,THOMPSON K G.Vitamin D metabolism and rickets in domestic animals:a review[J].Veterinary Pathology,2011,48(2):389-407.
[46]AHMADIEH H,ARABI A.Vitamins and bone health:beyond calcium and vitamin D[J].Nutrition Reviews,2011,69(10):584-598.
[47]ROBBINS J A,ARAGAKI A,CRANDALL C J,et al.Women’s Health Initiative clinical trials:interaction of calcium and vitamin D with hormone therapy[J].Menopause,2014,21(2):116-123.
[48]RODRIGUEZ-ESTIVAL J,MARTINEZ-HARO M,MON-SALVE-GONZALEZ L,et al.Interactions between endogenous and dietary antioxidants against Pb-induced oxidative stress in wild ungulates from a Pb polluted mining area[J].Science of the Total Environment,2011,409(14):2725-2733.
[49]SAUNDERS J R,KNOPPER L D,KOCH I,et al.Arsenic transformations and biomarkers in meadow voles(Microtus pennsylvanicus)living on an abandoned gold mine site in Montague,Nova Scotia,Canada[J].Science of the Total Environment,2010,408(4):829-835.
[50]CASTELLANOS P,DEL OLMO E,FERNANDEZ-SANTOS MR,et al.Increased chromatin fragmentation and reduced acrosome integrity in spermatozoa of red deer from lead polluted sites[J].Science of the Total Environment,2015,505:32-38.
[51]KNOTT J,GILBERT J,HOCCOM D G,et al.Implications for wildlife and humans of dietary exposure to lead from fragments of lead rifle bullets in deer shot in the UK[J].Science of the Total Environment,2010,409(1):95-99.
[52]CASTELLANOS P,REGLERO M M,TAGGART M A,et al.Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution[J].Reproductive Toxicology,2010,29(3):346-352.
[53]NRIAGU J O.A silent epidemic of environmental metal poisoning?[J]Environmental Pollution,1988,50(1-2):139-161.
[54]YOKEL R A,LASLEY S M,DORMAN D C.The speciation of metals in mammals influences their toxicokinetics and toxicodynamics and therefore human health risk assessment[J].Journal of Toxicology and Environmental Health Part B:Critical Reviews,2006,9(1):63-85.
[55]ABAM E,OKEDIRAN B S,ODUKOYA O O,et al.Reversal of ionoregulatory disruptions in occupational lead exposure by vitamin C[J].Environmental Toxicology and Pharmacology,2008,26(3):297-304.
[56]ADEMUYIWA O,UGBAJA R N,ROTIMI S O,et al.Erythrocyte acetylcholinesterase activity as a surrogate indicator of leadinduced neurotoxicity in occupational lead exposure in Abeoku ta,Nigeria[J].Environmental Toxicology and Pharmacology,2007,24(2):183-188.
[57]ADEMUYIWA O,UGBAJA R N,OJO D A,et al.Reversal of aminolevulinic acid dehydratase(ALAD)inhibition and reduction of erythrocyte protoporphyrin levels by vitamin C in occupational lead exposure in Abeokuta,Nigeria[J].Environmental Toxicology and Pharmacology,2005,20(3):404-411.
[58]HU H,ARO A,PAYTON M,et al.The relationship of bone and blood lead to hypertension.The Normative Aging Study[J].JAMA,1996,275(15):1171-1176.
[59]MUNTNER P,HE J,VUPPUTURI S,et al.Blood lead and chronic kidney disease in the general United States population:results from NHANESⅢ[J].Kidney International,2003,63(3):1044-1050.
[60]LIN J L,LIN-TAN D T,HSU K H,et al.Environmental lead exposure and progression of chronic renal diseases in patients without diabetes[J].The New England Journal of Medicine,2003,348(4):277-286.
[61]MENKE A,MUNTNER P,BATUMAN V,et al.Blood lead below 0.48 micromol/L(10 microg/dL)and mortality among USadults[J].Circulation,2006,114(13):1388-1394.
[62]HANDLOGTEN M E,SHIRAISHI N,AWATA H,et al.Extracellular Ca(2+)-sensing receptor is a promiscuous divalent cation sensor that responds to lead[J].American Journal of Physiology,2000,279(6):F1083-F1091.
[63]QU W,DIWAN B A,LIU J,et al.The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies[J].American Journal of Physiology,2002,160(3):1047-1056.
[64]BOZDAG G O,KAYA A,KOC A,et al.Characterization of a cD-NA from beta maritima that confers nickel tolerance in yeast[J].Gene,2014,538(2):251-257.
[65]MARTINEZ-LOPEZ S,MARTINEZ-SANCHEZ M J,PEREZ-SIRVENT C,et al.Screening of wild plants for use in the phytoremediation of mining-influenced soils containing arsenic in semiarid environments[J].Journal of Soils and Sediments,2014,14(4):794-809.
[2]BACKER L C,GRINDEM C B,CORBETT W T,et al.Pet dogs as sentinels for environmental contamination[J].Science of the Total Environment,2001,274(1-3):161-169.
[3]REGLERO M M,TAGGART M A,CASTELLANOS P,et al.Reduced sperm quality in relation to oxidative stress in red deer from a lead mining area[J].Environmental Pollution,2009,157(8-9):2209-2215.
[4]BEYER W N,GASTON G,BRAZZLE R,et al.Deer exposed to exceptionally high concentrations of lead near the Continental Mine in Idaho,USA[J].Environmental Toxicology and Chemistry,2007,26(5):1040-1046.
[5]RODRIGUEZ-ESTIVAL J,ALVAREZ-LLORET P,RODRI-GUEZ-NAVARRO A B,et al.Chronic effects of lead(Pb)on bone properties in red deer and wild boar:relationship with vitamins A and D3[J].Environmental Pollution,2013,174:142-149.
[6]RODRIGUEZ-ESTIVAL J,BARASONA J A,MATEO R.Blood Pb and delta-ALAD inhibition in cattle and sheep from a Pbpolluted mining area[J].Environmental Pollution,2012,160(1):118-124.
[7]REGLERO M M,MONSALVE-GONZALEZ L,TAGGART MA,et al.Transfer of metals to plants and red deer in an old lead mining area in Spain[J].Science of the Total Environment,2008,406(1-2):287-297.
[8]STANSLEY W,ROSCOE D E,HAWTHORNE E,et al.Food chain aspects of chlordane poisoning in birds and bats[J].Archives of Environmental Contamination and Toxicology,2001,40(2):285-291.
[9]FACEMIRE C F,GROSS T S,GUILLETTE L J.Reproductive impairment in the Florida panther:nature or nurture?[J].Environmental Health Perspectives,1995,103(suppl.4):79-86.
[10]CLATTERBUCK C A,LEWISON R L,DODDER N G,et al.Seabirds as regional biomonitors of legacy toxicants on an ur banized coastline[J].Science of the Total Environment,2017,619-620:460-469.
[11]ZHANG W W,MA J Z.Waterbirds as bioindicators of wetland heavy metal pollution[J].Procedia Environmental Sciences,2011,10:2769-2774.
[12]ALLEVA E,FRANCIA N,PANDOLFI M,et al.Organochlorine and heavy-metal contaminants in wild mammals and birds of Urbino-Pesaro Province,Italy:an analytic overview for potential bioindicators[J].Archives of Environmental Contamination and Toxicology,2006,51(1):123-134.
[13]KAABI R,ABDERRABBA M,GOMEZ-RUIZ S,et al.Bioinspired materials based on glutathione-functionalized SBA-15for electrochemical Cd(Ⅱ)detection[J].Microporous and Mesoporous Materials,2016,234:336-346.
[14]ABBASI N A,JASPERS V L,CHAUDHRY M J,et al.Influence of taxa,trophic level,and location on bioaccumulation of toxic metals in bird’s feathers:a preliminary biomonitoring study using multiple bird species from Pakistan[J].Chemosphere,2015,120:527-537.
[15]KOIVULA M J,EEVA T.Metal-related oxidative stress in birds[J].Environmental Pollution,2010,158(7):2359-2370.
[16]GARCIA-FERNANDEZ A J,ESPIN S,MARTINEZ-LOPEZE.Feathers as a biomonitoring tool of polyhalogenated compounds:a review[J].Environmental Science Technology,2013,47(7):3028-3043.
[17]SANCHEZ-VIROSTA P,ESPIN S,GARCIA-FERNANDEZ A J,et al.A review on exposure and effects of arsenic in passerine birds[J].Science of the Total Environment,2015,512-513:506-525.
[18]周立志,李进华,尹华宝,等.三种重金属元素在鹭卵中富集特征的初步研究[J].应用生态学报(ZHOU Li-zhi,LI Jin-hua,YIN Hua-bao,et al.Enrichment characteristics of heavy met als in heron eggs[J].Chinese Journal of Applied Ecology),2005,16(10):1932-1937.
[19]阮禄章,张迎梅,赵东芹,等.白鹭作为无锡太湖地区环境污染指示生物的研究[J].应用生态学报(RUAN Lu-zhang,ZHANGYing-mei,ZHAO Dong-qin,et al.Egretta garzetta as a bioindicator of environmental pollution in Tai Lake region[J].Chinese Journal of Applied Ecology),2003,14(2):263-268.
[20]LODENIUS M,SOLONEN T.The use of feathers of birds of prey as indicators of metal pollution[J].Ecotoxicology,2013,22(9):1319-1334.
[21]ESPIN S,MARTINEZ-LOPEZ E,LEON-ORTEGA M,et al.Factors that influence mercury concentrations in nestling eagle owls(Bubo bubo)[J].Science of the Total Environment,2014,470-471:1132-1139.
[22]RAINIO M J,KANERVA M,SALMINEN J P,et al.Oxidative status in nestlings of three small passerine species exposed to metal pollution[J].Science of the Total Environment,2013,454-455:466-473.
[23]宫茜茜,金志民,邹红菲.鸡西地区[树]麻雀组织中铅、镉、铬的残留量[J].东北林业大学学报(GONG Qian-qian,JIN Zhi-min,ZOU Hong-fei.Concentrations of lead,cadmium and chromium in Passer montanus at Jixi Mining Area in Heilongjiang Province[J].Journal of Northeast Forestry University,2012,40(6):95-98.
[24]吕尤,宫茜茜,李自亲.牡丹江市工业区麻雀体内重金属残留分析[J].生态与农村环境学报(L譈-You,GONG Qian-qian,LI Zi-qin.Heavy metal contents in organs of sparrow in Mudanjiang[J].Journal of Ecology and Rural Environment),2008,24(3):94-96.
[25]BURGER J.Temporal trends(1989-2011)in levels of mercury and other heavy metals in feathers of fledgling great egrets nesting in Barnegat Bay,NJ[J].Environmental Research,2013,122:11-17.
[26]KOUDDANE N,MOUHIR L,FEKHAOUI M,et al.Monitoring air pollution at Mohammedia(Morocco):Pb,Cd and Zn in the blood of pigeons(Columba livia)[J].Ecotoxicology,2016,25(4):720-726.
[27]ABDULLAH M,FASOLA M,MUHAMMAD A,et al.Avian feathers as a non-destructive bio-monitoring tool of trace metals signatures:a case study from severely contaminated areas[J].Chemosphere,2015,119:553-561.
[28]CARNEIRO M,COLACO B,BRANDAO R,et al.Assessment of the exposure to heavy metals in griffon vultures(Gyps fulvus)from the Iberian Peninsula[J].Ecotoxicology and Environmental Safety,2015,113:295-301.
[29]FENSTAD A A,BUSTNES J O,BINGHAM C G,et al.DNAdouble-strand breaks in incubating female common eiders(Somateria mollissima):comparison between a low and a high polluted area[J].Environmental Research,2016,151:297-303.
[30]TSIPOURA N,BURGER J,NEWHOUSE M,et al.Lead,mercury,cadmium,chromium,and arsenic levels in eggs,feathers,and tissues of Canada geese of the New Jersey Meadowlands[J].Environmental Research,2011,111(6):775-784.
[31]PLESSL C,JANDRISITS P,KRACHLER R,et al.Heavy metals in the mallard Anas platyrhynchos from eastern Austria[J].Science of the Total Environment,2017,580:670-676.
[32]COOPER Z,BRINGOLF R,COOPER R,et al.Heavy metal bioaccumulation in two passerines with differing migration strategies[J].Science of the Total Environment,2017,592:25-32.
[33]HASHMI M Z,MALIK R N,SHAHBAZ M.Heavy metals in eggshells of cattle egret(Bubulcus ibis)and little egret(Egretta garzetta)from the Punjab Province,Pakistan[J].Ecotoxicology and Environmental Safety,2013,89:158-165.
[34]NACCARI C,CRISTANI M,CIMINO F,et al.Common buzzards(Buteo buteo)bio-indicators of heavy metals pollution in Sicily(Italy)[J].Environment International,2009,35(3):594-598.
[35]FERREIRA D S E,FREIRE A P,SALGUEIRO A R,et al.Quantitative-spatial assessment of soil contamination in S.Francisco de Assis due to mining activity of the Panasqueira mine(Portugal)[J].Environmental Science and Pollution Research,2013,20(11):7534-7549.
[36]SEYFFERTH A L,MCCURDY S,SCHAEFER M V,et al.Arsenic concentrations in paddy soil and rice and health implica tions for major rice-growing regions of Cambodia[J].Environmental Science&Technology,2014,48(9):4699-4706.
[37]LI J,LI C,SUN H J,et al.Arsenic relative bioavailability in contaminated soils:comparison of animal models,dosing schemes,and biological end points[J].Environmental Science&Technology,2016,50(1):453-461.
[38]CHANG C Y,XU X H,LIU C P,et al.Heavy metal accumulation in balsam pear and cowpea related to the geochemical factors of variable-charge soils in the Pearl River Delta,South China[J].Environmental Science and Pollution Research,2014,16(7):1790-1798.
[39]SINGH R D,TIWARI R,KHAN H,et al.Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells[J].Toxicology Letters,2015,237:1-10.
[40]ADEMUYIWA O,AGARWAL R,CHANDRA R,et al.Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues[J].Journal of Trace Elements in Medicine and Biology,2010,24(3):207-211.
[41]JANKOVSKAI,MIHOLOVA D,LANGROVA I,et al.Influence of parasitism on the use of small terrestrial rodents in environmental pollution monitoring[J].Environmental Pollution,2009,157(8-9):2584-2586.
[42]XUE S,SHI L,WU C,et al.Cadmium,lead,and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines[J].Environmental Research,2017,156:23-30.
[43]KWOK C K,YANG S M,MAK N K,et al.Ecotoxicological study on sediments of Mai Po marshes,Hong Kong using organ isms and biomarkers[J].Ecotoxicology and Environmental Safety,2010,73(4):541-549.
[44]CHASAPIS C T,LOUTSIDOU A C,SPILIOPOULOU C A,et al.Zinc and human health:an update[J].Archives of Toxicology,2012,86(4):521-534.
[45]DITTMER K E,THOMPSON K G.Vitamin D metabolism and rickets in domestic animals:a review[J].Veterinary Pathology,2011,48(2):389-407.
[46]AHMADIEH H,ARABI A.Vitamins and bone health:beyond calcium and vitamin D[J].Nutrition Reviews,2011,69(10):584-598.
[47]ROBBINS J A,ARAGAKI A,CRANDALL C J,et al.Women’s Health Initiative clinical trials:interaction of calcium and vitamin D with hormone therapy[J].Menopause,2014,21(2):116-123.
[48]RODRIGUEZ-ESTIVAL J,MARTINEZ-HARO M,MON-SALVE-GONZALEZ L,et al.Interactions between endogenous and dietary antioxidants against Pb-induced oxidative stress in wild ungulates from a Pb polluted mining area[J].Science of the Total Environment,2011,409(14):2725-2733.
[49]SAUNDERS J R,KNOPPER L D,KOCH I,et al.Arsenic transformations and biomarkers in meadow voles(Microtus pennsylvanicus)living on an abandoned gold mine site in Montague,Nova Scotia,Canada[J].Science of the Total Environment,2010,408(4):829-835.
[50]CASTELLANOS P,DEL OLMO E,FERNANDEZ-SANTOS MR,et al.Increased chromatin fragmentation and reduced acrosome integrity in spermatozoa of red deer from lead polluted sites[J].Science of the Total Environment,2015,505:32-38.
[51]KNOTT J,GILBERT J,HOCCOM D G,et al.Implications for wildlife and humans of dietary exposure to lead from fragments of lead rifle bullets in deer shot in the UK[J].Science of the Total Environment,2010,409(1):95-99.
[52]CASTELLANOS P,REGLERO M M,TAGGART M A,et al.Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution[J].Reproductive Toxicology,2010,29(3):346-352.
[53]NRIAGU J O.A silent epidemic of environmental metal poisoning?[J]Environmental Pollution,1988,50(1-2):139-161.
[54]YOKEL R A,LASLEY S M,DORMAN D C.The speciation of metals in mammals influences their toxicokinetics and toxicodynamics and therefore human health risk assessment[J].Journal of Toxicology and Environmental Health Part B:Critical Reviews,2006,9(1):63-85.
[55]ABAM E,OKEDIRAN B S,ODUKOYA O O,et al.Reversal of ionoregulatory disruptions in occupational lead exposure by vitamin C[J].Environmental Toxicology and Pharmacology,2008,26(3):297-304.
[56]ADEMUYIWA O,UGBAJA R N,ROTIMI S O,et al.Erythrocyte acetylcholinesterase activity as a surrogate indicator of leadinduced neurotoxicity in occupational lead exposure in Abeoku ta,Nigeria[J].Environmental Toxicology and Pharmacology,2007,24(2):183-188.
[57]ADEMUYIWA O,UGBAJA R N,OJO D A,et al.Reversal of aminolevulinic acid dehydratase(ALAD)inhibition and reduction of erythrocyte protoporphyrin levels by vitamin C in occupational lead exposure in Abeokuta,Nigeria[J].Environmental Toxicology and Pharmacology,2005,20(3):404-411.
[58]HU H,ARO A,PAYTON M,et al.The relationship of bone and blood lead to hypertension.The Normative Aging Study[J].JAMA,1996,275(15):1171-1176.
[59]MUNTNER P,HE J,VUPPUTURI S,et al.Blood lead and chronic kidney disease in the general United States population:results from NHANESⅢ[J].Kidney International,2003,63(3):1044-1050.
[60]LIN J L,LIN-TAN D T,HSU K H,et al.Environmental lead exposure and progression of chronic renal diseases in patients without diabetes[J].The New England Journal of Medicine,2003,348(4):277-286.
[61]MENKE A,MUNTNER P,BATUMAN V,et al.Blood lead below 0.48 micromol/L(10 microg/dL)and mortality among USadults[J].Circulation,2006,114(13):1388-1394.
[62]HANDLOGTEN M E,SHIRAISHI N,AWATA H,et al.Extracellular Ca(2+)-sensing receptor is a promiscuous divalent cation sensor that responds to lead[J].American Journal of Physiology,2000,279(6):F1083-F1091.
[63]QU W,DIWAN B A,LIU J,et al.The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies[J].American Journal of Physiology,2002,160(3):1047-1056.
[64]BOZDAG G O,KAYA A,KOC A,et al.Characterization of a cD-NA from beta maritima that confers nickel tolerance in yeast[J].Gene,2014,538(2):251-257.
[65]MARTINEZ-LOPEZ S,MARTINEZ-SANCHEZ M J,PEREZ-SIRVENT C,et al.Screening of wild plants for use in the phytoremediation of mining-influenced soils containing arsenic in semiarid environments[J].Journal of Soils and Sediments,2014,14(4):794-809.