芹菜中的化学成分及对生殖系统影响的研究进展
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摘要
为进一步研究芹菜的药物价值及实际应用,本文总结了近年来芹菜中的化学成分及生物活性的相关研究,探究了芹菜中的化学成分对生殖系统的影响。芹菜中的化学成分主要包括黄酮、挥发油和其他成分等。芹菜对生殖系统的影响主要集中在性激素,生殖器官和生产方面。本文为芹菜更广泛的应用和相关疾病的治疗提供一定的理论基础,也为芹菜潜在价值的开发提供思路。
In order to explore the further value and practical application of celery,the chemical constituents and related biological activities of celery are summarized and the influence of celery on reproductive system is also investigated in this paper. The chemical constituents in celery mainly include flavonoid,volatile oils,and other contents. The effect of celery on the genital system mainly focuses on sex hormones,organs of generation and fertility rate. This paper provids a theoretical basis for the wider application of celery and the treatment of related diseases,also provides ideas for the development of the potential value of celery.
In order to explore the further value and practical application of celery,the chemical constituents and related biological activities of celery are summarized and the influence of celery on reproductive system is also investigated in this paper. The chemical constituents in celery mainly include flavonoid,volatile oils,and other contents. The effect of celery on the genital system mainly focuses on sex hormones,organs of generation and fertility rate. This paper provids a theoretical basis for the wider application of celery and the treatment of related diseases,also provides ideas for the development of the potential value of celery.
引文
[1]吴征镒.中国植物志[M].北京:科学出版社,2013.
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[3]Hounsome N,Hounsome B,Tomos D,et al.Plant metabolites and nutritional quality of vegetables[J].Journal of Food Science,2010,73(4):R48-R65.
[4]Gabrielsen J S,Tanrikut C.Chronic exposures and male fertility:The impacts of environment,diet,and drug use on spermatogenesis[J].Andrology,2016,4(4):648-661.
[5]Shojaei Z A,Ebrahimi A,Salimi M.Chemical composition of three ecotypes of wild celery(Kelussia odoratissima)[J].Journal of Herbs Spices & Medicinal Plants,2011,17(1):62-68.
[6]Cipák L.Study of antioxidant effect of apigenin,luteolin and quercetin by DNA protective method[J].Neoplasma,2001,48(2):104-107.
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[9]Zhou K,Zhao F,Liu Z,et al.Triterpenoids and flavonoids from celery(Apium graveolens)[J].Journal of Natural Products,2009,72(9):1563-1567.
[10]Lin L Z,Lu S,Harnly J M.Detection and quantification of glycosylated flavonoid malonates in celery,chinese celery,and celery seed by LC-DAD-ESI/MS[J].Journal of Agricultural & Food Chemistry,2007,55(4):1321-1326.
[11]Kim H P,Son K H,Chang H W,et al.Anti-inflammatory plant flavonoids and cellular action mechanisms[J].Journal of Pharmacological Sciences,2004,96(3):229-245.
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[23]Tongnuanchan P,Benjakul S.Essential oils:extraction,bioactivities,and their uses for food preservation[J].Journal of Food Science,2014,79(7):1231-1249.
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[38]Holscher H D.Dietary fiber and prebiotics and the gastrointestinal microbiota[J].Gut Microbes,2017,8(2):172-184.
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[40]Mongeau R,Siddiqui I R,Emery J,et al.Effect of dietary fiber concentrated from celery,parsnip,and rutabaga on intestinal function,serum cholesterol,and blood glucose response in rats[J].J Agric Food Chem,1990,38(1):195-200.
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[44]Hess R A,Bunick D,Lee K H,et al.A role for oestrogens in the male reproductive system[J].Nature,1997,390(6659):509-512.
[45]Magiakou M A,Mastorakos G,Webster E,et al.The hypothalamic-pituitary-adrenal axis and the female reproductive system[J].Annals of the New York Academy of Sciences,2010,816(1):42-56.
[46]Feek C M M D J.The hypothalamic-pituitary-adrenal axis[J].Best Practice & Research Clinical Endocrinology & Metabolism,1983,12(3):597-618.
[47]Madkour N K.Beneficial role of celery oil in lowering the di(2-ethylhexyl)phthalate-induced testicular damage[J].Toxicology & Industrial Health,2014,30(9):861-872.
[48]Kooti W,Ghasemi-Boroon M,Ghafourian M,et al.The effects of celery leave extract on male hormones in rats[J].J Herb Med Pharmacol,2015,4(2):56-60.
[49]李娴彧,姜恩魁,封利,等.侧脑室注射芹菜素对情期雌性大鼠生殖激素含量影响的研究[J].锦州医学院学报,2006,27(1):18-22.
[50]Modaresi M,Ghalamkari G,Jalalizand A.The Effect of celery(Apium graveolens)extract on the reproductive hormones in male mice[J].Apcbee Procedia,2012,4(1):99-104.
[51]Bail J C L,Laroche T,Marre-Fournier F,et al.Aromatase and 17β-hydroxysteroid dehydrogenase inhibition by flavonoids[J].Cancer Letters,1998,133(1):101-106.
[52]Jarabak J,Adams J A,Williams-Ashman H G,et al.Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function[J].Journal of Biological Chemistry,1962,237(2):345-357.
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[2]Nagella P,Ahmad A,Kim S J,et al.Chemical composition,antioxidant activity and larvicidal effects of essential oil from leaves of Apium graveolens[J].Immunopharmacol Immunotoxicol,2012,34(2):205-209.
[3]Hounsome N,Hounsome B,Tomos D,et al.Plant metabolites and nutritional quality of vegetables[J].Journal of Food Science,2010,73(4):R48-R65.
[4]Gabrielsen J S,Tanrikut C.Chronic exposures and male fertility:The impacts of environment,diet,and drug use on spermatogenesis[J].Andrology,2016,4(4):648-661.
[5]Shojaei Z A,Ebrahimi A,Salimi M.Chemical composition of three ecotypes of wild celery(Kelussia odoratissima)[J].Journal of Herbs Spices & Medicinal Plants,2011,17(1):62-68.
[6]Cipák L.Study of antioxidant effect of apigenin,luteolin and quercetin by DNA protective method[J].Neoplasma,2001,48(2):104-107.
[7]J N R,V N E,E H D,et al.Flavonoids:A review of probable mechanisms of action and potential applications[J].American Journal of Clinical Nutrition,2001,74(4):418-425.
[8]Crozier A,Lean M E J,Mcdonald M S,et al.Quantitative analysis of the flavonoid content of commercial tomatoes,onions,lettuce,and celery[J].Journal of Agricultural & Food Chemistry,1997,45(3):590-595.
[9]Zhou K,Zhao F,Liu Z,et al.Triterpenoids and flavonoids from celery(Apium graveolens)[J].Journal of Natural Products,2009,72(9):1563-1567.
[10]Lin L Z,Lu S,Harnly J M.Detection and quantification of glycosylated flavonoid malonates in celery,chinese celery,and celery seed by LC-DAD-ESI/MS[J].Journal of Agricultural & Food Chemistry,2007,55(4):1321-1326.
[11]Kim H P,Son K H,Chang H W,et al.Anti-inflammatory plant flavonoids and cellular action mechanisms[J].Journal of Pharmacological Sciences,2004,96(3):229-245.
[12]Marzocchella L,Fantini M,Benvenuto M,et al.Dietary flavonoids:Molecular mechanisms of action as anti-inflammatory agents[J].Recent Patents on Inflammation & Allergy Drug Discovery,2011,5(3):200-220.
[13]Halliwell B,Chirico S.Lipid peroxidation:Its mechanism,measurement,and significance[J].American Journal of Clinical Nutrition,1993,57(5 Suppl):715S-725S.
[14]Popovi M,Kaurinovi B,Trivi S,et al.Effect of celery(Apium graveolens)extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride[J].Phytotherapy Research,2010,20(7):531-537.
[15]Tanasawet S,Boonruamkaew P,Sukketsiri W,et al.Anxiolytic and free radical scavenging potential of Chinese celery(Apium graveolens)extract in mice[J].Asian Pacific Journal of Tropical Biomedicine,2017,7(1):20-26.
[16]Patil R H,Babu R L,Kumar M N,et al.Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells[J].Molecular & Cellular Biochemistry,2015,403(1-2):95-106.
[17]Chen C Y,Peng W H,Tsai K D,et al.Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages[J].Life Sciences,2007,81(23):1602-1614.
[18]Xin J,Yang Q,Zhang Y.Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide:Implications for effective treatment of lung cancer[J].International Journal of Nanomedicine,2017,12:5109-5118.
[19]Nelson N,Szekeres K,Iclozan C,et al.Apigenin:Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer[J].Plos One,2017,12(2):170-197.
[20]Li Z F,Hao C J,Wu Y H,et al.Protective effect of apigenin against myocardium injury in ischemia reperfusion rats by stimulating JAK2/STAT3 signal pathway[J].Int J Clin Exp Med 2018,11(1):118-124.
[21]Ren B,Qin W,Wu F,et al.Apigenin and naringenin regulate glucose and lipid metabolism,and ameliorate vascular dysfunction in type 2 diabetic rats[J].European Journal of Pharmacology,2016,773(1):13-23.
[22]Burt S.Essential oils:Their antibacterial properties and potential applications in foods-a review[J].International Journal of Food Microbiology,2004,94(3):223-253.
[23]Tongnuanchan P,Benjakul S.Essential oils:extraction,bioactivities,and their uses for food preservation[J].Journal of Food Science,2014,79(7):1231-1249.
[24]Sowbhagya H B.Chemistry,technology,and nutraceutical functions of celery(Apium graveolens L.):An overview[J].Critical Reviews in Food Science & Nutrition,2014,54(3):389-398.
[25]Helaly A A,Mady E,Eldekashy M H Z,et al.Phytochemical analysis of some celery accessions[J].Acta Phytopathologica Sinica,2015,148(1):B24-B28.
[26]Hamrounisellami I,Inessbettaieb,Soumayabourgou,et al.Essential oil and aroma composition of leaves,stalks and roots of celery(Apium graveolens var.dulce)from Tunisia[J].Journal of Essential Oil Research,2012,24(6):513-521.
[27]Lu Z G,Li W,Wang P J.Chemical composition and ability of scavenging DPPH radical of essential oil and residue from the celery seed[J].Advanced Materials Research,2011,4(1):18-21.
[28]阿布力米提·伊力,刘莉,阿吉艾克拜尔·艾萨,等.维吾尔医常用药材-芹菜籽挥发油化学成分的研究[J].天然产物研究与开发,2004,16(1):36-37.
[29]Ebadollahi A.Fumigant toxicity and repellent effect of seed essential oil of celery against lesser grain borer,rhyzopertha dominica F[J].Journal of essential oil-bearing plants JEOP,2018,21(1):146-154.
[30]Benelli G,Pavela R,Ricciutelli M,et al.Efficacy of the volatile oil from water celery(Helosciadium nodiflorum,Apiaceae)against the filariasis vector Culex quinquefasciatus,the housefly Musca domestica,and the African cotton leafworm Spodoptera littoralis[J].Chemistry & Biodiversity,2017,14(12):284-296.
[31]Khalil N,Ashour M,Fikry S,et al.Chemical composition and antimicrobial activity of the essential oils of selected Apiaceous fruits[J].Future Journal of Pharmaceutical Sciences,2018,4(1):1-5.
[32]Rai M,Zacchino S,Derita M.Essential oils and nanotechnology for treatment of microbial diseases[M].Boca Raton:CRC Press,2017.
[33]Abdoulaye,Ali I,Yi J G.A Review of recent advances in neuroprotective potential of 3-N-butylphthalide and its derivatives[J].BioMed Research International,2016,2016(1):1-9.
[34]Peng Y,Sun J,Hon S,et al.L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-β in a transgenic model of alzheimer’s disease[J].The Journal of Neuroscience,2010,30(24):8180-8189.
[35]Yang L,Li J,Xu S,et al.L-3-n-butylphthalide promotes neurogenesis and neuroplasticity in cerebral ischemic rats[J].CNS Neuroscience & Therapeutics,2015,21(9):733-741.
[36]Zhang L,Puchowicz M A,Lamanna J C,et al.Protective effect of Dl-3-n-butylphthalide on recovery from cardiac arrest and resuscitation in rats[J].Advances in Experimental Medicine and Biology,2016,923(1):31-36.
[37]赵全利,吉欣,吕奇,等.芹菜膳食纤维制备工艺的探讨[J].现代食品科技,2006,22(4):142-144.
[38]Holscher H D.Dietary fiber and prebiotics and the gastrointestinal microbiota[J].Gut Microbes,2017,8(2):172-184.
[39]Mudgil D,Barak S,Khatkar B S.Soluble fibre and cookie quality[J].Agro Food Industry Hi Tech,2012,23(3):15-17.
[40]Mongeau R,Siddiqui I R,Emery J,et al.Effect of dietary fiber concentrated from celery,parsnip,and rutabaga on intestinal function,serum cholesterol,and blood glucose response in rats[J].J Agric Food Chem,1990,38(1):195-200.
[41]Da C,Harris P J,Sims I M,et al.Polysaccharide compositions of collenchyma cell walls from celery(Apium graveolens L.)petioles[J].Bmc Plant Biology,2017,17(1):104-126.
[42]Nirmal K S P D.2.Biochemistry of vegetables:major classes of primary(carbohydrates,amino acids,fatty acids,vitamins,and organic acids)and secondary metabolites(terpenoids,phenolics,alkaloids,and sulfur-containing compounds)in vegetables[M].Wiley-Blackwell,2011.
[43]Kooti W,Moradi M,Peyro K,et al.The effect of celery(Apium graveolens L.)on fertility:A systematic review[J].J Complement Integr Med,2017,15(2):1-12.
[44]Hess R A,Bunick D,Lee K H,et al.A role for oestrogens in the male reproductive system[J].Nature,1997,390(6659):509-512.
[45]Magiakou M A,Mastorakos G,Webster E,et al.The hypothalamic-pituitary-adrenal axis and the female reproductive system[J].Annals of the New York Academy of Sciences,2010,816(1):42-56.
[46]Feek C M M D J.The hypothalamic-pituitary-adrenal axis[J].Best Practice & Research Clinical Endocrinology & Metabolism,1983,12(3):597-618.
[47]Madkour N K.Beneficial role of celery oil in lowering the di(2-ethylhexyl)phthalate-induced testicular damage[J].Toxicology & Industrial Health,2014,30(9):861-872.
[48]Kooti W,Ghasemi-Boroon M,Ghafourian M,et al.The effects of celery leave extract on male hormones in rats[J].J Herb Med Pharmacol,2015,4(2):56-60.
[49]李娴彧,姜恩魁,封利,等.侧脑室注射芹菜素对情期雌性大鼠生殖激素含量影响的研究[J].锦州医学院学报,2006,27(1):18-22.
[50]Modaresi M,Ghalamkari G,Jalalizand A.The Effect of celery(Apium graveolens)extract on the reproductive hormones in male mice[J].Apcbee Procedia,2012,4(1):99-104.
[51]Bail J C L,Laroche T,Marre-Fournier F,et al.Aromatase and 17β-hydroxysteroid dehydrogenase inhibition by flavonoids[J].Cancer Letters,1998,133(1):101-106.
[52]Jarabak J,Adams J A,Williams-Ashman H G,et al.Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function[J].Journal of Biological Chemistry,1962,237(2):345-357.
[53]Dall’eraa M A,Bangma C,Carroll P R,et al.Active surveillance for prostate cancer:A systematic review of the literature[J].European Urology,2012,62(6):976-983.
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