普瑞巴林对癌性神经病理性疼痛患者睡眠和抑郁的疗效
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摘要
目的探讨普瑞巴林联合吗啡、恩丹西酮、羟考酮控释片对癌性神经病理性疼痛患者睡眠和抑郁的影响。方法用随机数字法将178例癌性神经病理性疼痛患者分为2组,每组89例。对照组给予吗啡150.0mg和恩丹西酮16.0 mg,溶于0.9%氯化钠注射溶液150 m L中,滴注,完成后给予羟考酮控释片,口服,20 mg,2次/天。观察组加用普瑞巴林,口服,150 mg,2次/天。比较两组镇痛效果、睡眠情况(MOS量表)、抑郁情况[密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)]。结果观察组疼痛缓解率为8.89%,显著高于对照组的69.66%(P<0.05)。治疗后,观察组MOS-SS量表综合睡眠障碍指数、睡眠量、睡眠干扰、睡眠充足度显著改善(P<0.05),且优于对照组(P<0.05)。治疗后,两组HAMA、HAMD显著降低(P<0.05),且观察组HAMA、HAMD显著低于对照组(P<0.05)。结论普瑞巴林联合吗啡、恩丹西酮、羟考酮控释片可有效缓解癌性神经病理性疼痛患者的疼痛,改善睡眠质量和抑郁状态。
Objective To investigate the effects of pregabalin combined morphine,ondansetron,and oxycodone controlled release tablets on sleep and depression of patients with cancerous neuropathic pain. Methods 178 patients with cancerous neuropathic pain were divided into two groups by randomized digital method and each group had 89 cases. The control group was routinely given morphine,ondansetron and oxycodone controlled release tablets,and the observation group was added with pregabalin besides the drugs used in the control group. The analgesic effects,sleep( MOS scale) and depression( HAMA and HAMD) of two groups were compared. Results The pain relief rate of observation group was 89. 89%,which was significantly higher than that of control group( 69. 66%,P < 0. 05). After the treatment,the 9-items,SLPQ,SLPA and SLPD in MOS-SS table of observation group were significantly improved compared with the control group( P < 0. 05). After the treatment,HAMA and HAMD of two groups were significantly decreased( P <0. 05),and HAMA and HAMD of observation group were significantly lower than those of control group( P < 0. 05).Conclusion Pregabalin combined morphine may effectively relieve the pain of patients with cancerous neuropathic pain and improve sleep quality and depression.
Objective To investigate the effects of pregabalin combined morphine,ondansetron,and oxycodone controlled release tablets on sleep and depression of patients with cancerous neuropathic pain. Methods 178 patients with cancerous neuropathic pain were divided into two groups by randomized digital method and each group had 89 cases. The control group was routinely given morphine,ondansetron and oxycodone controlled release tablets,and the observation group was added with pregabalin besides the drugs used in the control group. The analgesic effects,sleep( MOS scale) and depression( HAMA and HAMD) of two groups were compared. Results The pain relief rate of observation group was 89. 89%,which was significantly higher than that of control group( 69. 66%,P < 0. 05). After the treatment,the 9-items,SLPQ,SLPA and SLPD in MOS-SS table of observation group were significantly improved compared with the control group( P < 0. 05). After the treatment,HAMA and HAMD of two groups were significantly decreased( P <0. 05),and HAMA and HAMD of observation group were significantly lower than those of control group( P < 0. 05).Conclusion Pregabalin combined morphine may effectively relieve the pain of patients with cancerous neuropathic pain and improve sleep quality and depression.
引文
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[11]郑昊龙,周晓虎,杜威,等.羟考酮缓释片联合普瑞巴林治疗中重度非癌性神经病理性疼痛临床观察[J].中国疼痛医学杂志,2016,22(5):389-392.
[12]汪庆玎,吴鹏.普瑞巴林联合阿片类药物治疗癌性神经病理性疼痛临床疗效观察[J].中国实用神经疾病杂志,2017,20(1):89-91.
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[14]缪保红.吗啡异丙嗪合用治疗晚期重度癌性疼痛27例临床观察[J].中国临床保健杂志,2007,10(4):397-398.
[15]杜红,程竞.普瑞巴林联合阿片类药物治疗癌性神经病理性疼痛的效果观察[J].中国现代普通外科进展,2016,19(12):981-983.
[2]何静,李嫚,刘聪颖,等.应用髂筋膜间隙阻滞减轻老年股骨近端骨折行股骨髁上和胫骨结节骨牵引的早期疼痛及术前宣教[J].中国临床保健杂志,2014,17(2):185-186.
[3]苏伟.富氢液联合羟考酮控释片对癌性神经病理性疼痛的临床疗效观察[J].天津药学,2016,28(3):33-35.
[4]李春香,乔三福.亚甲蓝硬膜外镇痛对癌痛及伴发神经病理性疼痛的疗效观察[J].临床和实验医学杂志,2016,15(11):1103-1105.
[5]王抒,乔田奎,袁素娟,等.奥施康定联合加巴喷丁对癌性神经病理性疼痛患者的效果观察[J].中国综合临床,2015,31(12):1107-1111.
[6]尚杰,陈玉龙,汪静,等.度洛西汀治疗癌性神经病理性疼痛伴抑郁患者的临床疗效[J].中华行为医学与脑科学杂志,2015,24(4):350-352.
[7]劳玲娟,艾卫民,严水根.羟考酮治疗晚期结肠癌癌性神经病理性疼痛的临床疗效和机制[J].中国生化药物杂志,2017,37(3):215-218.
[8]谢希晖,倪建锋,罗丽琼,等.药师参与镇痛辅助药物治疗癌性神经病理性疼痛效果分析[J].中国药事,2016,30(11):1161-1166.
[9]李登峰,颜明.富氢液联合羟考酮控释片对癌性神经病理性疼痛的临床疗效观察[J].中国医师杂志,2016,18(9):1329-1331,1335.
[10]杜红,程竞.普瑞巴林联合阿片类药物治疗癌性神经病理性疼痛的效果观察[J].中国现代普通外科进展,2016,19(12):981-983.
[11]郑昊龙,周晓虎,杜威,等.羟考酮缓释片联合普瑞巴林治疗中重度非癌性神经病理性疼痛临床观察[J].中国疼痛医学杂志,2016,22(5):389-392.
[12]汪庆玎,吴鹏.普瑞巴林联合阿片类药物治疗癌性神经病理性疼痛临床疗效观察[J].中国实用神经疾病杂志,2017,20(1):89-91.
[13]成宪江,刘维帅,王昆.神经妥乐平联合羟考酮控释片治疗癌性神经病理性疼痛的疗效观察[J].中国肿瘤临床,2015,42(11):546-549.
[14]缪保红.吗啡异丙嗪合用治疗晚期重度癌性疼痛27例临床观察[J].中国临床保健杂志,2007,10(4):397-398.
[15]杜红,程竞.普瑞巴林联合阿片类药物治疗癌性神经病理性疼痛的效果观察[J].中国现代普通外科进展,2016,19(12):981-983.