中药水煎液中槲皮素-金属配合物的研究
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摘要
目的为了探究中药水煎液中是否存在有机成分与金属微量元素形成的配合物。方法研究槲皮素与5种金属离子在热水中形成配合物的能力,并在此基础上,用高效液相色谱仪对甲醇和20%甲酸-甲醇分别溶解的四种含槲皮素的中药的水提物进行分析。结果槲皮素与Cu~(2+)和Fe~(3+)形成配合物的能力较强。用20%甲酸-甲醇做溶剂时,山楂、黄山贡菊、鱼腥草和紫花地丁水提物中槲皮素的峰面积较甲醇做溶剂时分别增加了37.55%、207.35%、378.53%和234.68%。结论在水煎煮过程中,槲皮素会与中药中存在的金属微量元素形成配合物。
引文
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[2] Wojcieszek J,Kwiatkowski P,Ruzik L.Speciation analysis and bioaccessibility evaluation of trace elements in goji berries ( Lycium Barbarum,L.) [J].J Chromatogr A,2017,1492:70.
[3] Weber G,Konieczyński P.Speciation of Mg,Mn and Zn in extracts of medicinal plants[J].Anal Bioanal Chem,2003,375(8):1067.
[4] Liu F,Pei F,Mariga A M,et al.Separation and speciation analysis of zinc from Flammulina velutipes[J].J Food Drug Anal,2015,23(4):630.
[5] Dueňas M,Surco-Laos F,González-Manzano S,et al.Antioxidant properties of major metabolites of quercetin[J].Eur Food Res Technol,2011,232(1):103.
[6] Amic A,Lucic B,Stepanic V,et al.,et al.Free radical scavenging potency of quercetin catecholic colonic metabolites:Thermodynamics of 2H+/2e- processes[J].Food Chen 2017,218:144.
[7] Derlindati E,Dall' Asta M,Ardigò D,et al.Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects[J].Food Funct,2012,3(11):1144.
[8] Boesch-Saadatmandi C,Loboda A,Wagner A E,et al.Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression:role of miR-155[J].J Nut Biochem,2011,22(3):293.
[9] Catarino M D,Talhi O,Rabahi A,et al.The Antiinflammatory Potential of Flavonoids:Mechanistic Aspects [J].Stud Nat Prod Chem.Elsevier,2016,48:65.
[10] Lesjak M,Beara I,Simin N,et al.Antioxidant and anti-inflammatory activities of quercetin and its derivatives[J].J Funct Foods,2018,40:68.
[11] Jones D J L,Lamb J H,Verschoyle R D,et al.Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity[J].Br J Camcer,2004,91(6):1213.
[12] Serban M C,Sahebkar A,Zanchetti A,et al.Effects of quercetin on blood pressure:a systematic review and meta‐analysis of randomized controlled trials[J].J Am Heart Assoc,2016,5(7):2003.
[13] Dajas F.Life or death:neuroprotective and anticancer effects of quercetin[J].J Ethnopharmacol,2012,143(2):383.
[14] Chuang C H,Yeh C L,Yeh S L,et al.Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms[J].J Nut Biochem,2016,33:45.
[15] 谭君,王伯初,祝连彩.槲皮素金属配合物的药理作用研究进展[J].中国药学杂志,2006,41(22):1688.
[16] 翟广玉,渠文涛,马海英,等.槲皮素金属配合物的研究进展[J].化学试剂,2013,35(2):140.
[17] 李婷,胡晓荣,郝阳.槲皮素金属配合物的研究进展[J].化学与生物工程,2012,29(12):19.
[18] Ghosh N,Chakraborty T,Mallick S,et al.Synthesis,characterization and study of antioxidant activity of quercetin-magnesium complex[J].Spectrochim Acta A Mol Biomol Spectrosc,2015,151:807.
[19] Bukhari S B,Memon S,Tahir M M,et al.Synthesis,characterization and investigation of antioxidant activity of cobalt-quercetin complex[J].J Mol Struct,2008,892(1-3):39.
[20] Bukhari S B,Memon S,Mahroof-Tahir M,et al.Synthesis,characterization and antioxidant activity copper-quercetin complex[J].Spectrochim Acta A Mol Biomol Spectrosc,2009,71(5):1901.
[21] Vimalraj S,Rajalakshmi S,Preeth D R,et al.Mixed-ligand copper (II) complex of quercetin regulate osteogenesis and angiogenesis[J].Mat Sci Eng C,2018,83:187.
[22] Torreggiani A,Tamba M,Trinchero A,et al.Copper (II)-Quercetin complexes in aqueous solutions:spectroscopic and kinetic properties[J].J Mol Struct,2005,744:759.
[23] Chen W,Sun S,Liang Y,et al.Antioxidant property of quercetin-Cr (III) complex:The role of Cr (III) ion[J].J Mol Struct,2009,918(1-3):194.
[24] Cornard J P,Merlin J C.Spectroscopic and structural study of complexes of quercetin with Al (III)[J].J Inorg Biochem,2002,92(1):19.
[25] Dehghan G,Khoshkam Z.Tin (II)-quercetin complex:Synthesis,spectral characterisation and antioxidant activity[J].Food Chem,2012,131(2):422.
[26] Kuntic V,Blagojevic S,Malecev D,et al.Spectrophotometric Investigation of the Pd(II)-Quercetin Complex in 50% Ethanol[J].Monatshefte Für Chemie,1998,129(1):41.
[27] Ren J,Meng S,Lekka C E,et al.Complexation of flavonoids with iron:structure and optical signatures[J].J Phys Chem B,2008,112(6):1845.
[28] Xiao L,Luo G,Tang Y,et al.Quercetin and iron metabolism:What we know and what we need to know[J].Food and Chemical Toxicology,2018,114:190.
[29] Ravichandran R,Rajendran M,Devapiriam D.Antioxidant study of quercetin and their metal complex and determination of stability constant by spectrophotometry method[J].Food Chem,2014,146:472.
[30] Zhou J,Wang L,Wang J,et al.Antioxidative and anti-tumour activities of solid quercetin metal (II) complexes[J].Transit Metal Chem,2001,26(1-2):57.
[31] Rusak G,Piantanida I,Bretschneider S,et al.Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA[J].J Inorg Biochem,2009,103(12):1597.
[32] Nowak D,Woznicka E,Kuzniar A,et al.Magnetism of the lanthanides (III) complexes with some polihydroxyflavones[J].J Alloys Comp,2006,425(1-2):59.