苦瓜桑椹复合饮的研制
|
摘要
目的探讨苦瓜桑椹复合饮的最优制备工艺。方法分别建立有效成分槲皮素和苦瓜素的高效液相色谱分析方法,探讨不同稳定剂羧甲基纤维素、海藻酸钠、明胶对苦瓜桑椹复合饮制剂生物利用度和稳定性的影响。结果成功建立苦瓜桑椹复合饮有效成分的高效液相色谱分析方法,得到选取0.1%海藻酸钠作为稳定剂有助于确保制剂生物利用度和稳定性。结论选取0.1%海藻酸钠作为苦瓜桑椹复合饮的稳定剂具有口感好、携带方便等优点,稳定性好,生物利用度高,对2型糖尿病的治疗具有一定的促进作用。
OBJECTIVE To optimize preparation process of thecompound beverage from balsam pear and mulberry. METHODS To establish an efficient method for simultaneously detecting both of quercetin and Charantin in the compound beverage of balsam pear and mulberry by high performance liquid chromatography( HPLC). To investigate the influences of stability and bioavailability on the compound beverage of balsam pear and mulberry by adding different stabilizing agents including Carboxymethyl cellulose,sodium alginate,gelatin etc. RESULTS Establish a method for the determination of effective constituent from the compound beverage of balsam pear and mulberry by HPLC. 1% sodium alginate as stabilizing agents can conduce to keep bioavailability and stability of it. CONCLUSION The compound beverage of balsam pear and mulberry including 1% sodium alginate as stabilizing agents with good mouthfeel is convenient to carry. It has high bioavailability and good stability,also has some treatment in type 2 diabetes mellitus.
OBJECTIVE To optimize preparation process of thecompound beverage from balsam pear and mulberry. METHODS To establish an efficient method for simultaneously detecting both of quercetin and Charantin in the compound beverage of balsam pear and mulberry by high performance liquid chromatography( HPLC). To investigate the influences of stability and bioavailability on the compound beverage of balsam pear and mulberry by adding different stabilizing agents including Carboxymethyl cellulose,sodium alginate,gelatin etc. RESULTS Establish a method for the determination of effective constituent from the compound beverage of balsam pear and mulberry by HPLC. 1% sodium alginate as stabilizing agents can conduce to keep bioavailability and stability of it. CONCLUSION The compound beverage of balsam pear and mulberry including 1% sodium alginate as stabilizing agents with good mouthfeel is convenient to carry. It has high bioavailability and good stability,also has some treatment in type 2 diabetes mellitus.
引文
[1]Xu Y,Wang L,He J et al.Prevalentand control of diabetes in Chinese adults[J].JAMA,2013,310(9):948-959.
[2]林杏娟.2型糖尿病合并早期糖尿病肾病的相关危险因素分析[J].当代医学,2013,19(20):5-6.
[3]Ayanian JZ,Landon BE,Newhouse JP et al.Racial and ethnic disparities among enrollees in Medicare Advantage plans[J].New Engl JMed,2014,371(24):2288-2297.
[4]孟艳秋,刘文虎,刘凤鑫,等.抗2型糖尿病药物研究进展[J].现代药物与临床,2013,28(3):461-464.
[5]张银堂,陈芳,孙焱焱,等.分散液液微萃取用于苦瓜HPLC指纹图谱的研究[J].广州化工,2011,12(17):8-10.
[6]夏清,黄艳菲,杨正明,等.HPLC法测定商品苦荞茶中槲皮素和山奈酚含量[J].西南大学学报(自然科学版),2014,15(10):200-204.
[7]Ahmed,I,Adeghate,E,Sharma,A et al.Effects of Momordica charantia fruit juiceonisletmorphology in the pancreas of the streptozotocin diabetic ra[tJ].Diabetes research clinical practice,1998,40(10):145-151.
[8]余小雁,韦国麟,林羽慧,等.新型口服苦瓜桑椹饮料的制备工艺研究[J].海峡药学,2015,27(5):27-30.
[9]赵骏,高岚.桑叶多糖的降糖降脂作用[J].天津中医药,2004,21(6):505-506.
[10]韦国麟,余小雁,邓义卫.苦瓜桑椹复合饮料对2型糖尿病大鼠胰岛素抵抗的影响[J].黑龙江医药,2013,26(6):53-57.
[2]林杏娟.2型糖尿病合并早期糖尿病肾病的相关危险因素分析[J].当代医学,2013,19(20):5-6.
[3]Ayanian JZ,Landon BE,Newhouse JP et al.Racial and ethnic disparities among enrollees in Medicare Advantage plans[J].New Engl JMed,2014,371(24):2288-2297.
[4]孟艳秋,刘文虎,刘凤鑫,等.抗2型糖尿病药物研究进展[J].现代药物与临床,2013,28(3):461-464.
[5]张银堂,陈芳,孙焱焱,等.分散液液微萃取用于苦瓜HPLC指纹图谱的研究[J].广州化工,2011,12(17):8-10.
[6]夏清,黄艳菲,杨正明,等.HPLC法测定商品苦荞茶中槲皮素和山奈酚含量[J].西南大学学报(自然科学版),2014,15(10):200-204.
[7]Ahmed,I,Adeghate,E,Sharma,A et al.Effects of Momordica charantia fruit juiceonisletmorphology in the pancreas of the streptozotocin diabetic ra[tJ].Diabetes research clinical practice,1998,40(10):145-151.
[8]余小雁,韦国麟,林羽慧,等.新型口服苦瓜桑椹饮料的制备工艺研究[J].海峡药学,2015,27(5):27-30.
[9]赵骏,高岚.桑叶多糖的降糖降脂作用[J].天津中医药,2004,21(6):505-506.
[10]韦国麟,余小雁,邓义卫.苦瓜桑椹复合饮料对2型糖尿病大鼠胰岛素抵抗的影响[J].黑龙江医药,2013,26(6):53-57.