超声介入在治疗婴幼儿头颈部淋巴管畸形中的应用
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摘要
目的观察超声介入注射博来霉素在婴幼儿头颈部淋巴管畸形(lymphatic malformation,LM)中的治疗效果。方法回顾性分析36例婴幼儿头颈部LM患儿的临床资料,使用超声介入注射博来霉素的方法,随访3～6个月。结果 36例患儿治疗结果,治愈率为94.44%,有效率为5.56%,未出现过敏、肺纤维化等严重不良反应。结论超声介入治疗婴幼儿头颈部LM,简单,定位精确,创伤小,可大大降低围术期风险,可考虑作为首选的治疗方式。
Objective To observe the curative effect of ultrasound intervention treatment of obleomycin injection in the treatment of head and neck lymphatic malformation among infants.Me thods The clinical data of 36 infants with head and neck lymphatic malformation were analyzed retrospectively.They were treated with ultrasound intervention treatment of obleomycin injection and given a follow-up study after 3 ～6 months.Re s ults The cure rate of those 36 infants was 94.44% and the effective rate was 5.56%.No serious adverse reactions,such as allergy and pulmonary fibrosis occurred.Conclus ion Ultrasound intervention treatment of large lymphatic malformation in head and neck of infants was convenient,accurate in localization and small in trauma,which can greatly reduce perioperative risk and could be considered as the preferred treatment.
Objective To observe the curative effect of ultrasound intervention treatment of obleomycin injection in the treatment of head and neck lymphatic malformation among infants.Me thods The clinical data of 36 infants with head and neck lymphatic malformation were analyzed retrospectively.They were treated with ultrasound intervention treatment of obleomycin injection and given a follow-up study after 3 ～6 months.Re s ults The cure rate of those 36 infants was 94.44% and the effective rate was 5.56%.No serious adverse reactions,such as allergy and pulmonary fibrosis occurred.Conclus ion Ultrasound intervention treatment of large lymphatic malformation in head and neck of infants was convenient,accurate in localization and small in trauma,which can greatly reduce perioperative risk and could be considered as the preferred treatment.
引文
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[9] Lee KH,Han SH,Yoon JS. Successful treatment of orbital lymphangioma with intralesional bleomycin and application of continuous negative pressure[J]. Korean J Ophthalmol,2015,29(1):70-72.
[10] Chakravarti A,Bhargava R. Lymphangioma circumscriptum of the tongue in children:successful treatment using intralesional bleomycin[J]. Int J Pediatr Otorhinolaryngol,2013,77(8):1367-1369.
[11]谭小云,张靖,周少毅,等.新生儿颈部大囊型淋巴管畸形的介入硬化治疗[J].中华小儿外科杂志,2013,34(10):725-728.
[12] Chen WL,Zhang B,Wang JG,et al. Surgical excision of cervicofacial giant macrocystic lymphatic malformations in infants and children[J]. Int J Pediatr Otorhinolaryngol,2009,73(6):833-837.
[13] Okazaki T,Iwatani S,Yanai T,et al. Treatment of lymphangioma in children:our experience of 128 cases[J].Journal of Pediatric Surgery,2007,42(2):386-389.
[14]韩涛,邹继军,陈海妮,等.单一中心婴幼儿淋巴管畸形治疗的效果分析[J].中华整形外科杂志,2017,33(2):84-90.
[2]中华医学会整形外科分会血管瘤和脉管畸形学组.血管瘤和脉管畸形诊断和治疗指南(2016版)[J].组织工程与重建外科,2016,12(2):63-93.
[3] Hanif AM,Saunders JA,Hawkins CM,et al. Use of percutaneous bleomycin sclerotherapy for orbital lymphatic malformations[J]. Orbit,2018(1):1-7.
[4] Sanlialp I,Karnak I,Tanyel FC,et al. Sclerotherapy for lymphangioma in children[J]. International Journal of Pediatric Otorhinolaryngology,2003,67(7):795.
[5] Waner M,Suen JY. Management of congenital vascular lesions of the head and neck[J]. Oncology,1995,9(10):989.
[6]赵福运.淋巴管畸形的诊断和治疗[J].中华口腔医学杂志,2008,43(6):339-342.
[7]郑家伟,秦中平,张志愿.口腔颌面部淋巴管畸形的治疗[J].上海口腔医学,2005,14(6):553-556.
[8] Hwang J,Lee YK,Jin SB. Treatment of Tongue Lymphangioma with Intralesional Combination Injection of Steroid,Bleomycin and Bevacizumab[J]. Archives of Craniofacial Surgery,2017,18(1):54.
[9] Lee KH,Han SH,Yoon JS. Successful treatment of orbital lymphangioma with intralesional bleomycin and application of continuous negative pressure[J]. Korean J Ophthalmol,2015,29(1):70-72.
[10] Chakravarti A,Bhargava R. Lymphangioma circumscriptum of the tongue in children:successful treatment using intralesional bleomycin[J]. Int J Pediatr Otorhinolaryngol,2013,77(8):1367-1369.
[11]谭小云,张靖,周少毅,等.新生儿颈部大囊型淋巴管畸形的介入硬化治疗[J].中华小儿外科杂志,2013,34(10):725-728.
[12] Chen WL,Zhang B,Wang JG,et al. Surgical excision of cervicofacial giant macrocystic lymphatic malformations in infants and children[J]. Int J Pediatr Otorhinolaryngol,2009,73(6):833-837.
[13] Okazaki T,Iwatani S,Yanai T,et al. Treatment of lymphangioma in children:our experience of 128 cases[J].Journal of Pediatric Surgery,2007,42(2):386-389.
[14]韩涛,邹继军,陈海妮,等.单一中心婴幼儿淋巴管畸形治疗的效果分析[J].中华整形外科杂志,2017,33(2):84-90.