普鲁兰多糖的改性处理研究进展
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摘要
通过对国内外普鲁兰多糖的改性处理进行分析和总结,从物理改性和化学改性两个方面介绍普鲁兰多糖改性处理的方法以及改性物的应用,概述普鲁兰多糖的改性处理研究进展,为进一步开发和应用普鲁兰多糖提供科学的研究基础。分析表明,普鲁兰多糖的改性处理可以改善其性能,或提供活性基团使其带有电负性,进一步拓展普鲁兰多糖的应用范围。然而,改性处理对普鲁兰多糖分子结构的变化的影响及官能团的取代位置还有待进一步的研究。
The research progress of pullulan at home and abroad was analyzed and summarized. The modification methods of pullulan and the application of modified materials were introduced from two aspects of physical modification and chemical modification. The research of the modification of pullulan provided a scientific research basis for further development and application of pullulan. Analysis showed that the modification of pullulan can improve its performance,or provide active groups to make it electronegatable,further expanding the application of pullulan. However,the effect of modification on the molecular structure of pullulan and the substitution position of functional groups had yet to be further studied.
The research progress of pullulan at home and abroad was analyzed and summarized. The modification methods of pullulan and the application of modified materials were introduced from two aspects of physical modification and chemical modification. The research of the modification of pullulan provided a scientific research basis for further development and application of pullulan. Analysis showed that the modification of pullulan can improve its performance,or provide active groups to make it electronegatable,further expanding the application of pullulan. However,the effect of modification on the molecular structure of pullulan and the substitution position of functional groups had yet to be further studied.
引文
[1]Cheng K C,Demirci A,Catchmark J M.Pullulan:biosynthesis,production,and applications[J].Applied Microbiology And Biotechnology,2011,92(1):29-44
[2]Hassannia-Kolaee M,Khodaiyan F,Pourahmad R,et al.Development of ecofriendly bionanocomposite:Whey protein isolate/pullulan films with nano-SiO2[J].International Journal Of Biological Macromolecules,2016,86:139-144
[3]常帆,贾凤安,吕睿,等.高分子量普鲁兰多糖保鲜复合膜的制备及性能研究[J].食品科技,2017,42(8):206-211
[4]Sheng L,Zhu G L,Tong Q Y.Effect of uracil on pullulan production by Aureobasidium pullulans CGMCC1234[J].Carbohydrate Polymers,2014,101:435-437
[5]Roukas T,Mantzouridou F.Effect of the aeration rate on pullulan production and fermentation broth theological properties in an airlift reactor[J].Journal Of Chemical Technology And Biotechnology,2001,76(4):371-376
[6]Rekha M R,Sharma C P.Blood compatibility and in vitro transfection studies on cationically modified pullulan for liver cell targeted gene delivery[J].Biomaterials,2009,30(34):6655-6664
[7]Sugumaran K R,Sindhu R V,Sukanya S,et al.Statistical studies on high molecular weight pullulan production in solid state fermentation using jack fruit seed[J].Carbohydrate Polymers,2013,98(1):854-860
[8]Leathers T D.Biotechnological production and applications of pullulan[J].Applied Microbiology And Biotechnology,2003,62(5/6):468-473
[9]Shao P,Niu B,Chen H,et al.Fabrication and characterization of tea polyphenols loaded pullulan-CMC electrospun nanofiber for fruit preservation[J].International Journal Of Biological Macromolecules,2018,107:1908-1914
[10]Zhang S,Wei F,Han X.An edible film of sodium alginate/pullulan incorporated with capsaicin[J].New Journal Of Chemistry,2018,42(21):17756-17761
[11]Lu H,Peng J,Miao K.Characteristic of pullulan and its application in food and biomedicine[J].Journal of Biology,2010,27(3):93-95
[12]Sugumaran K R,Ponnusami V.Review on production,downstream processing and characterization of microbial pullulan[J].Carbohydrate Polymers,2017,173:573-591
[13]卢辉官,彭景,缪康杰.普鲁兰的特性及其在食品和医学上的应用[J].生物学杂志,2010,27(3):93-95
[14]Liexi W.Biosynthesis and Application of Pullulan in Food Industry[J].Journal of Anhui Agricultural Sciences,2008,36(23):10184-10185,10273
[15]Li X,Xue W,Liu Y,et al.HLC/pullulan and pullulan hydrogels:their microstructure,engineering process and biocompatibility[J].Materials Science&Engineering C-Materials for Biological Applications,2016,58:1046-1057
[16]Singh R S,Kaur N,Kennedy J F.Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting[J].Carbohydrate Polymers,2015,123:190-207
[17]张欣然.羧甲基普鲁兰-氯化铝复合絮凝剂絮凝性能及机理研究[D].武汉:华中科技大学,2011
[18]Bang S,Ko Y-G,Kim W I,et al.Preventing postoperative tissue adhesion using injectable carboxymethyl cellulose-pullulan hydrogels[J].International Journal Of Biological Macromolecules,2017,105:886-893
[19]Laksee S,Puthong S,Kongkavitoon P,et al.Facile and green synthesis of pullulan derivative-stabilized Au nanoparticles as drug carriers for enhancing anticancer activity[J].Carbohydrate Polymers,2018,198:495-508
[20]Yang X-C,Niu Y-L,Zhao N-N,et al.A biocleavable pullulanbased vector via ATRP for liver cell-targeting gene delivery[J].Biomaterials,2014,35(12):3873-3884
[21]Guerrero J,Oliveira H,Catros S,et al.The Use of Total Human Bone Marrow Fraction in a Direct Three-Dimensional Expansion Approach for Bone Tissue Engineering Applications:Focus on Angiogenesis and Osteogenesis[J].Tissue Engineering Part A,2015,21(5/6):861-874
[22]Prajapati V D,Jani G K,Khanda S M.Pullulan:An exopolysaccharide and its various applications[J].Carbohydrate Polymers,2013,95(1):540-549
[23]Silva N H C S,Vilela C,Almeida A,et al.Pullulan-based nanocomposite films for functional food packaging:Exploiting lysozyme nanofibers as antibacterial and antioxidant reinforcing additives[J].Food Hydrocolloids,2018,77:921-930
[24]王大慧,巨晓敏,卫功元.表面活性剂提高生物转化合成普鲁兰的效率[J].食品科学,2019,28(3):1-10
[25]Singh R S,Kaur N,Sharma R,et al.Carbamoylethyl pullulan:QbDbased synthesis,characterization and corneal wound healing potential[J].International Journal of Biological Macromolecules,2018,118:2245-2255
[26]肖茜,童群义.普鲁兰多糖/海藻酸钠/羧甲基纤维素钠复合可食用包装膜性能的研究[J].食品工业科技,2009,30(5):286-288,292
[27]Diab T,Biliaderis C G,Gerasopoulos D,et al.Physicochemical properties and application of pullulan edible films and coatings in fruit preservation[J].Journal Of the Science Of Food And Agriculture,2001,81(10):988-1000
[28]Wu J,Zhong F,Li Y,et al.Preparation and characterization of pullulan-chitosan and pullulan-carboxymethyl chitosan blended films[J].Food Hydrocolloids,2013,30(1):82-91
[29]Kim J-Y,Choi Y-G,Kim S R B,et al.Humidity stability of tapioca starch-pullulan composite films[J].Food Hydrocolloids,2014,41:140-145
[30]Trevino-Garza M Z,Garcia S,Heredia N,et al.Layer-by-layer edible coatings based on mucilages,pullulan and chitosan and its effect on quality and preservation of fresh-cut pineapple(Ananas comosus)[J].Postharvest Biology And Technology,2017,128:63-75
[31]葛晨,商梦洁,陶双双,等.普鲁兰多糖/槐糖脂抑菌保鲜膜的制备[J].食品工业科技,2018,39(9):222-227
[32]Synowiec A,Gniewosz M,Krasniewska K,et al.Antimicrobial and antioxidant properties of pullulan film containing sweet basil extract and an evaluation of coating effectiveness in the prolongation of the shelf life of apples stored in refrigeration conditions[J].Innovative Food Science&Emerging Technologies,2014,23:171-181
[33]Wu S J,Chen J H.Using pullulan-based edible coatings to extend shelf-life of fresh-cut'Fuji'apples[J].International Journal of Biological Macromolecules,2013,55:254-257
[34]Jafari S M,Khanzadi M,Mirzaei H,et al.Hydrophobicity,thermal and micro-structural properties of whey protein concentrate-pullulan-beeswax films[J].International Journal Of Biological Macromolecules,2015,80:506-511
[35]Bercea M,Biliuta G,Avadanei M,et al.Self-healing hydrogels of oxidized pullulan and poly(vinyl alcohol)[J].Carbohydrate Polymers,2019,206:210-219
[36]Liang Y P,Zhao X,Ma P X,et al.pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery[J].Journal Of Colloid And Interface Science,2019,536:224-234
[37]Chen F,Yu S,Liu B,et al.An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering[J].Scientific Reports,2016,6:20014
[38]陈宏洋,张航,李星星,等.生物素化乙酰普鲁兰多糖耦联CD3纳米粒的制备及T细胞摄取效应[J].医学研究生学报,2018,31(10):1014-1019
[39]Ravi P R,Vats R,Balija J,et al.Modified pullulan nanoparticles for oral delivery of lopinavir:Formulation and pharmacokinetic evaluation[J].Carbohydrate Polymers,2014,110:320-328
[40]Yuan L,Cao Y,Luo Q,et al.Pullulan-Based Nanoparticle-HSAComplex Formation and Drug Release Influenced by Surface Charge[J].Nanoscale Research Letters,2018,13:317
[41]Mocanu G,Nichifor M,Picton L,et al.Preparation and characterization of anionic pullulan thermoassociative nanoparticles for drug delivery[J].Carbohydrate Polymers,2014,111:892-900
[42]Dionisio M,Cordeiro C,Remunan-Lopez C,et al.Pullulan-based nanoparticles as carriers for transmucosal protein delivery[J].European Journal of Pharmaceutical Sciences,2013,50(1):102-113
[43]Wang X,Zhang D,Wang J,et al.Succinyl pullulan-crosslinked carboxymethyl chitosan sponges for potential wound dressing[J].International Journal Of Polymeric Materials And Polymeric Biomaterials,2017,66(2):61-70
[44]Fernandes S C M,Sadocco P,Causio J,et al.Antimicrobial pullulan derivative prepared by grafting with 3-aminopropyltrimethoxysilane:Characterization and ability to form transparent films[J].Food Hydrocolloids,2014,35:247-252
[45]Soni S R,Kumari N,Bhunia B K,et al.Synthesis and characterization of a non-cytotoxic and biocompatible acrylamide grafted pullulan-Application in p H responsive controlled drug delivery[J].International Journal of Biological Macromolecules,2018,120(Pt A):753-762
[2]Hassannia-Kolaee M,Khodaiyan F,Pourahmad R,et al.Development of ecofriendly bionanocomposite:Whey protein isolate/pullulan films with nano-SiO2[J].International Journal Of Biological Macromolecules,2016,86:139-144
[3]常帆,贾凤安,吕睿,等.高分子量普鲁兰多糖保鲜复合膜的制备及性能研究[J].食品科技,2017,42(8):206-211
[4]Sheng L,Zhu G L,Tong Q Y.Effect of uracil on pullulan production by Aureobasidium pullulans CGMCC1234[J].Carbohydrate Polymers,2014,101:435-437
[5]Roukas T,Mantzouridou F.Effect of the aeration rate on pullulan production and fermentation broth theological properties in an airlift reactor[J].Journal Of Chemical Technology And Biotechnology,2001,76(4):371-376
[6]Rekha M R,Sharma C P.Blood compatibility and in vitro transfection studies on cationically modified pullulan for liver cell targeted gene delivery[J].Biomaterials,2009,30(34):6655-6664
[7]Sugumaran K R,Sindhu R V,Sukanya S,et al.Statistical studies on high molecular weight pullulan production in solid state fermentation using jack fruit seed[J].Carbohydrate Polymers,2013,98(1):854-860
[8]Leathers T D.Biotechnological production and applications of pullulan[J].Applied Microbiology And Biotechnology,2003,62(5/6):468-473
[9]Shao P,Niu B,Chen H,et al.Fabrication and characterization of tea polyphenols loaded pullulan-CMC electrospun nanofiber for fruit preservation[J].International Journal Of Biological Macromolecules,2018,107:1908-1914
[10]Zhang S,Wei F,Han X.An edible film of sodium alginate/pullulan incorporated with capsaicin[J].New Journal Of Chemistry,2018,42(21):17756-17761
[11]Lu H,Peng J,Miao K.Characteristic of pullulan and its application in food and biomedicine[J].Journal of Biology,2010,27(3):93-95
[12]Sugumaran K R,Ponnusami V.Review on production,downstream processing and characterization of microbial pullulan[J].Carbohydrate Polymers,2017,173:573-591
[13]卢辉官,彭景,缪康杰.普鲁兰的特性及其在食品和医学上的应用[J].生物学杂志,2010,27(3):93-95
[14]Liexi W.Biosynthesis and Application of Pullulan in Food Industry[J].Journal of Anhui Agricultural Sciences,2008,36(23):10184-10185,10273
[15]Li X,Xue W,Liu Y,et al.HLC/pullulan and pullulan hydrogels:their microstructure,engineering process and biocompatibility[J].Materials Science&Engineering C-Materials for Biological Applications,2016,58:1046-1057
[16]Singh R S,Kaur N,Kennedy J F.Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting[J].Carbohydrate Polymers,2015,123:190-207
[17]张欣然.羧甲基普鲁兰-氯化铝复合絮凝剂絮凝性能及机理研究[D].武汉:华中科技大学,2011
[18]Bang S,Ko Y-G,Kim W I,et al.Preventing postoperative tissue adhesion using injectable carboxymethyl cellulose-pullulan hydrogels[J].International Journal Of Biological Macromolecules,2017,105:886-893
[19]Laksee S,Puthong S,Kongkavitoon P,et al.Facile and green synthesis of pullulan derivative-stabilized Au nanoparticles as drug carriers for enhancing anticancer activity[J].Carbohydrate Polymers,2018,198:495-508
[20]Yang X-C,Niu Y-L,Zhao N-N,et al.A biocleavable pullulanbased vector via ATRP for liver cell-targeting gene delivery[J].Biomaterials,2014,35(12):3873-3884
[21]Guerrero J,Oliveira H,Catros S,et al.The Use of Total Human Bone Marrow Fraction in a Direct Three-Dimensional Expansion Approach for Bone Tissue Engineering Applications:Focus on Angiogenesis and Osteogenesis[J].Tissue Engineering Part A,2015,21(5/6):861-874
[22]Prajapati V D,Jani G K,Khanda S M.Pullulan:An exopolysaccharide and its various applications[J].Carbohydrate Polymers,2013,95(1):540-549
[23]Silva N H C S,Vilela C,Almeida A,et al.Pullulan-based nanocomposite films for functional food packaging:Exploiting lysozyme nanofibers as antibacterial and antioxidant reinforcing additives[J].Food Hydrocolloids,2018,77:921-930
[24]王大慧,巨晓敏,卫功元.表面活性剂提高生物转化合成普鲁兰的效率[J].食品科学,2019,28(3):1-10
[25]Singh R S,Kaur N,Sharma R,et al.Carbamoylethyl pullulan:QbDbased synthesis,characterization and corneal wound healing potential[J].International Journal of Biological Macromolecules,2018,118:2245-2255
[26]肖茜,童群义.普鲁兰多糖/海藻酸钠/羧甲基纤维素钠复合可食用包装膜性能的研究[J].食品工业科技,2009,30(5):286-288,292
[27]Diab T,Biliaderis C G,Gerasopoulos D,et al.Physicochemical properties and application of pullulan edible films and coatings in fruit preservation[J].Journal Of the Science Of Food And Agriculture,2001,81(10):988-1000
[28]Wu J,Zhong F,Li Y,et al.Preparation and characterization of pullulan-chitosan and pullulan-carboxymethyl chitosan blended films[J].Food Hydrocolloids,2013,30(1):82-91
[29]Kim J-Y,Choi Y-G,Kim S R B,et al.Humidity stability of tapioca starch-pullulan composite films[J].Food Hydrocolloids,2014,41:140-145
[30]Trevino-Garza M Z,Garcia S,Heredia N,et al.Layer-by-layer edible coatings based on mucilages,pullulan and chitosan and its effect on quality and preservation of fresh-cut pineapple(Ananas comosus)[J].Postharvest Biology And Technology,2017,128:63-75
[31]葛晨,商梦洁,陶双双,等.普鲁兰多糖/槐糖脂抑菌保鲜膜的制备[J].食品工业科技,2018,39(9):222-227
[32]Synowiec A,Gniewosz M,Krasniewska K,et al.Antimicrobial and antioxidant properties of pullulan film containing sweet basil extract and an evaluation of coating effectiveness in the prolongation of the shelf life of apples stored in refrigeration conditions[J].Innovative Food Science&Emerging Technologies,2014,23:171-181
[33]Wu S J,Chen J H.Using pullulan-based edible coatings to extend shelf-life of fresh-cut'Fuji'apples[J].International Journal of Biological Macromolecules,2013,55:254-257
[34]Jafari S M,Khanzadi M,Mirzaei H,et al.Hydrophobicity,thermal and micro-structural properties of whey protein concentrate-pullulan-beeswax films[J].International Journal Of Biological Macromolecules,2015,80:506-511
[35]Bercea M,Biliuta G,Avadanei M,et al.Self-healing hydrogels of oxidized pullulan and poly(vinyl alcohol)[J].Carbohydrate Polymers,2019,206:210-219
[36]Liang Y P,Zhao X,Ma P X,et al.pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery[J].Journal Of Colloid And Interface Science,2019,536:224-234
[37]Chen F,Yu S,Liu B,et al.An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering[J].Scientific Reports,2016,6:20014
[38]陈宏洋,张航,李星星,等.生物素化乙酰普鲁兰多糖耦联CD3纳米粒的制备及T细胞摄取效应[J].医学研究生学报,2018,31(10):1014-1019
[39]Ravi P R,Vats R,Balija J,et al.Modified pullulan nanoparticles for oral delivery of lopinavir:Formulation and pharmacokinetic evaluation[J].Carbohydrate Polymers,2014,110:320-328
[40]Yuan L,Cao Y,Luo Q,et al.Pullulan-Based Nanoparticle-HSAComplex Formation and Drug Release Influenced by Surface Charge[J].Nanoscale Research Letters,2018,13:317
[41]Mocanu G,Nichifor M,Picton L,et al.Preparation and characterization of anionic pullulan thermoassociative nanoparticles for drug delivery[J].Carbohydrate Polymers,2014,111:892-900
[42]Dionisio M,Cordeiro C,Remunan-Lopez C,et al.Pullulan-based nanoparticles as carriers for transmucosal protein delivery[J].European Journal of Pharmaceutical Sciences,2013,50(1):102-113
[43]Wang X,Zhang D,Wang J,et al.Succinyl pullulan-crosslinked carboxymethyl chitosan sponges for potential wound dressing[J].International Journal Of Polymeric Materials And Polymeric Biomaterials,2017,66(2):61-70
[44]Fernandes S C M,Sadocco P,Causio J,et al.Antimicrobial pullulan derivative prepared by grafting with 3-aminopropyltrimethoxysilane:Characterization and ability to form transparent films[J].Food Hydrocolloids,2014,35:247-252
[45]Soni S R,Kumari N,Bhunia B K,et al.Synthesis and characterization of a non-cytotoxic and biocompatible acrylamide grafted pullulan-Application in p H responsive controlled drug delivery[J].International Journal of Biological Macromolecules,2018,120(Pt A):753-762