血必净佐治老年重症肺炎伴呼吸衰竭临床评价
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摘要
目的探讨血必净佐治老年重症肺炎伴呼吸衰竭的临床疗效及对患者氧化应激状态的影响。方法选取医院2015年2月至2016年2月收治的老年重症肺炎伴呼吸衰竭患者86例,按随机数字表法分为对照组和研究组,各43例。两组患者均给予常规治疗,研究组患者加用血必净治疗,均治疗14 d。结果研究组总有效率为97. 67%,明显高于对照组的83. 72%(P <0. 05);治疗后,两组患者血清超氧化物歧化酶(SOD)水平均明显升高,丙二醛(MDA)、8-异前列腺素F2α(8-iso-PGF2α)水平均明显降低(P <0. 05),且研究组均明显优于对照组(P <0. 05);两组不良反应发生率相当(9. 30%比11. 63%,P> 0. 05)。结论血必净佐治老年重症肺炎伴呼吸衰竭临床疗效良好,可有效改善患者血清氧化应激指标水平,提高总有效率,且不增加不良反应。
Objective To investigate the clinical effect of Xuebijing Injection in the adjuvant treatment of elderly patients with severe pneumonia complicated with respiratory failure and its effect on oxidative stress. Methods Totally 86 elderly patients with severe pneumonia complicated with respiratory failure admitted to our hospital from February 2015 to February 2016 were selected and divided into the control group and the study group according to the random number table method,43 cases in each group. The patients in the two groups were given routine treatment,on this basis,the patients in the study group were treated with Xuebijing Injection. The patients in the two groups were treated for 14 d. Results The total effective rate of the study group was 97. 67%, which was significantly higher than 83. 72% of the control group( P < 0. 05). After treatment, the level of serum superoxide dismutase( SOD) in the two groups were significantly increased, while the levels of malondialdehyde( MDA) and 8-isomeric-prostaglandin F2α( 8-iso-PGF2α)were significantly decreased( P < 0. 05),and those in the study group were significantly better than those in the control group( P < 0. 05).The incidence rate of adverse reactions in the two groups was similar( 9. 30% vs. 11. 63%, P > 0. 05). Conclusion Xuebijing Injection is effective in the adjuvant treatment of elderly patients with severe pneumonia complicated with respiratory failure, it can effectively improve the levels of serum oxidative stress index and the total effective rate without increasing adverse reactions.
Objective To investigate the clinical effect of Xuebijing Injection in the adjuvant treatment of elderly patients with severe pneumonia complicated with respiratory failure and its effect on oxidative stress. Methods Totally 86 elderly patients with severe pneumonia complicated with respiratory failure admitted to our hospital from February 2015 to February 2016 were selected and divided into the control group and the study group according to the random number table method,43 cases in each group. The patients in the two groups were given routine treatment,on this basis,the patients in the study group were treated with Xuebijing Injection. The patients in the two groups were treated for 14 d. Results The total effective rate of the study group was 97. 67%, which was significantly higher than 83. 72% of the control group( P < 0. 05). After treatment, the level of serum superoxide dismutase( SOD) in the two groups were significantly increased, while the levels of malondialdehyde( MDA) and 8-isomeric-prostaglandin F2α( 8-iso-PGF2α)were significantly decreased( P < 0. 05),and those in the study group were significantly better than those in the control group( P < 0. 05).The incidence rate of adverse reactions in the two groups was similar( 9. 30% vs. 11. 63%, P > 0. 05). Conclusion Xuebijing Injection is effective in the adjuvant treatment of elderly patients with severe pneumonia complicated with respiratory failure, it can effectively improve the levels of serum oxidative stress index and the total effective rate without increasing adverse reactions.
引文
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[14]胡婷婷,蔡艳霞,王雅莉,等.系统性护理干预在NCPAP辅助治疗重症肺炎合并呼吸衰竭患儿中的应用效果[J].国际护理学杂志,2016,25(2):215-217.
[15]何莲,聂斌,徐奇,等.血必净联合抗菌药物治疗ICU重症肺炎患者的临床疗效研究[J].中华医院感染学杂志,2016,18(3):570-571.
[16]牛丽丽,夏建鸿,赵建荣,等.血必净治疗老年重症肺炎伴呼吸衰竭的疗效观察以及对患者机体炎症介质的影响[J].山西医药杂志,2017,46(12):1440-1443.
[2]张志强,马海英,冯宪军,等.重症肺炎合并重度急性呼吸窘迫综合征患者临床特点与预后影响因素分析[J].中华医院感染学杂志,2016,26(6):1297-1299.
[3]陈越芬,王迪麟,朱巧梅.不同肠内营养方式对老年呼吸衰竭患者营养状态和T细胞亚群的影响[J].中国药业,2017,26(12):59-62.
[4]王玉瑛,韩波,高怡玢,等.早期CPAP对小儿重症肺炎并呼吸衰竭血气指标及预后的影响[J].临床肺科杂志,2016,16(1):75-78.
[5]张红卫,徐元政.新雪颗粒联合抗生素治疗老年肺炎35例疗效观察[J].江苏大学学报(医学版),2003,13(6):538-539.
[6]邵丹丹,袁媛,何茜.纤维支气管镜下肺泡灌洗治疗肺炎伴呼吸衰竭的疗效分析[J].贵州医药,2017,41(7):752-754.
[7]李晓卿,王丽靖,胡英伟.早期使用糖皮质激素对重症肺炎合并呼吸衰竭患儿预后影响初探[J].中国小儿急救医学,2016,23(8):539-542.
[8]刘红,刘培政.血清降钙素原在婴幼儿重症肺炎早期诊断中的价值[J].实用临床医药杂志,2016,20(7):105-108.
[9]张金蓉,崔吉宏.在重症肺炎致呼吸衰竭抢救中无创呼吸机辅助呼吸的护理应用[J].实用临床医药杂志,2017,21(6):25-29.
[10]敖勇.纤维支气管镜肺泡灌洗对重症肺炎伴呼吸衰竭患者呼吸功能及炎症活动的影响[J].宁夏医科大学学报,2016,38(3):310-313.
[11]李斯南.肺泡灌洗对急诊重症肺炎合并呼吸衰竭患者血清学指标的影响[J].临床肺科杂志,2016,21(6):1142-1144.
[12] LODDING IP,SCHULTZ HH,JENSEN JU,et al. Cytomegalovirus Viral Load in Bronchoalveolar Lavage to Diagnose Lung Transplant Associated CMV Pneumonia[J]. Transplantation,2017,102(2):326-332.
[13]胡容.序贯机械通气治疗改善重症肺炎合并呼吸衰竭患者肺泡氧合功能、全身炎症反应综合征的研究[J].海南医学院学报,2016,22(22):2707-2710.
[14]胡婷婷,蔡艳霞,王雅莉,等.系统性护理干预在NCPAP辅助治疗重症肺炎合并呼吸衰竭患儿中的应用效果[J].国际护理学杂志,2016,25(2):215-217.
[15]何莲,聂斌,徐奇,等.血必净联合抗菌药物治疗ICU重症肺炎患者的临床疗效研究[J].中华医院感染学杂志,2016,18(3):570-571.
[16]牛丽丽,夏建鸿,赵建荣,等.血必净治疗老年重症肺炎伴呼吸衰竭的疗效观察以及对患者机体炎症介质的影响[J].山西医药杂志,2017,46(12):1440-1443.