基于数据挖掘技术研究治疗血管性痴呆方剂的组方配伍规律
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摘要
目的:基于中医传承辅助平台(V2.5)软件分析期刊与专利文献中治疗血管性痴呆(VD)方剂的组方用药规律。方法:筛选中国期刊全文数据库(CNKI)、维普期刊资源整合服务平台(VIP)、万方数据知识服务平台(Wangfang)和国家知识产权局专利检索与分析数据库(Patent Search and Analysis of SIPO)中近5年治疗VD的方剂,通过中医传承辅助平台(V2.5)软件构建方剂数据库,利用该软件集成的关联规则及熵聚类等数据挖掘算法,总结治疗VD方剂中的用药频次、常用药对、潜在药对及发现新方。结果:通过对155首治疗VD方剂所含药物的频次统计分析,得到治疗VD的常用药物19味,其中远志、黄芪、丹参、川芎和石菖蒲五味药物的使用频次最高;使用频次较高的药对有19个,其中川芎与石菖蒲、远志与石菖蒲、黄芪与石菖蒲配伍位居前3位;通过熵层次聚类分析算法发现关联系数较高的潜在药对26个及潜在新方13个。结论:CNKI、VIP、Wanfang、Patent Search and Analysis of SIPO中收录治疗VD的方剂多以活血化瘀、化痰开窍的药物为主,以益气安神、补肝益肾的药物为辅,挖掘得到的新方具有潜在的临床应用和新药开发价值。
Objective:Based on the software of Traditional Chinese Medicine Inheritance Assistance Platform(V2.5),to analyze the regularity of prescription medication for vascular dementia(VD)in periodicals and patent literature.Method:Screening of Chinese journal full-text database(CNKI),VIP journals resource integration service platform(VIP),Wanfang Data Knowledge Service Platform(Wanfang)and Patent Search and Analysis of SIPO in nearly five years prescriptions for treatment of VD.Through the Traditional Chinese Medicine Inheritance Assistance Platform(V2.5)to build prescription database,using the software integration and entropy clustering data mining association rules algorithm,summarizes the treatment of vascular dementia drug use frequency of the prescriptions,commonly used medicines,potential drugs,and found the new prescriptions.Result:Through statistical analysis of the frequencies of 155 prescriptions for VD,19 commonly used drugs for VD were obtained,among which Polygala tenuifolia,Astragalus membranaceus,Salvia miltiorrhiza,Ligusticum Chuanxiong and Acorus tatarinowii had the highest frequencies.19 pairs of medicines were used more frequently,among which Chuanxiong and Acorus tatarinowii,Polygala tenuifolia and Acorus tatarinowii,Astragalus membranaceus and Acorus tatarinowii were the top three.Entropy hierarchical clustering analysis was used to find 26 potential drugs with high correlation coefficient and 13 potential new drugs.Conclusion:The prescriptions for VD were included in CNKI,VIP,Wanfang,Patent Search and Analysis of SIPO,most of them are drugs for activating blood circulation to dissipate blood stasis and dissipating phlegm for resuscitation,supplemented by drugs for benefiting qi for tranquillization and tonify the liver and kidney,the new discoveries have potential clinical applications and new drug development values.
Objective:Based on the software of Traditional Chinese Medicine Inheritance Assistance Platform(V2.5),to analyze the regularity of prescription medication for vascular dementia(VD)in periodicals and patent literature.Method:Screening of Chinese journal full-text database(CNKI),VIP journals resource integration service platform(VIP),Wanfang Data Knowledge Service Platform(Wanfang)and Patent Search and Analysis of SIPO in nearly five years prescriptions for treatment of VD.Through the Traditional Chinese Medicine Inheritance Assistance Platform(V2.5)to build prescription database,using the software integration and entropy clustering data mining association rules algorithm,summarizes the treatment of vascular dementia drug use frequency of the prescriptions,commonly used medicines,potential drugs,and found the new prescriptions.Result:Through statistical analysis of the frequencies of 155 prescriptions for VD,19 commonly used drugs for VD were obtained,among which Polygala tenuifolia,Astragalus membranaceus,Salvia miltiorrhiza,Ligusticum Chuanxiong and Acorus tatarinowii had the highest frequencies.19 pairs of medicines were used more frequently,among which Chuanxiong and Acorus tatarinowii,Polygala tenuifolia and Acorus tatarinowii,Astragalus membranaceus and Acorus tatarinowii were the top three.Entropy hierarchical clustering analysis was used to find 26 potential drugs with high correlation coefficient and 13 potential new drugs.Conclusion:The prescriptions for VD were included in CNKI,VIP,Wanfang,Patent Search and Analysis of SIPO,most of them are drugs for activating blood circulation to dissipate blood stasis and dissipating phlegm for resuscitation,supplemented by drugs for benefiting qi for tranquillization and tonify the liver and kidney,the new discoveries have potential clinical applications and new drug development values.
引文
[1]钟汝佳,陶定波,乐卫东.血管性痴呆病因及发病机制的研究进展[J].转化医学杂志,2015,4(4):193-198.
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[4]赵艳青,滕晶.基于中医传承辅助平台系统的血管性痴呆组方用药规律分析[J].中国中医基础医学杂志,2015,21(6):739-741.
[5]中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011,44(2):142-147.
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[10]任浩,陈杰.补阳还五汤加味治疗血管性痴呆临床观察[J].山西中医,2014,30(9):13-14.
[11]王静,热孜万.痰瘀同治治疗血管性痴呆[J].新疆中医药,2005,23(5):3-5.
[12]周强.痰瘀同治治疗血管性痴呆的机理探析[J].福建中医药,2011,42(5):63-64.
[13]吴春岚,王骏,刘云,等.痰瘀同治法治疗血管性痴呆的理论探讨[J].中西医结合心脑血管病杂志,2012,10(2):225-226.
[14]傅会娟.宫洪涛教授治疗血管性痴呆的学术经验总结[D].郑州:河南中医药大学,2015.
[15]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术(中医药现代化),2009,11(2):225-228.
[16]陈建新.中医证候的复杂系统建模及其与疾病的相关性研究[D].北京:中国科学院自动化研究所,2008.
[2]Iadecola C.The pathobiology of vascular dementia[J].Neuron,2013,80(4):844-866.
[3]曲艳吉,卓琳,王华丽,等.1980-2011年中国社区55岁及以上人群中血管性痴呆流行病学的Meta分析[J].中国卒中杂志,2013,8(7):533-543.
[4]赵艳青,滕晶.基于中医传承辅助平台系统的血管性痴呆组方用药规律分析[J].中国中医基础医学杂志,2015,21(6):739-741.
[5]中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011,44(2):142-147.
[6]朱崇瑞.“益气调血、扶本培元”针法结合黄地散治疗血管性痴呆的临床观察[D].南京:南京中医药大学,2012.
[7]马青,唐民科,孙文燕.血管性痴呆中医发病机制现代研究述要[J].中华中医药杂志,2018,33(1):212-215.
[8]郭清,宫洪涛.从中医五脏论血管性痴呆的病机[J].中国中医药现代远程教育,2018,16(1):71-72.
[9]王新志,韩群英.中风脑病诊疗全书[M].北京:中国医药科技出版社,2000:267-337.
[10]任浩,陈杰.补阳还五汤加味治疗血管性痴呆临床观察[J].山西中医,2014,30(9):13-14.
[11]王静,热孜万.痰瘀同治治疗血管性痴呆[J].新疆中医药,2005,23(5):3-5.
[12]周强.痰瘀同治治疗血管性痴呆的机理探析[J].福建中医药,2011,42(5):63-64.
[13]吴春岚,王骏,刘云,等.痰瘀同治法治疗血管性痴呆的理论探讨[J].中西医结合心脑血管病杂志,2012,10(2):225-226.
[14]傅会娟.宫洪涛教授治疗血管性痴呆的学术经验总结[D].郑州:河南中医药大学,2015.
[15]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术(中医药现代化),2009,11(2):225-228.
[16]陈建新.中医证候的复杂系统建模及其与疾病的相关性研究[D].北京:中国科学院自动化研究所,2008.