基于新型生物标志物的耐甲氧西林金黄色葡萄球菌静脉感染模型制作与治疗监测
摘要
<正>耐甲氧西林金黄色葡萄球菌(methicillin resistant staphylococcus aureus,MRSA)是一种临床上常见的革兰氏染色阳性致病菌,其临床检出率逐年上升,居医院感染病原菌首位~([1])。由MRSA引起的感染与乙型肝炎、艾滋病并列为世界范围内3大难解决的感染性疾病[2]。MRSA的多重耐药性使得针对其治疗困难,且费用昂贵[3]。因此,采用新型生物标
引文
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[12]Cao C,Gu J,Zhang J. Soluble triggering receptor expressed on mye-loid cell-1(s TREM-1):a potential biomarker for the diagnosis ofinfectious diseases[J]. Front Med,2017,11(2):169-177.
[13]Bouchon A,Facchetti F,Weigand M A,et al. TREM-1 amplifies in-flammation and is a crucial mediator of septic shock[J]. Nature,2001,410(6832):1103-1107.
[14]Colonna M,Facchetti F. TREM-1(triggering receptor expressedon myeloid cells):a new player in acute inflammatory responses[J]. J Infect Dis,2003,187(Suppl2):S397-S401.
[2]杨华明,易滨.现代医院消毒学[M].北京人民军医出版社,2002:232-250.
[3]王婷婷,左钱飞,刘开云,等.耐甲氧西林金黄色葡萄球菌小鼠全身感染模型的建立与评价[J].中国实验动物学报,2012,20(6):61-64.
[4]王明强,张思森,刘小军,等.替考拉宁与万古霉素及利奈唑胺治疗MRSA感染患者的疗效评价[J].中华医院感染学杂志,2015,(17):3923-3924,3927.
[5]张萍萍,郭凌云,陈天明,等.严重感染生物标志物的研究进展[J].中华传染病杂志,2016,34(4):250-256.
[6]Wolkewitz M,Frank U,Philips G,et al. Mortality associated with in-hospital bacteraemia caused by Staphylococcus aureus:a multistateanalysis with follow-up beyond hospital discharge[J]. J AntimicrobChemother,2011,66(2):381-386.
[7]陈雪雨,彭秀华,杨玉琴,等.耐甲氧西林金黄色葡萄球菌诱导SKH-1无毛小鼠菌血症模型[J].中国实验动物学报,2011,19(6):512-516.
[8]Fung A W S,Beriault D,Diamandis E P,et al. The Role of Procalci-tonin in Diagnosis of Sepsis and Antibiotic Stewardship:Opportuni-ties and Challenges[J]. Clin Chem,2017,63(9):1436-1441.
[9]Kibe S,Adams K,Barlow G. Diagnostic and prognostic biomarkers ofsepsis in critical care[J]. J Antimicrob Chemother,2011,66(Sup-pl2):33-40.
[10]Tabl H A,Abed N T. Diagnostic Value of Presepsin in NeonatalSepsis[J]. Egypt J Immunol,2016,23(2):29-37.
[11] Amer H A,Ghareeb H,Lotfy N M,et al. Presepsin a DiagnosticMarker for Sepsis in Intensive Care Unit Patients[J]. Egypt J Im-munol,2016,23(2):109-118.
[12]Cao C,Gu J,Zhang J. Soluble triggering receptor expressed on mye-loid cell-1(s TREM-1):a potential biomarker for the diagnosis ofinfectious diseases[J]. Front Med,2017,11(2):169-177.
[13]Bouchon A,Facchetti F,Weigand M A,et al. TREM-1 amplifies in-flammation and is a crucial mediator of septic shock[J]. Nature,2001,410(6832):1103-1107.
[14]Colonna M,Facchetti F. TREM-1(triggering receptor expressedon myeloid cells):a new player in acute inflammatory responses[J]. J Infect Dis,2003,187(Suppl2):S397-S401.