心率变异检测在肿瘤患者中的研究进展
摘要
心率变异(HRV)检测是一种无创性的自主神经功能检测方式,已广泛应用于心血管疾病、内分泌系统疾病患者的自主神经功能评价。目前国内外临床研究已经将HRV分析应用于肿瘤领域。通过检测HRV对肿瘤患者的相关症状进行评价,分析放化疗和靶向治疗后的相关不良反应,评估肿瘤治疗药物的临床疗效,以及肿瘤患者自主神经功能和预后情况,有助于临床医师准确判断患者的疾病状态、药物疗效、疾病预后以及生存期。本文对HRV在肿瘤相关领域中的研究进展作一综述。
引文
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[15]史丽,王信凡,周经霞.生脉注射液对扩张型心肌病并心力衰竭患者疗效及心率变异性的影响[J].中药药理与临床,2017,33(3):177-180.
[16]Chauhan A,Sequeria A,Manderson C,et al.Exploring autonomic nervous system dysfunction in patients with cancer cachexia:a pilot study[J].Auton Neurosci,2012,166(1-2):93-95.
[17]Bettermann H,Kr鰖M,Girke M,et al.Heart rate dynamics and cardiorespiratory coordination in diabetic and breast cancer patients[J].Clin Physiol,2001,21(4):411-420.
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[19]Nevruz O,Yokusoglu M,Uzun M,et al.Cardiac autonomic functions are altered in patients with acute leukemia,assessed by heart rate variability[J].Tohoku J Exp Med,2007,211(2):121-126.
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[21]李爱国.晚期肿瘤患者心率变异性分析的临床意义[J].现代中西医结合杂志,2007,16(3):368-369.
[22]陈晨,刘海媛.不同分期恶性肿瘤患者的心率变异性分析[J].复旦学报(医学版),2009,36(4):413-416.
[23]Ekholm E,Rantanen V,Bergman M,et al.Docetaxel and autonomic cardiovascular control in anthracycline treated breast cancer patients[J].Anticancer Res,2000,20(3B):2045-2048.
[24]Ekholm E,Rantanen V,Syv鋘en K,et al.Docetaxel does not impair cardiac autonomic function in breast cancer patients previously treated with anthracyclines[J].Anticancer Drugs,2002,13(4):425-429.
[25]Salminen E,Syv鋘en K,Korpela J,et al.Docetaxel with epirubicin--investigations on cardiac safety[J].Anticancer Drugs,2003,14(1):73-77.
[26]梁利平,梁健,梁海荣.乳腺癌术后化疗患者动态心电图检查的临床价值[J].深圳中西医结合杂志,2015,25(23):70-71.
[27]孙芳毅,施靖,王红芳,等.表阿霉素对合并糖尿病的早期乳腺癌患者心率变异性影响[J].肿瘤学杂志,2017,23(11):992-995.
[28]McIntyre WF,Oqab Z,Seaborn GE,et al.Changes in plasma hormones and heart rate variability in patients receiving the cardiotoxic anti-cancer agent bevacizumab[J].Int JCardiol,2016,219:25-26.
[29]De Sanctis V,Bossi P,Sanguineti G,et al.Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies:literature review and consensus statements[J].Crit Rev Oncol Hematol,2016,100:147-166.
[30]刘家斌,李广生.放射性脑损伤机制及放射保护研究进展[J].赣南医学院学报,2010,30(1):161-162.
[31]蔡联英,张琴,杨苏萍,等.鼻咽癌患者放疗前后心率变异性及对胃排空功能影响的研究[J].中国临床新医学,2012,5(11):997-1000.
[32]张琴,张雅莉,何宁,等.鼻咽癌患者放射治疗后动态心电图及QT离散度和心率变异性改变的探讨[J].江苏实用心电学杂志,2014,23(4):236-240.
[33]靳艳辉.鼻咽癌患者放疗后动态心电图及QT离散度与心率变异性变化的相关性研究[J].医学综述,2015,21(23):4348-4350.
[34]张雅莉,田晓芬,唐文红,等.鼻咽癌患者不同放疗剂量下心率变异与心电图改变的研究[J].临床和实验医学杂志,2017,16(11):1090-1093.
[35]Ye JJ,Chuang CC,Tai YT,et al.Use of heart rate variability and photoplethysmograph-derived parameters as assessment signals of radiofrequency therapy efficacy for chronic pain[J].Pain Practice,2017,17(7):879-885.
[36]Chien TJ,Liu CY,Lu RH,et al.Therapeutic efficacy of Traditional Chinese medicine,"Kuan-Sin-Yin",in patients undergoing chemotherapy for advanced colon cancer-Acontrolled trial[J].Complement Ther Med,2016,29:204-212.
[37]Por?ba M,Por?ba R,Ga?P,et al.Heart rate variability and heart rate turbulence in patients with hematologic malignancies subjected to high-dose chemotherapy in the course of hematopoietic stem cell transplantation[J].Ann Noninvasive Electrocardiol,2014,19(2):157-165.
[38]Wannamethee G,Shaper AG,Macfarlane PW.Heart rate,physical activity,and mortality from cancer and other noncardiovascular diseases[J].Am J Epidemiol,1993,137(7):735-748.
[39]Hoffmann J,Grimm W,Menz V,et al.Prognostic value of heart rate variability analysis in patients with carcinoid syndrome[J].Digestion,2001,63(1):35-42.
[40]De Couck M,van Brummelen D,Schallier D,et al.The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients[J].Oncol Rep,2013,30(5):2435-2441.
[41]Chiang JK,Koo M,Kuo TB,et al.Association between cardiovascular autonomic functions and time to death in patients with terminal hepatocellular carcinoma[J].J Pain Symptom Manage,2010,39(4):673-679.
[42]Kim DH,Kim JA,Choi YS,et al.Heart rate variability and length of survival in hospice cancer patients[J].J Korean Med Sci,2010,25(8):1140-1145.
[43]Wang YM,Wu HT,Huang EY,et al.Heart rate variability is associated with survival in patients with brain metastasis:a preliminary report[J].Biomed Res Int,2013,2013:503421.
[44]Guo Y,Palmer JL,Strasser F,et al.Heart rate variability as a measure of autonomic dysfunction in men with advanced cancer[J].Eur J Cancer Care(Engl),2013,22(5):612-616.
[45]Kim K,Chae J,Lee S.The role of heart rate variability in advanced non-small-cell lung cancer patients[J].J Palliat Care,2015,31(2):103-108.
[46]Mouton C,Ronson A,Razavi D,et al.The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer[J].Auton Neurosci,2012,166(1-2):96-99.
[47]Zhou X,Ma Z,Zhang L,et al.Heart rate variability in the prediction of survival in patients with cancer:a systematic review and meta-analysis[J].J Psychosom Res,2016,89:20-25.
[2]Bruera E,Villamayor R,Roca E,et al.Q-T interval prolongation and ventricular fibrillation with i.v.domperidone[J].Cancer Treat Rep,1986,70(4):545-546.
[3]Strasser F,Luftner D,Possinger K,et al.Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexiacachexia syndrome:a multicenter,phase III,randomized,double-blind,placebo-controlled clinical trial from the CannabisIn-Cachexia-Study-Group[J].J Clin Oncol,2006,24(21):3394-3400.
[4]Nelson K,Walsh D,Sheehan F.Cancer and chemotherapyrelated upper gastrointestinal symptoms:the role of abnormal gastric motor function and its evaluation in cancer patients[J].Support Care Cancer,2002,10(6):455-461.
[5]Guo Y,Koshy S,Hui D,et al.Prognostic value of heart rate variability in patients with cancer[J].J Clin Neurophysiol,2015,32(6):516-520.
[6]Lombardi F,Belletti S,Battezzati PM,et al.MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation[J].J Cardiovasc Med(Hagerstown),2011,12(1):37-42.
[7]郭晓琳.心率变异性分析临床应用研究近况[J].心血管病防治知识(学术版),2017(7):143-144.
[8]郭小玉,李方洁.基于心率变异性近似熵分析的冠心病慢性稳定性心绞痛虚实证候的混沌特征研究[J].中国中西医结合杂志,2017,37(3):297-301.
[9]Chen Y,Yu Y,Zou W,et al.Association between cardiac autonomic nervous dysfunction and the severity of coronary lesions in patients with stable coronary artery disease[J].JInt Med Res,2018,46(9):3729-3740.
[10]La Rovere MT,Pinna GD,Maestri R,et al.Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients[J].Circulation,2003,107(4):565-570.
[11]La Rovere MT,Bigger JT Jr,Marcus FI,et al.Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction.ATRAMI(Autonomic Tone and Reflexes After Myocardial Infarction)Investigators[J].Lancet,1998,351(9101):478-484.
[12]Huikuri HV,M鋕ikallio TH,Peng CK,et al.Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction[J].Circulation,2000,101(1):47-53.
[13]Taranto-Montemurro L,Messineo L,Perger E,et al.Cardiac sympathetic hyperactivity in patients with chronic obstructive pulmonary disease and obstructive sleep apnea[J].COPD,2016,13(6):706-711.
[14]Koichubekov BK,Sorokina MA,Laryushina YM,et al.Nonlinear analyses of heart rate variability in hypertension[J].Ann Cardiol Angeiol(Paris),2018,67(3):174-179.
[15]史丽,王信凡,周经霞.生脉注射液对扩张型心肌病并心力衰竭患者疗效及心率变异性的影响[J].中药药理与临床,2017,33(3):177-180.
[16]Chauhan A,Sequeria A,Manderson C,et al.Exploring autonomic nervous system dysfunction in patients with cancer cachexia:a pilot study[J].Auton Neurosci,2012,166(1-2):93-95.
[17]Bettermann H,Kr鰖M,Girke M,et al.Heart rate dynamics and cardiorespiratory coordination in diabetic and breast cancer patients[J].Clin Physiol,2001,21(4):411-420.
[18]Crosswell AD,Lockwood KG,Ganz PA,et al.Low heart rate variability and cancer-related fatigue in breast cancer survivors[J].Psychoneuroendocrinology,2014,45:58-66.
[19]Nevruz O,Yokusoglu M,Uzun M,et al.Cardiac autonomic functions are altered in patients with acute leukemia,assessed by heart rate variability[J].Tohoku J Exp Med,2007,211(2):121-126.
[20]熊萍,连捷.恶性肿瘤患者的心率变异性临床初探[J].实用医技杂志,2006,13(1):17-18.
[21]李爱国.晚期肿瘤患者心率变异性分析的临床意义[J].现代中西医结合杂志,2007,16(3):368-369.
[22]陈晨,刘海媛.不同分期恶性肿瘤患者的心率变异性分析[J].复旦学报(医学版),2009,36(4):413-416.
[23]Ekholm E,Rantanen V,Bergman M,et al.Docetaxel and autonomic cardiovascular control in anthracycline treated breast cancer patients[J].Anticancer Res,2000,20(3B):2045-2048.
[24]Ekholm E,Rantanen V,Syv鋘en K,et al.Docetaxel does not impair cardiac autonomic function in breast cancer patients previously treated with anthracyclines[J].Anticancer Drugs,2002,13(4):425-429.
[25]Salminen E,Syv鋘en K,Korpela J,et al.Docetaxel with epirubicin--investigations on cardiac safety[J].Anticancer Drugs,2003,14(1):73-77.
[26]梁利平,梁健,梁海荣.乳腺癌术后化疗患者动态心电图检查的临床价值[J].深圳中西医结合杂志,2015,25(23):70-71.
[27]孙芳毅,施靖,王红芳,等.表阿霉素对合并糖尿病的早期乳腺癌患者心率变异性影响[J].肿瘤学杂志,2017,23(11):992-995.
[28]McIntyre WF,Oqab Z,Seaborn GE,et al.Changes in plasma hormones and heart rate variability in patients receiving the cardiotoxic anti-cancer agent bevacizumab[J].Int JCardiol,2016,219:25-26.
[29]De Sanctis V,Bossi P,Sanguineti G,et al.Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies:literature review and consensus statements[J].Crit Rev Oncol Hematol,2016,100:147-166.
[30]刘家斌,李广生.放射性脑损伤机制及放射保护研究进展[J].赣南医学院学报,2010,30(1):161-162.
[31]蔡联英,张琴,杨苏萍,等.鼻咽癌患者放疗前后心率变异性及对胃排空功能影响的研究[J].中国临床新医学,2012,5(11):997-1000.
[32]张琴,张雅莉,何宁,等.鼻咽癌患者放射治疗后动态心电图及QT离散度和心率变异性改变的探讨[J].江苏实用心电学杂志,2014,23(4):236-240.
[33]靳艳辉.鼻咽癌患者放疗后动态心电图及QT离散度与心率变异性变化的相关性研究[J].医学综述,2015,21(23):4348-4350.
[34]张雅莉,田晓芬,唐文红,等.鼻咽癌患者不同放疗剂量下心率变异与心电图改变的研究[J].临床和实验医学杂志,2017,16(11):1090-1093.
[35]Ye JJ,Chuang CC,Tai YT,et al.Use of heart rate variability and photoplethysmograph-derived parameters as assessment signals of radiofrequency therapy efficacy for chronic pain[J].Pain Practice,2017,17(7):879-885.
[36]Chien TJ,Liu CY,Lu RH,et al.Therapeutic efficacy of Traditional Chinese medicine,"Kuan-Sin-Yin",in patients undergoing chemotherapy for advanced colon cancer-Acontrolled trial[J].Complement Ther Med,2016,29:204-212.
[37]Por?ba M,Por?ba R,Ga?P,et al.Heart rate variability and heart rate turbulence in patients with hematologic malignancies subjected to high-dose chemotherapy in the course of hematopoietic stem cell transplantation[J].Ann Noninvasive Electrocardiol,2014,19(2):157-165.
[38]Wannamethee G,Shaper AG,Macfarlane PW.Heart rate,physical activity,and mortality from cancer and other noncardiovascular diseases[J].Am J Epidemiol,1993,137(7):735-748.
[39]Hoffmann J,Grimm W,Menz V,et al.Prognostic value of heart rate variability analysis in patients with carcinoid syndrome[J].Digestion,2001,63(1):35-42.
[40]De Couck M,van Brummelen D,Schallier D,et al.The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients[J].Oncol Rep,2013,30(5):2435-2441.
[41]Chiang JK,Koo M,Kuo TB,et al.Association between cardiovascular autonomic functions and time to death in patients with terminal hepatocellular carcinoma[J].J Pain Symptom Manage,2010,39(4):673-679.
[42]Kim DH,Kim JA,Choi YS,et al.Heart rate variability and length of survival in hospice cancer patients[J].J Korean Med Sci,2010,25(8):1140-1145.
[43]Wang YM,Wu HT,Huang EY,et al.Heart rate variability is associated with survival in patients with brain metastasis:a preliminary report[J].Biomed Res Int,2013,2013:503421.
[44]Guo Y,Palmer JL,Strasser F,et al.Heart rate variability as a measure of autonomic dysfunction in men with advanced cancer[J].Eur J Cancer Care(Engl),2013,22(5):612-616.
[45]Kim K,Chae J,Lee S.The role of heart rate variability in advanced non-small-cell lung cancer patients[J].J Palliat Care,2015,31(2):103-108.
[46]Mouton C,Ronson A,Razavi D,et al.The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer[J].Auton Neurosci,2012,166(1-2):96-99.
[47]Zhou X,Ma Z,Zhang L,et al.Heart rate variability in the prediction of survival in patients with cancer:a systematic review and meta-analysis[J].J Psychosom Res,2016,89:20-25.