低分子肝素联合硫酸镁治疗对PE患者血清中sFlt-1、25-羟基维生素D、D-二聚体、vWF水平的影响
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摘要
目的研究低分子肝素联合硫酸镁对子痫前期患者血清中sFlt-1、25-羟基维生素D、D-二聚体、vWF水平的影响。方法选取2015年4月至2017年4月武汉市第五医院收治的90例子痫前期患者为研究对象,按随机数字表法分观察组和对照组,每组45例。对照组给予常规硫酸镁治疗,观察组在对照组基础上服用低分子肝素联合治疗,比较两组患者治疗效果,以及治疗前后sFlt-1、25-羟基维生素D、D-二聚体、vWF水平,并记录患者妊娠并发症。结果治疗后,观察组临床总有效率显著高于对照组(P <0.05)。观察组sFlt-1低于对照组,25-羟基维生素D高于对照组(P <0.05)。观察组D-二聚体、vWF水平均显著低于对照组(P <0.05)。观察组妊娠并发症发生率显著低于对照组(P <0.05)。结论运用低分子肝素联合硫酸镁治疗子痫前期患者,疗效显著,可有效降低血压,改善患者微循环,并降低妊娠并发症发生率,值得推广。
Objective To study the effects of low molecular weight heparin(LMWH) combined with magnesium sulfate on levels of serum sFlt-1, 25-hydroxyvitamin D, D-dimer(D-D) and vWF in patients with preeclampsia(PE).Methods 90 patients with PE who were admitted to the Fifth Hospital in Wuhan from April 2015 to April 2017 were selected as subjects. They were divided into the observation group and the control group by the random number table method, 45 patients in each group. The control group was treated with magnesium sulfate and the observation group was treated with LMWH combined with magnesium sulfate. The curative effect and the levels of sFlt-1, 25-hydroxyvitamin D, D-D and vWF before and after the treatment were compared between the two groups. Pregnancy complications were recorded. Results After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group(P <0.05). SFlt-1 in the observation group was lower than that in the control group, and 25-hydroxyvitamin D in the observation group was higher than that in the control group(P <0.05). The levels of D-dimer and v WF in the observation group were significantly lower than those in the control group(P <0.05). The incidence of pregnancy complications in the observation group was significantly lower than that in the control group(P <0.05). Conclusions The treatment of LMWH combined with magnesium sulfate is effective in patients with PE. It can effectively decrease blood pressure, improve microcirculation of patients, and reduce the incidence of pregnancy complications.
Objective To study the effects of low molecular weight heparin(LMWH) combined with magnesium sulfate on levels of serum sFlt-1, 25-hydroxyvitamin D, D-dimer(D-D) and vWF in patients with preeclampsia(PE).Methods 90 patients with PE who were admitted to the Fifth Hospital in Wuhan from April 2015 to April 2017 were selected as subjects. They were divided into the observation group and the control group by the random number table method, 45 patients in each group. The control group was treated with magnesium sulfate and the observation group was treated with LMWH combined with magnesium sulfate. The curative effect and the levels of sFlt-1, 25-hydroxyvitamin D, D-D and vWF before and after the treatment were compared between the two groups. Pregnancy complications were recorded. Results After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group(P <0.05). SFlt-1 in the observation group was lower than that in the control group, and 25-hydroxyvitamin D in the observation group was higher than that in the control group(P <0.05). The levels of D-dimer and v WF in the observation group were significantly lower than those in the control group(P <0.05). The incidence of pregnancy complications in the observation group was significantly lower than that in the control group(P <0.05). Conclusions The treatment of LMWH combined with magnesium sulfate is effective in patients with PE. It can effectively decrease blood pressure, improve microcirculation of patients, and reduce the incidence of pregnancy complications.
引文
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[4]徐郁.子痫前期患者血清s Eng与sFlt-1的表达水平及意义[J].实用临床医药杂志,2016,20(5):174-175.
[5]颜敏,瞿新.25-羟基维生素D3诊断子痫前期的价值[J].中国妇幼保健,2018,33(4):787-789.
[6]马立苹,陈媛媛,张西艺,等.低分子肝素钠联合硫酸镁对重度子痫前期患者血清高敏C反应蛋白和D-二聚体的影响分析[J].检验医学与临床,2016,13(14):1943-1945.