3014例人乳头瘤病毒分型检测结果分析
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摘要
目的:了解常居广州地区的性病高发人群最近一年人乳头瘤病毒(HPV)的感染情况及其型别分布,为防治HPV感染提供最新的理论依据。方法:回顾性分析我院2018年1月至12月3 014例性病高发人群HPV的检测结果,并初步探讨HPV与性别、年龄及人类免疫缺陷病毒(HIV)的相关性。结果:3 014例样本中男730例(24.22%),女2 284例(75.78%),型别以HPV6、11、16、52、58为主,检出率依次为8.36%(252/3014)、7.83%(236/3014)、6.74%(203/3014)、5.97%(180/3014)、4.64%(140/3014)。男性任一型HPV、低危型HPV、高危型HPV、单纯低危型HPV感染检出率依次为67.81%(495/730)、53.29%(389/730)、45.75%(334/730)、22.05%(161/730),均明显高于女性(P值均<0.001),但男性单纯高危型HPV感染检出率和女性比较则无统计学差异(P>0.05)。HPV感染在15～24岁和65～74岁这两个年龄段检出率最高,大致成"U"形分布。3 014例中有345例为HIV感染者,HIV感染者任一型HPV、低危型HPV、高危型HPV、单纯低危型HPV感染检出率依次为84.06%(290/345)、64.35%(222/345)、66.96%(231/345)、17.10%(59/345),均明显高于总人群(P值均<0.001),但HIV感染者单纯高危型HPV感染检出率和总人群比较则无明显差异(χ~2=2.00,P>0.05)。结论:常居广州地区性病高发人群最近一年流行的HPV型别为HPV6、11、16、52、58,表现出与性别、年龄、HIV感染相关的特点,加强HIV感染者的防治工作对降低本地区HPV感染率有重要意义。
Objective:To determine the prevalence and genotype distribution of HPV in Guangzhou in last year in order to provide the latest evidence for the prevention and treatment of HPV infection. Methods: HPV types and their correlations with gender, age and HIV were retrospectively analyzed in 3 014 samples from our hospital from January to December,2018. Results: A total of 3 014 patients, including 730(24.22%) males and 2 284(75.78%) females, were included in the analysis. Common types were HPV6, 11, 16, 52 and 58, accounting for 8.36%(252/3014), 7.83%(236/3014), 6.74%(203/3014), 5.97%(180/3014) and 4.64%(140/3014), respectively. In males, 67.81%(495/730) were HPV positive(P<0.001 vs. females). Positive rates of low-risk, high-risk and simple low-risk HPV were 53.29%(389/730), 45.75%(334/730) and 22.05%(161/730), respectively(all P<0.001 vs. females). However, the positive rates of simple high-risk HPV did not differ significantly between males and females(P>0.05). Higher positive rates of HPV were found in age groups of 15～24 and 65～74 years, depicting a trend of "U" shape over age groups. Among 345 out of 3 014 patients with HIV positive, 84.06%(290/345) were HPV positive(P<0.001 vs. overall HPV patients); Positive rates of low-risk, high-risk and simple low-risk HPV were 64.35%(222/345), 66.96%(231/345), and 17.10%(59/345) respectively(all P<0.001 vs. overall HPV patients). But positive rate of simple high-risk HPV did not differ significantly between HIV-infected and overall HPV patients(P>0.05). Conclusions: The most common types of HPV in Guangzhou are HPV 6, 11, 16, 52 and 58 in the last year. The prevalence of HPV is related to gender, age and HIV infection. Strengthening the prevention and treatment of HIV infection are critical for reduction of the HPV infection in Guangzhou.
Objective:To determine the prevalence and genotype distribution of HPV in Guangzhou in last year in order to provide the latest evidence for the prevention and treatment of HPV infection. Methods: HPV types and their correlations with gender, age and HIV were retrospectively analyzed in 3 014 samples from our hospital from January to December,2018. Results: A total of 3 014 patients, including 730(24.22%) males and 2 284(75.78%) females, were included in the analysis. Common types were HPV6, 11, 16, 52 and 58, accounting for 8.36%(252/3014), 7.83%(236/3014), 6.74%(203/3014), 5.97%(180/3014) and 4.64%(140/3014), respectively. In males, 67.81%(495/730) were HPV positive(P<0.001 vs. females). Positive rates of low-risk, high-risk and simple low-risk HPV were 53.29%(389/730), 45.75%(334/730) and 22.05%(161/730), respectively(all P<0.001 vs. females). However, the positive rates of simple high-risk HPV did not differ significantly between males and females(P>0.05). Higher positive rates of HPV were found in age groups of 15～24 and 65～74 years, depicting a trend of "U" shape over age groups. Among 345 out of 3 014 patients with HIV positive, 84.06%(290/345) were HPV positive(P<0.001 vs. overall HPV patients); Positive rates of low-risk, high-risk and simple low-risk HPV were 64.35%(222/345), 66.96%(231/345), and 17.10%(59/345) respectively(all P<0.001 vs. overall HPV patients). But positive rate of simple high-risk HPV did not differ significantly between HIV-infected and overall HPV patients(P>0.05). Conclusions: The most common types of HPV in Guangzhou are HPV 6, 11, 16, 52 and 58 in the last year. The prevalence of HPV is related to gender, age and HIV infection. Strengthening the prevention and treatment of HIV infection are critical for reduction of the HPV infection in Guangzhou.
引文
[1] 刘晗,柯吴坚,杨立刚.2015美国疾病控制中心人乳头瘤病毒感染及肛门生殖器疣治疗指南[J].皮肤性病诊疗学杂志,2015,22(5):410-414.
[2] 张艺丹,张海萍.HIV合并人乳头瘤病毒感染现状与诊断[J].中国艾滋病性病,2018,24(2):213-215.
[3] STANLEY M A.Genital human papillomavirus infections:current and prospective therapies[J].J Gen Virol,2012,93( Pt 4):681-691.
[4] SIEGLER E,SHINER M,SEGEV Y,et al.Prevalence and genotype distribution of HPV types in women at risk for cervical neoplasia in Israel[J].Isr Med Assoc J,2017,19(10):635-639.
[5] 许召杰,邓业巍,李瑞.肛周尖锐湿疣组织HPV检测与型别分析[J].中华实验和临床病毒学杂志,2017,31(1):35-37.
[6] 凌勇活,孙菲,张霞,等.347例尖锐湿疣患者人乳头瘤病毒基因型检测及分析[J].皮肤性病诊疗学杂志,2016,23(3):164-167.
[7] 张晓辉,黄怀球,刘晗,等.广州市男男性接触者肛肠尖锐湿疣HPV感染型别分析[J].皮肤性病诊疗学杂志,2015,22(4):285-289.
[8] 何彩华,曾祥兴.人乳头瘤病毒基因型检测及其人群分布特征[J].国际免疫学杂志,2014,37(6):549-553.
[9] 杨海丽,林力峰,孙冰纯.人乳头状瘤病毒感染的年龄分布特点探讨[J].河北医药,2015,37(4):601-603.
[10] 李英,卢斯汉,胡荣欣,等.广州地区男男性接触者肛门人类乳头瘤病毒感染现况及危险因素分析[J].广东医学,2017,38(21):3327-3332.
[11] 赵敏,张小林,邱红艳,等.MSM人群中HIV合并HPV感染及其亚型分析[J].中国艾滋病性病,2013,19(4):239-240,247.
[2] 张艺丹,张海萍.HIV合并人乳头瘤病毒感染现状与诊断[J].中国艾滋病性病,2018,24(2):213-215.
[3] STANLEY M A.Genital human papillomavirus infections:current and prospective therapies[J].J Gen Virol,2012,93( Pt 4):681-691.
[4] SIEGLER E,SHINER M,SEGEV Y,et al.Prevalence and genotype distribution of HPV types in women at risk for cervical neoplasia in Israel[J].Isr Med Assoc J,2017,19(10):635-639.
[5] 许召杰,邓业巍,李瑞.肛周尖锐湿疣组织HPV检测与型别分析[J].中华实验和临床病毒学杂志,2017,31(1):35-37.
[6] 凌勇活,孙菲,张霞,等.347例尖锐湿疣患者人乳头瘤病毒基因型检测及分析[J].皮肤性病诊疗学杂志,2016,23(3):164-167.
[7] 张晓辉,黄怀球,刘晗,等.广州市男男性接触者肛肠尖锐湿疣HPV感染型别分析[J].皮肤性病诊疗学杂志,2015,22(4):285-289.
[8] 何彩华,曾祥兴.人乳头瘤病毒基因型检测及其人群分布特征[J].国际免疫学杂志,2014,37(6):549-553.
[9] 杨海丽,林力峰,孙冰纯.人乳头状瘤病毒感染的年龄分布特点探讨[J].河北医药,2015,37(4):601-603.
[10] 李英,卢斯汉,胡荣欣,等.广州地区男男性接触者肛门人类乳头瘤病毒感染现况及危险因素分析[J].广东医学,2017,38(21):3327-3332.
[11] 赵敏,张小林,邱红艳,等.MSM人群中HIV合并HPV感染及其亚型分析[J].中国艾滋病性病,2013,19(4):239-240,247.