身痛逐瘀汤联合塞来昔布治疗腰间盘突出症/腰肌劳损(瘀血)随机平行对照研究
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摘要
[目的]观察身痛逐瘀汤联合塞来昔布治疗腰间盘突出症/腰肌劳损(瘀血)疗效。[方法]使用随机平行对照方法,将96例门诊患者按就诊顺序号抽签方法随机分为两组。对照组48例塞来昔布,0.2g/次,1次/d。治疗组48例身痛逐瘀汤(桃仁、红花、当归、牛膝各12g,川芎、没药、五灵脂、地龙、甘草、莪术、三棱、乳香、青皮各8g,秦艽、羌活、香附各4g),水煎400mL,1剂/d,早晚温服;塞来昔布治疗同对照组。连续治疗2周为1疗程。观测临床表现、VAS评分、不良反应。治疗1疗程(4周),判定疗效。[结果]治疗组临床痊愈29例,显效11例,有效6例,无效2例,总有效率95.83%;对照组临床痊愈20例,显效12例,有效8例,无效8例,总有效率83.33%;治疗组疗效优于对照组(P<0.05)。VAS评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]身痛逐瘀汤联合塞来昔布治疗腰间盘突出症/腰肌劳损(瘀血),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Shentong Zhuyu decoction combined with celecoxib on Lumbar disc herniation/lumbar muscle strain(Yuxue). [Method] 96 outpatients were randomly divided into two groups by drawing lots according to the order of visiting. In the control group, 48 cases of celecoxib,0.2 g/time, once a day. In the treatment group, 48 cases of Shentong Zhuyu decoction(Taoren, Honghua,Danggui, Niuxi each 12 g, Chuanxiong, Moyao, Wulingzhi, Dilong, Gancao, Ezhu, Sanleng,Ruxiang, Qingpi each 8 g, Qinjiao, Qianghuo, Xiangfu each 4 g), decocted 400 mL, 1 dose/d, warm clothes in the morning and evening; Celecoxib was treated with the control group. Continuous treatment for 2 weeks is a course of treatment. Clinical manifestations, VAS scores and adverse reactions were observed. One course of treatment(4 weeks) was used to determine the curative effect. [Result] In the treatment group, 29 cases were cured, 11 cases were markedly effective, 6 cases were effective and 2 cases were ineffective, the total effective rate was95.83%. In the control group, 20 cases were cured, 12 cases were markedly effective, 8 cases were effective and 8 cases were ineffective, the total effective rate was 83.33%. The curative effect of the treatment group was better than that of the control group(P<0.05). VAS scores were improved in both groups(P<0.01), and the improvement in treatment group was better than that in control group(P<0.01). [Conclusion] Shentong Zhuyu decoction combined with celecoxib in the treatment of Lumbar disc herniation/lumbar muscle strain(Yuxue) has satisfactory curative effect and no serious adverse reactions, which is worthy of promotion.
[Objective] To observe the curative effect of Shentong Zhuyu decoction combined with celecoxib on Lumbar disc herniation/lumbar muscle strain(Yuxue). [Method] 96 outpatients were randomly divided into two groups by drawing lots according to the order of visiting. In the control group, 48 cases of celecoxib,0.2 g/time, once a day. In the treatment group, 48 cases of Shentong Zhuyu decoction(Taoren, Honghua,Danggui, Niuxi each 12 g, Chuanxiong, Moyao, Wulingzhi, Dilong, Gancao, Ezhu, Sanleng,Ruxiang, Qingpi each 8 g, Qinjiao, Qianghuo, Xiangfu each 4 g), decocted 400 mL, 1 dose/d, warm clothes in the morning and evening; Celecoxib was treated with the control group. Continuous treatment for 2 weeks is a course of treatment. Clinical manifestations, VAS scores and adverse reactions were observed. One course of treatment(4 weeks) was used to determine the curative effect. [Result] In the treatment group, 29 cases were cured, 11 cases were markedly effective, 6 cases were effective and 2 cases were ineffective, the total effective rate was95.83%. In the control group, 20 cases were cured, 12 cases were markedly effective, 8 cases were effective and 8 cases were ineffective, the total effective rate was 83.33%. The curative effect of the treatment group was better than that of the control group(P<0.05). VAS scores were improved in both groups(P<0.01), and the improvement in treatment group was better than that in control group(P<0.01). [Conclusion] Shentong Zhuyu decoction combined with celecoxib in the treatment of Lumbar disc herniation/lumbar muscle strain(Yuxue) has satisfactory curative effect and no serious adverse reactions, which is worthy of promotion.
引文
[1]戴力扬.腰背痛的流行病学[J].颈腰痛杂志,2000,21(2):162-164.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2017-01-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]周仲瑛.中医内科学[M].北京:中国中医药出版社,2004:518.
[4]冯天有.有关腰椎间盘突出症诊断与治疗商榷[J].中国中西医结合杂志,1991,11(4):237-238.
[5]陈仲,靳安民,张积利,等.慢性腰肌劳损的修正诊断和对因治疗[J].广东医学,2011,32(18):2416-2418.
[6]中国康复医学会脊柱脊髓专业委员会专家组.中国急/慢性非特异性腰背痛诊疗专家共识[J].中国脊柱脊髓杂志,2016,26(12):134-1138.
[7]郑贵良.腰痛的病因和分类[J].甘肃医药,2011,30(7):408-409.
[8]蒋夏,李长根.非甾体抗炎药的胃肠道损伤[J].国际麻醉学与复苏杂志,1995,16(6):377-380.
[9]李云,赵胜芳.塞来昔布的药理性质及临床应用[J].青岛医药卫生,2003,35(2):118-119.
[10]曹卉娟,邢建民,刘建平.视觉模拟评分法在症状类结局评价测量中的应用[J].中医杂志,2009,50(7):600-602.
[11]辛波,许志效.中医学对腰腿痛的认识[J].广西中医药,2004,27(1):60.
[12]黄帝内经素问[M].北京:人民卫生出版社,2009:155.
[13]邓中甲.方剂学[M].7版.北京:中国中医药出版社,2010:180.
[14]高学敏.中药学[M].北京:中国中医药出版社,2007.
[15]崔学瑞.身痛逐瘀汤治疗老年腰腿痛60例[J].中国中医药现代远程教育,2010,8(5):20.
[16]谢新利,高志刚.身痛逐瘀汤加减治疗腰椎间盘突出症62例[J].中国民间疗法,2013,21(7):45.
[17]李元明.身痛逐瘀汤加减治疗腰椎间盘突出症[J].中国中医骨伤科杂志,2001,9(4):39-40.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2017-01-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]周仲瑛.中医内科学[M].北京:中国中医药出版社,2004:518.
[4]冯天有.有关腰椎间盘突出症诊断与治疗商榷[J].中国中西医结合杂志,1991,11(4):237-238.
[5]陈仲,靳安民,张积利,等.慢性腰肌劳损的修正诊断和对因治疗[J].广东医学,2011,32(18):2416-2418.
[6]中国康复医学会脊柱脊髓专业委员会专家组.中国急/慢性非特异性腰背痛诊疗专家共识[J].中国脊柱脊髓杂志,2016,26(12):134-1138.
[7]郑贵良.腰痛的病因和分类[J].甘肃医药,2011,30(7):408-409.
[8]蒋夏,李长根.非甾体抗炎药的胃肠道损伤[J].国际麻醉学与复苏杂志,1995,16(6):377-380.
[9]李云,赵胜芳.塞来昔布的药理性质及临床应用[J].青岛医药卫生,2003,35(2):118-119.
[10]曹卉娟,邢建民,刘建平.视觉模拟评分法在症状类结局评价测量中的应用[J].中医杂志,2009,50(7):600-602.
[11]辛波,许志效.中医学对腰腿痛的认识[J].广西中医药,2004,27(1):60.
[12]黄帝内经素问[M].北京:人民卫生出版社,2009:155.
[13]邓中甲.方剂学[M].7版.北京:中国中医药出版社,2010:180.
[14]高学敏.中药学[M].北京:中国中医药出版社,2007.
[15]崔学瑞.身痛逐瘀汤治疗老年腰腿痛60例[J].中国中医药现代远程教育,2010,8(5):20.
[16]谢新利,高志刚.身痛逐瘀汤加减治疗腰椎间盘突出症62例[J].中国民间疗法,2013,21(7):45.
[17]李元明.身痛逐瘀汤加减治疗腰椎间盘突出症[J].中国中医骨伤科杂志,2001,9(4):39-40.